scholarly journals The Study of Placental Vascularization Using Type AGO II Plastic Substances

2019 ◽  
Vol 56 (1) ◽  
pp. 171-173
Author(s):  
Catalin Dumitru ◽  
Izabella Petre ◽  
Marius Craina ◽  
Lavinia Cristina Moleriu ◽  
Nicolae Suciu ◽  
...  
Keyword(s):  
Hydrochloric Acid ◽  
Growth And Development ◽  
Blood Circulation ◽  
Normal Development ◽  
Corrosive Action ◽  
Placental Blood ◽  
Standardized Method

Placental blood circulation has certain features that allow the exchange of nutrients between the maternal and fetus blood, respectively allow exchanges of nutrients between the mother and the fetus. We studied 50 human placentas. The method used in the case of our study is a standardized method of the Laboratory of Anatomy and Embryology, Victor Babes University of Medicine and Pharmacy, Timisoara, for over 50 years. The making of corrosion concoction followed the recipe of the laboratory using type AGO II plastic substances, differently coloured and then subjected to the corrosive action of hydrochloric acid. The model of corrosion preparations showed the distributions known as dichotomic and magisterial distribution. The normal development of placenta remains a major factor in the growth and development of the fetus, and maternal-fetal vasculature in the placenta is essential in this regard.

scholarly journals Macroscopic Examination of Placental Vascularization with a Corrosive Agent in Pregnant Women Diagnosed with Thrombophilia

2017 ◽  
Vol 54 (4) ◽  
pp. 678-681
Author(s):  
Diana Camelia Bonte ◽  
Olivera Iordache ◽  
Izabella Petre ◽  
Marius Craina ◽  
Veronica Daniela Chiriac ◽  
...  
Keyword(s):  
Pregnant Woman ◽  
Hydrochloric Acid ◽  
Pregnant Women ◽  
Growth And Development ◽  
Normal Development ◽  
Placental Development ◽  
Local Component ◽  
Placental Angiogenesis ◽  
Vascular Morphogenesis ◽  
Macroscopic Examination

The normal development of the placenta is a major factor in the fetus s growth and development, whilst the maternal-fetal placental vasculature is essential in this regard. During placentation, there is an ongoing process, which combines angiogenesis with vasculogenesis, as demonstrated by numerous studies, which reveal important roles of various known angiogenic factors, while other studies show the roles of different classes of factors in vascular morphogenesis nonspecific to the placenta. The method used in the case of our study is a standardized method of the Laboratory of Anatomy and Embryology, Victor Babes University of Medicine and Pharmacy, Timişoara, for over 50 years. The making of corrosion concoction followed the recipe of the laboratory using type AGO II plastic substances, differently colored and then subjected to the corrosive action of hydrochloric acid. During the routine check outs all the pregnant woman�s were diagnosed with thrombophilia. The examination of the placental parameters - shape, weight, thickness - is important as a preliminary stage for the study of the placental architecture. The normal placental development remains a major factor in the growth and development of the fetus, and the maternal-fetal placental vasculature is essential in this regard. Placental angiogenesis has a different local component of angiogenesis, found in other anatomical regions.

scholarly journals Inactivation of the Nuclear Receptor Coactivator RAP250 in Mice Results in Placental Vascular Dysfunction

2003 ◽  
Vol 23 (4) ◽  
pp. 1260-1268 ◽  
Author(s):  
Per Antonson ◽  
Gertrud U. Schuster ◽  
Ling Wang ◽  
Björn Rozell ◽  
Elin Holter ◽  
...  
Keyword(s):  
Nuclear Receptors ◽  
Nuclear Receptor ◽  
Blood Circulation ◽  
Transcriptional Activity ◽  
Vascular Dysfunction ◽  
Diverse Group ◽  
Placental Development ◽  
Nuclear Receptor Coactivator ◽  
The Past ◽  
Placental Blood

ABSTRACT Coactivators constitute a diverse group of proteins that are essential for optimal transcriptional activity of nuclear receptors. In the past few years many coactivators have been identified but it is still unclear whether these proteins interact indiscriminately with all nuclear receptors and whether there is some redundancy in their functions. We have previously cloned and characterized RAP250 (ASC-2/PRIP/TRBP/NRC), an LXXLL-containing coactivator for nuclear receptors. In order to study its biological role, Rap250 null mice were generated by gene targeting. Here we show that genetic disruption of Rap250 results in embryonic lethality at embryonic day (E) 13.5. Histological examination of placentas revealed a dramatically reduced spongiotrophoblast layer, a collapse of blood vessels in the region bordering the spongiotrophoblast, and labyrinthine layers in placentas from Rap250−/− embryos. These findings suggest that the lethality of Rap250−/− embryos is the result of obstructed placental blood circulation. Moreover, the transcriptional activity of PPARγ is reduced in fibroblasts derived from Rap250−/− embryos, suggesting that RAP250 is an essential coactivator for this nuclear receptor in the placenta. Our results demonstrate that RAP250 is necessary for placental development and thus essential for embryonic development.

scholarly journals PENGARUH PIJAT BAYI TERHADAP DURASI TIDUR PADA BAYI UMUR 1-3 BULAN

2019 ◽  
Vol 7 (2) ◽  
pp. 1
Author(s):  
Gusti Ayu Pramita Aswitami ◽  
Ni Putu Mirah Yunita Udayani
Keyword(s):  
Sleep Duration ◽  
Brain Function ◽  
Growth And Development ◽  
Blood Circulation ◽  
Wilcoxon Test ◽  
Control Group ◽  
Infant Sleep ◽  
Infant Massage ◽  
Main Requirement ◽  
A Value

Sleep is the baby's main requirement because when the baby falls asleep growth and development will be optimal and there will be an increase in brain function and body metabolism. In infants aged 1-3 months have a sleep duration of 14 hours-18 hours per day. Baby's growth and development will be less optimal if there is a sleep disorder. Baby massage is one way to overcome the problem of sleeping in a baby. Baby massage is a gentle rubbing motion on the surface of the baby's body from face to foot. This massage will help relax the baby's muscles and facilitate blood circulation so that the baby becomes calmer and sleeps more soundly. This study aims to determine the effect of infant massage on sleep duration in infants aged 1-3 months. The design of this study used a pre-experimental design with the design of one group pretest-posttest design without a control group. Samples are infants aged 1-3 months, totaling 42 people selected by purposive sampling. The variables measured in this study were infant massage and sleep duration. This study used a statistical test paired t-test (a = 0.05). The results of this study are that there is an effect of infant massage on the duration of infant sleep, this is confirmed by the value of Wilcoxon test with sig 0,000 which then tested the hypothesis with a value of α = 0.05. With a sig value of 0,000

Development of a placental blood circulation in rat embryos in vitro

Development ◽  
1977 ◽  
Vol 37 (1) ◽  
pp. 227-235
Author(s):  
D. A. T. New ◽  
P. T. Coppola
Keyword(s):  
Total Protein ◽  
Blood Circulation ◽  
Maternal Blood ◽  
Yolk Sac ◽  
Rat Embryos ◽  
Placental Blood ◽  
Foetal Blood

Rat embryos explanted with their membranes at head-fold stage (9½ days gestation) formed an allantoic placenta which enlarged in culture and developed a foetal blood circulation. Embryos explanted at early somite stages (10½ days) also formed a growing allantoic placenta but only after removal of most of the ectoplacental trophoblast. Assays of total protein in the embryo and placenta suggested that, in the absence of a maternal blood circulation to the placenta, embryo and placenta compete for the respiratory and nutritional resources obtained through the yolk-sac.

Prenatal and infant conditioning, the mother schema, and the origins of music and religion

2009 ◽  
Vol 13 (2_suppl) ◽  
pp. 119-150 ◽  
Author(s):  
Richard Parncutt
Keyword(s):  
Blood Circulation ◽  
Body Movement ◽  
Altered States ◽  
States Of Consciousness ◽  
Adaptive Value ◽  
Audible Sound ◽  
Gestational Week ◽  
Placental Blood ◽  
Personal Qualities ◽  
Music And Religion

Existing theories of the origins of music and religion fail to account directly and convincingly for their universal emotional power and behavioural costliness. The theory of prenatal origins is based on empirically observable phenomena and involves prenatal classical conditioning, postnatal operant conditioning and the adaptive value of mother-infant bonding. The human fetus can perceive sound and acceleration from gestational week 20. The most salient sounds for the fetus are internal to the mother's body and associated with vocalisation, blood circulation, impacts (footfalls), and digestion. The protomusical sensitivity of infants may be based on prenatal associations between the mother's changing physical and emotional state and concomitant changes in both hormone levels in the placental blood and prenatally audible sound/movement patterns. Protomusical aspects of motherese, play and ritual may have emerged during a multigenerational process of operational conditioning on the basis of prenatally established associations among sound, movement and emotion. The infant's multimodal cognitive representation of its mother (mother schema) begins to develop before birth and may underlie music's personal qualities, religion's supernatural agents, and the link between the two. Prenatal theory can contribute to an explanation of musical universal such as specific features of rhythm and melody and associations between music and body movement, as well as universal commonalities of musical and religious behaviour and experience such as meaning, fulfilment, and altered states of consciousness.

scholarly journals Hemostasis in pregnant, parturient and puerperal women with preeclampsia

2020 ◽  
Vol 14 (4) ◽  
pp. 469-478
Author(s):  
M. G. Mustafin ◽  
E. Yu. Yupatov ◽  
T. E. Kurmanbaev ◽  
R. M. Nibiullina ◽  
Yu. L. Timoshkova ◽  
...  
Keyword(s):  
Cesarean Section ◽  
Pregnant Women ◽  
Postoperative Period ◽  
Blood Circulation ◽  
Perinatal Outcomes ◽  
International Normalized Ratio ◽  
Coagulation System ◽  
Specific Complication ◽  
Placental Blood ◽  
Adverse Perinatal Outcomes

Introduction. Preeclampsia (PE) is a specific complication of pregnancy holding a lead place in maternal and perinatal morbidity and mortality worldwide. The development of PE in the maternal body is accompanied by severe hypercoagulation, disturbed anticoagulation and fibrinolytic systems. As a result, vascular microthrombosis in diverse organs with developing endothelial dysfunction, impaired utero-placental blood circulation emerge that leads to adverse perinatal outcomes.Aim: to study status of coagulation arm in pregnant women with moderate and severe PE, after delivery by cesarean section, to optimize management of the postoperative period.Materials and Methods. There were enrolled 50 pregnant women with PE: 16 with moderate and 34 with severe PE after surgical delivery. A status of coagulation arm was examined by evaluating major parameters in coagulogram (fibrinogen, activated partial thromboplastin time, prothrombin, international normalized ratio) as well as assay for early diagnostics of blood clotting disorders to reveal bleeding and thrombosis risks.Results. It was found that prior to surgery patients with severe PE had significantly increased clot growth rate (V) by 1.09-fold (p = 0.001), relative clot density (D) by 1.15-fold (p = 0.001), and time of spontaneous clot appearance (Tsp) was accelerated by 2-fold (p = 0.001) compared to moderate PE. After surgical delivery, patients from both groups had changes evidencing about activated coagulation system: increased V, D, as well as the Tsp. Upon that, all such parameters in patients with severe PE were significantly elevated: the V – by 1.25-fold (p = 0.005); the D – by 1.1-fold (p = 0.02); the Tsp was accelerated by 2-fold (p = 0.03) compared to patients with moderate PE. All parameters in both groups tended to normalize on day 5 after surgical delivery, but patients with severe PE were shown to have significantly increased the V – by 1.5-fold (p = 0.001); the D – by 1.14-fold (p = 0.001); the clot size – by 1.14-fold (p = 0.001); the Tsp – accelerated by 41 % (p = 0.001) compared to patients with moderate PE.Conclusion. Thus, patients with moderate and severe PE after surgical delivery by cesarean section were featured with markedly activated coagulation hemostasis, which may justify a prolonged use of low-molecular-weight heparins in the postoperative period, especially in patients with PE.

The effect of balanced feeding on the fertility of animals

2021 ◽  
Vol 66 (05) ◽  
pp. 14-18
Author(s):  
Suliddin Ağamalı oğlu Abbasov ◽  
◽  
Səbuhi Nəbi oğlu Məmmədov ◽  
Keyword(s):  
Growth And Development ◽  
High Efficiency ◽  
Normal Development ◽  
Physiological State ◽  
Feed Mixture ◽  
Growth Variability ◽  
On Demand ◽  
Complete Diet ◽  
Offspring Growth ◽  
Positive Results

Positive results have been obtained in the implementation of our research at the Livestock and Equestrian Training Center of ADAU on the basis of the recipes we have envisaged, along with the strong feed component, the feed norm and the share of feed in the required norm. The introduction of fully balanced feedings based on recipes has affected the milk yield of animals, as well as the fertility of cows, in addition to strengthening the dynamics of growth and development of young. One of the most widely used premixes on our farm is Ruminant-5322 Ekomix BKB, which has a high efficiency with the following saturation. A premix is a complementary feed mixture that is necessary for its composition and body and is essential to create a fully balanced feed portion. Depending on the abundance of feed available on the farm, it is possible to maintain a complete diet depending on the physiological state of the animals. On the basis of this nutrition, the dynamics of the growth of young animals, the normal development of the child in the womb during the drying period and the formation of the mother's reproductive cycle on demand are determined. Fertility activation is associated not only with the formation of 65 to 80 days in cows, but also with the stabilization of the follicles and the achievement of a form of superovulation. In our research, we found this not only in healthy cows, but also in cows that had difficult labor. Of the 18 cows on the farm, three gave birth to twins, which means that 16.7% of the cows gave birth to twins. Key words: Balanced feed, genotype, male, offspring, growth, variability, productivity

scholarly journals Differential Expression of the Three Multicopper Oxidases from Myxococcus xanthus

2007 ◽  
Vol 189 (13) ◽  
pp. 4887-4898 ◽  
Author(s):  
María Celestina Sánchez-Sutil ◽  
Nuria Gómez-Santos ◽  
Aurelio Moraleda-Muñoz ◽  
Lígia O. Martins ◽  
Juana Pérez ◽  
...  
Keyword(s):  
Adaptive Response ◽  
Growth And Development ◽  
Normal Development ◽  
Myxococcus Xanthus ◽  
Copper Resistance ◽  
Copper Tolerance ◽  
Deletion Mutants ◽  
Fruiting Bodies ◽  
Multicopper Oxidases ◽  
Copper Addition

ABSTRACT Myxococcus xanthus is a soil bacterium that undergoes a unique life cycle among the prokaryotes upon starvation, which includes the formation of macroscopic structures, the fruiting bodies, and the differentiation of vegetative rods into coccoid myxospores. This peculiarity offers the opportunity to study the copper response in this bacterium in two different stages. In fact, M. xanthus vegetative rods exhibit 15-fold-greater resistance against copper than developing cells. However, cells preadapted to this metal reach the same levels of resistance during both stages. Analysis of the M. xanthus genome reveals that many of the genes involved in copper resistance are redundant, three of which encode proteins of the multicopper oxidase family (MCO). Each MCO gene exhibits a different expression profile in response to external copper addition. Promoters of cuoA and cuoB respond to Cu(II) ions during growth and development; however, they show a 10-fold-increased copper sensitivity during development. The promoter of cuoC shows copper-independent induction upon starvation, but it is copper up-regulated during growth. Phenotypic analyses of deletion mutants reveal that CuoB is involved in the primary copper-adaptive response; CuoA and CuoC are necessary for the maintenance of copper tolerance; and CuoC is required for normal development. These roles seem to be carried out through cuprous oxidase activity.

scholarly journals The Normal Development of the Lymphoid Mass in the Golden Hamster and its Relationship to the Effects of Thymectomy

Blood ◽  
1965 ◽  
Vol 25 (4) ◽  
pp. 511-521 ◽  
Author(s):  
MARVIN M. ADNER ◽  
JOSEPH D. SHERMAN ◽  
WILLIAM DAMESHEK
Keyword(s):  
Lymph Node ◽  
Mesenteric Lymph Node ◽  
Golden Hamster ◽  
Growth And Development ◽  
Normal Development ◽  
Maximum Size ◽  
Lymphoid Organ ◽  
Wasting Disease ◽  
Mesenteric Lymph ◽  
Accelerated Growth

Abstract A study of lymphoid organ sections and imprints of normal hamsters from fetal to adult state revealed a sequential pattern of organ structure and growth. The thymus developed an adult structure by 1 week, maximum size at 6 weeks. The mesenteric lymph node had an adult structure by 4 weeks, the spleen by 6 weeks, with an accelerated growth of both organs between 6 to 8 weeks. The growth and development of the peripheral lymphoid organs appears to be under thymic control until the attainment of a "critical peripheral lymphoid mass." This appears capable of functioning independently of thymic control. Thymectomy is effective in producing lymphoid atrophy with resultant immunosuppression and wasting disease only if performed prior to the attainment of the "critical peripheral lymphoid mass."

Development of Swallowing Function Along the Prenatal to Postnatal Continuum

2008 ◽  
Vol 17 (3) ◽  
pp. 78-83
Author(s):  
Donna Scarborough ◽  
Jeri Miller ◽  
Kara Fletcher
Keyword(s):  
Decision Making ◽  
Growth And Development ◽  
Clinical Decision Making ◽  
Normal Development ◽  
Clinical Decision ◽  
In Utero ◽  
Postnatal Period ◽  
Decision Making Process ◽  
Swallowing Function ◽  
Ongoing Research

Abstract Developmental information is the cornerstone of diagnosis and intervention in pediatric dysphagia. Ongoing research has refined specific parameters of growth and development of the swallow from the prenatal through the postnatal period. The intent of this article is to review the latest findings regarding normal development of feeding/swallowing from the time the fetus is in utero through the postnatal period. This information may provide clinicians valuable tools to make adaptations within the clinical decision making process.

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