Effects of Chinese herbal medicine Guanxinkang on lipid metabolism and serum C-reactive protein, amyloid A protein, and fibrinogen in apolipoprotein E-knockout mice with atherosclerosis

2011 ◽  
Vol 9 (3) ◽  
pp. 306-312 ◽  
Author(s):  
Mei-jiao Mao
Keyword(s):  
Lipid Metabolism ◽  
Herbal Medicine ◽  
Apolipoprotein E ◽  
Chinese Herbal Medicine ◽  
Knockout Mice ◽  
C Reactive Protein ◽  
Reactive Protein ◽  
Amyloid A ◽  
Chinese Herbal ◽  
Apolipoprotein E Knockout Mice

scholarly journals Native C-Reactive Protein Increases Whereas Modified C-Reactive Protein Reduces Atherosclerosis in Apolipoprotein E–Knockout Mice

Circulation ◽  
2005 ◽  
Vol 112 (7) ◽  
pp. 1016-1023 ◽  
Author(s):  
Susanne B. Schwedler ◽  
Kerstin Amann ◽  
Konstanze Wernicke ◽  
Alexander Krebs ◽  
Matthias Nauck ◽  
...  
Keyword(s):  
Apolipoprotein E ◽  
Knockout Mice ◽  
C Reactive Protein ◽  
Reactive Protein ◽  
Apolipoprotein E Knockout Mice

scholarly journals SAT-659 Micro/Nanoparticles from Antidiabetic Chinese Herbal Medicine Soup Increase Bioavailability of Phytochemicals and Regulate Glucose and Lipid Metabolism

2020 ◽  
Vol 4 (Supplement_1) ◽  
Author(s):  
Lijing Ke ◽  
Pingfan Rao
Keyword(s):  
Skeletal Muscle ◽  
Lipid Metabolism ◽  
Blood Glucose ◽  
Herbal Medicine ◽  
Glucose Tolerance ◽  
Chinese Herbal Medicine ◽  
Therapeutic Effects ◽  
Chinese Herbal ◽  
Glucose And Lipid Metabolism

Abstract Herbal soups have always been a popular option for treating oxidative stress-related chronic diseases including diabetes. Various components of these soups have been studied in the hope to identify the active principles, mainly focusing on the individual phytochemicals. As we have revealed previously, the micro/nanoparticles (MNPs) formed incidentally during the boiling water extraction of herbal soups may be bioactive and functional. This study aims to elucidate the underlying mechanism of the biological functions of these MNPs. A Chinese herbal medicine soup prepared by Radix Puerariae lobatae, ginger and other three herbs, namely Ge-Gen-Qin-Lian-Tang, was employed here, as it was proven to be effective in treating type 2 diabetes clinically. The soup was separated with high-speed centrifuge (15600×g) to obtain the supernatant (solutes and nanoparticles) and sediments (MNPs), and determined for the content of three bioactive phytochemicals, e.g. puerarin, berberine and baicalin. Their hypoglycemic, hypolipidemic and antioxidant effects were determined on streptozotocin (STZ)-induced Type 2 diabetic Wistar male rats fed on high fat-high sugar diet. The animals were divided into six groups (normal control, diabetic model, whole soup, supernatant, MNPs and metformin, 8 rats each), recording weight, diet, excretion, mental status, etc. The fasting blood glucose and oral glucose tolerance test were conducted regularly. Eight weeks after the administration, the rats were sacrificed after anesthesia. Abdominal aorta blood and tissue samples of pancreas, heart, skeletal muscle, liver, kidney, spleen were collected. The glycated hemoglobin, glucose, lipid, insulin, glucagon, AMPK, SOD, puerarin, berberine, baicalin in blood plasma, insulin in pancreas, SOD in tissues, AMPK in skeletal muscle were measured. Liver tissue sections were observed with HE staining. Statistical analysis (t-test) were performed. The MNPs reduced blood glucose, ameliorated glucose tolerance, elevated insulin secretion and significantly improve glucose and lipid metabolism (P <0.05), showing stronger effects than the supernatant components. Notably, MNPs elevated the AMPK level in skeletal muscle, even more potently than the whole soup. The therapeutic effects of MNPs on the liver damage were even stronger than metformin. Meanwhile, MNPs promoted absorption of puerarin, berberine and baicalin and increase their concentration in blood (P <0.05). Therefore, the MNPs from the herbal soup exhibited more potent effects than the soluble components on ameliorating glucose and lipid metabolism and pancreatic functions of diabetic rats. The actions of these MNPs provide a new perspective for understanding the antidiabetic effects of herbal soups and serve as a vehicle for the multiple phytochemicals to synergistically possess therapeutic effects.

scholarly journals Effects of Chinese herbal medicine Pugongying for reducing the application of antibiotics in breastfeeding women with acute mastitis: study protocol of a randomized, active-controlled, outcome assessor-blinded trial

2021 ◽  
Author(s):  
Xinyan Jin ◽  
Chunli Lu ◽  
Jianping Liu ◽  
Yingyi Fan ◽  
Jinhe Xiao ◽  
...  
Keyword(s):  
Clinical Practice ◽  
Herbal Medicine ◽  
Chinese Herbal Medicine ◽  
Health Condition ◽  
Lactating Women ◽  
Outcome Assessor ◽  
Reactive Protein ◽  
Chinese Herbal ◽  
Chinese Patent ◽  
Acute Mastitis

Abstract • Background: Acute mastitis influences the health condition and quality of life of the infants and mothers during the lactation. Pugongying (a kind of Chinese patent medicine, Herba Taraxaci) has shown benefits in lactating women with acute mastitis in clinical practice. However, there is no solid evidence to support its effectiveness and safety.• Methods: A three-arm, multicenter, randomized, active-controlled, outcome assessor-blinded clinical trial will be undergoing in three hospitals in Beijing. 306 participants will be randomly assigned into three groups in 1:1:1 ratio with Pugongying alone, cefdinir alone, and combination of Pugongying and cefdinir for 3-day intervention drugs administration. And in combination of Pugongying and cefdinir group, the participants will be administrated with 2-day cefdinir and 3-day Pugongying. The primary outcomes are resolution of fever, visual analogue scale (VAS) scores of breast pain, and the size of the breast mass by palpation. The secondary outcomes are the patency of milk, Traditional Chinese Medicine (TCM) symptoms scores, white blood cell count, the percentage of neutrophil and C-reactive protein, relapse at 3th day of follow up after completion of treatment, and safety assessment including routine blood, liver and renal function and electrocardiography. Besides, the incidence of surgery and the quantity of additional intervention drugs will also be evaluated.• Discussion: The results of this trial are expected to confirm whether Chinese herbal medicine Pugongying could alleviate the symptoms and signs in lactating women with acute mastitis, and they could reduce application of cefdinir in clinical practice.• Trial registration: ClinicalTrials.gov [Home - ClinicalTrials.gov], ID: NCT03756324. Registered on December 18th 2018. https://www.clinicaltrials.gov/ct2/show/NCT03756324?cond=Acute+mastitis&draw=2&rank=1

The effect of the chinese herbal medicine Dai-Kenchu-To on intestinal blood flow

2001 ◽  
Vol 120 (5) ◽  
pp. A248-A248
Author(s):  
N KAWASAKI ◽  
K NARIAI ◽  
M NAKAO ◽  
K NAKADA ◽  
N HANYUU ◽  
...  
Keyword(s):  
Blood Flow ◽  
Herbal Medicine ◽  
Chinese Herbal Medicine ◽  
Intestinal Blood Flow ◽  
Chinese Herbal
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