Novel modulators to overcome P-glycoprotein-mediated multidrug resistance in tumor cells

2004 ◽  
Vol 42 (11) ◽  
pp. 644-645 ◽  
Author(s):  
H. Müller ◽  
W. Klinkhammer ◽  
M.U. Kassack ◽  
N. Eckstein ◽  
M. Wiese
Keyword(s):  
Multidrug Resistance ◽  
Tumor Cells ◽  
P Glycoprotein

scholarly journals Intercellular transfer of P-glycoprotein mediates acquired multidrug resistance in tumor cells

2005 ◽  
Vol 102 (6) ◽  
pp. 1933-1938 ◽  
Author(s):  
A. Levchenko ◽  
B. M. Mehta ◽  
X. Niu ◽  
G. Kang ◽  
L. Villafania ◽  
...  
Keyword(s):  
Multidrug Resistance ◽  
Tumor Cells ◽  
Intercellular Transfer ◽  
P Glycoprotein

Pyronaridine, a novel modulator of P-glycoprotein-mediated multidrug resistance in tumor cells in vitro and in vivo

2004 ◽  
Vol 319 (4) ◽  
pp. 1124-1131 ◽  
Author(s):  
Jing Qi ◽  
Shubin Wang ◽  
Guying Liu ◽  
Hui Peng ◽  
Jinhong Wang ◽  
...  
Keyword(s):  
Multidrug Resistance ◽  
Tumor Cells ◽  
P Glycoprotein

scholarly journals Inhibition of Tumor Cells Multidrug Resistance by Cucumarioside A2-2, Frondoside A and their Complexes with Cholesterol

2013 ◽  
Vol 8 (10) ◽  
pp. 1934578X1300801 ◽  
Author(s):  
Ekaterina S. Menchinskaya ◽  
Dmitry L. Aminin ◽  
Sergey A. Avilov ◽  
Aleksandra S. Silchenko ◽  
Pelageya V. Andryjashchenko ◽  
...  
Keyword(s):  
Multidrug Resistance ◽  
Membrane Transport ◽  
Tumor Cells ◽  
Fluorescent Probe ◽  
Sea Cucumber ◽  
Ehrlich Carcinoma ◽  
P Glycoprotein ◽  
Potential Inhibitors ◽  
In Cells

In non-cytotoxic concentrations, frondoside A (1) from the sea cucumber Cucumaria okhotensis and cucumarioside A2-2 (2) from C. japonica, as well as their complexes with cholesterol block the activity of membrane transport P-glycoprotein in cells of the ascite form of mouse Ehrlich carcinoma. They prevent in this way an efflux of fluorescent probe Calcein from the cells. Since the blocking of P-glycoprotein activity results in decrease of multidrug resistance, these glycosides and their complexes with cholesterol may be considered as potential inhibitors of multidrug resistance of tumor cells.

scholarly journals Bromocriptine Reverses P-Glycoprotein-mediated Multidrug Resistance in Tumor Cells

2002 ◽  
Vol 93 (2) ◽  
pp. 209-215 ◽  
Author(s):  
Nobuaki Shiraki ◽  
Keiko Okamura ◽  
Jin Tokunaga ◽  
Takafumi Ohmura ◽  
Kazuto Yasuda ◽  
...  
Keyword(s):  
Multidrug Resistance ◽  
Tumor Cells ◽  
P Glycoprotein

A New Class of 1-Aryl-5,6-dihydropyrrolo[2,1-a]isoquinoline Derivatives as Reversers of P-Glycoprotein-Mediated Multidrug Resistance in Tumor Cells

ChemMedChem ◽  
2018 ◽  
Vol 13 (15) ◽  
pp. 1588-1596 ◽  
Author(s):  
Alisa A. Nevskaya ◽  
Maria D. Matveeva ◽  
Tatiana N. Borisova ◽  
Mauro Niso ◽  
Nicola A. Colabufo ◽  
...  
Keyword(s):  
Multidrug Resistance ◽  
Tumor Cells ◽  
New Class ◽  
P Glycoprotein ◽  
Isoquinoline Derivatives

The activity of latent benzoperimidine esters to inhibit P-glycoprotein and multidrug resistance-associated protein 1 dependent efflux of pirarubicin from several lines of multidrug resistant tumor cells

2004 ◽  
Vol 28 (4) ◽  
pp. 283-293 ◽  
Author(s):  
Dorota Głowacka-Rogacka ◽  
Małgorzata Arciemiuk ◽  
Agnieszka Kupiec ◽  
Maria M. Bontemps-Gracz ◽  
Edward Borowski ◽  
...  
Keyword(s):  
Multidrug Resistance ◽  
Tumor Cells ◽  
Multidrug Resistant ◽  
P Glycoprotein

Kendarimide A, a novel peptide reversing P-glycoprotein-mediated multidrug resistance in tumor cells, from a marine sponge of Haliclona sp.

Tetrahedron ◽  
2004 ◽  
Vol 60 (33) ◽  
pp. 7053-7059 ◽  
Author(s):  
Shunji Aoki ◽  
Liwei Cao ◽  
Kouhei Matsui ◽  
Rachmaniar Rachmat ◽  
Shin-ichi Akiyama ◽  
...  
Keyword(s):  
Multidrug Resistance ◽  
Tumor Cells ◽  
Marine Sponge ◽  
P Glycoprotein
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