scholarly journals Visceral Hypersensitivity and Altered Colonic Motility in Type 2 Diabetic Rat

2015 ◽  
Vol 21 (4) ◽  
pp. 581-588 ◽  
Author(s):  
Tae Sik Sung ◽  
Jun-Ho La ◽  
Tong Mook Kang ◽  
Tae Wan Kim ◽  
Il-Suk Yang
Keyword(s):  
Colonic Motility ◽  
Visceral Hypersensitivity ◽  
Diabetic Rat ◽  
Type 2 Diabetic

scholarly journals An anxiolytic drug buspirone ameliorates hyperglycemia and endothelial dysfunction in type 2 diabetic rat model

2020 ◽  
Vol 45 (4) ◽  
pp. 397-404
Author(s):  
Tugba Gurpinar Çavuşoğlu ◽  
Ertan Darıverenli ◽  
Kamil Vural ◽  
Nuran Ekerbicer ◽  
Cevval Ulman ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Blood Glucose ◽  
Endothelial Dysfunction ◽  
Vascular Function ◽  
Fasting Blood Glucose ◽  
Diabetic Rats ◽  
Diabetic Rat ◽  
Insulin Levels ◽  
Type 2 Diabetic

AbstractObjectivesType 2 diabetes is a common metabolic disease and anxiety disorders are very common among diabetics. Buspirone is used in the treatment of anxiety, also having blood glucose-lowering effects. The aim of the study was to investigate the effects of buspirone on the glucose and lipid metabolism as well as vascular function in type 2 diabetic rats.MethodsA type 2-diabetic model was induced through a high-fat diet for eight weeks followed by the administration of low-dose streptozotocin (35 mg/kg, intraperitoneal) in rats. Buspirone was given at two different doses (1.5 mg/kg/d and 5 mg/kg/d) and combined with metformin (300 mg/kg/d). The fasting glucose and insulin levels, lipid profile were analyzed, and vascular response measured from the thoracic aorta was also evaluated.ResultsBoth doses of buspirone caused a significant improvement in fasting blood glucose levels. In particular, the buspirone treatment, combined with metformin, improved endothelial dysfunction and was found to be correlated with decreased nitrate/nitrite levels.ConclusionsBuspirone may be effective in the treatment of type 2 diabetes, either alone or in combination with other treatments, particularly in terms of endothelial dysfunction, inflammation and impaired blood glucose, and insulin levels.

scholarly journals COMP-Angiopoietin-1 Promotes Cavernous Angiogenesis in a Type 2 Diabetic Rat Model

2013 ◽  
Vol 28 (5) ◽  
pp. 725 ◽  
Author(s):  
Sun-Ouck Kim ◽  
Hyun-Suk Lee ◽  
Kyuyoun Ahn ◽  
Kwangsung Park
Keyword(s):  
Rat Model ◽  
Diabetic Rat ◽  
Diabetic Rat Model ◽  
Type 2 Diabetic ◽  
Angiopoietin 1

The Effect of α-Lipoic Acid on Proteinuria and Renal TGFβ Expression in Obese Type 2 Diabetic Rat Model

2008 ◽  
Vol 32 (1) ◽  
pp. 21
Author(s):  
Seok Woo Kang ◽  
Seong Jin Lee ◽  
Dong-Sun Kim ◽  
Tae Wha Kim
Keyword(s):  
Lipoic Acid ◽  
Rat Model ◽  
Diabetic Rat ◽  
Diabetic Rat Model ◽  
Type 2 Diabetic

scholarly journals Effects of liraglutide on heart function and myocardial perfusion entropy in a type-2 diabetic rat model

2020 ◽  
Vol 12 (2-4) ◽  
pp. 212
Author(s):  
M. Canu ◽  
A. Carabelli ◽  
M. Debiossat ◽  
A. Broisat ◽  
M. Desvignes ◽  
...  
Keyword(s):  
Myocardial Perfusion ◽  
Rat Model ◽  
Heart Function ◽  
Diabetic Rat ◽  
Diabetic Rat Model ◽  
Type 2 Diabetic

Losartan improves aortic endothelium-dependent relaxation via proline-rich tyrosine kinase 2/Src/Akt pathway in type 2 diabetic Goto-Kakizaki rats

2011 ◽  
Vol 301 (6) ◽  
pp. H2383-H2394 ◽  
Author(s):  
Shingo Nemoto ◽  
Tsuneo Kobayashi ◽  
Kumiko Taguchi ◽  
Takayuki Matsumoto ◽  
Katsuo Kamata
Keyword(s):  
Nitric Oxide ◽  
Tyrosine Kinase ◽  
Vascular Complications ◽  
Akt Pathway ◽  
Diabetic Rat ◽  
Tyrosine Kinase 2 ◽  
Endothelium Dependent Relaxation ◽  
Type 2 Diabetic ◽  
Losartan Treatment

In diabetic states, endothelial dysfunction is related to vascular complications. We hypothesized that insulin-induced relaxation and the associated proline-rich tyrosine kinase 2 (Pyk2)/Src/Akt pathway would be abnormal in aortas from the Goto-Kakizaki (GK) type 2 diabetic rat, which exhibits hyperglycemia/insulin resistance, and that losartan treatment of such rats (25 mg·kg−1·day−1 for 2 wk) would correct these abnormalities. Endothelium-dependent relaxation was by measuring isometric force in helical strips of aortas from four groups, each of 30 rats: normal Wistar (control), GK (diabetic), losartan-treated normal, and losartan-treated GK. Pyk2, Src, and Akt/endothelial nitric oxide synthase (eNOS) signaling-pathway protein levels and activities were assayed mainly by Western blotting and partly by immunohistochemistry. In GK (vs. age-matched control) aortas, various insulin-stimulated levels [nitric oxide production and the phosphorylations of eNOS at Ser1177, of Akt at Thr308, of phosphoinositide-dependent kinase-1 (PDK1) at Ser241, of Src at Tyr416, and of Pyk2 at Tyr579] were all significantly decreased and unaffected by either Src inhibitor (PP2) or Pyk2 inhibitor (AG17), while the insulin-stimulated levels of insulin receptor substrate (IRS)-1 phosphorylation at Ser307, total-eNOS, and total-Akt were significantly increased. Losartan treatment normalized these altered levels. The insulin-stimulated phosphorylation levels of Src/PDK1/Akt/eNOS, but not of Pyk2, were decreased by PP2 in control and losartan-treated GK, but not in GK, aortas. These results suggest that in the GK diabetic aorta increased phospho-IRS-1 (at Ser307) and decreased Pyk2/Src activity inhibit insulin-induced stimulation of the PDK/Akt/eNOS pathway. The observed increase in phospho-IRS-1 (at Ser307) may result from increased angiotensin II activity.

Sign in / Sign up

Export Citation Format

Share Document