Establishment of a rat model of alcoholic liver fibrosis induced by complex factors

2006 ◽  
Vol 4 (3) ◽  
pp. 281-284 ◽  
Author(s):  
Lei Wang
Keyword(s):  
Liver Fibrosis ◽  
Rat Model

F.N.10 PHARMACOLOGICAL ANTAGONISM OF ENDOCANNABINOID CB1 RECEPTOR AMELIORATES LIVER FIBROSIS IN A RAT MODEL OF ADVANCED CIRRHOSIS

2010 ◽  
Vol 42 ◽  
pp. S36-S37
Author(s):  
F.A. Giannone ◽  
M. Domenicali ◽  
M. Baldassarre ◽  
G. Di Pompo ◽  
M. Bernardi ◽  
...  
Keyword(s):  
Liver Fibrosis ◽  
Rat Model ◽  
Cb1 Receptor ◽  
Advanced Cirrhosis

scholarly journals Treatment with Melatonin Improves Cognitive Behavior and Motor Skills in a Rat Model of Liver Fibrosis

2019 ◽  
Vol 18 (1) ◽  
pp. 101-108 ◽  
Author(s):  
Paola Haeger ◽  
Antoine Bouchet ◽  
Carolina Ossandon ◽  
Gustavo Bresky
Keyword(s):  
Liver Fibrosis ◽  
Motor Skills ◽  
Rat Model ◽  
Cognitive Behavior

scholarly journals Mo1431 – Inflammatory Bowel Disease (IBD) Induces Biliary Damage and Liver Fibrosis in an IBD Rat Model

2019 ◽  
Vol 156 (6) ◽  
pp. S-1305-S-1306
Author(s):  
Shannon Glaser ◽  
Lixian Chen ◽  
April O'Brien ◽  
Walter Cromer ◽  
Gianfranco Alpini ◽  
...  
Keyword(s):  
Inflammatory Bowel Disease ◽  
Liver Fibrosis ◽  
Rat Model ◽  
Bowel Disease ◽  
Inflammatory Bowel

scholarly journals Protective Effect of Ursolic Acid on the Intestinal Mucosal Barrier in a Rat Model of Liver Fibrosis

2019 ◽  
Vol 10 ◽  
Author(s):  
Wang Zhang ◽  
Dakai Gan ◽  
Jie Jian ◽  
Chenkai Huang ◽  
Fangyun Luo ◽  
...  
Keyword(s):  
Liver Fibrosis ◽  
Protective Effect ◽  
Ursolic Acid ◽  
Rat Model ◽  
Mucosal Barrier ◽  
Intestinal Mucosal Barrier

scholarly journals Using IVIM-MRI and R2⁎ Mapping to Differentiate Early Stage Liver Fibrosis in a Rat Model of Radiation-Induced Liver Fibrosis

2018 ◽  
Vol 2018 ◽  
pp. 1-9 ◽  
Author(s):  
Jianye Liang ◽  
Xiubao Song ◽  
Zeyu Xiao ◽  
Hanwei Chen ◽  
Changzheng Shi ◽  
...  
Keyword(s):  
Liver Fibrosis ◽  
Rat Model ◽  
Early Stage ◽  
Blue Staining ◽  
Pathological Examination ◽  
Strong Positive Correlation ◽  
Radiation Induced ◽  
Motion Mri ◽  
Right Lobe ◽  
D Values

Rationale and Objectives. To investigate the utility of intravoxel incoherent motion MRI (IVIM-MRI) and R2⁎ mapping in diagnosing early stage liver fibrosis in a radiation-induced rat model. Materials and Methods. Thirty rats were randomly divided into three groups with 10 rats in each group. Liver fibrosis was induced by exposure of right lobe of liver in each animal to 20 Gy of radiation. MRI examination was conducted at baseline, one month, two months, and three months after radiation using T1WI, T2WI, IVIM-DWI, and R2⁎ sequences. The pathological examination included hematoxylin eosin, masson trichrome, and prussian blue staining. D, D⁎, f, and R2⁎ values were measured in both left and right lobes for quantitative analysis. Results. Regarding the surviving 23 rats, eight rats were diagnosed with stage F0, ten with stage F1, and five with stage F2 liver fibrosis using METAVIR Scores. The D values of right lobes decreased (P<0.05), and R2⁎ values increased (P<0.01) significantly as fibrosis levels increased. But there was no statistical difference in D⁎ (P=0.970) and f values (P=0.079). R2⁎ value showed a strong positive correlation (r=0.819, P<0.001), while D value showed a negative correlation with fibrosis stages (r=-0.424, P<0.001). D⁎ (r=0.029, P=0.744) and f values (r=-0.055, P=0.536) were poorly correlated with fibrosis levels. Conclusion. IVIM-MRI and R2⁎ mapping are useful techniques for evaluating the severity of liver fibrosis in a radiation-induced rat model, and R2⁎ value is the most sensitive parameter in detecting early stage fibrosis.

Protein fingerprinting of the extracellular matrix remodelling in a rat model of liver fibrosis-a serological evaluation

2012 ◽  
Vol 33 (3) ◽  
pp. 439-447 ◽  
Author(s):  
Diana J. Leeming ◽  
Inger Byrjalsen ◽  
Wladimiro Jiménez ◽  
Claus Christiansen ◽  
Morten A. Karsdal
Keyword(s):  
Extracellular Matrix ◽  
Liver Fibrosis ◽  
Rat Model ◽  
Protein Fingerprinting ◽  
Extracellular Matrix Remodelling

Liver Fibrosis Impairs Hepatic Pharmacokinetics of Liver Transplant Drugs in the Rat Model

2010 ◽  
Vol 25 (5) ◽  
pp. 442-449 ◽  
Author(s):  
Yu-Hong Zou ◽  
Xin Liu ◽  
Alexander M. Khlentzos ◽  
Peyman Asadian ◽  
Peng Li ◽  
...  
Keyword(s):  
Liver Fibrosis ◽  
Liver Transplant ◽  
Rat Model

Tu1613 Cranial Infusion of Melatonin in a Rat Model of Extrahepatic Cholestasis Reduces Biliary Proliferation and Liver Fibrosis

2016 ◽  
Vol 150 (4) ◽  
pp. S1149
Author(s):  
Matthew McMillin ◽  
Sharon DeMorrow ◽  
Julie Venter ◽  
Gabriel Frampton ◽  
Haibo Bai ◽  
...  
Keyword(s):  
Liver Fibrosis ◽  
Rat Model ◽  
Extrahepatic Cholestasis
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