Effect of vitamin B6 deficiency on the expression of glycogen phosphorylase mRNA in rat liver and skeletal muscle

1994 ◽  
Vol 50 (2) ◽  
pp. 127-129 ◽  
Author(s):  
T. Oka ◽  
N. Komori ◽  
M. Kuwahata ◽  
I. Suzuki ◽  
M. Okada ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Rat Liver ◽  
Vitamin B6 ◽  
Glycogen Phosphorylase ◽  
Vitamin B6 Deficiency

scholarly journals Decarboxylation of S-Adenosyl-L-methionine in Vitamin B6 Deficiency in Rat Liver.

1976 ◽  
Vol 30b ◽  
pp. 121-124 ◽  
Author(s):  
Pekka Hannonen ◽  
Vernon D. Parker ◽  
Alvin Ronlán ◽  
Charles Larsen ◽  
Per Halfdan Nielsen ◽  
...  
Keyword(s):  
Rat Liver ◽  
Vitamin B6 ◽  
Vitamin B6 Deficiency

scholarly journals Vitamin B6 deficiency causes activation of RNA polymerase and general enhancement of gene expression in rat liver

FEBS Letters ◽  
1993 ◽  
Vol 331 (1-2) ◽  
pp. 162-164 ◽  
Author(s):  
Tatsuzo Oka ◽  
Naomi Komori ◽  
Masashi Kuwahata ◽  
Toshihiro Sassa ◽  
Isao Suzuki ◽  
...  
Keyword(s):  
Gene Expression ◽  
Rna Polymerase ◽  
Rat Liver ◽  
Vitamin B6 ◽  
Vitamin B6 Deficiency

scholarly journals Measurement of the turnover of glycogen phosphorylase by GC/MS using stable isotope derivatives of pyridoxine (vitamin B6)

1996 ◽  
Vol 317 (2) ◽  
pp. 613-619 ◽  
Author(s):  
Robert J. BEYNON ◽  
Deborah M. LEYLAND ◽  
Richard P. EVERSHED ◽  
Richard H. T. EDWARDS ◽  
Stephen P. COBURN
Keyword(s):  
Skeletal Muscle ◽  
Stable Isotope ◽  
Vitamin B6 ◽  
Glycogen Phosphorylase ◽  
The Body ◽  
Non Invasive ◽  
Isotope Abundance ◽  
Invasive Method ◽  
Kinetics Of ◽  
Derivatives Of

The majority of vitamin B6 in the body is in skeletal muscle, bound as the cofactor pyridoxal 5´-phosphate to one abundant protein, glycogen phosphorylase. Previous work has established that radiolabelled vitamin B6 can be used as a turnover label for glycogen phosphorylase. In this study, a stable isotope derivative of pyridoxine {dideuterated pyridoxine; 3-hydroxy-4-(hydroxymethyl)-5-[hydroxymethyl-2H2]-2-methylpyridine} ([2H2]PN) has been used as a metabolic tracer to study the kinetics of labelling of the body pools of vitamin B6 in mice. A non-invasive method was developed in which the isotope abundance of the urinary excretory product of vitamin B6 metabolism, 4-pyridoxic acid, was analysed by GC/MS. The change in isotope abundance of urinary 4-pyridoxic acid following administration of [2H2]PN reflects the kinetics of labelling of the body pools of vitamin B6, and yields, non-invasively, the rate of degradation of glycogen phosphorylase.

scholarly journals Vitamin B6 deficiency affects antioxidant defences in rat liver and heart

IUBMB Life ◽  
1998 ◽  
Vol 46 (4) ◽  
pp. 689-697 ◽  
Author(s):  
Luciana Cabrini ◽  
Raffaella Bergami ◽  
Diana Fiorentini ◽  
Mario Marchetti ◽  
Laura Landi ◽  
...  
Keyword(s):  
Rat Liver ◽  
Vitamin B6 ◽  
Antioxidant Defences ◽  
Vitamin B6 Deficiency
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