scholarly journals EARLY PREGNANCY AND ENDOTHELIAL DYSFUNCTION

2020 ◽  
Vol 73 (4) ◽  
pp. 743-745
Author(s):  
Lyudmyla V. Dubyk ◽  
Oleksandr M. Yuzko ◽  
Nataliia V. Chernetska ◽  
Tetiana R. Kolotylo
Keyword(s):  
Endothelial Dysfunction ◽  
Pregnant Women ◽  
Nitrogen Oxide ◽  
Functional State ◽  
Early Pregnancy ◽  
Prognostic Value ◽  
Opposite Pattern ◽  
Endothelin 1 ◽  
Definition Of ◽  
Complicated Pregnancy

The aim is to analyze the value of endothelial dysfunction markers during pregnancy. Materials and methods: We have examined 153 pregnant women to identify endothelial dysfunction markers of endothelin-1, nitrogen oxide (NO) that have been studied using immunoenzymometric sets for an uncomplicated and complicated pregnancy. Results: We found that the concentration of endothelin-1 repeatedly exceeded the rates in pregnant women with miscarriages than during physiological pregnancy. The diametrically opposite pattern concerns the level of nitrogen oxide. These changes in the markers of the functional state of the endothelin indicate the development of the dysfunction of this system in women with the pathology of pregnancy. Conclusions: Consequently, endothelial dysfunction can be considered to be one of the reasons for miscarriage in the examined women. Therefore, the definition of markers of endothelial dysfunction has prognostic value.

scholarly journals PATHOGENESIS OF ENDOTHELIAL DYSFUNCTION IN DIABETIC RETINOPATHY DURING STREPTOZOTOCIN-INDUCED DIABETES MELLITUS

2019 ◽  
Vol 19 (3) ◽  
pp. 161-165
Author(s):  
Ya. V. Sirman ◽  
I. V. Savytskyi
Keyword(s):  
Diabetes Mellitus ◽  
Diabetic Retinopathy ◽  
Endothelial Dysfunction ◽  
Functional State ◽  
Von Willebrand Factor ◽  
Male Rats ◽  
Endothelin 1 ◽  
Study Results ◽  
Von Willebrand ◽  
Willebrand Factor

One of the main diabetes complications that can lead to the disability of patients is diabetic retinopathy. The purpose of the study was to investigate endothelial dysfunction markers in modelled diabetic retinopathy. Material and methods. The experiment was conducted on male rats of the Wistar line, weighing 180-220 grams, up to 3 months of age (inclusive). During the experiment, the animals were divided into two groups. The 1st group included 20 intact animals; the 2nd group had 60 animals with modelled diabetes mellitus and non-proliferative diabetic retinopathy. Results and discussion. Having studied endothelial nitric oxide synthase, we have found out significant differences (p <0.001) when comparing the findings obtained in the 2nd group with the findings of the intact animals. The 2nd group rats were simulated with diabetic retinopathy without following correction. We also observed the decreasing dynamics of this index. For a more detailed study of the functional state of the endothelium and its disruption, we selected the von Willebrand factor, which is one of the common markers showing the damage to the functional state of the endothelium. In the group with simulated pathology, the level of the investigated marker increased compared with intact animals (p <0.001). There was an increase in endothelin-1 level (p <0.001) in the laboratory rats with modelled diabetic retinopathy. Conclusion. The study results have proven that our experimental model of diabetes mellitus and one of its complications, diabetic retinopathy is accompanied by the development of endothelial dysfunction. There has been found as increase in the von Willebrand factor in the modelled pathological process. We have detected an increase in endothelin-1, a marker of vasoconstriction and endothelial dysfunction, 30 days since the beginning of the experiment. Inhibition of endothelial NO synthase activity indicates an impairment of the physiological NO synthesis.

scholarly journals Periodic Assessment of Antenatal and Post Natal Serum Endothelin-1 (ET-1) and Nitric Oxide (NO) Levels in Hypertensive Disorders of Pregnancy (HDP)

2020 ◽  
Vol 18 (2) ◽  
Author(s):  
Hidayah I ◽  
Tariq A.R. ◽  
N.A. Jamani ◽  
Maizura M.Z.
Keyword(s):  
Nitric Oxide ◽  
Endothelial Dysfunction ◽  
Pregnant Women ◽  
Disease Risk ◽  
Chronic Hypertension ◽  
Hypertensive Disorders Of Pregnancy ◽  
Sample Collection ◽  
Endothelin 1 ◽  
Hypertensive Disorders ◽  
Potent Vasoconstrictor

Hypertensive Disorders of Pregnancy (HDP) is an independent risk factor of cardiovascular (CVS) disease with endothelial dysfunction postulated to be the pathophysiology. Endothelin-1 (ET-1), a potent vasoconstrictor, has been identified as a pivotal mediator in HDP. Disturbances in nitric oxide (NO) bioavailability found in endothelial dysfunction may increase susceptibility to cardiovascular diseases such as hypertension. The study aims to determine serial ET-1 and NO levels in patients with HDP and its role in persistent endothelial dysfunction. Thirty-six pregnant women from the following categories (i) normal pregnant women (Control) (ii) chronic hypertension during pregnancy (CH) and (iii) pregnancy induced hypertension (PIH) participated in this study. Blood pressure indices measurements and sample collection were done at antepartum (32 weeks) and postpartum (8 weeks and 12 weeks). ET-1 and serum NO were measured using the Human ET-1 (Endothelin-1) ELISA Kit and Nitric Oxide (total) detection kit respectively. Results: Serum ET-1 was significantly higher in patients with CH (55.3 pg/ml) and PIH (35.6 pg/ml) compared to Control (11.8 pg/ml) during antenatal until 3 months postpartum (CH 38.3 pg/ml, PIH 29.5 pg/ml, Control 1.9 pg/ml). This was accompanied by significantly lower levels of serum NO in HDP patients. Persistently higher than normal levels of ET-1 and lower than normal levels of NO up to 3 months postpartum in patients with history of HDP indicate presence of persistent endothelial dysfunction despite BP normalisation in PIH patients. Long term NO/ET-1 imbalance may account for the increased CVS disease risk.

Endothelin-1 and nitrogen oxide metabolites in risk diagnostics of arterial hypertension in persons of young and middle ages occupied in harmful working conditions

2021 ◽  
Vol 66 (9) ◽  
pp. 525-532
Author(s):  
I. A. Umnyagina ◽  
T. V. Blinova ◽  
L. A. Strakhova ◽  
Yu. V. Ivanova ◽  
V. V. Troshin ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Endothelial Dysfunction ◽  
Arterial Hypertension ◽  
Nitrogen Oxide ◽  
Working Conditions ◽  
Vascular Tone ◽  
Public Health Problem ◽  
Global Public Health ◽  
Occupational Factors ◽  
Endothelin 1

Hypertension is a global public health problem. One of the reasons contributing to the development of arterial hypertension is endothelial dysfunction, which is expressed in the imbalance of vasoactive indicators of vascular tone - nitrogen oxide and endothelin-1. Monitoring the indicators of endothelial dysfunction in workers exposed to harmful occupational factors will help to identify a risk group for the development of occupationally caused diseases of the cardiovascular system and, in particular, arterial hypertension, for early implementation of preventive measures. This study aims to identify the relationship between endothelin-1, nitrogen oxide metabolites and blood pressure in young and middle-aged people occupied in harmful working conditions, to evaluate the studied parameters as possible markers for diagnosing the risk of hypertension. Two hundred thirty-six (236) employees of young and middle age were examined of one of the metallurgical plants of the Nizhny Novgorod region. In order to characterize the state of vascular tone, a coefficient was used that represents the ratio of the concentration of nitrogen oxide (μmol/L) to endothelin-1 (pg/ml) (NOx/ET-1). It was revealed that in one-third of people with normal and high normal blood pressure, the NOx/ET-1 value was 2-3 times less than in people with optimal blood pressure, which indicates the occurrence of endothelial dysfunction and the possible development of persistent arterial hypertension. Harmful occupational factors negatively affect vascular tone - the value of NOx/ET-1 in individuals exposed to harmful factors was 3-4 times less than in individuals not subjected to such exposure. The NOx/ET-1 coefficient can be used as an informative indicator when monitoring health conditions with an in-depth examination of working people; it can be a criterion for the risk of developing hypertension.

Improving medical-diagnostic actions of the flu during pregnancy

10.12737/8626 ◽  
2015 ◽  
Vol 9 (1) ◽  
pp. 0-0
Author(s):  
Шатунова ◽  
E. Shatunova ◽  
Калиматова ◽  
D. Kalimatova ◽  
Лимарева ◽  
...  
Keyword(s):  
Endothelial Dysfunction ◽  
Pregnant Women ◽  
Perinatal Outcomes ◽  
Correlation Coefficients ◽  
Respiratory Illness ◽  
Premature Delivery ◽  
Pregnancy And Childbirth ◽  
Medical Diagnostic ◽  
Vascular Endothelial Factor ◽  
Definition Of

Surveyed 202 pregnant women with a diagnosis of influenza medium (n=154) and severe (n=48) severity. An algorithm for management of pregnant women with influenza, which is monitoring the level of markers of endothelial dysfunction; it is shown that its use in clinical practice can reduce the frequency of complications of pregnancy and childbirth and to improve perinatal outcomes. The results were statistically evaluate the relationship between indicators of pregnancy and childbirth, and the dynamics of the concentrations of markers of endothelial dysfunction has revealed the presence of stable relationships indicators (statistically significant correlation coefficients Spearman moderate strength). In particular, it is shown that the vascular endothelial factor concentration is negatively associated with the incidence of intrauterine growth retardation, preeclampsia, placental insufficiency, anemia and threatened premature delivery, polyhydramnios. The results of the study, indicating the high prognostic value of the levels of markers of endothelial dysfunction, allow us to propose the inclusion of estimates of these parameters in the algorithm of management of pregnant women with influenza for the timely appointment of preventive and diagnostic and treatment activities in order to reduce the frequency of complications of pregnancy and childbirth and improve perinatal outcomes. The obtained results allow to conclude that pregnant women with symptoms of ARI (influenza) shows the definition of the levels of markers of endothelial dysfunction, a survey is recommended during the first indications of the disease. It is reasonable assessment of markers of endothelial dysfunction in this category pregnant in the dynamics after 1-2 months after acute respiratory illness.

scholarly journals The Role of Endothelial Dysfunction Markers in Pregnant Women with Chorion Detachment, Included in the Program of Auxiliary Reproductive Technologies

2017 ◽  
Vol 24 (3) ◽  
Author(s):  
Natalya Lytvyn
Keyword(s):  
Endothelial Dysfunction ◽  
Pregnant Women ◽  
Reproductive Function ◽  
Reproductive Technologies ◽  
The Body ◽  
Control Group ◽  
Vitro Fertilization ◽  
Endothelin 1

An urgent medical and social problem is the restoration of reproductive function of womenwho suffer from infertility, which became possible due to auxiliary reproductive technologies. Women with induced pregnancy make thegroup of a high-risk on miscarriage, due to interrelated processes –immunological disorders and endothelial dysfunction that occur in the body of pregnant women after the use of extracorporal fertilization programs, and can lead to the chorion detachment and the formation of subchorionic hematomas.The purpose of the study is to determine the role of endothelial dysfunction as one of the leading factors that determine the development of a local non-progressive chorion detachment in infertile patients included in the program of auxiliary reproductive technologies.Materials and methods. We have examined 130 pregnant women, who were divided into groups: the control group included 30 women, whose pregnancy occurred in the natural cycle and with uncomplicated gestational course; the main group – 50 patients with induced pregnancy and risk factors of the occurrence of chorion detachment, who wereperformed the proposed pre-gravidapreparation; the comparative group – 50 pregnant women who received a standard scheme of pregnancy management before and after in-vitro fertilization. A general clinical examination, ultrasound examination, homocysteine level determination, endothelin-1 and nitrogen oxide metabolites were performed.Results. In women included into the program of auxiliary reproductive technologies with local chorion detachment were recorded changes of vascular endothelial function with a possible increase in endothelin-1 production and a decrease of the nitric oxidesynthesis. During the induced pregnancy with the presence of subchorionic hematoma, an increase of the level of endothelium-damaging factor of homocysteine was noted.Conclusions.This study identifies the parameters that reflect the main links of endothelial dysfunction and can be used as markers of local chorion detachment.

Is it possible the prediction of placental dysfunction?

2016 ◽  
pp. 23-27
Author(s):  
S.I. Zhuk ◽  
◽  
Yu.M. Melnik ◽  
N.V. Pehnio ◽  
◽  
...  
Keyword(s):  
Growth Factor ◽  
Pregnant Women ◽  
Dynamic Control ◽  
Clinical Signs ◽  
Control Group ◽  
Morphological Examination ◽  
Endothelin 1 ◽  
Pregnancy And Childbirth ◽  
Placental Dysfunction ◽  
Complicated Pregnancy

The purpose of the study: the study of the initiating mechanisms of development of violations of the fetal-placental relationship to develop prognostic criteria, tactics of pregnancy and delivery in women at high risk. Materials and methods. In the period from 2013 to 2015 a comprehensive examination of 334 pregnant women, which depending on the peculiarities of pregnancy and childbirth were divided into groups. The control group consisted of 236 pregnant women with uncomplicated gestational period, no morphological signs of placental dysfunction. The main group (OG) included 98 patients with a complicated pregnancy who had revealed violations of the fetal-placental relationship, which was confirmed by morphological examination of the placenta immediate postpartum period. Depending on options of course of gestation period pregnant OG were divided into subgroups: subgroup I – 31 pregnant signs of preeclampsia of different severity; subgroup II – 33 pregnant women with clinical and morphological signs of placental dysfunction, subgroup III – 34 pregnant women with threatened miscarriage and premature birth. In addition, to evaluate the effectiveness of prediction and diagnosis of disorders of fetal-placental relationship was highlighted in the comparison group (GP), which included 32 pregnant women with risk factors for placental dysfunction, which carried out the monitoring of the pregnancy by the proposed algorithm. Results. Due to the datas of high-frequency dopplerometry was determined that decline of cerebro-placental index can be the sign of placental dysfunction (p<0.05). At women with placental insufficiency the reliable increase of endothelin-1 (p<0.05), decline of vascular endothelial growth factor (p<0.05) and placental growth factor (p<0.05), increase of interleukin-1b maintenance (p<0.05) and interleukin-3 reduction (p<0.05) were set. It was proven that during placental dysfunction with an absence of high variableness episodes and STV value less than 4,0 points immediate delivery was necessary. Conclusion. It was developed the monitoring, that based on the prognostic markers determination and dynamic control of pregnancy and it allowed to predict placental dysfunction and decrease its clinical signs during pregnancy in 2,5 time and unfavorable delivery outcomes in 1,7 times. Key words: placental dysfunction, prediction, endothelin-1, growth factor, interleukin, dopplerometry, cardiotocography.

scholarly journals Periodic Assessment Of Antenatal And Post Natal Serum Endothelin1 and Nitric Oxide Levels In Hypertensive Disorders Of Pregnancy

2018 ◽  
Vol 17 (1) ◽  
Author(s):  
Hidayatul Radziah Ismawi ◽  
Tariq Abdul Razaq ◽  
Maizura Mohd. Zainudin ◽  
Nur Jasmine Aida Jamani
Keyword(s):  
Nitric Oxide ◽  
Blood Pressure ◽  
Endothelial Dysfunction ◽  
Pregnant Women ◽  
Post Partum ◽  
Chronic Hypertension ◽  
Hypertensive Disorder ◽  
Sample Collection ◽  
Endothelin 1 ◽  
Potent Vasoconstrictor

Introduction: Hypertensive Disorder of Pregnancy (HDP) is an independent risk factor of cardiovascular (CVS) disease with persistent endothelial dysfunction, that occurs after the initial insult during pregnancy and persists post partum postulated to be the pathophysiology. Endothelin-1 (ET-1), a potent vasoconstrictor, has been identified as a pivotal mediator in both essential hypertension and HDP. Disturbances in Nitric Oxide (NO) bioavailability found in endothelial dysfunction may increase susceptibility to cardiovascular diseases such as hypertension. Materials and Methods: Thirty six pregnant women at 30-36 weeks period of gestation from the following categories (i) pregnancy induced hypertension (PIH) (ii) chronic hypertension during pregnancy (CH) and (iii) normal pregnant women (Control). Blood pressure indices measurements and sample collection was done at antepartum (30-36 weeks), post partum (8 weeks and 12 weeks). Endothelin-1 was measured using the Human ET-1 (Endothelin-1) ELISA Kit and serum NO was measured using the Nitric Oxide (total) detection kit. Results: All blood pressure indices were significantly higher in HDP patients compared to control during antenatal and post partum periods. Serum ET-1 was significantly higher in patients with HDP compared to control during antenatal until 3 months post partum. This was accompanied by significantly lower levels of serum NO in HDP patients. Conclusion: ET-1 levels in patients with history of HDP irrespective of post partum blood pressure contributes to persistent endothelial dysfunction.

Markers of endothelial dysfunction in pregnant after flu during pregnancy: performance and prognostic significance

10.12737/7374 ◽  
2014 ◽  
Vol 8 (1) ◽  
pp. 0-0
Author(s):  
Калиматова ◽  
D. Kalimatova ◽  
Шатунова ◽  
E. Shatunova
Keyword(s):  
Endothelial Dysfunction ◽  
Pregnant Women ◽  
Prognostic Significance ◽  
Perinatal Outcomes ◽  
Correlation Coefficients ◽  
Control Group ◽  
Endothelial Protein C Receptor ◽  
Definition Of ◽  
Somatic Diseases ◽  
Endothelial Growth Factor

It was performed the study of endothelial dysfunction markers dynamics in pregnant with influenza and evaluation of the prognostic significance of these parameters. It analyzed the data 44 included pregnant women (average age of 28,2±7,3 years) diagnosed with flu mean (n=26) and severe (n=18) degrees. 22 pregnant women with no evidence of infectious and somatic diseases in the control group (mean age 27,2±5,4 years). The diagnosis of highly pathogenic H1N1 was confirmed using virological examination, all patients were hospitalized. Found that pregnant women who have had the flu during gestation, it reveals significant shifts of the levels of markers of endothelial dysfunction in blood plasma: reducing the concentration of vascular endothelial growth factor (VEGF) reduced compared with healthy pregnant women and increased levels of endothelial protein C receptor along with increasing concentrations endothelin-1. It is shown that with increasing severity of flu during pregnancy, the severity of the imbalance of these markers is increased. The presence of significant correlation coefficients significant moderate force between the frequency of complications of pregnancy, childbirth and perinatal outcomes and degree of changes in the concentrations of markers of endothelial dysfunction. It is concluded that high prognostic value of assessing these factors, it is proposed to include them in the definition of an algorithm for pregnant women with influenza.

Early predictors of placental dysfunction

2016 ◽  
pp. 25-28
Author(s):  
J.M. Melnik ◽  
◽  
A.A. Shlyahtina ◽  
Keyword(s):  
Vascular Endothelial Growth Factor ◽  
Growth Factor ◽  
Pregnant Women ◽  
Umbilical Artery ◽  
Placental Growth Factor ◽  
Vascular Endothelial ◽  
Endothelin 1 ◽  
Placental Dysfunction ◽  
Early Predictors ◽  
Endothelial Growth Factor

The article presents the predictors of placental dysfunction on the early stage of pregnancy. The objective: the search for prognostic markers and criteria for the occurrence of placental insufficiency in the early stages of the gestational process to optimize the pregnancy and labor with improved perinatal outcomes. Patients and methods. To solve this goal in the period from 2013 to 2015 were conducted a comprehensive survey of 334 pregnant women, which depending on the peculiarities of pregnancy and childbirth were divided into groups. The control group consisted of 236 pregnant women with uncomplicated gestational period, no morphological signs of placental dysfunction. The study group included 98 patients with a complicated pregnancy who had revealed violations of the fetal-placental relations, which was confirmed by morphological examination of the placenta in the postpartum period. Results. It was found that pregnant women with placental insufficiency in the first trimester of pregnancy have higher levels of interleukin-1B (IL-1v) and interleukin-3 (IL-3) in comparison with physiological pregnancy, as well as there is a direct significant correlation between IL-1v and pulsative index (PI) in the spiral (r=0.84) and uterine artery (r=0.77), and the inverse correlation between the level of IL-3 and PI in the terminal branches of the umbilical artery (r=-0.69). Verified an inverse relationship between the concentration of endothelin-1, the level of vascular endothelial growth factor (r=-0.87) and placental growth factor (r=-0.73), and also a direct link between the content of endothelin-1 and PI in spiral arteries (r=0.89), uterine artery (r=0.83) and the terminal branches of the umbilical artery (r=0.79). Conclusion. Thus, it is proven that early predictors of placental dysfunction can be considered the concentration of endothelin-1, vascular endothelial growth factor, placental growth factor, interleukin-1, interleukin-3, and the indices of pulsative index. Key words: placental dysfunction, predictors, endothelin-1, vascular endothelial growth factor, placental growth factor, interleukin, pulsative index.

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