Anti-osteoporotic activity of methanolic extract of an Indian herbal formula NR/CAL/06 in ovariectomized rats

2011 ◽  
Vol 9 (10) ◽  
pp. 1125-1132 ◽  
Author(s):  
P Srikanta
Keyword(s):  
Methanolic Extract ◽  
Ovariectomized Rats ◽  
Herbal Formula

scholarly journals Estrogenic Effects of the Herbal Formula, Menoprogen, in Ovariectomized Rats

2010 ◽  
Vol 33 (3) ◽  
pp. 455-460 ◽  
Author(s):  
Hong Ma ◽  
Mi Hwa Chung ◽  
Ye Lu ◽  
Tsutomu Nishihara ◽  
Masao Hattori
Keyword(s):  
Ovariectomized Rats ◽  
Herbal Formula ◽  
Estrogenic Effects

scholarly journals Methanolic Extract of Ceplukan Leaf (Physalis minimaL.) Attenuates Ventricular Fibrosis through Inhibition of TNF-αin Ovariectomized Rats

2016 ◽  
Vol 2016 ◽  
pp. 1-7 ◽  
Author(s):  
Bayu Lestari ◽  
Nur Permatasari ◽  
Mohammad Saifur Rohman
Keyword(s):  
Heart Failure ◽  
Treatment Group ◽  
Wistar Rats ◽  
Methanolic Extract ◽  
Ovariectomized Rats ◽  
Dependent Manner ◽  
Estrogen Level ◽  
Menopausal Women ◽  
Ventricular Fibrosis ◽  
Dose Dependent

The increase of heart failure prevalence on menopausal women was correlated with the decrease of estrogen level. The aim of this study is to investigate the effects of ceplukan leaf (Physalis minimaL.), which contains phytoestrogen physalin and withanolides, on ventricular TNF-αlevel and fibrosis in ovariectomized rats. Wistar rats were divided into six groups (control (—); OVX 5: 5-week ovariectomy (OVX); OVX 9: 9-week ovariectomy; treatments I, II, and III: 9-weeks OVX + 4-week ceplukan leaf’s methanolic extract doses 500, 1500, and 2500 mg/kgBW, resp.). TNF-αlevels were measured with ELISA. Fibrosis was counted as blue colored tissues percentage using Masson’s Trichrome staining. This study showed that prolonged hypoestrogen increases ventricular fibrosis (p<0.05). Ceplukan leaf treatment also resulted in a decrease of ventricular fibrosis and TNF-αlevel in dose dependent manner compared to without treatment group (p<0.05). Furthermore, the TNF-αlevel was normalized in 2500 mg/kgBWPhysalis minimaL. (p<0.05) treatment. The reduction of fibrosis positively correlated with TNF-αlevel (p<0.05,r=0.873). Methanolic extract of ceplukan leaf decreases ventricular fibrosis through the inhibition of ventricular TNF-αlevel in ovariectomized rats.

scholarly journals Treatment with QiBaoMeiRan, a Kidney-Invigorating Chinese Herbal Formula, Antagonizes Estrogen Decline in Ovariectomized Rats

2014 ◽  
Vol 17 (4) ◽  
pp. 372-381 ◽  
Author(s):  
Ying Xu ◽  
Xiao-ping Ma ◽  
Jie Ding ◽  
Zhen-li Liu ◽  
Zhi-qian Song ◽  
...  
Keyword(s):  
Ovariectomized Rats ◽  
Herbal Formula ◽  
Chinese Herbal Formula ◽  
Chinese Herbal

scholarly journals Evaluation of estrogenic potential by herbal formula, HPC 03 for in vitro and in vivo

Reproduction ◽  
2018 ◽  
Vol 155 (2) ◽  
pp. 103-113 ◽  
Author(s):  
Bo Yoon Chang ◽  
Dae Sung Kim ◽  
Hye Soo Kim ◽  
Sung Yeon Kim
Keyword(s):  
Estrogen Receptor ◽  
Ovariectomized Rats ◽  
Herbal Formula ◽  
Mineral Density ◽  
Bone Mineral Density Loss ◽  
Ovx Rats ◽  
Estrogenic Potential ◽  
Mcf 7

HPC 03 is herbal formula that consists of extracts from Angelica gigas, Cnidium officinale Makino and Cinnamomum cassia Presl. The present study evaluated the estrogenic potential of HPC 03 by using in vitro and in vivo models. The regulatory mechanisms of HPC 03 in estrogen-dependent MCF-7 cells were assessed. HPC 03 induced the proliferation of estrogen receptor-positive MCF-7 cells, and the proliferation was blocked by the addition of the estrogen antagonist tamoxifen. The estrogen receptorα/β luciferase activities were significantly increased by HPC 03 treatment, which also increased the mRNA expression of the estrogen-responsive genes Psen2, Pgr and Ctsd. Also, we evaluated the ameliorative effects of HPC 03 on menopausal symptoms in ovariectomized rats. HPC 03 treatment in OVX rats significantly affected the uterine weight, increased the expression of estrogen-responsive genes Pgr and Psen2 in uterus, increased bone mineral density loss in the femur and inhibited body weight increase. Serum E2, collagen type 1 and osteocalcin were significantly increased, while serum LH, FSH and ALP were decreased compared with OVX rats. HPC 03 may be a promising candidate for the treatment of menopause, but further research is necessary to determine whether the observed effects also occur in humans.

scholarly journals In VivoStudy on the Pharmacological Interactions between a Chinese Herbal Formula ELP and Antiresorptive Drugs to Counteract Osteoporosis

2012 ◽  
Vol 2012 ◽  
pp. 1-11 ◽  
Author(s):  
Chun-Hay Ko ◽  
Wing-Sum Siu ◽  
Hing-Lok Wong ◽  
Si Gao ◽  
Wai-Ting Shum ◽  
...  
Keyword(s):  
Synergistic Effects ◽  
Ovariectomized Rats ◽  
Therapeutic Effects ◽  
Herbal Formula ◽  
Mineral Density ◽  
Chinese Herbal Formula ◽  
Chinese Herbal ◽  
Pharmacological Interactions ◽  
Long Term Treatment ◽  
Antiresorptive Drugs

Antiresorptive drugs, alendronate and raloxifene, are effective in lowering bone mineral density (BMD) loss in postmenopausal women. However, long-term treatment may be associated with serious side effects. Our research group has recently discovered that a Chinese herbal formula, ELP, could significantly reduce BMD loss in animal and human studies. Therefore, the present study aimed to investigate the potential synergistic bone-protective effects of different herb-drug combinations using ovariectomized rats. To assess the efficacy of different combinations, the total BMD was monitored biweekly in the 8-week course of daily oral treatment. Bone microarchitecture, bone strength, and deoxypyridinoline level were also determined after 8 weeks. From our results, coadministration of ELP and raloxifene increased the total tibial BMD by 5.26% (2.5 mg/kg/day of raloxifene;P=0.014) and 5.94% (0.25 mg/kg/day of raloxifene;P=0.026) when compared with the respective dosage groups with raloxifene alone. Similar synergistic effects were also observed in BMD increase at distal femur (0.25 mg/kg/day;P=0.001) and reduction in urinary deoxypyridinoline crosslink excretion (2.5 and 0.25 mg/kg/day; bothP=0.02). However, such interactions could not be observed in all alendronate-treated groups. Our data provide first evidence that ELP could synergistically enhance the therapeutic effects of raloxifene, so that the clinical dosage of raloxifene could be reduced.

Antiosteoporotic activity of Er-Xian Decoction, a traditional Chinese herbal formula, in ovariectomized rats

2006 ◽  
Vol 108 (1) ◽  
pp. 96-102 ◽  
Author(s):  
Hua Nian ◽  
Lu-Ping Qin ◽  
Qiao-Yan Zhang ◽  
Han-Chen Zheng ◽  
Yuan Yu ◽  
...  
Keyword(s):  
Ovariectomized Rats ◽  
Herbal Formula ◽  
Chinese Herbal Formula ◽  
Chinese Herbal

Estrogenic effects of pomegranate extracts in ovariectomized rats

Planta Medica ◽  
2008 ◽  
Vol 74 (09) ◽  
Author(s):  
W Promprom ◽  
W Lijuan ◽  
P Munglue ◽  
P Kupittayanant ◽  
K Indrapichate ◽  
...  
Keyword(s):  
Ovariectomized Rats ◽  
Estrogenic Effects
Sign in / Sign up

Export Citation Format

Share Document