scholarly journals Effect of Chinese herbal medicine treatment on plasma lipid profile and hepatic lipid metabolism in Hetian broiler

2017 ◽  
Vol 96 (6) ◽  
pp. 1918-1924 ◽  
Author(s):  
Z. Xie ◽  
J. Zhang ◽  
S. Ma ◽  
X. Huang ◽  
Y. Huang
Keyword(s):  
Lipid Metabolism ◽  
Herbal Medicine ◽  
Lipid Profile ◽  
Chinese Herbal Medicine ◽  
Plasma Lipid ◽  
Plasma Lipid Profile ◽  
Hepatic Lipid Metabolism ◽  
Hepatic Lipid ◽  
Chinese Herbal

scholarly journals Tribbles-1: a novel regulator of hepatic lipid metabolism in humans

2015 ◽  
Vol 43 (5) ◽  
pp. 1079-1084 ◽  
Author(s):  
Robert C. Bauer ◽  
Batuhan O. Yenilmez ◽  
Daniel J. Rader
Keyword(s):  
Lipid Metabolism ◽  
Plasma Lipids ◽  
Association Studies ◽  
Plasma Lipid ◽  
Genome Wide Association Studies ◽  
Dependent Manner ◽  
Hepatic Lipogenesis ◽  
Hepatic Lipid Metabolism ◽  
Alcoholic Fatty Liver ◽  
Hepatic Lipid

The protein tribbles-1, encoded by the gene TRIB1, is increasingly recognized as a major regulator of multiple cellular and physiological processes in humans. Recent human genetic studies, as well as molecular biological approaches, have implicated this intriguing protein in the aetiology of multiple human diseases, including myeloid leukaemia, Crohn's disease, non-alcoholic fatty liver disease (NAFLD), dyslipidaemia and coronary artery disease (CAD). Genome-wide association studies (GWAS) have repeatedly identified variants at the genomic TRIB1 locus as being significantly associated with multiple plasma lipid traits and cardiovascular disease (CVD) in humans. The involvement of TRIB1 in hepatic lipid metabolism has been validated through viral-mediated hepatic overexpression of the gene in mice; increasing levels of TRIB1 decreased plasma lipids in a dose-dependent manner. Additional studies have implicated TRIB1 in the regulation of hepatic lipogenesis and NAFLD. The exact mechanisms of TRIB1 regulation of both plasma lipids and hepatic lipogenesis remain undetermined, although multiple signalling pathways and transcription factors have been implicated in tribbles-1 function. Recent reports have been aimed at developing TRIB1-based lipid therapeutics. In summary, tribbles-1 is an important modulator of human energy metabolism and metabolic syndromes and worthy of future studies aimed at investigating its potential as a therapeutic target.

scholarly journals SAT-659 Micro/Nanoparticles from Antidiabetic Chinese Herbal Medicine Soup Increase Bioavailability of Phytochemicals and Regulate Glucose and Lipid Metabolism

2020 ◽  
Vol 4 (Supplement_1) ◽  
Author(s):  
Lijing Ke ◽  
Pingfan Rao
Keyword(s):  
Skeletal Muscle ◽  
Lipid Metabolism ◽  
Blood Glucose ◽  
Herbal Medicine ◽  
Glucose Tolerance ◽  
Chinese Herbal Medicine ◽  
Therapeutic Effects ◽  
Chinese Herbal ◽  
Glucose And Lipid Metabolism

Abstract Herbal soups have always been a popular option for treating oxidative stress-related chronic diseases including diabetes. Various components of these soups have been studied in the hope to identify the active principles, mainly focusing on the individual phytochemicals. As we have revealed previously, the micro/nanoparticles (MNPs) formed incidentally during the boiling water extraction of herbal soups may be bioactive and functional. This study aims to elucidate the underlying mechanism of the biological functions of these MNPs. A Chinese herbal medicine soup prepared by Radix Puerariae lobatae, ginger and other three herbs, namely Ge-Gen-Qin-Lian-Tang, was employed here, as it was proven to be effective in treating type 2 diabetes clinically. The soup was separated with high-speed centrifuge (15600×g) to obtain the supernatant (solutes and nanoparticles) and sediments (MNPs), and determined for the content of three bioactive phytochemicals, e.g. puerarin, berberine and baicalin. Their hypoglycemic, hypolipidemic and antioxidant effects were determined on streptozotocin (STZ)-induced Type 2 diabetic Wistar male rats fed on high fat-high sugar diet. The animals were divided into six groups (normal control, diabetic model, whole soup, supernatant, MNPs and metformin, 8 rats each), recording weight, diet, excretion, mental status, etc. The fasting blood glucose and oral glucose tolerance test were conducted regularly. Eight weeks after the administration, the rats were sacrificed after anesthesia. Abdominal aorta blood and tissue samples of pancreas, heart, skeletal muscle, liver, kidney, spleen were collected. The glycated hemoglobin, glucose, lipid, insulin, glucagon, AMPK, SOD, puerarin, berberine, baicalin in blood plasma, insulin in pancreas, SOD in tissues, AMPK in skeletal muscle were measured. Liver tissue sections were observed with HE staining. Statistical analysis (t-test) were performed. The MNPs reduced blood glucose, ameliorated glucose tolerance, elevated insulin secretion and significantly improve glucose and lipid metabolism (P <0.05), showing stronger effects than the supernatant components. Notably, MNPs elevated the AMPK level in skeletal muscle, even more potently than the whole soup. The therapeutic effects of MNPs on the liver damage were even stronger than metformin. Meanwhile, MNPs promoted absorption of puerarin, berberine and baicalin and increase their concentration in blood (P <0.05). Therefore, the MNPs from the herbal soup exhibited more potent effects than the soluble components on ameliorating glucose and lipid metabolism and pancreatic functions of diabetic rats. The actions of these MNPs provide a new perspective for understanding the antidiabetic effects of herbal soups and serve as a vehicle for the multiple phytochemicals to synergistically possess therapeutic effects.

scholarly journals Plasma lipidomics distinguishes NASH and fibrosis from simple fatty liver in children

2020 ◽  
Author(s):  
Jake P. Mann ◽  
Samuel Furse ◽  
Stuart G. Snowden ◽  
Anna Alisi ◽  
Laura G. Draijer ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
Lipid Metabolism ◽  
Liver Biopsy ◽  
Fatty Liver ◽  
Lipid Profile ◽  
Plasma Lipid ◽  
Diagnostic Model ◽  
Plasma Lipid Profile ◽  
Alcoholic Fatty Liver ◽  
Lipid Species

SummaryBackgroundNon-alcoholic fatty liver disease (NAFLD) is a condition characterised by insulin resistance and altered lipid metabolism. Evaluation of the serum lipid profile of children with NAFLD offers the opportunity to understand these perturbations and identify biomarkers to distinguish non-alcoholic steatohepatitis (NASH) and fibrosis from ‘simple’ fatty liver (NAFL).AimTo investigate the plasma lipid profile of children with NAFLD to: (a) gain insight into lipid metabolism in NAFL and NASH; (b) explore the potential of their use as biomarkers.MethodsUntargeted lipidomics was performed on fasting plasma samples were collected from children: 19 lean control, 65 obese controls (without NAFLD), and 222 children with NAFLD, of whom 120 had undergone liver biopsy to identify 34 with NAFL and 86 with NASH. Associations between lipid species and liver histology were assessed using regression adjusted for age and sex.ResultsHistological severity of paediatric NAFLD was associated with altered in lipid metabolism in multiple classes, including: higher free cholesterol, higher phosphatidylserine, higher lyso-phosphatidylcholines, and lower polyunsaturated di- and triglycerides. Many of these associations remained after adjusting for insulin resistance and were not replicated in obese controls. The plasma lipid profile generated a diagnostic model that accurately predicted NAFL versus NASH or fibrosis on liver biopsy.ConclusionsHistological severity of NAFLD in children is associated with perturbation of multiple lipid pathways, several apparently independent of insulin resistance. These data provide proof-of-concept that plasma lipidomics can distinguish simple fatty liver from NASH or fibrosis in children.

The effect of the chinese herbal medicine Dai-Kenchu-To on intestinal blood flow

2001 ◽  
Vol 120 (5) ◽  
pp. A248-A248
Author(s):  
N KAWASAKI ◽  
K NARIAI ◽  
M NAKAO ◽  
K NAKADA ◽  
N HANYUU ◽  
...  
Keyword(s):  
Blood Flow ◽  
Herbal Medicine ◽  
Chinese Herbal Medicine ◽  
Intestinal Blood Flow ◽  
Chinese Herbal

Altered hepatic lipid metabolism in leptin-deficlent mice

2001 ◽  
Vol 120 (5) ◽  
pp. A546-A546
Author(s):  
D SWARTZBASILE ◽  
M GOLDBLATT ◽  
C SVATEK ◽  
M WALTERS ◽  
S CHOI ◽  
...  
Keyword(s):  
Lipid Metabolism ◽  
Hepatic Lipid Metabolism ◽  
Hepatic Lipid
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