Antihepatotoxic activity of Saussurea lappa extract on D-galactosamine and lipopolysaccharide-induced hepatitis in mice

2009 ◽  
Vol 24 (S2) ◽  
pp. S229-S232 ◽  
Author(s):  
Sheikh Yaeesh ◽  
Qamar Jamal ◽  
Abdul Jabbar Shah ◽  
Anwarul Hassan Gilani
Keyword(s):  
Saussurea Lappa ◽  
Antihepatotoxic Activity

Anti-microbial Activity of Saussurea lappa C.B. Clarke Roots

2011 ◽  
Vol 16 (4) ◽  
pp. 376-380 ◽  
Author(s):  
Kyung-Mi Chang ◽  
Soo-Im Choi ◽  
Sophia J. Chung ◽  
Gun-Hee Kim
Keyword(s):  
Microbial Activity ◽  
Saussurea Lappa

scholarly journals Antihepatotoxic Activity of Phyllanthus atropurpureus Cultivated in Egypt

2011 ◽  
Vol 66 (9-10) ◽  
pp. 447-452 ◽  
Author(s):  
Taha Sarg ◽  
Afaf Abdel Ghani ◽  
Rawia Zayed ◽  
May El-Sayed
Keyword(s):  
Liver Injury ◽  
Active Ingredient ◽  
Ornamental Plants ◽  
Hepatoprotective Activity ◽  
Maximum Activity ◽  
Phytochemical Analysis ◽  
Root Extract ◽  
Aerial Parts ◽  
Serum Aspartate Aminotransferase ◽  
Antihepatotoxic Activity

The genus Phyllanthus (family Euphorbiaceae) is considered one of the important medicinal and ornamental plants. A phytochemical analysis of the extracts was performed to search for the active ingredient. Results of the investigation of the hepatoprotective activity of Phyllanthus atropurpureus Boj. Hort. Maurit. revealed that the activities of alcoholic extracts of its aerial parts and roots were quite similar to those of silymarin. Both of them improve the parameters of CCl4-induced liver injury including serum aspartate aminotransferase and alanine aminotransferase. Among the extracts tested, the root extract showed maximum activity compared to the aerial parts extract and to silymarin.

Guaianolides from Saussurea lappa

1995 ◽  
Vol 40 (6) ◽  
pp. 1713-1715 ◽  
Author(s):  
P Kalsi
Keyword(s):  
Saussurea Lappa

Inhibition of TNF-α-Induced Inflammation by Sesquiterpene Lactones from Saussurea lappa and Semi-Synthetic Analogues

Planta Medica ◽  
2017 ◽  
Vol 84 (05) ◽  
pp. 329-335 ◽  
Author(s):  
Siwattra Choodej ◽  
Khanitha Pudhom ◽  
Tohru Mitsunaga
Keyword(s):  
High Efficiency ◽  
Sesquiterpene Lactones ◽  
Significant Activity ◽  
Synthetic Analogues ◽  
Necrosis Factor Alpha ◽  
Saussurea Lappa ◽  
Tnf Α ◽  
Ic50 Values ◽  
Reduced Toxicity ◽  
Dehydrocostus Lactone

We investigated the tumor necrosis factor-alpha (TNF-α) inhibitory activity of sesquiterpenes from Saussurea lappa root extracts. According to the hexane and EtOAc extracts showing significant activity with IC50 values of 0.5 and 1.0 µg/mL, respectively, chromatographic fractionation of the extracts was performed and led to the isolation of 10 sesquiterpenes (1–10). Costunolide (1), a major compound, and dehydrocostus lactone (4) exhibited high efficiency in decreasing TNF-α levels, with IC50 values of 2.05 and 2.06 µM, respectively. In addition, sesquiterpene analogues were synthesized to establish their structure-activity relationship (SAR) profile. Among the semi-synthetic analogues, compounds 6a and 16 showed the most potent activity with IC50 values of 1.84 and 1.97 µM, respectively. More importantly, compound 6a showed less toxicity than costunolide and 16. These results provided the first SAR profile of sesquiterpene lactones and indicated that the α-methylene-γ-lactone moiety plays a crucial role in TNF-α inhibition. Additionally, the epoxide derivative 6a might represent a lead compound for further anti-TNF-α therapies, owing to its potent activity and reduced toxicity.

Costunolide, a sesquiterpene lactone from Saussurea lappa, inhibits the VEGFR KDR/Flk-1 signaling pathway

2002 ◽  
Vol 187 (1-2) ◽  
pp. 129-133 ◽  
Author(s):  
Sei-Joon Jeong ◽  
Takashi Itokawa ◽  
Masabumi Shibuya ◽  
Michihiko Kuwano ◽  
Mayumi Ono ◽  
...  
Keyword(s):  
Sesquiterpene Lactone ◽  
Signaling Pathway ◽  
Saussurea Lappa

scholarly journals Elucidating genes involved in sesquiterpenoid and flavonoid biosynthetic pathways in Saussurea lappa by de novo leaf transcriptome analysis

Genomics ◽  
2019 ◽  
Vol 111 (6) ◽  
pp. 1474-1482 ◽  
Author(s):  
Savita Bains ◽  
Vasundhara Thakur ◽  
Jagdeep Kaur ◽  
Kashmir Singh ◽  
Ravneet Kaur
Keyword(s):  
Transcriptome Analysis ◽  
De Novo ◽  
Biosynthetic Pathways ◽  
Saussurea Lappa ◽  
Leaf Transcriptome

scholarly journals Anti-oxidant Activity of Saussurea lappa C.B. Clarke Roots

2012 ◽  
Vol 17 (4) ◽  
pp. 306-309 ◽  
Author(s):  
Kyung-Mi Chang ◽  
Soo-Im Choi ◽  
Gun-Hee Kim
Keyword(s):  
Saussurea Lappa ◽  
Anti Oxidant
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