Control of oxygen delivery within skeletal muscle

2005 ◽  
pp. 23-24
Author(s):  
Paul McDonough ◽  
Brad Behnke ◽  
Danielle Padilla ◽  
Timothy Musch ◽  
David Poole
Keyword(s):  
Skeletal Muscle ◽  
Oxygen Delivery

scholarly journals Fatigability and Cardiorespiratory Impairments in Parkinson’s Disease: Potential Non-Motor Barriers to Activity Performance

2020 ◽  
Vol 5 (4) ◽  
pp. 78
Author(s):  
Andrew E. Pechstein ◽  
Jared M. Gollie ◽  
Andrew A. Guccione
Keyword(s):  
Skeletal Muscle ◽  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Cardiorespiratory Fitness ◽  
Oxygen Delivery ◽  
Disease Diagnosis ◽  
Rate Of Change ◽  
Motor Symptom ◽  
Biological Aging ◽  
Over Time

Parkinson’s disease (PD) is the second most common neurodegenerative condition after Alzheimer’s disease, affecting an estimated 160 per 100,000 people 65 years of age or older. Fatigue is a debilitating non-motor symptom frequently reported in PD, often manifesting prior to disease diagnosis, persisting over time, and negatively affecting quality of life. Fatigability, on the other hand, is distinct from fatigue and describes the magnitude or rate of change over time in the performance of activity (i.e., performance fatigability) and sensations regulating the integrity of the performer (i.e., perceived fatigability). While fatigability has been relatively understudied in PD as compared to fatigue, it has been hypothesized that the presence of elevated levels of fatigability in PD results from the interactions of homeostatic, psychological, and central factors. Evidence from exercise studies supports the premise that greater disturbances in metabolic homeostasis may underly elevated levels of fatigability in people with PD when engaging in physical activity. Cardiorespiratory impairments constraining oxygen delivery and utilization may contribute to the metabolic alterations and excessive fatigability experienced in individuals with PD. Cardiorespiratory fitness is often reduced in people with PD, likely due to the combined effects of biological aging and impairments specific to the disease. Decreases in oxygen delivery (e.g., reduced cardiac output and impaired blood pressure responses) and oxygen utilization (e.g., reduced skeletal muscle oxidative capacity) compromise skeletal muscle respiration, forcing increased reliance on anaerobic metabolism. Thus, the assessment of fatigability in people with PD may provide valuable information regarding the functional status of people with PD not obtained with measures of fatigue. Moreover, interventions that target cardiorespiratory fitness may improve fatigability, movement performance, and health outcomes in this patient population.

scholarly journals Potentiation of cGMP signaling increases oxygen delivery and oxidative metabolism in contracting skeletal muscle of older but not young humans

2015 ◽  
Vol 3 (8) ◽  
pp. e12508 ◽  
Author(s):  
Michael Nyberg ◽  
Peter Piil ◽  
Jon Egelund ◽  
Randy S. Sprague ◽  
Stefan P. Mortensen ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Oxidative Metabolism ◽  
Oxygen Delivery ◽  
Cgmp Signaling

scholarly journals Effect of acute normovolemic hemodilution on distribution of blood flow and tissue oxygenation in dog skeletal muscle

1999 ◽  
Vol 86 (3) ◽  
pp. 860-866 ◽  
Author(s):  
Jörg Hutter ◽  
Oliver Habler ◽  
Martin Kleen ◽  
Matthias Tiede ◽  
Armin Podtschaske ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Blood Flow ◽  
Oxygen Delivery ◽  
Tissue Oxygenation ◽  
Relative Dispersion ◽  
Homogeneous Distribution ◽  
Allogenic Blood Transfusion ◽  
Acute Normovolemic Hemodilution ◽  
Muscle Perfusion ◽  
Normovolemic Hemodilution

Acute normovolemic hemodilution (ANH) is efficient in reducing allogenic blood transfusion needs during elective surgery. Tissue oxygenation is maintained by increased cardiac output and oxygen extraction and, presumably, a more homogeneous tissue perfusion. The aim of this study was to investigate blood flow distribution and oxygenation of skeletal muscle. ANH from hematocrit of 36 ± 3 to 20 ± 1% was performed in 22 splenectomized, anesthetized beagles (17 analyzed) ventilated with room air. Normovolemia was confirmed by measurement of blood volume. Distribution of perfusion within skeletal muscle was determined by using radioactive microspheres. Tissue oxygen partial pressure was assessed with a polarographic platinum surface electrode. Cardiac index (3.69 ± 0.79 vs. 4.79 ± 0.73 l ⋅ min−1 ⋅ m−2) and muscle perfusion (4.07 ± 0.44 vs. 5.18 ± 0.36 ml ⋅ 100 g−1 ⋅ min−1) were increased at hematocrit of 20%. Oxygen delivery to skeletal muscle was reduced to 74% of baseline values (0.64 ± 0.06 vs. 0.48 ± 0.03 ml O2 ⋅ 100 g−1 ⋅ min−1). Nevertheless, tissue [Formula: see text] was preserved (27.4 ± 1.3 vs. 29.9 ± 1.4 Torr). Heterogeneity of muscle perfusion (relative dispersion) was reduced after ANH (20.0 ± 2.2 vs. 13.9 ± 1.5%). We conclude that a more homogeneous distribution of perfusion is one mechanism for the preservation of tissue oxygenation after moderate ANH, despite reduced oxygen delivery.

Antioxidant Supplementation Improves Oxygen Delivery And Blood Flow To Exercising Skeletal Muscle In COPD

2010 ◽  
Author(s):  
Jamie D. Conklin ◽  
Joel D. Trinity ◽  
Markus Amann ◽  
Annette Fjeldstad ◽  
D. W. Wray ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Blood Flow ◽  
Oxygen Delivery ◽  
Antioxidant Supplementation

scholarly journals Near-infrared diffuse correlation spectroscopy tracks changes in oxygen delivery and utilization during exercise with and without isolated arterial compression

2020 ◽  
Vol 318 (1) ◽  
pp. R81-R88
Author(s):  
Wesley J. Tucker ◽  
Ryan Rosenberry ◽  
Darian Trojacek ◽  
Belinda Sanchez ◽  
Robert F. Bentley ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Blood Flow ◽  
Radial Artery ◽  
Brachial Artery ◽  
Oxygen Delivery ◽  
Near Infrared ◽  
Correlation Spectroscopy ◽  
Flow Index ◽  
Artery Blood Flow ◽  
Diffuse Correlation Spectroscopy

Near-infrared diffuse correlation spectroscopy (NIR-DCS) is an emerging technology for simultaneous measurement of skeletal muscle microvascular oxygen delivery and utilization during exercise. The extent to which NIR-DCS can track acute changes in oxygen delivery and utilization has not yet been fully established. To address this knowledge gap, 14 healthy men performed rhythmic handgrip exercise at 30% maximal voluntary contraction, with and without isolated brachial artery compression, designed to acutely reduce convective oxygen delivery to the exercising muscle. Radial artery blood flow (Duplex Ultrasound) and NIR-DCS derived variables [blood flow index (BFI), tissue oxygen saturation ([Formula: see text]), and metabolic rate of oxygen ([Formula: see text])] were simultaneously measured. During exercise, both radial artery blood flow (+51.6 ± 20.3 mL/min) and DCS-derived BFI (+155.0 ± 82.2%) increased significantly ( P < 0.001), whereas [Formula: see text] decreased −7.9 ± 6.2% ( P = 0.002) from rest. Brachial artery compression during exercise caused a significant reduction in both radial artery blood flow (−32.0 ± 19.5 mL/min, P = 0.001) and DCS-derived BFI (−57.3 ± 51.1%, P = 0.01) and a further reduction of [Formula: see text] (−5.6 ± 3.8%, P = 0.001) compared with exercise without compression. [Formula: see text] was not significantly reduced during arterial compression ( P = 0.83) due to compensatory reductions in [Formula: see text], driven by increases in deoxyhemoglobin/myoglobin (+7.1 ± 6.1 μM, P = 0.01; an index of oxygen extraction). Together, these proof-of-concept data help to further validate NIR-DCS as an effective tool to assess the determinants of skeletal muscle oxygen consumption at the level of the microvasculature during exercise.

scholarly journals Understanding near infrared spectroscopy and its application to skeletal muscle research

2019 ◽  
Vol 126 (5) ◽  
pp. 1360-1376 ◽  
Author(s):  
Thomas J. Barstow
Keyword(s):  
Skeletal Muscle ◽  
Infrared Spectroscopy ◽  
Near Infrared Spectroscopy ◽  
Oxygen Delivery ◽  
Near Infrared ◽  
Control Mechanisms ◽  
Oxygen Utilization ◽  
Muscle Research ◽  
Athletic Field ◽  
Nirs Data

Near infrared spectroscopy (NIRS) is a powerful noninvasive tool with which to study the matching of oxygen delivery to oxygen utilization and the number of new publications utilizing this technique has increased exponentially in the last 20 yr. By measuring the state of oxygenation of the primary heme compounds in skeletal muscle (hemoglobin and myoglobin), greater understanding of the underlying control mechanisms that couple perfusive and diffusive oxygen delivery to oxidative metabolism can be gained from the laboratory to the athletic field to the intensive care unit or emergency room. However, the field of NIRS has been complicated by the diversity of instrumentation, the inherent limitations of some of these technologies, the associated diversity of terminology, and a general lack of standardization of protocols. This Cores of Reproducibility in Physiology (CORP) will describe in basic but important detail the most common methodologies of NIRS, their strengths and limitations, and discuss some of the potential confounding factors that can affect the quality and reproducibility of NIRS data. Recommendations are provided to reduce the variability and errors in data collection, analysis, and interpretation. The goal of this CORP is to provide readers with a greater understanding of the methodology, limitations, and best practices so as to improve the reproducibility of NIRS research in skeletal muscle.

Sign in / Sign up

Export Citation Format

Share Document