The effect of low-intensity transcranial ultrasound stimulation on neural oscillation and hemodynamics in the mouse visual cortex depends on anesthesia level and ultrasound intensity

2021 ◽  
pp. 1-1
Author(s):  
Yi Yuan ◽  
Kaiqing Zhang ◽  
Yiyao Zhang ◽  
Jiaqing Yan ◽  
Zhijie Wang ◽  
...  
Keyword(s):  
Visual Cortex ◽  
Transcranial Ultrasound ◽  
Neural Oscillation ◽  
Low Intensity ◽  
Ultrasound Stimulation ◽  
Ultrasound Intensity ◽  
Anesthesia Level ◽  
Mouse Visual Cortex

scholarly journals Neuromodulation Effect of Very Low Intensity Transcranial Ultrasound Stimulation on Multiple Nuclei in Rat Brain

2021 ◽  
Vol 13 ◽  
Author(s):  
Yingjian Liu ◽  
Gang Wang ◽  
Chao Cao ◽  
Gaorui Zhang ◽  
Emily B. Tanzi ◽  
...  
Keyword(s):  
Field Potential ◽  
High Amplitude ◽  
Transcranial Ultrasound ◽  
Spectrum Estimation ◽  
Rhythmic Pattern ◽  
Neural Oscillation ◽  
Time Frequency ◽  
Low Intensity ◽  
Ultrasound Stimulation ◽  
High Gamma

ObjectiveLow-intensity transcranial ultrasound stimulation (TUS) is a non-invasive neuromodulation technique with high spatial resolution and feasible penetration depth. To date, the mechanisms of TUS modulated neural oscillations are not fully understood. This study designed a very low acoustic intensity (AI) TUS system that produces considerably reduced AI Ultrasound pulses (ISPTA < 0.5 W/cm2) when compared to previous methods used to measure regional neural oscillation patterns under different TUS parameters.MethodsWe recorded the local field potential (LFP) of five brain nuclei under TUS with three groups of simulating parameters. Spectrum estimation, time-frequency analysis (TFA), and relative power analysis methods have been applied to investigate neural oscillation patterns under different stimulation parameters.ResultsUnder PRF, 500 Hz and 1 kHz TUS, high-amplitude LFP activity with the auto-rhythmic pattern appeared in selected nuclei when ISPTA exceeded 12 mW/cm2. With TFA, high-frequency energy (slow gamma and high gamma) was significantly increased during the auto-rhythmic patterns. We observed an initial plateau in nuclei response when ISPTA reached 16.4 mW/cm2 for RPF 500 Hz and 20.8 mW/cm2 for RPF 1 kHz. The number of responding nuclei started decreasing while ISPTA continued increasing. Under 1.5 kHz TUS, no auto-rhythmic patterns have been observed, but slow frequency power was increased during TUS. TUS inhibited most of the frequency band and generated obvious slow waves (theta and delta band) when stimulated at RPF = 1.5 kHz, ISPTA = 8.8 mW/cm2.ConclusionThese results demonstrate that very low intensity Transcranial Ultrasound Stimulation (VLTUS) exerts significant neuromodulator effects under specific parameters in rat models and may be a valid tool to study neuronal physiology.

Low-Intensity Pulsed Ultrasound Stimulation Induces Coupling Between Ripple Neural Activity and Hemodynamics in the Mouse Visual Cortex

2018 ◽  
Vol 29 (7) ◽  
pp. 3220-3223 ◽  
Author(s):  
Yi Yuan ◽  
Zhijie Wang ◽  
Xingran Wang ◽  
Jiaqing Yan ◽  
Mengyang Liu ◽  
...  
Keyword(s):  
Visual Cortex ◽  
Neural Activity ◽  
Field Potential ◽  
Correlation Coefficients ◽  
Neurovascular Coupling ◽  
Pulsed Ultrasound ◽  
Low Intensity Pulsed Ultrasound ◽  
Low Intensity ◽  
Ultrasound Stimulation ◽  
Mouse Visual Cortex

Abstract Several studies have separately investigated neural activities and hemodynamic responses induced by low-intensity pulsed ultrasound stimulation (LIPUS), less is known about their coupling under LIPUS. This study aims to investigate the neurovascular coupling with LIPUS by measuring neural activity and hemodynamics. We found that the relative power and sample entropy of local field potential at the ripple band have a significant correlation to relative cerebral blood flow over time (correlation coefficients: 0.66 ± 0.13 [P < 0.01] and −0.58 ± 0.11 [P < 0.05]). These results demonstrate that LIPUS can induce neurovascular coupling in the mouse visual cortex.

Antidepressant-Like Effect of Low-Intensity Transcranial Ultrasound Stimulation

2019 ◽  
Vol 66 (2) ◽  
pp. 411-420 ◽  
Author(s):  
Daqu Zhang ◽  
Hangdao Li ◽  
Junfeng Sun ◽  
Weiwei Hu ◽  
Wen Jin ◽  
...  
Keyword(s):  
Transcranial Ultrasound ◽  
Low Intensity ◽  
Ultrasound Stimulation
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