scholarly journals Efeito da melatonina exógena no estresse oxidativo provocado pelo exercício físico

2017 ◽  
Vol 86 (2) ◽  
Author(s):  
Claudia Costa de Moraes Coutinho ◽  
Cintia Mussi Alvim Stocchero
Keyword(s):  
Oxidative Stress ◽  
Exercise Performance ◽  
Physical Training ◽  
Experimental Studies ◽  
Physical Exertion ◽  
Sports Performance ◽  
Cellular Processes ◽  
Markers Of Oxidative Stress ◽  
Exercise Induced ◽  
And Oxidative Stress

Introdução: Na prática desportiva competitiva, pesquisadores da fisiologia humana buscam novas descobertas, tanto no campo do treinamento físico como na suplementação de substâncias que possam contribuir para uma melhora do desempenho esportivo, diminuindo a fadiga e contribuindo para a recuperação. Recentemente, a melatonina tem sido alvo de pesquisas por apresentar propriedades que modulam processos celulares intimamente ligados à produção de energia e apresentar propriedades antioxidativas.Objetivo: Avaliar como a suplementação de melatonina pode atenuar o dano oxidativo da célula induzido pelo exercício.Métodos: Nesta revisão narrativa, foram consultadas as bases na literatura PubMed e Elsevier, utilizando os termos “melatonin AND oxidative stress in exercise", “melatonin AND exercise performance”, “melatonin supplementation AND exercise”, desde o ano 2000 até 2016.Resultados e Discussão: Seis estudos de desenho experimental fizeram parte desta revisão. A melatonina foi suplementada antes do esforço físico e os parâmetros bioquímicos foram mensurados antes, durante e depois do mesmo. Os estudos apontaram diminuição dos marcadores de estresse oxidativo utilizando-se melatonina. Todavia, há controvérsias quanto à utilização dos reagentes laboratoriais para esses marcadores.Conclusão: A literatura mostra que a suplementação de melatonina promove melhora no padrão oxidativo a partir da diminuição dos níveis de marcadores da oxidação no sangue e nos tecidos. Tal suplementação mostrou-se benéfica e segura para atletas que, devido às altas cargas de treinamento físico, estão cronicamente expostos a ataques mais severos do estresse oxidativo pelo treinamento físico.Effect of Exogenous Melatonin on the Exercise Induced Oxidative StressAbstractIntroduction: In competitive sport, researchers in human physiology seek new discoveries, both in the field of physical training and in the supplementation of substances that can contribute to an improvement in sports performance, reducing fatigue and contributing to recovery. Recently, melatonin has been subject of research because of its modulating actions in cellular processes, closely linked to the production of energy and because of its antioxidative properties.Objective: To evaluate how melatonin supplementation can attenuate the oxidative stress of the cell induced by exerciseMethods: In this narrative review, searches in the literature were performed in PubMed and Elsevier bases using the terms "melatonin AND oxidative stress in exercise"; "melatonin AND exercise performance"; "melatonin supplementation AND exercise", from 2000 to 2016.Results and Discussion: Six experimental studies were part of this review. Melatonin was supplemented before physical exertion and the biochemical parameters were measured before, during and after the exercise test. The studies indicated a decrease in the markers of oxidative stress using melatonin. However, there are controversies regarding the use of laboratory reagents for those markers.Conclusion: The literature shows that melatonin supplementation promotes improvement in the oxidative pattern by decreasing levels of oxidation markers in blood and tissues. Such supplementation has proved to be beneficial and safe for athletes who, due to the high loads of physical training, are chronically exposed to more severe attacks of oxidative stress related to physical training.  

scholarly journals Effect of Cocoa Products and Its Polyphenolic Constituents on Exercise Performance and Exercise-Induced Muscle Damage and Inflammation: A Review of Clinical Trials

Nutrients ◽  
2019 ◽  
Vol 11 (7) ◽  
pp. 1471 ◽  
Author(s):  
Marika Massaro ◽  
Egeria Scoditti ◽  
Maria Carluccio ◽  
Antonia Kaltsatou ◽  
Antonio Cicchella
Keyword(s):  
Oxidative Stress ◽  
Clinical Trials ◽  
Exercise Performance ◽  
Randomized Clinical Trials ◽  
Cell Damage ◽  
Experimental Studies ◽  
Muscle Performance ◽  
Cocoa Products ◽  
Exercise Induced ◽  
Polyphenol Intake

In recent years, the consumption of chocolate and, in particular, dark chocolate has been “rehabilitated” due to its high content of cocoa antioxidant polyphenols. Although it is recognized that regular exercise improves energy metabolism and muscle performance, excessive or unaccustomed exercise may induce cell damage and impair muscle function by triggering oxidative stress and tissue inflammation. The aim of this review was to revise the available data from literature on the effects of cocoa polyphenols on exercise-associated tissue damage and impairment of exercise performance. To this aim, PubMed and Web of Science databases were searched with the following keywords: “intervention studies”, “cocoa polyphenols”, “exercise training”, “inflammation”, “oxidative stress”, and “exercise performance”. We selected thirteen randomized clinical trials on cocoa ingestion that involved a total of 200 well-trained athletes. The retrieved data indicate that acute, sub-chronic, and chronic cocoa polyphenol intake may reduce exercise-induced oxidative stress but not inflammation, while mixed results are observed in terms of exercise performance and recovery. The interpretation of available results on the anti-oxidative and anti-inflammatory activities of cocoa polyphenols remains questionable, likely due to the variety of physiological networks involved. Further experimental studies are mandatory to clarify the role of cocoa polyphenol supplementation in exercise-mediated inflammation.

scholarly journals Polyphenols in Exercise Performance and Prevention of Exercise-Induced Muscle Damage

2013 ◽  
Vol 2013 ◽  
pp. 1-9 ◽  
Author(s):  
Marco Malaguti ◽  
Cristina Angeloni ◽  
Silvana Hrelia
Keyword(s):  
Oxidative Stress ◽  
Protective Effect ◽  
Muscle Damage ◽  
Exercise Performance ◽  
Healthy Lifestyle ◽  
Time Data ◽  
Positive Effects ◽  
Exercise Induced ◽  
Dietary Strategies ◽  
And Oxidative Stress

Although moderate physical exercise is considered an essential component of a healthy lifestyle that leads the organism to adapt itself to different stresses, exercise, especially when exhaustive, is also known to induce oxidative stress, inflammation, and muscle damage. Many efforts have been carried out to identify dietary strategies or micronutrients able to prevent or at least attenuate the exercise-induced muscle damage and stress. Unfortunately most studies have failed to show protection, and at the present time data supporting the protective effect of micronutrients, as antioxidant vitamins, are weak and trivial. This review focuses on those polyphenols, present in the plant kingdom, that have been recently suggested to exert some positive effects on exercise-induced muscle damage and oxidative stress. In the last decade flavonoids as quercetin, catechins, and other polyphenols as resveratrol have caught the scientists attention. However, at the present time drawing a clear and definitive conclusion seems to be untimely.

Differential susceptibility of a few members of the nasuta–albomicans complex of Drosophila to paraquat-induced lethality and oxidative stress

Genome ◽  
2011 ◽  
Vol 54 (10) ◽  
pp. 829-835 ◽  
Author(s):  
Mysore S. Ranjini ◽  
Ravikumar Hosamani ◽  
Muralidhara ◽  
Nallur B. Ramachandra
Keyword(s):  
Oxidative Stress ◽  
Biochemical Analysis ◽  
Reduced Glutathione ◽  
Differential Susceptibility ◽  
Activity Levels ◽  
Oxygen Species ◽  
Stress Markers ◽  
The Status ◽  
Markers Of Oxidative Stress ◽  
And Oxidative Stress

The evolution of karyotypically stabilized short-lived (SL) and long-lived (LL) cytoraces in the laboratory have been established and validated through our previous lifespan studies. In the present investigation, we examined the possible reason(s) for the differential longevity among selected members of SL and LL cytoraces, employing the well known paraquat (PQ) resistance bioassay. Exposure of these races to varying concentrations of PQ revealed relatively higher resistance among LL cytoraces than SL cytoraces, as evident by the lower incidence of mortality. Biochemical analysis for endogenous markers of oxidative stress revealed that LL-2 cytorace exhibited lower reactive oxygen species (ROS) and lipid peroxidation (LPO) levels, higher activity levels of superoxide dismutase (SOD), and coupled with higher levels of reduced glutathione (GSH) compared with the levels found in SL-2 cytorace. These findings suggest that the higher susceptibility of SL cytoraces to PQ challenge may be, at least in part, related to the higher endogenous levels of oxidative stress markers. Although the precise mechanisms responsible for the longer longevity among LL cytoraces of the nasuta–albomicans complex of Drosophila merits further investigation, our data suggest that the relatively longer lifespan may be related to the status of endogenous markers that renders them more resistant towards oxidative-stress-mediated lethality, as evident in the PQ assay.

Daphnetin Ameliorates Corticosterone-Induced Depressive-Like Behavior and Oxidative Stress in Mice Via Nuclear Factor Erythroid 2-Related Factor/Heme Oxygenase-1 Pathway

2021 ◽  
Vol 19 (4) ◽  
pp. 470-476
Author(s):  
Chao Liu ◽  
Chao Liang ◽  
Jie Huang
Keyword(s):  
Oxidative Stress ◽  
Consumption Rate ◽  
Tail Suspension Test ◽  
Protein Carbonyl ◽  
Heme Oxygenase 1 ◽  
Related Factor ◽  
Sucrose Consumption ◽  
Markers Of Oxidative Stress ◽  
Swimming Test ◽  
And Oxidative Stress

We have investigated the effect of daphnetin on depressive-like behavior and oxidative stress caused by corticosterone in mice. To this end, we have analyzed the effect of corticosterone alone and combination of corticosterone and daphnetin on three behavioral indices of depressive-like behavior - sucrose consumption rate, forced swimming test, and tail suspension test as well as biochemical markers of oxidative stress - malondialdehyde, nitrite, protein carbonyl, nonprotein sulfhydryl and glutathione contents as well as hippocampal cell apoptosis. The results support the conclusion that daphnetin diminished corticosterone induced depressive like behavior and oxidative stress by activating Nrf2/HO-1 pathway.

246 Effects of Feeding Thermally Processed Spray-dried Egg Whites on Growth Performance, Apparent Digestibility, and Oxidative Stress in Nursery Pigs

2021 ◽  
Vol 99 (Supplement_1) ◽  
pp. 91-92
Author(s):  
Victoria C Wilson ◽  
Brian J Kerr
Keyword(s):  
Oxidative Stress ◽  
Growth Performance ◽  
Liver Tissue ◽  
Protein Carbonyls ◽  
Nursery Pigs ◽  
Thermally Processed ◽  
Markers Of Oxidative Stress ◽  
Dietary Treatments ◽  
And Oxidative Stress ◽  
Spray Dried

Abstract The objectives of this study were to determine if feeding thermally processed (TP, heated at 100°C for 120 h) spray-dried egg whites (SDEW) to nursery pigs would impact growth performance, apparent total tract digestibility (ATTD) of GE, N, and S, and oxidative stress. Thirty-two barrows, (initial BW 7.1 kg) were randomly assigned to dietary treatments with 1 pig per pen. In a preliminary study, thermally processing SDEW at 100°C for 120 h increased protein carbonyls (PC) from 6 µmol/g to 19.4 µmol/g (P ≤ 0.01). Diets included either 12% SDEW, 6% TP-SDEW plus 6% SDEW, or 12% TP-SDEW. The experiment lasted 24 d for collection of growth performance data, while plasma was collected on d 21 and liver tissue harvested on d 24 to analyze for markers of oxidative stress. Feces were collected on d 22 for measures of ATTD. Daily gain, daily feed intake, feed efficiency, and ATTD of GE were not found to be different among dietary treatments (P ≥ 0.57). In contrast, ATTD of N (P = 0.11) and S (P = 0.03) were found to increase with increasing protein oxidation in the diet. There was no change in the plasma or liver F2-isoprostanes and 8-hydroxy-2’-deoxyguanosine among dietary treatments (P ≥ 0.28). An increase in plasma PC (P = 0.02) was observed in pigs fed 12% TP-SDEW compared to pigs fed 12% SDEW and pigs fed 6% TP-SDEW. In contrast, a decrease in liver tissue PC (P = 0.04) was observed in pigs fed 6% TP-SDEW compared to pigs fed 12% SDEW and 12% TP-SDEW. These results indicate that feeding TP-SDEW does not affect growth performance, ATTD of GE, and oxidative stress as indicated by F2-isoprostanes or 8-hydroxy-2’-deoxyguanosine; but appeared to have variable effects on oxidative stress as measured by PC.

scholarly journals Effect of Ambrotose AO® on resting and exercise-induced antioxidant capacity and oxidative stress in healthy adults

2010 ◽  
Vol 9 (1) ◽  
Author(s):  
Richard J Bloomer ◽  
Robert E Canale ◽  
Megan M Blankenship ◽  
Kelsey H Fisher-Wellman
Keyword(s):  
Oxidative Stress ◽  
Antioxidant Capacity ◽  
Healthy Adults ◽  
Exercise Induced ◽  
And Oxidative Stress
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