scholarly journals Focused Transcranial Ultrasound for Treatment of Neurodegenerative Dementia

2019 ◽  
Vol 3 (1) ◽  
Author(s):  
Nicodemus Natalie Eleanor ◽  
Becerra Sergio ◽  
Kuhn Taylor P ◽  
Packham Hannah R ◽  
Duncan John ◽  
...  
Keyword(s):  
Transcranial Ultrasound ◽  
Neurodegenerative Dementia

scholarly journals Focused transcranial ultrasound for treatment of neurodegenerative dementia

2019 ◽  
Vol 5 (1) ◽  
pp. 374-381 ◽  
Author(s):  
Natalie Eleanor Nicodemus ◽  
Sergio Becerra ◽  
Taylor P. Kuhn ◽  
Hannah R. Packham ◽  
John Duncan ◽  
...  
Keyword(s):  
Transcranial Ultrasound ◽  
Neurodegenerative Dementia

scholarly journals Effects of Transcranial Ultrasound Stimulation on Trigeminal Blink Reflex Excitability

2021 ◽  
Vol 11 (5) ◽  
pp. 645
Author(s):  
Andrea Guerra ◽  
Edoardo Vicenzini ◽  
Ettore Cioffi ◽  
Donato Colella ◽  
Antonio Cannavacciuolo ◽  
...  
Keyword(s):  
Substantia Nigra ◽  
Superior Colliculus ◽  
Blink Reflex ◽  
Transcranial Ultrasound ◽  
Recovery Cycle ◽  
Brain Areas ◽  
Nucleus Raphe Magnus ◽  
Ultrasound Stimulation ◽  
Raphe Magnus ◽  
Interstimulus Intervals

Recent evidence indicates that transcranial ultrasound stimulation (TUS) modulates sensorimotor cortex excitability. However, no study has assessed possible TUS effects on the excitability of deeper brain areas, such as the brainstem. In this study, we investigated whether TUS delivered on the substantia nigra, superior colliculus, and nucleus raphe magnus modulates the excitability of trigeminal blink reflex, a reliable neurophysiological technique to assess brainstem functions in humans. The recovery cycle of the trigeminal blink reflex (interstimulus intervals of 250 and 500 ms) was tested before (T0), and 3 (T1) and 30 min (T2) after TUS. The effects of substantia nigra-TUS, superior colliculus-TUS, nucleus raphe magnus-TUS and sham-TUS were assessed in separate and randomized sessions. In the superior colliculus-TUS session, the conditioned R2 area increased at T1 compared with T0, while T2 and T0 values did not differ. Results were independent of the interstimulus intervals tested and were not related to trigeminal blink reflex baseline (T0) excitability. Conversely, the conditioned R2 area was comparable at T0, T1, and T2 in the nucleus raphe magnus-TUS and substantia nigra-TUS sessions. Our findings demonstrate that the excitability of brainstem circuits, as evaluated by testing the recovery cycle of the trigeminal blink reflex, can be increased by TUS. This result may reflect the modulation of inhibitory interneurons within the superior colliculus.

scholarly journals Herpes Zoster Does Not Increase the Risk of Neurodegenerative Dementia: A Case-Control Study

2021 ◽  
Vol 36 ◽  
pp. 153331752110065
Author(s):  
Hyo Geun Choi ◽  
Bum Jung Park ◽  
Jae Sung Lim ◽  
Song Yong Sim ◽  
Yoon Jung Jung ◽  
...  
Keyword(s):  
Herpes Zoster ◽  
Case Control Study ◽  
Matched Control ◽  
National Sample ◽  
Case Control ◽  
Herpes Zoster Infection ◽  
Neurodegenerative Dementia ◽  
National Cohort ◽  
Korean National Health Insurance ◽  
Control Study

Objective: This study was conducted to evaluate the association between neurodegenerative dementia and herpes zoster infection (HZI) using a national sample cohort. Methods: From the national cohort study conducted by the Korean National Health Insurance Service, we extracted data for patients with neurodegenerative dementia and for 1:4 matched control participants and searched the patient histories for HZI. Results: The adjusted odds ratio (OR) for HZI was 0.90 (95% CI = 0.84-0.97) in the dementia group. According to the subgroup analysis, the adjusted OR for HZI was 0.91 (95% confidence interval [CI] = 0.83 -1.00) in the < 80 years old group, 0.88 (95% CI = 0.78 -1.00) in the ≥ 80 years old group, 0.77 (95% CI = 0.66-0.89) in men and 0.96 (95% CI = 0.88 -1.05) in women. Conclusions: We concluded that HZI does not increase the risk of neurodegenerative dementia in individuals of any age or of either sex.

Transcranial ultrasound diagnosis of intracranial lesions in children with headaches

2002 ◽  
Vol 26 (1) ◽  
pp. 43-46 ◽  
Author(s):  
Huei-Shyong Wang ◽  
Meng-Fai Kuo ◽  
Song-Chei Huang ◽  
Ming-Liang Chou ◽  
Po-Chen Hung ◽  
...  
Keyword(s):  
Ultrasound Diagnosis ◽  
Transcranial Ultrasound ◽  
Intracranial Lesions

Clinical and Neuroimaging Characterization of Chinese Dementia Patients with PSEN1 and PSEN2 Mutations

2014 ◽  
Vol 39 (1-2) ◽  
pp. 32-40 ◽  
Author(s):  
Zhihong Shi ◽  
Ying Wang ◽  
Shuai Liu ◽  
Mengyuan Liu ◽  
Shuling Liu ◽  
...  
Keyword(s):  
Early Onset ◽  
Late Onset ◽  
Novel Mutation ◽  
Chinese Patients ◽  
Phenotypic Traits ◽  
Chinese Han ◽  
Risk Variants ◽  
Dementia Patients ◽  
Positron Emission ◽  
Neurodegenerative Dementia

Background: Alzheimer's disease (AD) and frontotemporal dementia (FTD) are two common forms of primary neurodegenerative dementia. Mutations in 3 genes (PSEN1, PSEN2, and APP) have been identified in patients with early-onset AD. Methods: We performed gene sequencing in PSEN1, PSEN2, and APP in 61 AD and 35 FTD Chinese patients. Amyloid load using 11C-labeled Pittsburgh compound B (11C-PIB) positron emission tomography (PET) and cerebral glucose metabolism using 18F-fludeoxyglucose PET were evaluated in patients carrying mutations. Results: We identified 1 known pathogenic PSEN1 (p.His163Arg, c.488A>G) mutation and 3 novel PSEN2 mutations in 6 patients. The novel mutation PSEN2 (p.His169Asn, c.505C>A) was identified in 1 patient with familial late-onset AD and in 1 sporadic FTD patient. The PSEN2 (p.Val214Leu, c.640G>T; p.Lys82Arg, c.245A>G) mutations were identified in 2 early-onset AD patients and 1 early-onset AD patient, respectively. Three patients with PSEN2 mutations were observed to have PIB retention on the cortex and striatum. One patient with the FTD phenotype was not observed to have PIB retention. Conclusion: PSEN2 mutations are common in the Chinese Han population with a history of AD and FTD. Pathogenic mutations or risk variants in the PSEN2 gene can influence both FTD and AD phenotypic traits and show variations in neuroimaging characterization. © 2014 S. Karger AG, Basel

scholarly journals Normal Findings on Pretreatment Transcranial Ultrasound in Patients Treated with Sonothrombolysis

2014 ◽  
Vol 3 (1) ◽  
pp. 1-8
Author(s):  
Elias Johansson ◽  
Thomas Gu ◽  
Per Wester
Keyword(s):  
Transcranial Ultrasound

scholarly journals Telemedicine-Guided Carotid and Transcranial Ultrasound

Stroke ◽  
2006 ◽  
Vol 37 (1) ◽  
pp. 229-230 ◽  
Author(s):  
Robert Mikulik ◽  
Andrei V. Alexandrov ◽  
Marc Ribo ◽  
Zsolt Garami ◽  
Nichole A. Porche ◽  
...  
Keyword(s):  
Transcranial Ultrasound
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