scholarly journals Investigation of Pharmacological Responses to an Anti-Diabetic Drug Pioglitazone in Female Spontaneously Diabetic Torii (SDT) Fatty Rats, A New Obese Type 2 Diabetic Rat

2017 ◽  
Vol 1 (1) ◽  
Author(s):  
Y Murai ◽  
K Miyajima ◽  
M Shinohara ◽  
T Yamada ◽  
T Ohta
Keyword(s):  
Diabetic Rat ◽  
Type 2 Diabetic

scholarly journals An anxiolytic drug buspirone ameliorates hyperglycemia and endothelial dysfunction in type 2 diabetic rat model

2020 ◽  
Vol 45 (4) ◽  
pp. 397-404
Author(s):  
Tugba Gurpinar Çavuşoğlu ◽  
Ertan Darıverenli ◽  
Kamil Vural ◽  
Nuran Ekerbicer ◽  
Cevval Ulman ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Blood Glucose ◽  
Endothelial Dysfunction ◽  
Vascular Function ◽  
Fasting Blood Glucose ◽  
Diabetic Rats ◽  
Diabetic Rat ◽  
Insulin Levels ◽  
Type 2 Diabetic

AbstractObjectivesType 2 diabetes is a common metabolic disease and anxiety disorders are very common among diabetics. Buspirone is used in the treatment of anxiety, also having blood glucose-lowering effects. The aim of the study was to investigate the effects of buspirone on the glucose and lipid metabolism as well as vascular function in type 2 diabetic rats.MethodsA type 2-diabetic model was induced through a high-fat diet for eight weeks followed by the administration of low-dose streptozotocin (35 mg/kg, intraperitoneal) in rats. Buspirone was given at two different doses (1.5 mg/kg/d and 5 mg/kg/d) and combined with metformin (300 mg/kg/d). The fasting glucose and insulin levels, lipid profile were analyzed, and vascular response measured from the thoracic aorta was also evaluated.ResultsBoth doses of buspirone caused a significant improvement in fasting blood glucose levels. In particular, the buspirone treatment, combined with metformin, improved endothelial dysfunction and was found to be correlated with decreased nitrate/nitrite levels.ConclusionsBuspirone may be effective in the treatment of type 2 diabetes, either alone or in combination with other treatments, particularly in terms of endothelial dysfunction, inflammation and impaired blood glucose, and insulin levels.

scholarly journals COMP-Angiopoietin-1 Promotes Cavernous Angiogenesis in a Type 2 Diabetic Rat Model

2013 ◽  
Vol 28 (5) ◽  
pp. 725 ◽  
Author(s):  
Sun-Ouck Kim ◽  
Hyun-Suk Lee ◽  
Kyuyoun Ahn ◽  
Kwangsung Park
Keyword(s):  
Rat Model ◽  
Diabetic Rat ◽  
Diabetic Rat Model ◽  
Type 2 Diabetic ◽  
Angiopoietin 1

scholarly journals Visceral Hypersensitivity and Altered Colonic Motility in Type 2 Diabetic Rat

2015 ◽  
Vol 21 (4) ◽  
pp. 581-588 ◽  
Author(s):  
Tae Sik Sung ◽  
Jun-Ho La ◽  
Tong Mook Kang ◽  
Tae Wan Kim ◽  
Il-Suk Yang
Keyword(s):  
Colonic Motility ◽  
Visceral Hypersensitivity ◽  
Diabetic Rat ◽  
Type 2 Diabetic

The Effect of α-Lipoic Acid on Proteinuria and Renal TGFβ Expression in Obese Type 2 Diabetic Rat Model

2008 ◽  
Vol 32 (1) ◽  
pp. 21
Author(s):  
Seok Woo Kang ◽  
Seong Jin Lee ◽  
Dong-Sun Kim ◽  
Tae Wha Kim
Keyword(s):  
Lipoic Acid ◽  
Rat Model ◽  
Diabetic Rat ◽  
Diabetic Rat Model ◽  
Type 2 Diabetic

scholarly journals Effects of liraglutide on heart function and myocardial perfusion entropy in a type-2 diabetic rat model

2020 ◽  
Vol 12 (2-4) ◽  
pp. 212
Author(s):  
M. Canu ◽  
A. Carabelli ◽  
M. Debiossat ◽  
A. Broisat ◽  
M. Desvignes ◽  
...  
Keyword(s):  
Myocardial Perfusion ◽  
Rat Model ◽  
Heart Function ◽  
Diabetic Rat ◽  
Diabetic Rat Model ◽  
Type 2 Diabetic
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