Antihepatotoxic activity of Euphorbia neriifolia extract against N-nitrosodiethylamine-induced hepatocarcinogenesis in mice

2012 ◽  
pp. 1303-1309 ◽  
Author(s):  
V Sharma
Keyword(s):  
Antihepatotoxic Activity

scholarly journals Antihepatotoxic Activity of Phyllanthus atropurpureus Cultivated in Egypt

2011 ◽  
Vol 66 (9-10) ◽  
pp. 447-452 ◽  
Author(s):  
Taha Sarg ◽  
Afaf Abdel Ghani ◽  
Rawia Zayed ◽  
May El-Sayed
Keyword(s):  
Liver Injury ◽  
Active Ingredient ◽  
Ornamental Plants ◽  
Hepatoprotective Activity ◽  
Maximum Activity ◽  
Phytochemical Analysis ◽  
Root Extract ◽  
Aerial Parts ◽  
Serum Aspartate Aminotransferase ◽  
Antihepatotoxic Activity

The genus Phyllanthus (family Euphorbiaceae) is considered one of the important medicinal and ornamental plants. A phytochemical analysis of the extracts was performed to search for the active ingredient. Results of the investigation of the hepatoprotective activity of Phyllanthus atropurpureus Boj. Hort. Maurit. revealed that the activities of alcoholic extracts of its aerial parts and roots were quite similar to those of silymarin. Both of them improve the parameters of CCl4-induced liver injury including serum aspartate aminotransferase and alanine aminotransferase. Among the extracts tested, the root extract showed maximum activity compared to the aerial parts extract and to silymarin.

scholarly journals Exploration of Hepatoprotective Potential and Phytochemicals of Ziziphus oxyphylla Edgew

2020 ◽  
Vol 40 (04) ◽  
pp. 431-436
Author(s):  
Abdullah .
Keyword(s):  
Superoxide Dismutase ◽  
Methanolic Extract ◽  
Histopathological Examination ◽  
Liver Weight ◽  
2D Nmr ◽  
Chloroform Fraction ◽  
Hypotonic Solution ◽  
2D Nmr Spectroscopy ◽  
Hepatic Diseases ◽  
Antihepatotoxic Activity

Ziziphus oxyphylla Edgew (ZO) has been traditionally used for the treatment of hepatic diseases in Pakistan. The current study was carried out to investigate the effectiveness and mechanism underlying hepatoprotective effect of ZO. Hepatoprotective potential of root extracts (crude methanolic extract and subsequent fractions) was investigated against carbon tetrachloride (CCl4) induced hepatotoxicity in BALB/c mice via determination of serum biomarkers, antioxidant enzymes (catalase, superoxide dismutase), lipid peroxidation and histopathology. Membrane stabilizing activity was determined via inhibition of hypotonic solution and heat-induced hemolysis. Crude methanolic extract and chloroform fraction ameliorated CCl4 induced elevated levels of alanine transaminase (ALT), alkaline phosphatase (ALP), total proteins (TP), total bilirubin (TB) and reversed the antioxidants imbalance in terms of catalase (CAT), superoxide dismutase (SOD) and reduced malondialdehyde (MDA) level. Crude methanol extract inhibited hemolysis induced by hypotonic solution and heat. Histopathological examination of liver specimens of extracts administered mice exhibited recovery from CCl4 induced pathological changes. Moreover, CCl4 induced alteration in body and liver weight was countered by the administration of ZO. Compounds betulinic acid (AZO1), ceanothic acid (AZO2) and zizybrenalic acid (AZO3) were isolated from chloroform fraction of the plant. The structures of compounds were deduced using 1D-and 2D-NMR spectroscopy techniques. The results show that Ziziphus oxyphylla roots extract possess antihepatotoxic activity mediated by the protection of anti-oxidant defense system and membrane-stabilizing activity, probably due to the presence of pentacyclic triterpenes

Assay Methods for Antihepatotoxic Activity Using Peroxide-Induced Cytotoxicity in Primary Cultured Hepatocytes1

Planta Medica ◽  
1985 ◽  
Vol 51 (01) ◽  
pp. 50-52 ◽  
Author(s):  
Yoshinobu Kiso ◽  
Osamu Kato ◽  
Hiroshi Hikino
Keyword(s):  
Assay Methods ◽  
Antihepatotoxic Activity

Antihepatotoxic activity of Saussurea lappa extract on D-galactosamine and lipopolysaccharide-induced hepatitis in mice

2009 ◽  
Vol 24 (S2) ◽  
pp. S229-S232 ◽  
Author(s):  
Sheikh Yaeesh ◽  
Qamar Jamal ◽  
Abdul Jabbar Shah ◽  
Anwarul Hassan Gilani
Keyword(s):  
Saussurea Lappa ◽  
Antihepatotoxic Activity

Mechanism of Antihepatotoxic Activity of Wuweizisu C and Gomisin A

Planta Medica ◽  
1985 ◽  
Vol 51 (04) ◽  
pp. 331-334 ◽  
Author(s):  
Yoshinobu Kiso ◽  
Masahiro Tohkin ◽  
Hiroshi Hikino ◽  
Yukinobu Ikeya ◽  
Heihachiro Taguchi
Keyword(s):  
Gomisin A ◽  
Antihepatotoxic Activity

Chemical Investigation and Antihepatotoxic Activity of Thespesia populnea

1995 ◽  
Vol 33 (4) ◽  
pp. 305-310 ◽  
Author(s):  
Annie Shirwaikar ◽  
A. Vasanth Kumar ◽  
B. R. Krishnanand ◽  
K. K. Sreenivasan
Keyword(s):  
Chemical Investigation ◽  
Thespesia Populnea ◽  
Antihepatotoxic Activity
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