scholarly journals Magnesium pemoline: Effects on spontaneous activity, stimulus responsivity and food intake

1968 ◽  
Vol 12 (5) ◽  
pp. 177-178 ◽  
Author(s):  
J. Gianutsos ◽  
Rosamond Gianutsos ◽  
Yasuko Filby
Keyword(s):  
Food Intake ◽  
Spontaneous Activity ◽  
Magnesium Pemoline

scholarly journals Depression of spontaneous activity in goldfish by magnesium pemoline

1972 ◽  
Vol 28 (5) ◽  
pp. 293-294 ◽  
Author(s):  
Larry P. Gonzalez ◽  
S. Thomas Elder
Keyword(s):  
Spontaneous Activity ◽  
Magnesium Pemoline

Adaptation to Forced Exercise in the Rat

1958 ◽  
Vol 193 (2) ◽  
pp. 350-354 ◽  
Author(s):  
Barbara M. Thomas ◽  
A. T. Miller
Keyword(s):  
Body Weight ◽  
Food Intake ◽  
Spontaneous Activity ◽  
Recovery Period ◽  
Initial Response ◽  
Treadmill Running ◽  
Albino Rats ◽  
Exercise Load ◽  
Partial Restoration ◽  
Exercise Treadmill

The influence of forced exercise (treadmill running) on food intake, body weight and spontaneous activity was studied in male albino rats. The initial response to gradually increasing exercise load was a decrease in food intake and body weight on exercise days, with compensatory increase in both factors on rest days (week-ends). By the time exercise had been increased to 1 mile/day, food intake on exercise days had returned to normal or slightly above, and food intake on rest days was significantly elevated. During the recovery period following the exercise experiment, food intake remained elevated despite the absence of a significant weight deficit. Overnight spontaneous activity was strikingly reduced in exercised rats, with only partial restoration on rest days, and with gradual return to normal during the postexercise recovery period.

Blocking ActRIIB signaling and restoring appetite reverses cachexia and improves survival in mice with lung cancer

2021 ◽  
Author(s):  
Andre Lima Queiroz ◽  
Shakti Ramsamooj ◽  
Ezequiel Dantas ◽  
Elizabeth Zunica ◽  
Roger Liang ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Skeletal Muscle ◽  
Food Intake ◽  
Spontaneous Activity ◽  
Negative Energy ◽  
Skeletal Muscle Atrophy ◽  
Metabolic Dysfunction ◽  
Ghrelin Receptor ◽  
Beneficial Effects ◽  
Reverse Anorexia

Abstract The cancer anorexia-cachexia syndrome (CACS) is a common, debilitating condition with limited therapeutic options. The defining feature of CACS is weight loss, which suggests a state of negative energy balance. It is unclear whether this net reduction in energy is due solely to anorexia or if a combination of anorexia and increased energy expenditure (EE) occurs. To address this question, we induced lung cancer in mice and measured changes in food intake, EE, and body composition. Mice with CACS developed reductions in food intake, spontaneous activity, and EE. There was severe atrophy and markers of metabolic dysfunction in the adipose and skeletal muscle tissues as compared to mice without CACS and pair-fed wild-type mice. We used anamorelin fumarate (Ana), a ghrelin receptor agonist, alone or in combination ActRIIB-Fc, a ligand trap for TGF-β/activin family members, to reverse anorexia and skeletal muscle atrophy, respectively. Ana effectively increased food intake and the combination of drugs increased lean mass, restored spontaneous activity, and improved overall survival. These beneficial effects were limited to female mice. Our findings suggest that multimodal, gender-specific, therapies are needed to reverse CACS.

Curt Richter: Spontaneous activity and food intake

Appetite ◽  
2007 ◽  
Vol 49 (2) ◽  
pp. 368-375 ◽  
Author(s):  
Timothy H. Moran ◽  
Kellie L.K. Tamashiro
Keyword(s):  
Food Intake ◽  
Spontaneous Activity

EFFECT OF METHYLPHENIDATE ON SPONTANEOUS ACTIVITY, FOOD INTAKE, AND COLD TOLERANCE OF PROPYLTHIOURACIL-TREATED RATS

1964 ◽  
Vol 42 (4) ◽  
pp. 415-429 ◽  
Author(s):  
Melvin J. Fregly ◽  
Bruce A. Black
Keyword(s):  
Body Weight ◽  
Locomotor Activity ◽  
Food Intake ◽  
Spontaneous Activity ◽  
Cold Tolerance ◽  
Cold Exposure ◽  
Activity Level ◽  
Ambient Temperatures ◽  
And Control ◽  
Dose Levels

Dietary administration of methylphenidate to rats increases locomotor activity (tilt cage method) roughly in proportion to the logarithm of the dose ingested. The results suggest that a dose of 62 mg methylphenidate/kg body wt. per day increases activity level by 50%. At higher dose levels, a tolerance appears to develop and is characterized by high initial levels of activity (days 1 to 3) followed by reduction of activity to a new stable level (days 4 to 6). Methylphenidate increases activity level and decreases food intake and body weight of both hypothyroid (propylthiouracil-treated) and control rats subjected to ambient temperatures of 10, 15, 20, and 28 °C. It fails to increase the tolerance of hypothyroid rats either to chronic (10 and 15 °C) or to acute (5 °C) cold exposure.

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