Poly(ethylene Glycol) Diacrylate-Nanogels Synthesized by Mini-emulsion Polymerization

2019 ◽  
Vol 56 (3) ◽  
pp. 514-519
Author(s):  
Anita Laura Radu ◽  
Ana Mihaela Gavrila ◽  
Bogdan Cursaru ◽  
Catalina Paula Spatarelu ◽  
Teodor Sandu ◽  
...  
Keyword(s):  
Molecular Weight ◽  
Ethylene Glycol ◽  
Biomedical Applications ◽  
Gel Permeation Chromatography ◽  
Poly Ethylene Glycol ◽  
Glycol Diacrylate ◽  
Synthesis Parameters ◽  
Transmission Electron ◽  
Hydrophilic Lipophilic Balance ◽  
Poly Ethylene

New nanogels (NGs) with tailored properties were obtained using a mini-emulsion technique, from poly(ethylene glycol) diacrylate (PEGDA) self-crosslinking macromers of various molecular weight. By modifying synthesis parameters (hydrophilic-lipophilic balance, emulsifier and the ratio of organic-aqueous medium), optimum recipes of NGs were selected. Therefore, the molecular weight distribution and the functionalization degree of the PEGDA2000 macromer were assessed by Gel Permeation Chromatography (GPC) and Nuclear Magnetic Resonance (NMR), respectively. Furthermore, the PEGDA-NGs were investigated by Dynamic Light Scattering (DLS) and Transmission Electron Microscopy (TEM) for size distributions and morphology. DLS and TEM results confirm that these new PEGDA-NGs hold potential for biomedical applications.

scholarly journals Controlling Fluid Diffusion and Release through Mixed-Molecular-Weight Poly(ethylene) Glycol Diacrylate (PEGDA) Hydrogels

Materials ◽  
2019 ◽  
Vol 12 (20) ◽  
pp. 3381 ◽  
Author(s):  
Kieran O’Donnell ◽  
Adrian Boyd ◽  
Brian J. Meenan
Keyword(s):  
Tissue Engineering ◽  
Molecular Weight ◽  
Ethylene Glycol ◽  
Mesh Size ◽  
Material Structure ◽  
Poly Ethylene Glycol ◽  
Glycol Diacrylate ◽  
Fluorescence Measurements ◽  
Fluid Permeability ◽  
Poly Ethylene

Due to their inherent ability to swell in the presence of aqueous solutions, hydrogels offer a means for the delivery of therapeutic agents in a range of applications. In the context of designing functional tissue-engineering scaffolds, their role in providing for the diffusion of nutrients to cells is of specific interest. In particular, the facility to provide such nutrients over a prolonged period within the core of a 3D scaffold is a critical consideration for the prevention of cell death and associated tissue-scaffold failure. The work reported here seeks to address this issue via fabrication of hybrid 3D scaffolds with a component fabricated from mixed-molecular-weight hydrogel formulations capable of storing and releasing nutrient solutions over a predetermined time period. To this end, poly(ethylene) glycol diacrylate hydrogel blends comprising mixtures of PEGDA-575 Mw and PEGDA-2000 Mw were prepared via UV polymerization. The effects of addition of the higher-molecular-weight component and the associated photoinitiator concentration on mesh size and corresponding fluid permeability have been investigated by diffusion and release measurements using a Theophylline as an aqueous nutrient model solution. Fluid permeability across the hydrogel films has also been determined using a Rhodamine B solution and associated fluorescence measurements. The results indicate that addition of PEGDA-2000 Mw to PEGDA-575 Mw coupled with the use of a specific photoinitiator concentration provides a means to change mesh size in a hydrogel network while still retaining an overall microporous material structure. The range of mesh sizes created and their distribution in a 3D construct provides for the conditions required for a more prolonged nutrient release profile for tissue-engineering applications.

scholarly journals Composite Nanogels Based on Zeolite-Poly(ethylene glycol) Diacrylate for Controlled Drug Delivery

Nanomaterials ◽  
2020 ◽  
Vol 10 (2) ◽  
pp. 195 ◽  
Author(s):  
Catalina Paula Spatarelu ◽  
Anita-Laura (Radu) Chiriac ◽  
Bogdan Cursaru ◽  
Tanta-Verona Iordache ◽  
Ana-Mihaela Gavrila ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Ethylene Glycol ◽  
Natural Zeolite ◽  
Drug Loading ◽  
Controlled Drug Delivery ◽  
Poly Ethylene Glycol ◽  
Glycol Diacrylate ◽  
Preparation Conditions ◽  
Transmission Electron ◽  
Poly Ethylene

This study presents the design of novel composites nanogels, based on poly(ethylene glycol) diacrylate and natural zeolite particles, that are able to act as materials with controlled drug delivery properties. Natural zeolite–nanogels composite, with varying zeolite contents, were obtained by an inverse mini-emulsion technique and loaded with 5-fluorouracil, a widely used chemotherapeutic drug. Herein, the possibility of adjusting final properties by means of modifying the preparation conditions was investigated. The prepared composite nanogels are characterized by dynamic light scattering (DLS), transmission electron microscopy (TEM), Fourier transform infrared spectroscopy (FTIR), and thermogravimetric analysis (TGA). In light of this tunable drug-loading capability, swelling behaviour, and cytotoxicity, these composite nanogels could be highly attractive as drug reservoirs.

scholarly journals Nanogels obtained by gamma radiation induced polymerization

Polimery ◽  
2021 ◽  
Vol 66 (9) ◽  
pp. 451-458
Author(s):  
Nur Fathin Amirah Shafie ◽  
Mohd Yusof Hamzah ◽  
Roshafima Rasit Ali
Keyword(s):  
Light Scattering ◽  
Dynamic Light Scattering ◽  
Zeta Potential ◽  
Ethylene Glycol ◽  
Gamma Radiation ◽  
Biomedical Applications ◽  
Poly Ethylene Glycol ◽  
Glycol Diacrylate ◽  
Radiation Induced ◽  
Poly Ethylene

The influence of 2-(dimethylamino)ethyl methacrylate (DMAEMA) concentration on the temperature sensitivity of nanogels based on N-isopropylacrylamide (NIPAAM), poly(vinylpyrrolidone) (PVP), poly(ethylene glycol) diacrylate (PEGDA) by gamma radiation induced polymerization was investigated. Dynamic light scattering (DLS) and zeta potential measurements were used to characterize the nanogels. Temperature has been found to cause the nanogel particles to swell and shirnkage, allowing controlled dosing of the drug contained in capsules. The developed nanogels are promising materials with great potential for biomedical applications.

scholarly journals Transparent Low Molecular Weight Poly(Ethylene Glycol) Diacrylate-Based Hydrogels as Film Media for Photoswitchable Drugs

Polymers ◽  
2017 ◽  
Vol 9 (12) ◽  
pp. 639 ◽  
Author(s):  
Théophile Pelras ◽  
Sarah Glass ◽  
Tom Scherzer ◽  
Christian Elsner ◽  
Agnes Schulze ◽  
...  
Keyword(s):  
Molecular Weight ◽  
Ethylene Glycol ◽  
Low Molecular Weight ◽  
Poly Ethylene Glycol ◽  
Glycol Diacrylate ◽  
Poly Ethylene

Non-toxic polyester urethanes based on poly(lactic acid), poly(ethylene glycol) and lysine diisocyanate

2016 ◽  
Vol 32 (3) ◽  
pp. 225-241 ◽  
Author(s):  
Alena Pavelková ◽  
Pavel Kucharczyk ◽  
Zdenka Kuceková ◽  
Jiří Zedník ◽  
Vladimír Sedlařík
Keyword(s):  
Molecular Weight ◽  
Lactic Acid ◽  
Ethylene Glycol ◽  
Biomedical Applications ◽  
Hydrolytic Degradation ◽  
Chain Extension ◽  
Poly Lactic Acid ◽  
Side Reactions ◽  
Poly Ethylene Glycol ◽  
Poly Ethylene

Poly(lactic acid)-based polymers are highly suitable for temporary biomedical applications, such as tissue support or drug delivery systems. Copolymers of different molecular weight based on poly(lactic acid) and poly(ethylene glycol) were prepared by polycondensation, catalysed by hydrochloric acid. A chain-extension reaction with l-lysine ethyl ester diisocyanate was employed afterwards to obtain polyester urethanes with enhanced properties. The GPC results showed that the molecular weights of the products reached about 50,000 g·mol−1 and the hydrolytic progress was rapid in the first 2 weeks; the drop in Mn equalled approximately 70%. Additionally, elemental analysis of the buffer medium proved that hydrolytic degradation was more rapid in the first stage. Tensile-strength testing revealed that ductility increased alongside reduced molecular weight of poly(ethylene glycol), also suggesting that polymer branching occurred due to side reactions of isocyanate. Based on the envisaged biomedical applications for these polymers, cytotoxicity tests were carried out and the cytotoxic effect was only moderate in the case of 100% polymer extract prepared according to ISO standard 10993-12. In their research, the authors focused on preparing metal-free, catalysed synthesis of polyester urethanes, which could prove useful to numerous biomedical applications.

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