scholarly journals Protective Effect of Ursolic Acid on the Intestinal Mucosal Barrier in a Rat Model of Liver Fibrosis

2019 ◽  
Vol 10 ◽  
Author(s):  
Wang Zhang ◽  
Dakai Gan ◽  
Jie Jian ◽  
Chenkai Huang ◽  
Fangyun Luo ◽  
...  
Keyword(s):  
Liver Fibrosis ◽  
Protective Effect ◽  
Ursolic Acid ◽  
Rat Model ◽  
Mucosal Barrier ◽  
Intestinal Mucosal Barrier

scholarly journals Protective effect and mechanism of fucoidan on intestinal mucosal barrier function in NOD mice

2020 ◽  
Vol 31 (1) ◽  
pp. 939-953
Author(s):  
Ting Sun ◽  
Hui Liang ◽  
Meilan Xue ◽  
Ying Liu ◽  
Anjing Gong ◽  
...  
Keyword(s):  
Protective Effect ◽  
Barrier Function ◽  
Nod Mice ◽  
Mucosal Barrier ◽  
Intestinal Mucosal Barrier ◽  
Mucosal Barrier Function

Effect of Shenfu injection on intestinal mucosal barrier in a rat model of sepsis

2015 ◽  
Vol 33 (9) ◽  
pp. 1237-1243 ◽  
Author(s):  
Wan Wu ◽  
Rong-lin Jiang ◽  
Ling-cong Wang ◽  
Shu Lei ◽  
Xi Xing ◽  
...  
Keyword(s):  
Rat Model ◽  
Mucosal Barrier ◽  
Shenfu Injection ◽  
Intestinal Mucosal Barrier

scholarly journals Low Molecular Seleno-Aminopolysaccharides Protect the Intestinal Mucosal Barrier of Rats under Weaning Stress

2019 ◽  
Vol 20 (22) ◽  
pp. 5727 ◽  
Author(s):  
Zheng-Shun Wen ◽  
Ming Du ◽  
Zhen Tang ◽  
Tian-Yi Zhou ◽  
Zhong-Shan Zhang ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Protective Effect ◽  
Intestinal Mucosa ◽  
Expression Level ◽  
Mucosal Barrier ◽  
Intestinal Damage ◽  
Intestinal Tissue ◽  
Intestinal Mucosal Barrier ◽  
Weaning Stress ◽  
Nrf2 Signaling Pathway

Low molecular seleno-aminopolysaccharide (LSA) was synthesized with sodium selenite and low molecular aminopolysaccharide (LA), which is an organic selenium compound. This study is aimed to investigate the protective effect of LSA on the intestinal mucosal barrier in weaning stress rats by detecting the intestinal tissue morphology and function, mucosal thickness and permeability, the structure of MUC2, antioxidant index, the expression level of intracellular transcription factor NF-E2-related factor 2 (Nrf2), and its related factors. The results showed that LSA significantly increased the height of intestinal villi (p < 0.05) and increased the thickness of intestinal mucosa and the number of goblet cells, which indicated that LSA has a protective effect on the intestinal mucosal barrier that is damaged by weaning. Moreover, LSA significantly reduced the level of DAO, D-LA, and LPS compared with the weaning group (p < 0.05), which indicated that LSA reduced the intestinal damage and permeability of weaning rats. In addition, LSA could increase the number and length of glycans chains and the abundance of acid glycans structures in the MUC2 structure, which indicated that LSA alleviated the changes of intestinal mucus protein structure. LSA significantly increased the levels of GSH-Px, SOD, LDH, and CAT, while it decreased the level of MDA in serum and intestinal tissue, which suggested that LSA significantly enhanced the antioxidant capacity and reduced oxidative stress of weaning rats. RT-PCR results showed that LSA significantly increased the expression level of antioxidant genes (GSH-Px, SOD, Nrf2, HO-1), glycosyltransferase genes (GalNT1, GalNT3, GalNT7) and mucin gene (MUC2) in intestinal mucosa (p < 0.05). The results of western blot showed that the LSA activated the Nrf2 signaling pathway by down-regulating the expression of Keap1and up-regulating the expression of Nrf2, and protected the intestinal mucosa from oxidative stress. Overall, LSA could play a protective role in intestinal mucosal barrier of weaning rats by activating the Nrf2 pathway and alleviating the alnormal change of mucin MUC2.

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