Effects of medicinal extract for tonifying kidney to relieve asthma on glucocorticoid receptor expression in lung tissues of rats with bronchial asthma

2010 ◽  
pp. 785-789 ◽  
Author(s):  
KH Shi
Keyword(s):  
Glucocorticoid Receptor ◽  
Bronchial Asthma ◽  
Receptor Expression

Vitamin D decreasesin vitroglucocorticoid sensitivity via down regulation of glucocorticoid receptor expression

2015 ◽  
Author(s):  
Narjes Nasiri Ansari ◽  
Eliana Spilioti ◽  
Vasiliki Kalotychou ◽  
Geena Dalagiorgou ◽  
Paraskevi Moutsatsou ◽  
...  
Keyword(s):  
Vitamin D ◽  
Glucocorticoid Receptor ◽  
Receptor Expression ◽  
Down Regulation

Decreased glucocorticoid receptor expression during critical illness

2019 ◽  
Vol 49 (4) ◽  
pp. e13073 ◽  
Author(s):  
Alice G. Vassiliou ◽  
Georgios Floros ◽  
Edison Jahaj ◽  
Georgios Stamogiannos ◽  
Sofianna Gennimata ◽  
...  
Keyword(s):  
Critical Illness ◽  
Glucocorticoid Receptor ◽  
Receptor Expression

Differential autoregulation of glucocorticoid receptor expression in human T- and B-cell lines.

Endocrinology ◽  
1993 ◽  
Vol 133 (1) ◽  
pp. 248-256 ◽  
Author(s):  
R R Denton ◽  
L P Eisen ◽  
M S Elsasser ◽  
J M Harmon
Keyword(s):  
Glucocorticoid Receptor ◽  
B Cell ◽  
Cell Lines ◽  
Receptor Expression

Transcriptional transactivation functions localized to the glucocorticoid receptor N terminus are necessary for steroid induction of lymphocyte apoptosis

1992 ◽  
Vol 12 (2) ◽  
pp. 589-597
Author(s):  
E S Dieken ◽  
R L Miesfeld
Keyword(s):  
Transcriptional Regulation ◽  
Glucocorticoid Receptor ◽  
Target Genes ◽  
Dominant Negative ◽  
Receptor Expression ◽  
Transactivation Domain ◽  
Lymphocyte Apoptosis ◽  
Murine Cell Line ◽  
N Terminus ◽  
Simplex Virus

Genetic studies have suggested that transcriptional regulation of specific target genes (by either induction or repression) is the molecular basis of glucocorticoid-mediated lymphocyte apoptosis. To examine the role of transcriptional regulation more directly, we developed a complementation assay utilizing stable transfection of wild-type (wt) and mutant (nti) glucocorticoid receptor (GR) cDNA constructs into a GR-deficient S49 murine cell line (7r). Our data confirm that the level of functional GR is rate limiting for S49 apoptosis and moreover that the GR amino terminus (N terminus), which as been deleted from the nti GR, is absolutely required for complementation in this system. Surprisingly, we found that at physiological levels of receptor, expression of the nti GR in cells containing wt GR results in enhanced dexamethasone sensitivity rather than a dominant negative phenotype. One interpretation of these data is that DNA binding by wt-nti heterodimers may be functionally similar to that of wt-wt homodimers, indicating that GRE occupancy by at least one transactivation domain may be sufficient to induce the hormonal response. To determine whether acidic activating sequences such as those localized to the GR N terminus are important in the induction of lymphocyte apoptosis, we tested the activity of a chimeric receptor in which we replaced the entire GR N terminus with sequences from the herpes simplex virus VP16 protein. Our results demonstrate that 7r cells expressing VP-GR fusions are indeed steroid sensitive, strongly supporting the idea that S49 apoptosis is dependent on transcriptional regulation of specific genes which respond to acidic activating domains, implying that induction, rather than repression, may be the critical initiating event.

scholarly journals Glucocorticoid receptor expression on circulating leukocytes in healthy and asthmatic adolescents in response to exercise

2017 ◽  
Vol 82 (2) ◽  
pp. 261-271 ◽  
Author(s):  
Kim D Lu ◽  
Dan Cooper ◽  
Fadia Haddad ◽  
Frank Zaldivar ◽  
Monica Kraft ◽  
...  
Keyword(s):  
Glucocorticoid Receptor ◽  
Receptor Expression ◽  
Response To Exercise

scholarly journals Enduring, Handling-Evoked Enhancement of Hippocampal Memory Function and Glucocorticoid Receptor Expression Involves Activation of the Corticotropin-Releasing Factor Type 1 Receptor

Endocrinology ◽  
2005 ◽  
Vol 146 (9) ◽  
pp. 4090-4096 ◽  
Author(s):  
Kristina A. Fenoglio ◽  
Kristen L. Brunson ◽  
Sarit Avishai-Eliner ◽  
Blake A. Stone ◽  
Bhumika J. Kapadia ◽  
...  
Keyword(s):  
Glucocorticoid Receptor ◽  
Memory Function ◽  
Corticotropin Releasing Factor ◽  
Receptor Expression ◽  
Factor Type
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