scholarly journals Enduring, Handling-Evoked Enhancement of Hippocampal Memory Function and Glucocorticoid Receptor Expression Involves Activation of the Corticotropin-Releasing Factor Type 1 Receptor

Endocrinology ◽  
2005 ◽  
Vol 146 (9) ◽  
pp. 4090-4096 ◽  
Author(s):  
Kristina A. Fenoglio ◽  
Kristen L. Brunson ◽  
Sarit Avishai-Eliner ◽  
Blake A. Stone ◽  
Bhumika J. Kapadia ◽  
...  
Keyword(s):  
Glucocorticoid Receptor ◽  
Memory Function ◽  
Corticotropin Releasing Factor ◽  
Receptor Expression ◽  
Factor Type

Altered corticosteroid metabolism differentially affects pituitary corticotropin response

2002 ◽  
Vol 282 (2) ◽  
pp. E466-E473 ◽  
Author(s):  
Junko Hanafusa ◽  
Tomoatsu Mune ◽  
Tetsuya Tanahashi ◽  
Yukinori Isomura ◽  
Tetsuya Suwa ◽  
...  
Keyword(s):  
Glycyrrhizic Acid ◽  
Mrna Level ◽  
Hydroxysteroid Dehydrogenase ◽  
Corticotropin Releasing Factor ◽  
Receptor Expression ◽  
Mrna Levels ◽  
Basal Plasma ◽  
Corticosterone Response ◽  
Pituitary Adrenal Axis

To evaluate the effects of altered corticosteroid metabolism on the hypothalamic-pituitary-adrenal axis, we examined rats treated with glycyrrhizic acid (G rats) or rifampicin (R rats) for 7 days. The half-life of exogenously administered hydrocortisone as a substitute for corticosterone was longer in G rats and shorter in R rats, with no differences in basal plasma levels of ACTH or corticosterone. The ACTH responses to human corticotropin-releasing factor (CRF) or insulin-induced hypoglycemia were greater in G rats and tended to be smaller in R rats compared with those in the control rats, whereas the corticosterone response was similar. No difference was observed in the content and mRNA level of hypothalamic CRF among the groups. The number and mRNA level of CRF receptor and type 1 11β-hydroxysteroid dehydrogenase (11-HSD1) mRNA level in the pituitary were increased in G rats but not changed in R rats, suggesting that chronically increased intrapituitary corticosterone upregulates pituitary CRF receptor expression. In contrast, CRF mRNA levels in the pituitary were increased in R rats. Our data indicate novel mechanisms of corticosteroid metabolic modulation and the involvement of pituitary 11-HSD1 and CRF in glucocorticoid feedback physiology.

scholarly journals Evaluation of 99mTc-ZIGF1R:4551-GGGC affibody molecule, a new probe for imaging of insulin-like growth factor type 1 receptor expression

Amino Acids ◽  
2014 ◽  
Vol 47 (2) ◽  
pp. 303-315 ◽  
Author(s):  
Bogdan Mitran ◽  
Mohamed Altai ◽  
Camilla Hofström ◽  
Hadis Honarvar ◽  
Mattias Sandström ◽  
...  
Keyword(s):  
Growth Factor ◽  
Receptor Expression ◽  
Insulin Like Growth Factor ◽  
Affibody Molecule ◽  
Factor Type

scholarly journals Distinct Conformations of the Corticotropin Releasing Factor Type 1 Receptor Adopted following Agonist and Antagonist Binding Are Differentially Regulated

2005 ◽  
Vol 280 (12) ◽  
pp. 11560-11568 ◽  
Author(s):  
Stephen J. Perry ◽  
Sachiko Junger ◽  
Trudy A. Kohout ◽  
Sam R.J. Hoare ◽  
R. Scott Struthers ◽  
...  
Keyword(s):  
Corticotropin Releasing Factor ◽  
Agonist And Antagonist ◽  
Antagonist Binding ◽  
Factor Type

PET imaging of insulin-like growth factor type 1 receptor expression with a 64Cu-labeled Affibody molecule

Amino Acids ◽  
2015 ◽  
Vol 47 (7) ◽  
pp. 1409-1419 ◽  
Author(s):  
Xinhui Su ◽  
Kai Cheng ◽  
Yang Liu ◽  
Xiang Hu ◽  
Shuxian Meng ◽  
...  
Keyword(s):  
Growth Factor ◽  
Pet Imaging ◽  
Receptor Expression ◽  
Insulin Like Growth Factor ◽  
Affibody Molecule ◽  
Factor Type

The genomic organization of the human corticotropin-releasing factor type-1 receptor

Gene ◽  
1998 ◽  
Vol 219 (1-2) ◽  
pp. 125-130 ◽  
Author(s):  
Ken Sakai ◽  
Masao Yamada ◽  
Nobuo Horiba ◽  
Makoto Wakui ◽  
Hiroshi Demura ◽  
...  
Keyword(s):  
Genomic Organization ◽  
Corticotropin Releasing Factor ◽  
Factor Type
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