scholarly journals Immunotherapy with imiquimod and interferon alfa for metastasized Merkel cell carcinoma

2016 ◽  
Vol 23 (2) ◽  
pp. 150 ◽  
Author(s):  
R.U. Wahl ◽  
T. Braunschweig ◽  
A. Ghassemi ◽  
A. Rübben
Keyword(s):  
Lymph Node ◽  
Cell Carcinoma ◽  
Merkel Cell Carcinoma ◽  
Lymph Node Metastases ◽  
Neuroendocrine Tumour ◽  
Regional Lymph Node ◽  
Pegylated Interferon ◽  
Interferon Alfa ◽  
Merkel Cell ◽  
Node Metastases

Merkel cell carcinoma (mcc) is a highly aggressive neuroendocrine tumour of the skin. Remission rates are high with chemotherapy in patients with metastasis, but without any improvement in overall survival.We present the case of a 90-year-old woman with facial mcc. After radiation and surgery, the mcc recurred with widespread cutaneous and regional lymph node metastases. The metastases were treated with weekly intralesional injections of 1–2×106 IU interferon alfa-2a, accompanied by topical imiquimod 5% cream 3 times weekly. After partial regression, subcutaneous pegylated interferon alfa-2b was added at a dose of 30 μg weekly, which was then increased to 50 μg weekly. At 4 months after the start of immunotherapy, all cutaneous metastases and the intralesionally treated lymph node metastases receded. Interruption or reduction of systemic interferon application resulted in locoregional relapses that were successfully treated with surgery or intralesional interferon injections. The patient remains alive 30 months after initiation of immunotherapy, suggesting that locally metastasized mcc might be able to be controlled with local and systemic immunotherapy.

scholarly journals Expression of Merkelcell polyomavirus (MCPyV) large T-antigen in Merkel cell carcinoma lymph node metastases predicts poor outcome

PLoS ONE ◽  
2017 ◽  
Vol 12 (8) ◽  
pp. e0180426 ◽  
Author(s):  
Georg Haymerle ◽  
Stefan Janik ◽  
Alexandra Fochtmann ◽  
Johannes Pammer ◽  
Helga Schachner ◽  
...  
Keyword(s):  
Lymph Node ◽  
Cell Carcinoma ◽  
Merkel Cell Carcinoma ◽  
Lymph Node Metastases ◽  
T Antigen ◽  
Merkel Cell ◽  
Large T Antigen ◽  
Poor Outcome ◽  
Node Metastases

scholarly journals Merkel Cell Carcinoma with Lymphoepithelioma-Like Pattern: A Case Report of an Exceedingly Rare Variant of Merkel Cell Carcinoma with Lymph Node Metastases at Presentation

2011 ◽  
Vol 2011 ◽  
pp. 1-4
Author(s):  
Soumaya Ben Abdelkrim ◽  
Abdelmajid Dhouibi ◽  
Adnène Moussa ◽  
Rim Hadhri ◽  
Leila Njim ◽  
...  
Keyword(s):  
Case Report ◽  
Lymph Node ◽  
Cell Carcinoma ◽  
Merkel Cell Carcinoma ◽  
Lymph Node Metastases ◽  
Host Response ◽  
Good Prognosis ◽  
Merkel Cell ◽  
Lymphoid Stroma ◽  
Node Metastases

Merkel cell carcinoma (MCC) or primary neuroendocrine carcinoma of the skin is a rare neoplasm with aggressive behavior. Primary lymphoepithelioma-like (LEL) carcinoma of the skin is a recently described exceptional tumor, with a relatively good prognosis, and is characterized by a neoplastic epithelial component associated with a dense lymphoid stroma. Rarely, MCC shows a marked lymphocytic host response or can even mimic a LEL carcinoma. We report a new case of MCC mimicking an LEL carcinoma in a 72-year-old male; the diagnosis of MCC was made on the basis of the morphology and immunohistochemical findings. We present through this case an exceptional pattern of MCC which can be misleading, and we insist on differential diagnoses.

Lymph Node Metastases of Merkel Cell Carcinoma from Unknown Primary Site: Report of Three Cases

2008 ◽  
Vol 94 (5) ◽  
pp. 758-761 ◽  
Author(s):  
Luigi De Cicco ◽  
Andrea Vavassori ◽  
Barbara A Jereczek-Fossa ◽  
Giancarlo Pruneri ◽  
Gianpiero Catalano ◽  
...  
Keyword(s):  
Lymph Node ◽  
Cell Carcinoma ◽  
Merkel Cell Carcinoma ◽  
Lymph Node Metastases ◽  
Primary Site ◽  
Unknown Primary ◽  
Merkel Cell ◽  
Unknown Primary Site ◽  
Node Metastases

Frequency and prognosis of metastasis to liver, lung, bone and brain from Merkel cell carcinoma

2020 ◽  
Vol 16 (16) ◽  
pp. 1101-1113 ◽  
Author(s):  
Yi-Jun Xia ◽  
Dong-Sheng Cao ◽  
Jun Zhao ◽  
Bang-Zhong Zhu ◽  
Juan Xie
Keyword(s):  
Lymph Node ◽  
Cell Carcinoma ◽  
Merkel Cell Carcinoma ◽  
Distant Metastasis ◽  
Regional Lymph Node ◽  
Distant Metastases ◽  
Lymph Node Biopsy ◽  
Merkel Cell ◽  
Factors Affecting ◽  
Node Removal

Aim: To describe the factors affecting distant metastasis of Merkel cell carcinoma (MCC) and the prognosis of metastatic MCC. Materials & methods: The MCC patient information was downloaded from the SEER database. Logistic regression and Cox proportional hazard models were conducted to screen for significant factors. Results: A total of 3449 patients were enrolled. Surgery and chemotherapy were significantly correlated with the occurrence of distant metastasis. In the cause-specific survival rate of MCC, regional lymph node removal, sentinel lymph node biopsy, radiation and chemotherapy can significantly reduce the prognostic risk of patients with distant metastases. Conclusion: Our study screened out the factors affecting the distant metastasis and prognosis of MCC and more prospective studies are needed to verify our findings.

scholarly journals Features Predicting Sentinel Lymph Node Positivity in Merkel Cell Carcinoma

2011 ◽  
Vol 29 (8) ◽  
pp. 1036-1041 ◽  
Author(s):  
Jennifer L. Schwartz ◽  
Kent A. Griffith ◽  
Lori Lowe ◽  
Sandra L. Wong ◽  
Scott A. McLean ◽  
...  
Keyword(s):  
Lymph Node ◽  
Sentinel Lymph Node ◽  
Cell Carcinoma ◽  
Merkel Cell Carcinoma ◽  
Growth Pattern ◽  
Regional Lymph Node ◽  
Mitotic Rate ◽  
Tumor Thickness ◽  
Merkel Cell ◽  
Primary Tumors

Purpose Merkel cell carcinoma (MCC) is a relatively rare, potentially aggressive cutaneous malignancy. We examined the clinical and histologic features of primary MCC that may correlate with the probability of a positive sentinel lymph node (SLN). Methods Ninety-five patients with MCC who underwent SLN biopsy at the University of Michigan were identified. SLN biopsy was performed on 97 primary tumors, and an SLN was identified in 93 instances. These were reviewed for clinical and histologic features and associated SLN positivity. Univariate associations between these characteristics and a positive SLN were tested for by using either the χ2 or the Fisher's exact test. A backward elimination algorithm was used to help create a best multiple variable model to explain a positive SLN. Results SLN positivity was significantly associated with the clinical size of the lesion, greatest horizontal histologic dimension, tumor thickness, mitotic rate, and histologic growth pattern. Two competing multivariate models were generated to predict a positive SLN. The histologic growth pattern was present in both models and combined with either tumor thickness or mitotic rate. Conclusion Increasing clinical size, increasing tumor thickness, increasing mitotic rate, and infiltrative tumor growth pattern were significantly associated with a greater likelihood of a positive SLN. By using the growth pattern and tumor thickness model, no subgroup of patients was predicted to have a lower than 15% to 20% likelihood of a positive SLN. This suggests that all patients presenting with MCC without clinical evidence of regional lymph node disease should be considered for SLN biopsy.

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