Study on tumor cells' multidrug resistance and its reversion by Chinese herbs

2003 ◽  
Vol 1 (3) ◽  
pp. 221-225 ◽  
Author(s):  
Xin-Yi Chen
Keyword(s):  
Multidrug Resistance ◽  
Tumor Cells ◽  
Chinese Herbs

Effect of block architecture on the ability of polyalkylene oxides to overcome multidrug resistance of tumor cells

2006 ◽  
Vol 16 (4) ◽  
pp. 259-265 ◽  
Author(s):  
D.N. Pavlov ◽  
N.A. Alexandrova ◽  
O.O. Krylova ◽  
P. Pohl ◽  
N.S. Melik-Nubarov
Keyword(s):  
Multidrug Resistance ◽  
Tumor Cells

FK-506 (fujimycin) reverses the multidrug resistance of tumor cells in vitro

1991 ◽  
Vol 2 (3) ◽  
pp. 279-284 ◽  
Author(s):  
Albin Pourtier-Manzanedo ◽  
Danièle Boesch ◽  
Francis Loor
Keyword(s):  
Multidrug Resistance ◽  
Tumor Cells ◽  
Fk 506

Clinical relevance of transmembrane drug efflux as a mechanism of multidrug resistance.

1998 ◽  
Vol 16 (11) ◽  
pp. 3674-3690 ◽  
Author(s):  
D M Bradshaw ◽  
R J Arceci
Keyword(s):  
Drug Resistance ◽  
Cell Death ◽  
Multidrug Resistance ◽  
Programmed Cell Death ◽  
Tumor Cells ◽  
Efflux Pump ◽  
Active Form ◽  
Cytotoxic Agents ◽  
Transport Systems ◽  
Drug Efflux

For cytotoxic agents to have an effect on tumor cells, drugs must first be transported into the cell, potentially be metabolized to an active form, and interact appropriately with target molecules. A final common pathway of cytotoxic agents is usually the initiation of programmed cell death, or apoptosis. Tumor cells overcome the effects of cytotoxic agents at one or more of these levels. The classic multidrug-resistance (MDR) phenotype, as mediated by the drug efflux pump, P-glycoprotein, is one of the most extensively studied mechanisms of drug resistance. Additional drug transporters, such as the multidrug resistance-associated proteins (MRPs), have also been identified and can convey drug-resistance phenotypes. Important questions remain as to how and whether such transport systems can be specifically measured and effectively targeted to improve therapeutic outcomes. Furthermore, alterations in drug targets, drug metabolism, repair of DNA damage caused by drugs, and the inability to initiate programmed cell death can all contribute to drug resistance and must be ultimately considered in the explanation of tumor-cell resistance to therapy. Continued exploration of the pharmacologic methods to circumvent drug resistance, as well as strategies that involve targeted therapy and immunomodulation, should increase the specificity and efficacy of treatments for patients with cancer.

scholarly journals Intercellular transfer of P-glycoprotein mediates acquired multidrug resistance in tumor cells

2005 ◽  
Vol 102 (6) ◽  
pp. 1933-1938 ◽  
Author(s):  
A. Levchenko ◽  
B. M. Mehta ◽  
X. Niu ◽  
G. Kang ◽  
L. Villafania ◽  
...  
Keyword(s):  
Multidrug Resistance ◽  
Tumor Cells ◽  
Intercellular Transfer ◽  
P Glycoprotein

Synthesis of 2-phenylimidazo[2,1-b]benzothiazole derivatives as modulators of multidrug resistance for tumor cells

1997 ◽  
Vol 34 (6) ◽  
pp. 1763-1767 ◽  
Author(s):  
Shigeyuki Tasaka ◽  
Hirokazu Tanabe ◽  
Yoshiyuki Sasaki ◽  
Toshiki Machida ◽  
Mayumi Iino ◽  
...  
Keyword(s):  
Multidrug Resistance ◽  
Tumor Cells ◽  
Benzothiazole Derivatives

scholarly journals Reversal of Multidrug Resistance by 7-O-Benzoylpyripyropene A in Multidrug-Resistant Tumor Cells.

2000 ◽  
Vol 53 (10) ◽  
pp. 1201-1206 ◽  
Author(s):  
MUN-CHUAL RHO ◽  
MASAHIKO HAYASHI ◽  
AKIKO FUKAMI ◽  
RIKA OBATA ◽  
TOSHIAKI SUNAZUKA ◽  
...  
Keyword(s):  
Multidrug Resistance ◽  
Tumor Cells ◽  
Multidrug Resistant

Novel modulators to overcome P-glycoprotein-mediated multidrug resistance in tumor cells

2004 ◽  
Vol 42 (11) ◽  
pp. 644-645 ◽  
Author(s):  
H. Müller ◽  
W. Klinkhammer ◽  
M.U. Kassack ◽  
N. Eckstein ◽  
M. Wiese
Keyword(s):  
Multidrug Resistance ◽  
Tumor Cells ◽  
P Glycoprotein

Expression of CD147 Mediates Tumor Cells Invasion and Multidrug Resistance in Hepatocellular Carcinoma

2008 ◽  
Vol 26 (10) ◽  
pp. 977-983 ◽  
Author(s):  
Li Jia ◽  
Henggui Xu ◽  
Yongfu Zhao ◽  
Lili Jiang ◽  
Jingda Yu ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Multidrug Resistance ◽  
Tumor Cells
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