scholarly journals Factors Contributing to the High Prevalence of Vitamin B6 Deficiency in US: A Systematic Review

2018 ◽  
Vol 2 (1) ◽  
Author(s):  
Tang Ying ◽  
Xu Minji ◽  
Kuo Shiu-Ming
Keyword(s):  
Systematic Review ◽  
Vitamin B6 ◽  
High Prevalence ◽  
Vitamin B6 Deficiency

scholarly journals Vitamin B6 deficiency disrupts serotonin signaling in pancreatic islets and induces gestational diabetes in mice

2021 ◽  
Vol 4 (1) ◽  
Author(s):  
Ashley M. Fields ◽  
Kevin Welle ◽  
Elaine S. Ho ◽  
Clementina Mesaros ◽  
Martha Susiarjo
Keyword(s):  
Cell Proliferation ◽  
Insulin Secretion ◽  
Pancreatic Islets ◽  
Glucose Intolerance ◽  
Vitamin B6 ◽  
Serotonin Receptor ◽  
Dependent Manner ◽  
Β Cell ◽  
Vitamin B6 Deficiency ◽  
Maternal Glucose

AbstractIn pancreatic islets, catabolism of tryptophan into serotonin and serotonin receptor 2B (HTR2B) activation is crucial for β-cell proliferation and maternal glucose regulation during pregnancy. Factors that reduce serotonin synthesis and perturb HTR2B signaling are associated with decreased β-cell number, impaired insulin secretion, and gestational glucose intolerance in mice. Albeit the tryptophan-serotonin pathway is dependent on vitamin B6 bioavailability, how vitamin B6 deficiency impacts β-cell proliferation during pregnancy has not been investigated. In this study, we created a vitamin B6 deficient mouse model and investigated how gestational deficiency influences maternal glucose tolerance. Our studies show that gestational vitamin B6 deficiency decreases serotonin levels in maternal pancreatic islets and reduces β-cell proliferation in an HTR2B-dependent manner. These changes were associated with glucose intolerance and insulin resistance, however insulin secretion remained intact. Our findings suggest that vitamin B6 deficiency-induced gestational glucose intolerance involves additional mechanisms that are complex and insulin independent.

Oral Myofunctional and Articulation Disorders in Children with Malocclusions: A Systematic Review

2021 ◽  
pp. 1-16
Author(s):  
Zoë Thijs ◽  
Laura Bruneel ◽  
Guy De Pauw ◽  
Kristiane M. Van Lierde
Keyword(s):  
Systematic Review ◽  
Risk Of Bias ◽  
Open Bite ◽  
Anterior Open Bite ◽  
Eligibility Criteria ◽  
High Prevalence ◽  
Tongue Position ◽  
Articulation Disorders ◽  
Level 2 ◽  
Unclear Risk

<b><i>Background:</i></b> Relationships between malocclusion and orofacial myofunctional disorders (OMD), as well as malocclusions and articulation disorders (AD) have been described, though the exact relationships remain unclear. Given the high prevalence of these disorders in children, more clarity is needed. <b><i>Summary:</i></b> The purpose of this study was to determine the association between OMD (specifically, bruxism, deviate swallowing, caudal resting tongue posture, and biting habits), AD, and malocclusions in children and adolescents aged between 3 and 18 years. To conduct a systematic review, 4 databases were searched (MEDLINE, Embase, Web of Science, and Scopus). The identified articles were screened for the eligibility criteria. Data were extracted from the selected articles and quality assessment was performed using the tool of Munn et al. [Int J Health Policy Manag. 2014;3:123–81] in consensus. Using the search strategy, the authors identified 2,652 articles after the removal of duplicates. After reviewing the eligibility criteria, 17 articles were included in this study. One of the included articles was deemed to have an unclear risk of bias, whereas all other articles were considered to have a low risk of bias. The articles showed a relationship between anterior open bite and apico-alveolar articulatory distortions, as well as between anterior open bite and deviate swallowing. For the biting habits, bruxism, and low tongue position no clear conclusions could be drawn. <b><i>Key Messages:</i></b> The current review suggests a link between specific types of malocclusion and OMD and AD. However, more high-quality evidence (level 1 and level 2, Oxford Levels of Evidence) is needed to clarify the cooccurrence of other OMD, AD, and malocclusions.

scholarly journals A Systematic Review and Meta-Analysis of Pharmacogenetic Studies in Patients with Chronic Kidney Disease

2021 ◽  
Vol 22 (9) ◽  
pp. 4480
Author(s):  
Maria Tziastoudi ◽  
Georgios Pissas ◽  
Georgios Raptis ◽  
Christos Cholevas ◽  
Theodoros Eleftheriadis ◽  
...  
Keyword(s):  
Systematic Review ◽  
Chronic Kidney Disease ◽  
Kidney Disease ◽  
Meta Analysis ◽  
Public Health Problem ◽  
Response To Treatment ◽  
Genotype Distribution ◽  
Global Public Health ◽  
High Prevalence ◽  
Additive Inheritance

Chronic kidney disease (CKD) is an important global public health problem due to its high prevalence and morbidity. Although the treatment of nephrology patients has changed considerably, ineffectiveness and side effects of medications represent a major issue. In an effort to elucidate the contribution of genetic variants located in several genes in the response to treatment of patients with CKD, we performed a systematic review and meta-analysis of all available pharmacogenetics studies. The association between genotype distribution and response to medication was examined using the dominant, recessive, and additive inheritance models. Subgroup analysis based on ethnicity was also performed. In total, 29 studies were included in the meta-analysis, which examined the association of 11 genes (16 polymorphisms) with the response to treatment regarding CKD. Among the 29 studies, 18 studies included patients with renal transplantation, 8 involved patients with nephrotic syndrome, and 3 studies included patients with lupus nephritis. The present meta-analysis provides strong evidence for the contribution of variants harbored in the ABCB1, IL-10, ITPA, MIF, and TNF genes that creates some genetic predisposition that reduces effectiveness or is associated with adverse events of medications used in CKD.

scholarly journals Corrigendum to: The role of hyperhomocysteinemia as well as folate, vitamin B6 and B12 deficiencies in osteoporosis – a systematic review

2020 ◽  
Vol 0 (0) ◽  
Author(s):  
Markus Herrmann ◽  
Johannes Peter Schmidt ◽  
Natalia Umanskaya ◽  
Alexandra Wagner ◽  
Omid Taban-Shomal ◽  
...  
Keyword(s):  
Systematic Review ◽  
Vitamin B6

Reaction patterns of cell organelles in vitamin B6 deficiency

1980 ◽  
Vol 170 (4) ◽  
pp. 376-387 ◽  
Author(s):  
U.N. Riede ◽  
W. Sandritter ◽  
A. Pietzsch ◽  
R. Rohrbach
Keyword(s):  
Vitamin B6 ◽  
Cell Organelles ◽  
Vitamin B6 Deficiency ◽  
Reaction Patterns

A Cartilage Matrix Deficiency Experimentally Induced by Vitamin B6 Deficiency

1998 ◽  
Vol 217 (1) ◽  
pp. 97-103 ◽  
Author(s):  
P. G. Masse ◽  
I. Ziv ◽  
D. E. C. Cole ◽  
J. D. Mahuren ◽  
S. M. Donovan ◽  
...  
Keyword(s):  
Vitamin B6 ◽  
Cartilage Matrix ◽  
Vitamin B6 Deficiency ◽  
Experimentally Induced

Effect of vitamin B6 deficiency on the expression of glycogen phosphorylase mRNA in rat liver and skeletal muscle

1994 ◽  
Vol 50 (2) ◽  
pp. 127-129 ◽  
Author(s):  
T. Oka ◽  
N. Komori ◽  
M. Kuwahata ◽  
I. Suzuki ◽  
M. Okada ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Rat Liver ◽  
Vitamin B6 ◽  
Glycogen Phosphorylase ◽  
Vitamin B6 Deficiency

The Effect of Moderate Vitamin B6 Deficiency on Immunological and Hematological Parameters of Adult Female Rats

1990 ◽  
Vol 587 (1) ◽  
pp. 292-293
Author(s):  
D. S. KELLEY ◽  
M. C. SCHAEFFER ◽  
D. A. SAMPSON ◽  
P. C. TAYLOR ◽  
Y. M. RIVERA
Keyword(s):  
Adult Female ◽  
Vitamin B6 ◽  
Hematological Parameters ◽  
Female Rats ◽  
Vitamin B6 Deficiency
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