Syndromes and pathological mechanism of insulin resistance in traditional Chinese medicine

2005 ◽  
Vol 3 (1) ◽  
pp. 63-65 ◽  
Author(s):  
Qin Feng
Keyword(s):  
Insulin Resistance ◽  
Chinese Medicine ◽  
Traditional Chinese Medicine ◽  
Pathological Mechanism

A diet formula of Puerariae radix, Lycium barbarum, Crataegus pinnatifida, and Polygonati rhizoma alleviates insulin resistance and hepatic steatosis in CD-1 mice and HepG2 cells

2014 ◽  
Vol 5 (5) ◽  
pp. 1038-1049 ◽  
Author(s):  
Jia Liu ◽  
HongJuan Zhang ◽  
BaoPing Ji ◽  
ShengBao Cai ◽  
RuoJun Wang ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
Chinese Medicine ◽  
Traditional Chinese Medicine ◽  
Hepatic Steatosis ◽  
Hepg2 Cells ◽  
Multiple Target ◽  
Lycium Barbarum ◽  
Puerariae Radix ◽  
Crataegus Pinnatifida ◽  
Target Organs

According to the principles of traditional Chinese medicine, medicinal and edible herbs exhibit holistic effects through their actions on multiple target organs.

scholarly journals The Mechanism of Phillyrin from the Leaves of Forsythia suspensa for Improving Insulin Resistance

2019 ◽  
Vol 2019 ◽  
pp. 1-7 ◽  
Author(s):  
Xiaoqing Xu ◽  
Fatma S. A. Saadeldeen ◽  
Lanting Xu ◽  
Yingying Zhao ◽  
Jinfeng Wei ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
Chinese Medicine ◽  
Traditional Chinese Medicine ◽  
Western Blot ◽  
Protein Phosphorylation ◽  
Glucose Uptake ◽  
Glucose Oxidase ◽  
Glucose Consumption ◽  
Significant Activity ◽  
Forsythia Suspensa

Three lignans, phillyrin, forsythia ester A, and rosin-β-D-furan glucose, were isolated from Forsythia suspensa which is a famous Traditional Chinese Medicine used for clearing heat and detoxifying, reducing swelling and dispersing knot, and dispersing wind heat. In this study, the effects of phillyrin, forsythia ester A, and rosin-β-D-furan glucose on insulin resistance of 3T3-L1 adipocytes were investigated by the method of glucose oxidase-peroxidase (GOD-POD) and the mechanism was assayed by the method of western blot. The results indicated that phillyrin, forsythia ester A, and rosin-β-D-furan glucose could improve the glucose uptake in 3T3-L1 adipocytes under insulin resistance (IR). Among them, phillyrin showed significant activity in increasing glucose consumption at the concentrations of 100 μM and 200 μM (P < 0.001). The mechanism of improving insulin resistance may be that phillyrin could raise the protein phosphorylation of IRS-1 and Akt and the expression levels of GLUT4 protein.

Improving insulin resistance with traditional Chinese medicine in type 2 diabetic patients

Endocrine ◽  
2009 ◽  
Vol 36 (2) ◽  
pp. 268-274 ◽  
Author(s):  
Menglei Chao ◽  
Dajin Zou ◽  
Yifei Zhang ◽  
Yuhong Chen ◽  
Miao Wang ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
Chinese Medicine ◽  
Traditional Chinese Medicine ◽  
Diabetic Patients ◽  
Type 2 Diabetic Patients ◽  
Type 2 Diabetic

scholarly journals Electroacupuncture Alleviates Postoperative Cognitive Dysfunction in Aged Rats by Inhibiting Hippocampal Neuroinflammation Activated via Microglia/TLRs Pathway

2017 ◽  
Vol 2017 ◽  
pp. 1-10 ◽  
Author(s):  
Pei-pei Feng ◽  
Pu Deng ◽  
Li-hua Liu ◽  
Qi Ai ◽  
Jie Yin ◽  
...  
Keyword(s):  
Chinese Medicine ◽  
Traditional Chinese Medicine ◽  
Cognitive Dysfunction ◽  
Water Maze ◽  
Postoperative Cognitive Dysfunction ◽  
Experimental Studies ◽  
Aged Rats ◽  
Pathological Mechanism ◽  
Probe Test ◽  
Better Than

Neuroinflammation has been suggested to be involved in the pathogenesis of postoperative cognitive dysfunction (POCD). Electroacupuncture (EA) is an irreplaceable method in traditional Chinese medicine that is used for treating neurodegenerative diseases in clinical and experimental studies. The aim of this study was to examine whether EA improves cognitive dysfunction caused by surgery and to investigate the pathological mechanism of TLR2 and TLR4 in the hippocampus of aged rats. A rat model of POCD was established and treated with EA or minocycline. Both EA- and minocycline-treated rats performed significantly better than untreated operated rats in spatial memory tasks of the Morris water maze (MWM) test, spending comparatively greater amounts of time in the target zone during the probe test. Additionally, decreased levels of proinflammatory cytokines (IL-1β, IL-6, TNF-α, and HMGB1) and decreased TLR2 and TLR4 protein expression in the hippocampus of EA- and minocycline-treated rats were detected. Our data suggested that EA treatment alleviated the cognition performance deficit and neuroinflammation in aged rats following surgery, which may be mediated by inhibiting the expression of hippocampal neuroinflammatory cytokines through the microglia/TLR2/4 pathway.

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