scholarly journals Etiology of bloodstream infections at a population level during 2013-2017 in the Autonomous Community of Valencia, Spain

2020 ◽  
Vol 33 (3) ◽  
pp. 200-206
Author(s):  
Laura Ruiz-Azcona ◽  
Miguel Santibañez ◽  
Adelina Gimeno ◽  
Francisco Javier Roig ◽  
Hermelinda Vanaclocha ◽  
...  
Keyword(s):  
Antibiotic Therapy ◽  
Bloodstream Infections ◽  
Population Level ◽  
Empirical Treatment ◽  
Autonomous Community ◽  
Coagulase Negative Staphylococci ◽  
Mortality And Morbidity ◽  
Enterococcus Spp ◽  
Key Factor ◽  
Selection Of

Introduction. Bloodstream Infections has become in one of the priorities for the antimicrobial stewardship teams due to their high mortality and morbidity rates. Usually, the first antibiotic treatment for this pathology must be empirical, without microbiology data about the microorganism involved. For this reason, the population studies about the etiology of bacteremia are a key factor to improve the selection of the empirical treatment, because they describe the main microorganisms associated to this pathology in each area, and this data could facilitate the selection of correct antibiotic therapy. Material and methods. This study describes the etiology of bloodstream infections in the Southeast of Spain. The etiology of bacteremia was analysed by a retrospective review of all age-ranged patients from every public hospital in the Autonomous Community of Valencia (approximately 5,000,000 inhabitants) for five years. Results. A total of 92,097 isolates were obtained, 44.5% of them were coagulase-negative staphylococci. Enterobacteriales was the most prevalent group and an increase in frequency was observed along the time. Streptococcus spp. were the second microorganisms more frequently isolated. Next, the most prevalent were Staphylococcus aureus and Enterococcus spp., both with a stable incidence along the study. Finally, Pseudomonas aeruginosa was the fifth microorganism more frequently solated. Conclusions. These data constitute a useful tool that can help in the choice of empirical treatment for bloodstream infections, since the knowledge of local epidemiology is key to prescribe a fast and appropriate antibiotic therapy, aspect capital to improve survival.

scholarly journals 226. Nine-year Survey of Bloodstream Infections (BSIs) across Six Types of Solid-organ Transplant (SOT) at a Large University Medical Center

2019 ◽  
Vol 6 (Supplement_2) ◽  
pp. S131-S131
Author(s):  
Deanna Buehrle ◽  
Cornelius J Clancy ◽  
Ryan Rivosecchi ◽  
Lloyd Clarke ◽  
Minh-Hong Nguyen
Keyword(s):  
Medical Center ◽  
Organ Transplant ◽  
Bloodstream Infections ◽  
Median Number ◽  
Solid Organ ◽  
Drug Resistant ◽  
Candida Spp ◽  
Coagulase Negative Staphylococci ◽  
Enterococcus Spp ◽  
Organ Specific

Abstract Background BSIs are common in SOT patients. We surveyed BSIs across 6 types of SOT over 9 years at our center. Methods We conducted a retrospective study of BSI among patients transplanted from January 2010 to January 2019. Single blood cultures positive for coagulase-negative staphylococci, Corynebacterium, Bacillus, or Propionibacterium were excluded. Results 3,358 patients underwent SOT, including kidney (K, 43%, 1432), lung (Lu, 23%, 778), liver (Li, 21%, 700), heart (H, 8%, 256), pancreas (P, 4%, 149), and small bowel/multivisceral (SB/MV 1%, 43). 16% (529) of patients had ≥1 episode of BSI. There were 770 BSIs; 14% (105/770) were recurrent. Median number of BSI was 1/patient (range: 1 to 7). BSI rates were highest among SB/MV patients (53%), followed by Lu (22%), Li (20%), P (15%), H (14%) and K patients (14%) (Figure 1). 20% (156), 24% (187) and 7% (52) of BSI occurred at ≤30 d, 31–180 d, and 181–365 d after SOT, respectively. BSI rates at ≤ and >180 d post-SOT were 3.6 and 0.65/1000 pt-d, respectively (P < 0.0001). Most common bacteria were Enterobacteriaceae (35%) and Enterococcus spp. (22%). Candida spp. accounted for 6% (49/770) of BSIs. Enterobactericeae were most common among intra-abdominal SOT patients, whereas Enterococcus and non-fermenting Gram-negatives were most common in Lu patients (Figure 2). 8% (65) of BSI was polymicrobial. From 2016 to 2018, 15% (14/96) of Enterobacteriaceae BSIs were multi-drug-resistant (MDR); 8% (8/96) were extensively drug resistant (XDR). 23% (3/13) of P. aeruginosa were MDR (all XDR). 70% (14/20) and 5% (1/20) of E. faecium and E. faecalis were vancomycin-resistant, respectively. Thirty-day mortality following BSI diagnosis was highest for H (31%), followed by Lu (15%), Li (10%), P (9%) and SB/MV (4%) patients. Patients with bacteremia had higher mortality than patients with no bacteremia (Figure 3). Conclusion BSIs are common after SOT, and associated with significant short- and long-term mortality. Almost half of BSIs occur within the first 6 months of SOT, when BSI rates are significantly higher than at later time points. Predominant BSI pathogens differ between SOT types; as such, empiric antimicrobial therapy decisions should be organ-specific. At our center, MDR and XDR Gram-negative bacteria and VRE are common; centers should use overall SOT and organ-specific antibiograms to drive empiric antimicrobial strategies. Disclosures All authors: No reported disclosures.

scholarly journals Healthcare-Associated Laboratory-Confirmed Bloodstream Infections—Species Diversity and Resistance Mechanisms, a Four-Year Retrospective Laboratory-Based Study in the South of Poland

2021 ◽  
Vol 18 (5) ◽  
pp. 2785
Author(s):  
Agnieszka Chmielarczyk ◽  
Monika Pomorska-Wesołowska ◽  
Dorota Romaniszyn ◽  
Jadwiga Wójkowska-Mach
Keyword(s):  
Bloodstream Infections ◽  
Diagnostic Techniques ◽  
Resistance Mechanisms ◽  
Infection Prevention And Control ◽  
The South ◽  
Coagulase Negative Staphylococci ◽  
Aminoglycoside Resistance ◽  
Gram Negative ◽  
Maldi Tof ◽  
Carbapenem Resistant

Introduction: Regardless of the country, advancements in medical care and infection prevention and control of bloodstream infections (BSIs) are an enormous burden of modern medicine. Objectives: The aim of our study was to describe the epidemiology and drug-resistance of laboratory-confirmed BSI (LC-BSIs) among adult patients of 16 hospitals in the south of Poland. Patients and methods: Data on 4218 LC-BSIs were collected between 2016–2019. The identification of the strains was performed using MALDI-TOF. Resistance mechanisms were investigated according to European Committee on Antimicrobial Susceptibility Testing, EUCAST recommendations. Results: Blood cultures were collected from 8899 patients, and LC-BSIs were confirmed in 47.4%. The prevalence of Gram-positive bacteria was 70.9%, Gram-negative 27.8% and yeast 1.4%. The most frequently isolated genus was Staphylococcus (50% of all LC-BSIs), with a domination of coagulase-negative staphylococci, while Escherichia coli (13.7%) was the most frequent Gram-negative bacterium. Over 4 years, 108 (2.6%) bacteria were isolated only once, including species from the human microbiota as well as environmental and zoonotic microorganisms. The highest methicillin resistant Staphylococcus aureus (MRSA) prevalence was in intensive care units (ICUs) (55.6%) but S. aureus with resistance to macrolides, lincosamides and streptogramins B (MLSB) in surgery was 66.7%. The highest prevalence of E. faecalis with a high-level aminoglycoside resistance (HLAR) mechanism was in ICUs, (84.6%), while E. faecium-HLAR in surgery was 83.3%. All cocci were fully glycopeptide-sensitive. Carbapenem-resistant Gram-negative bacilli were detected only in non-fermentative bacilli group, with prevalence 70% and more. Conclusions: The BSI microbiology in Polish hospitals was similar to those reported in other studies, but the prevalence of MRSA and enterococci-HLAR was higher than expected, as was the prevalence of carbapenem-resistant non-fermentative bacilli. Modern diagnostic techniques, such as MALDI-TOF, guarantee reliable diagnosis.

scholarly journals Male circumcision and global HIV/AIDS epidemic challenges

2019 ◽  
Vol 25 (1) ◽  
Author(s):  
Emiola Oluwabunmi Olapade-Olaopa ◽  
Mudasiru Adebayo Salami ◽  
Taiwo Akeem Lawal
Keyword(s):  
Sexual Behavior ◽  
Male Circumcision ◽  
Preventive Measure ◽  
Population Level ◽  
Surgical Removal ◽  
Main Body ◽  
Prevention Measures ◽  
Mortality And Morbidity ◽  
Aids Epidemic ◽  
Hiv Aids

Abstract Background Given the devastating mortality and morbidity associated with HIV/AIDS, many potential prevention measures against HIV infection continue to be explored. Most prevention methods are in the realm of sexual behavior change. However, of all aspects of human behavior, it is sexual behavior that is least amenable to change. Newer and simpler interventions are therefore required. Male circumcision, the surgical removal of some or all of the foreskin (or prepuce) from the penis, is one of the ways being promoted as a preventive measure. This paper reviews the scientific basis and evidence for the efficacy of male circumcision within the context of the global challenges involved. Main body We reviewed articles with emphasis on male circumcision and HIV/AIDS transmission. Published abstracts of presentations at international scientific meetings were also reviewed. Conclusions Current epidemiological evidence supports the promotion of male circumcision for HIV prevention, especially in populations with high HIV prevalence and low circumcision rates. Three notable randomized control trials strengthen the case for applied research studies to demonstrate that safe male circumcision is protective at the population level, particularly as ideal and well-resourced conditions of a randomized trial are often not replicated in other service delivery settings. Ethically and culturally responsive strategies in promoting circumcision in a culturally heterogenous world need to be developed, too. Male circumcision should also be viewed as a complementary measure along with other proven approaches to turn the HIV/AIDS epidemic around.

scholarly journals Procedure for the Selection of Rubber Compound in Rubber-Metal Springs for Vibration Isolation

Polymers ◽  
2020 ◽  
Vol 12 (8) ◽  
pp. 1737
Author(s):  
Milan Banić ◽  
Dušan Stamenković ◽  
Aleksandar Miltenović ◽  
Dragan Jovanović ◽  
Milan Tica
Keyword(s):  
Numerical Simulation ◽  
Constitutive Model ◽  
Vibration Isolation ◽  
Correct Selection ◽  
Virtual Experiment ◽  
Rubber Compound ◽  
Key Factor ◽  
Railway Engineering ◽  
Selection Of

The selection of a rubber compound has a determining influence on the final characteristics of rubber-metal springs. Therefore, the correct selection of a rubber compound is a key factor for development of rubber-metal vibration isolation springs with required characteristics. The procedure for the selection of the rubber compound for vibration isolation of rubber-metal springs has been proposed, so that the rubber-metal elements have the necessary characteristics, especially in terms of deflection. The procedure is based on numerical simulation of spring deflection with Bergström-Boyce constitutive model in virtual experiment, with a goal to determine which parameters of the constitutive model will lead to spring required deflection. The procedure was verified by case study defined to select rubber compound for a rubber–metal spring used in railway engineering.

scholarly journals Selection of Adequate Species for Degraded Areas by Oil‐Exploitation Industry as a Key Factor for Recovery Forest in the Ecuadorian Amazon

2016 ◽  
Vol 27 (7) ◽  
pp. 1771-1780 ◽  
Author(s):  
Jaime Villacís ◽  
Cristina Armas ◽  
Susana Hang ◽  
Fernando Casanoves
Keyword(s):  
Oil Exploitation ◽  
Ecuadorian Amazon ◽  
Key Factor ◽  
Selection Of

scholarly journals NEW INSIGHT ON EPIDEMIOLOGY AND MANAGEMENT OF BACTERIAL BLOODSTREAM INFECTION IN PATIENTS WITH HEMATOLOGICAL MALIGNACIES

2015 ◽  
Vol 7 ◽  
pp. e2015044 ◽  
Author(s):  
Sara Lo Menzo ◽  
Giulia La Martire ◽  
Giancarlo Ceccarelli ◽  
Mario Venditti
Keyword(s):  
Febrile Neutropenia ◽  
Bloodstream Infections ◽  
Multidrug Resistant ◽  
Empirical Treatment ◽  
Rational Approach ◽  
Attributable Mortality ◽  
Low Grade ◽  
Gram Positive ◽  
Adequate Treatment ◽  
Gram Negative

Bloodstream infections (BSI) are an important cause of morbidity and mortality in onco-hematologic patients. The Gram-negative etiology was the main responsible of the febrile neutropenia in the sixties and its impact declined due to the use of fluoroquinolone prophylaxis; this situation was followed by the gradual emergence of Gram-positive bacteria also following of the increased use of intravascular devices and the introduction of new chemotherapeutic strategies. In the last decade the Gram-negative etiology is raising again because of the emergence of resistant strains that make questionable the usefulness of currentstrategies for prophylaxis and empirical treatment. Gram-negative BSI attributable mortality is relevant and the appropriate empirical treatment significantly improves the prognosis; on the other hand the delayed adequate treatment of Gram-positive BSI does not seem to have an high impact on survival. The clinician has to be aware of the epidemiology of his institution and of colonizations of his patients in order to choose the most appropriate empiric therapy. Ina setting of high endemicity of multidrug-resistant infections, even the choice of a targeted therapy can be a challenge, often requiring strategies based on off-label prescriptions and low grade evidences.In this review we summarize the current evidences for the best targeted therapies for difficult to treat bacteria BSIs and future perspectives in this topic. We also provide a flow chart for a rational approach to the empirical treatment of febrile neutropenia in a multidrug resistant high prevalence setting.

scholarly journals Genomic Analysis of Multiresistant Staphylococcus capitis Associated with Neonatal Sepsis

2018 ◽  
Vol 62 (11) ◽  
Author(s):  
Glen P. Carter ◽  
James E. Ussher ◽  
Anders Gonçalves Da Silva ◽  
Sarah L. Baines ◽  
Helen Heffernan ◽  
...  
Keyword(s):  
Neonatal Sepsis ◽  
Neonatal Intensive Care ◽  
Genomic Analysis ◽  
Bloodstream Infections ◽  
Multidrug Resistant ◽  
Comparative Genomic ◽  
Coagulase Negative Staphylococci ◽  
Content Type ◽  
Staphylococcus Capitis ◽  
Hospital Infection Control

ABSTRACT Coagulase-negative staphylococci (CoNS), such as Staphylococcus capitis, are major causes of bloodstream infections in neonatal intensive care units (NICUs). Recently, a distinct clone of S. capitis (designated S. capitis NRCS-A) has emerged as an important pathogen in NICUs internationally. Here, 122 S. capitis isolates from New Zealand (NZ) underwent whole-genome sequencing (WGS), and these data were supplemented with publicly available S. capitis sequence reads. Phylogenetic and comparative genomic analyses were performed, as were phenotypic assessments of antimicrobial resistance, biofilm formation, and plasmid segregational stability on representative isolates. A distinct lineage of S. capitis was identified in NZ associated with neonates and the NICU environment. Isolates from this lineage produced increased levels of biofilm, displayed higher levels of tolerance to chlorhexidine, and were multidrug resistant. Although similar to globally circulating NICU-associated S. capitis strains at a core-genome level, NZ NICU S. capitis isolates carried a novel stably maintained multidrug-resistant plasmid that was not present in non-NICU isolates. Neonatal blood culture isolates were indistinguishable from environmental S. capitis isolates found on fomites, such as stethoscopes and neonatal incubators, but were generally distinct from those isolates carried by NICU staff. This work implicates the NICU environment as a potential reservoir for neonatal sepsis caused by S. capitis and highlights the capacity of genomics-based tracking and surveillance to inform future hospital infection control practices aimed at containing the spread of this important neonatal pathogen.

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