Effects of Colloidal Oatmeal Topical Atopic Dermatitis Cream on Skin Microbiome and Skin Barrier Properties

2020 ◽  
Vol 19 (5) ◽  
pp. 524-531
Author(s):  
Kimberly Capone ◽  
Frank Kirchner ◽  
Shifra Klein ◽  
Neena Tierney
Keyword(s):  
Atopic Dermatitis ◽  
Skin Barrier ◽  
Barrier Properties ◽  
Skin Microbiome

scholarly journals Efficacy of Phototherapy With 308-nm Excimer Light for Skin Microbiome Dysbiosis and Skin Barrier Dysfunction in Canine Atopic Dermatitis

2021 ◽  
Vol 8 ◽  
Author(s):  
Ju-Yong Park ◽  
Seon-Myeong Kim ◽  
Jung-Hyun Kim
Keyword(s):  
Atopic Dermatitis ◽  
Relative Abundance ◽  
Barrier Function ◽  
Therapeutic Option ◽  
Clinical Signs ◽  
Skin Barrier ◽  
Skin Barrier Function ◽  
Skin Microbiome ◽  
Canine Atopic Dermatitis ◽  
Allergic Skin

The management of canine atopic dermatitis, an allergic skin disorder, is challenging. To investigate the effect of phototherapy using a 308-nm excimer light as a topical treatment for canine atopic dermatitis, 10 dogs with canine atopic dermatitis and 10 with non-allergic skin were enrolled in this study. Phototherapy was applied every 7 days for a total of 2 months. The skin microbiome, skin barrier function, and clinical outcomes were evaluated after phototherapy. Phototherapy significantly changed the composition of the skin microbiome of dogs with atopic dermatitis and significantly increased the relative abundance of the phyla Actinobacteria and Cyanobacteria. It significantly alleviated the clinical signs of canine atopic dermatitis without serious adverse effects. Transepidermal water loss, as a measure of skin barrier function, significantly decreased after phototherapy. In addition, phototherapy increased microbial diversity and decreased the relative abundance of Staphylococcus pseudintermedius associated with the severity of canine atopic dermatitis. These results suggest that the excimer light therapy is a suitable and safe therapeutic option for canine atopic dermatitis, which is also a spontaneous animal model of atopic dermatitis.

Human β-defensin-2 as a marker for disease severity and skin barrier properties in atopic dermatitis

2013 ◽  
Vol 169 (3) ◽  
pp. 587-593 ◽  
Author(s):  
M.-L. Clausen ◽  
J.M. Jungersted ◽  
P.S. Andersen ◽  
H.-C. Slotved ◽  
K.A. Krogfelt ◽  
...  
Keyword(s):  
Atopic Dermatitis ◽  
Disease Severity ◽  
Skin Barrier ◽  
Barrier Properties

scholarly journals Biologic Therapy of Moderate and Severe Forms of Atopic Dermatitis in Children

2020 ◽  
Vol 19 (6) ◽  
pp. 432-443
Author(s):  
Nikolay N. Murashkin ◽  
Leyla S. Namazova-Baranova ◽  
Leonid A. Opryatin ◽  
Roman V. Epishev ◽  
Alexander I. Materikin ◽  
...  
Keyword(s):  
Atopic Dermatitis ◽  
Chronic Inflammation ◽  
Biologic Therapy ◽  
Pediatric Population ◽  
Normal Skin ◽  
Skin Barrier ◽  
Skin Microbiome ◽  
Barrier Dysfunction ◽  
Microbial Dysbiosis ◽  
Unaffected Skin

Atopic dermatitis (AD) is the disease with chronic inflammation, epidermal barrier dysfunction and microbial dysbiosis. AD is widespread, including pediatric population. The article discusses the disease’s pathogenesis: skin barrier deficiency, immunological causes of chronic inflammation, characteristics of normal skin microbiome and its disorders on both affected and unaffected skin of children with AD. Main principles of systemic treatment for moderate and severe forms of disease are considered. Features of targeted therapy with dupilumab (IL 4/IL 13 inhibitor) in children with moderate and severe forms of AD are discussed. The overview of the research results on the dupilumab efficacy and safety is presented.

scholarly journals Innovations in the Therapy of Atopic Dermatitis Complicated by a Secondary Infection

2018 ◽  
Vol 15 (4) ◽  
pp. 318-323
Author(s):  
Nikolay N. Murashkin ◽  
Alexander I. Materikin ◽  
Eduard T. Ambarchian ◽  
Roman V. Epishev ◽  
Dmitriy V. Fedorov
Keyword(s):  
Staphylococcus Aureus ◽  
Atopic Dermatitis ◽  
Marked Decrease ◽  
Secondary Infection ◽  
Skin Barrier ◽  
Barrier Properties ◽  
Pathogenic Microorganisms ◽  
High Efficacy ◽  
Microbiome Composition ◽  
Immunological Barrier

Reduced skin barrier properties in patients with atopic dermatitis (AtD) are largely caused by microbiome changes and extensive Staphylococcus aureus colonisation of the skin. In this regard, the integument of patients with AtD requires constant care and the use of various emollients. The inclusion of lysates of non-pathogenic microorganisms and prebiotics in the composition of emollients ensures the normalisation of the microbiome composition and the immunological barrier of the skin. The article presents the results of our own observations on the application of two cosmetic scin-care products for damaged skin with vitamin F in children with AtD complicated by a secondary infection, while the composition of one of the products is additionally enriched with ceramides and prebiotics. The safety and high efficacy of both products have been shown, however, the presence of ceramides and prebiotics in the emollient composition makes it possible to achieve a marked decrease in the degree of S. aureus colonisation of the skin.

scholarly journals Quorum sensing between bacterial species on the skin protects against epidermal injury in atopic dermatitis

2019 ◽  
Vol 11 (490) ◽  
pp. eaat8329 ◽  
Author(s):  
Michael R. Williams ◽  
Stephen K. Costa ◽  
Livia S. Zaramela ◽  
Shadi Khalil ◽  
Daniel A. Todd ◽  
...  
Keyword(s):  
Atopic Dermatitis ◽  
Quorum Sensing ◽  
Normal Skin ◽  
Bacterial Species ◽  
Skin Barrier ◽  
Toxin Production ◽  
Skin Microbiome ◽  
Coagulase Negative Staphylococci ◽  
Normal Human Skin ◽  
Autoinducing Peptides

Colonization of the skin by Staphylococcus aureus is associated with exacerbation of atopic dermatitis (AD), but any direct mechanism through which dysbiosis of the skin microbiome may influence the development of AD is unknown. Here, we show that proteases and phenol-soluble modulin α (PSMα) secreted by S. aureus lead to endogenous epidermal proteolysis and skin barrier damage that promoted inflammation in mice. We further show that clinical isolates of different coagulase-negative staphylococci (CoNS) species residing on normal skin produced autoinducing peptides that inhibited the S. aureus agr system, in turn decreasing PSMα expression. These autoinducing peptides from skin microbiome CoNS species potently suppressed PSMα expression in S. aureus isolates from subjects with AD without inhibiting S. aureus growth. Metagenomic analysis of the AD skin microbiome revealed that the increase in the relative abundance of S. aureus in patients with active AD correlated with a lower CoNS autoinducing peptides to S. aureus ratio, thus overcoming the peptides’ capacity to inhibit the S. aureus agr system. Characterization of a S. hominis clinical isolate identified an autoinducing peptide (SYNVCGGYF) as a highly potent inhibitor of S. aureus agr activity, capable of preventing S. aureus–mediated epithelial damage and inflammation on murine skin. Together, these findings show how members of the normal human skin microbiome can contribute to epithelial barrier homeostasis by using quorum sensing to inhibit S. aureus toxin production.

scholarly journals Staphylococcus aureus colonization on antecubital non-exacerbated atopic dermatitis patient compared to healthy children

2019 ◽  
Author(s):  
Nur Khamidah ◽  
Evy Ervianti ◽  
Hari Sukanto
Keyword(s):  
Staphylococcus Aureus ◽  
Atopic Dermatitis ◽  
Skin Barrier ◽  
Atopic Dermatitis Patient ◽  
Control Group ◽  
Healthy Children ◽  
Skin Microbiome ◽  
Cross Sectional ◽  
History Of ◽  
Cross Sectional Design

Atopic dermatitis is chronic pruritic inflammatory skin disease affects one third of children in the world, and the highest number of child`s skin problems in Indonesia. The complex role of the skin microbiome in the pathogenesis of atopic dermatitis is being elucidated. Interaction between skin barrier defects, and immunological factors can change the skin microbiome, and increased Staphylococcus aureus colonization. The aim of this study was to compare the colony of Staphylococcus aureus from antecubital fossa of non-exacerbated atopic dermatitis children to healthy children without history of atopic dermatitis. A comparative observational analytic with cross sectional design, examined antecubital swab culture from 17 non-exacerbated atopic dermatitis patients and 17 controls to investigate the presence of Staphylococcus aureus and density of the colonization. Staphylococcus aureus skin colonization was seen in 5 patients (29.41%) in non-exacerbated atopic dermatitis patients but none in control group (statistically significant with p=0.044), relative risk 2.417. All of positive colonization revealed moderate and heavy bacterial growth (104->105 cfu/cm2). This finding supports previous study that atopic dermatitis prone to colonized with Staphylococcus aureus.

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