Benzodiazepine blockade of passive-avoidance task in mice: A state-dependent phenomenon

1979 ◽  
Vol 61 (1) ◽  
pp. 25-28 ◽  
Author(s):  
J. B. Patel ◽  
V. B. Ciofalo ◽  
L. C. Iorio
Keyword(s):  
Passive Avoidance ◽  
Passive Avoidance Task ◽  
Avoidance Task ◽  
State Dependent

N-methyl-D-aspartate Receptors are Involved in the Effect of Lithium on Passive Avoidance Memory in Mice

2009 ◽  
Vol 24 (S1) ◽  
pp. 1-1
Author(s):  
M.-R. Zarrindast ◽  
H. Niasari ◽  
S. Ahmadi ◽  
B. Shafaghi
Keyword(s):  
Nmda Receptor ◽  
Passive Avoidance ◽  
Receptor Agonist ◽  
Nmda Receptor Antagonist ◽  
Passive Avoidance Task ◽  
Avoidance Task ◽  
Test Administration ◽  
Mk 801 ◽  
Memory Assessment ◽  
State Dependent

In the present study, the effects of intracerebroventricular (i.c.v.) injections of N-methyl-D-aspartate (NMDA) receptor agonist and antagonist on the lithium state-dependent memory have been investigated. For memory assessment, one-trial step-down passive avoidance task was used in adult male NMRI mice. Post-training intraperitoneal (i.p.) administration of lithium (10 mg/kg) impaired the memory of passive avoidance task. Pre-test administration of the same dose of the drug (10 mg/kg) restored impairment of memory by lithium given after training. This is known as state-dependent memory. In addition, pre-test administration of both NMDA receptor agonist (NMDA; 0.01 and 0.1 ng/mouse, i.c.v.) and the non-competitive NMDA receptor antagonist, MK-801 (0.1 and 0.5 mg/mouse, i.c.v) also restored impairment of memory induced by post-training lithium. On the other hand, pre-test co-administration of ineffective dose of NMDA (0.001 ng/mouse, i.c.v.) or MK-801 (0.001 mg/mouse, i.c.v) with lower doses of lithium (1.25, 2.5 and 5 mg/kg, i.p.) increased the restoration of memory by lithium. The results suggest that NMDA receptors are involved, at least partly, in the lithium state-dependent memory of passive avoidance task.

Is anisomycin-induced amnesia for a passive avoidance task in chicks the result of state-dependent learning?

1989 ◽  
Vol 49 (2) ◽  
pp. 179-184 ◽  
Author(s):  
D.W. Lee ◽  
A.M. Perlmutter ◽  
D.S. Beniston ◽  
E.L. Bennett ◽  
M.R. Rosenzweig
Keyword(s):  
Passive Avoidance ◽  
Passive Avoidance Task ◽  
Avoidance Task ◽  
State Dependent Learning ◽  
State Dependent ◽  
Dependent Learning
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