scholarly journals Composite Nanogels Based on Zeolite-Poly(ethylene glycol) Diacrylate for Controlled Drug Delivery

Nanomaterials ◽  
2020 ◽  
Vol 10 (2) ◽  
pp. 195 ◽  
Author(s):  
Catalina Paula Spatarelu ◽  
Anita-Laura (Radu) Chiriac ◽  
Bogdan Cursaru ◽  
Tanta-Verona Iordache ◽  
Ana-Mihaela Gavrila ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Ethylene Glycol ◽  
Natural Zeolite ◽  
Drug Loading ◽  
Controlled Drug Delivery ◽  
Poly Ethylene Glycol ◽  
Glycol Diacrylate ◽  
Preparation Conditions ◽  
Transmission Electron ◽  
Poly Ethylene

This study presents the design of novel composites nanogels, based on poly(ethylene glycol) diacrylate and natural zeolite particles, that are able to act as materials with controlled drug delivery properties. Natural zeolite–nanogels composite, with varying zeolite contents, were obtained by an inverse mini-emulsion technique and loaded with 5-fluorouracil, a widely used chemotherapeutic drug. Herein, the possibility of adjusting final properties by means of modifying the preparation conditions was investigated. The prepared composite nanogels are characterized by dynamic light scattering (DLS), transmission electron microscopy (TEM), Fourier transform infrared spectroscopy (FTIR), and thermogravimetric analysis (TGA). In light of this tunable drug-loading capability, swelling behaviour, and cytotoxicity, these composite nanogels could be highly attractive as drug reservoirs.

Drug Delivery From Poly(ethylene glycol) Diacrylate Scaffolds Produced by DLC Based Micro-Stereolithography

2014 ◽  
Vol 346 (1) ◽  
pp. 43-47 ◽  
Author(s):  
Mark Vehse ◽  
Svea Petersen ◽  
Katrin Sternberg ◽  
Klaus-Peter Schmitz ◽  
Hermann Seitz
Keyword(s):  
Drug Delivery ◽  
Ethylene Glycol ◽  
Poly Ethylene Glycol ◽  
Glycol Diacrylate ◽  
Poly Ethylene

scholarly journals Development of UV-Reactive Electrospinning Method Based on Poly(ethylene glycol) diacrylate Crosslinking

2020 ◽  
Vol 6 (3) ◽  
pp. 189-192
Author(s):  
Jennifer Huling ◽  
Beate Lyko ◽  
Sabine Illner ◽  
Nicklas Fiedler ◽  
Niels Grabow ◽  
...  
Keyword(s):  
Ethylene Glycol ◽  
Uv Light ◽  
Light Exposure ◽  
Drug Loading ◽  
High Surface ◽  
Solvent Evaporation ◽  
Water Soluble ◽  
Poly Ethylene Glycol ◽  
Glycol Diacrylate ◽  
Poly Ethylene

AbstractElectrospinning is a popular method for creating nonwoven fiber materials for a wide variety of applications. In the field of biomaterials, electrospun materials are favoured because of a high surface-to-volume ratio which can be useful for drug loading and release, and because nanoscale fibers mimic native tissue structures, improving cell interactions. However limitations exist with regards to traditional solvent evaporation-based electrospinning techniques. A new area of research into reactive electrospinning is investigating methods of electrospinning that rely on in situ crosslinking rather than solvent evaporation to stabilize fibers. These techniques can potentially reduce the waste of excess solvents and make it easier to electrospin water soluble polymers. In this work, UV photocrosslinked PEGDA is evaluated as a material for reactive electrospinning. To facilitate the electrospinning process poly(ethylene glycol) diacrylate (PEGDA) is combined with polyvinyl alcohol (PVA). PEGDA/PVA solutions can be successfully electrospun under constant UV light exposure to initiate the crosslinking of the PEGDA. Reactive electrospun fibers appear more stable immediately after spinning and after washing with water, indicating successful photo crosslinking.

Poly(ethylene Glycol) Diacrylate-Nanogels Synthesized by Mini-emulsion Polymerization

2019 ◽  
Vol 56 (3) ◽  
pp. 514-519
Author(s):  
Anita Laura Radu ◽  
Ana Mihaela Gavrila ◽  
Bogdan Cursaru ◽  
Catalina Paula Spatarelu ◽  
Teodor Sandu ◽  
...  
Keyword(s):  
Molecular Weight ◽  
Ethylene Glycol ◽  
Biomedical Applications ◽  
Gel Permeation Chromatography ◽  
Poly Ethylene Glycol ◽  
Glycol Diacrylate ◽  
Synthesis Parameters ◽  
Transmission Electron ◽  
Hydrophilic Lipophilic Balance ◽  
Poly Ethylene

New nanogels (NGs) with tailored properties were obtained using a mini-emulsion technique, from poly(ethylene glycol) diacrylate (PEGDA) self-crosslinking macromers of various molecular weight. By modifying synthesis parameters (hydrophilic-lipophilic balance, emulsifier and the ratio of organic-aqueous medium), optimum recipes of NGs were selected. Therefore, the molecular weight distribution and the functionalization degree of the PEGDA2000 macromer were assessed by Gel Permeation Chromatography (GPC) and Nuclear Magnetic Resonance (NMR), respectively. Furthermore, the PEGDA-NGs were investigated by Dynamic Light Scattering (DLS) and Transmission Electron Microscopy (TEM) for size distributions and morphology. DLS and TEM results confirm that these new PEGDA-NGs hold potential for biomedical applications.

scholarly journals Gel Polymer Electrolytes Based on Cross-Linked Poly(ethylene glycol) Diacrylate for Calcium-Ion Conduction

ACS Omega ◽  
2021 ◽  
Author(s):  
Saeid Biria ◽  
Shreyas Pathreeker ◽  
Francielli S. Genier ◽  
Fu-Hao Chen ◽  
Hansheng Li ◽  
...  
Keyword(s):  
Ethylene Glycol ◽  
Polymer Electrolytes ◽  
Calcium Ion ◽  
Gel Polymer Electrolytes ◽  
Poly Ethylene Glycol ◽  
Ion Conduction ◽  
Glycol Diacrylate ◽  
Poly Ethylene
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