Improving medical-diagnostic actions of the flu during pregnancy

10.12737/8626 ◽  
2015 ◽  
Vol 9 (1) ◽  
pp. 0-0
Author(s):  
Шатунова ◽  
E. Shatunova ◽  
Калиматова ◽  
D. Kalimatova ◽  
Лимарева ◽  
...  
Keyword(s):  
Endothelial Dysfunction ◽  
Pregnant Women ◽  
Perinatal Outcomes ◽  
Correlation Coefficients ◽  
Respiratory Illness ◽  
Premature Delivery ◽  
Pregnancy And Childbirth ◽  
Medical Diagnostic ◽  
Vascular Endothelial Factor ◽  
Definition Of

Surveyed 202 pregnant women with a diagnosis of influenza medium (n=154) and severe (n=48) severity. An algorithm for management of pregnant women with influenza, which is monitoring the level of markers of endothelial dysfunction; it is shown that its use in clinical practice can reduce the frequency of complications of pregnancy and childbirth and to improve perinatal outcomes. The results were statistically evaluate the relationship between indicators of pregnancy and childbirth, and the dynamics of the concentrations of markers of endothelial dysfunction has revealed the presence of stable relationships indicators (statistically significant correlation coefficients Spearman moderate strength). In particular, it is shown that the vascular endothelial factor concentration is negatively associated with the incidence of intrauterine growth retardation, preeclampsia, placental insufficiency, anemia and threatened premature delivery, polyhydramnios. The results of the study, indicating the high prognostic value of the levels of markers of endothelial dysfunction, allow us to propose the inclusion of estimates of these parameters in the algorithm of management of pregnant women with influenza for the timely appointment of preventive and diagnostic and treatment activities in order to reduce the frequency of complications of pregnancy and childbirth and improve perinatal outcomes. The obtained results allow to conclude that pregnant women with symptoms of ARI (influenza) shows the definition of the levels of markers of endothelial dysfunction, a survey is recommended during the first indications of the disease. It is reasonable assessment of markers of endothelial dysfunction in this category pregnant in the dynamics after 1-2 months after acute respiratory illness.

Markers of endothelial dysfunction in pregnant after flu during pregnancy: performance and prognostic significance

10.12737/7374 ◽  
2014 ◽  
Vol 8 (1) ◽  
pp. 0-0
Author(s):  
Калиматова ◽  
D. Kalimatova ◽  
Шатунова ◽  
E. Shatunova
Keyword(s):  
Endothelial Dysfunction ◽  
Pregnant Women ◽  
Prognostic Significance ◽  
Perinatal Outcomes ◽  
Correlation Coefficients ◽  
Control Group ◽  
Endothelial Protein C Receptor ◽  
Definition Of ◽  
Somatic Diseases ◽  
Endothelial Growth Factor

It was performed the study of endothelial dysfunction markers dynamics in pregnant with influenza and evaluation of the prognostic significance of these parameters. It analyzed the data 44 included pregnant women (average age of 28,2±7,3 years) diagnosed with flu mean (n=26) and severe (n=18) degrees. 22 pregnant women with no evidence of infectious and somatic diseases in the control group (mean age 27,2±5,4 years). The diagnosis of highly pathogenic H1N1 was confirmed using virological examination, all patients were hospitalized. Found that pregnant women who have had the flu during gestation, it reveals significant shifts of the levels of markers of endothelial dysfunction in blood plasma: reducing the concentration of vascular endothelial growth factor (VEGF) reduced compared with healthy pregnant women and increased levels of endothelial protein C receptor along with increasing concentrations endothelin-1. It is shown that with increasing severity of flu during pregnancy, the severity of the imbalance of these markers is increased. The presence of significant correlation coefficients significant moderate force between the frequency of complications of pregnancy, childbirth and perinatal outcomes and degree of changes in the concentrations of markers of endothelial dysfunction. It is concluded that high prognostic value of assessing these factors, it is proposed to include them in the definition of an algorithm for pregnant women with influenza.

PERINATAL ASPECTS OF PREGNANCY AND CHILDBIRTH ON THE BACKGROUND OF VITAMIN D LACK IN PREGNANT WOMEN

2021 ◽  
Vol 74 (10) ◽  
pp. 2585-2587
Author(s):  
Vitaliy V. Maliar
Keyword(s):  
Vitamin D ◽  
Blood Serum ◽  
Pregnant Women ◽  
Perinatal Outcomes ◽  
Fetal Distress ◽  
Test System ◽  
Perinatal Complications ◽  
Pregnancy And Childbirth ◽  
Wide Range ◽  
Pregnancy And Delivery

The aim: To study the features of the course of gestation and perinatal outcomes of delivery in women with vitamin D lack. Materials and methods: The article presents the results of studies of the characteristics of the course of pregnancy and delivery outcomes in 50 patients with vitamin D lack compared with a group of 50 somatically healthy pregnant women with normal level of 25 (OH) D. In order to establish a lack of vitamin D in pregnant women in the 10-12, 20-22, 30-32 weeks of gestation electrochemiluminiscence method by using a test system EURIMMUN (Germany) in the blood serum level of 25-hydroxycalciferol (25 (OH) D) in pregnant women. Results: When analyzing the structure of complications in women with vitamin D lack during pregnancy and childbirth we found out that risk of premature birth and premature births dominated among all the complications, respectively (58.0% and 36.0%) against (12.0% and 16.0%), p <0.05. Vitamin D lack in pregnant women is often associated with a wide range of obstetric and perinatal complications, namely: preeclampsia, gestational diabetes, bacterial vaginosis , premature rupture of membranes, placental abruption, abnormal labor activity, fetal distress that required delivery by Caesarean section. Conclusions: An analysis of the course of pregnancy and childbirth in women of thematic groups proved the expediency of an individual approach to the therapy of obstetric pathology among women with vitamin D lack. Despite the level of 25 (OH) D in the blood serum of a pregnant woman of 30 ng / ml and below, it is advisable to prescribe vitamin D for prophylaxes and treatment of Vitamin D deficiency in mother and fetus.

Frequency and weight of complications of pregnancy and childbirth at women with tuberculosis of various localization in Krasnoyarskiy kraY

2014 ◽  
Vol 63 (3) ◽  
pp. 58-65
Author(s):  
Svetlana Anatolyevna Vetushenko ◽  
Tatyana Grigoryevna Zakharova
Keyword(s):  
Pregnant Women ◽  
Premature Birth ◽  
Clinical Manifestations ◽  
Perinatal Outcomes ◽  
Maternity Hospital ◽  
Obstetric Complications ◽  
Medical Monitoring ◽  
Pregnancy And Childbirth ◽  
Prevention And Treatment

The purpose of researches - to reveal clinical manifestations of obstetric complications at pregnant women with tuberculosis of various localization on the basis of results of medical monitoring, and also to establish the complications of fetoplatsentarny insufficiency taking place in the studied period, at pregnant women with tuberculosis according to localizations of tubercular process. During medical monitoring stories of families of 210 women with tuberculosis of various localization and a condition of their newborns during 2006-2013 on the basis of interdistrict maternity hospital N 4 of Krasnoyarsk, profiled on this pathology are analysed. As a result of the analysis of structure of obstetric complications at women with tuberculosis in the territory of Krasnoyarsk Kray it is established: from 210 pregnant women at 76 there were no complications; at 133 pregnant women with FPN clinical manifestations are noted it are 43 cases of a hypoxia of a fruit, 31 cases of SZRP, 14 cases of SZRP with a hypoxia, thus clinical manifestations were accompanied by lack of water and abundance of water at the level of 22 and 4 cases respectively; in the same group the increase in number of complications of pregnancy by a preeklampsiya, anomalies of patrimonial activity, premature birth at the level of 51, 16 and 28 cases respectively is looked through. From only 133 pregnant women with placentary insufficiency 11 cases of childbirth without clinical manifestations of FPN are noted. The revealed number of clinical manifestations of placentary insufficiency and other complications of pregnancy says that at pregnant women with a disease of tuberculosis these indicators many times is more, than at pregnant women without disease of tuberculosis. The established structure of obstetric complications at pregnant women with tuberculosis of various localization highlighted prevalence of FPN proceeding with heavy clinical manifestations, such as SZRP, the fruit hypoxia, and also revealed most often meeting complications of pregnancy, such as a preeklampsiya, abnormal patrimonial activity, premature birth. It is the indication for development of effective measures of prevention and treatment of these complications, their forecasting from early terms of pregnancy for improvement of perinatal outcomes.

Influence of Arterial Hypertension on the Pregnancy in Women with RH-Negative Blood

2015 ◽  
Vol 22 (3) ◽  
pp. 56-62
Author(s):  
Тамазаева ◽  
Kh. Tamazaeva ◽  
Омаров ◽  
N.S. Omarov
Keyword(s):  
Arterial Hypertension ◽  
Pregnant Women ◽  
High Titer ◽  
Perinatal Outcomes ◽  
Control Group ◽  
Threatened Premature Birth ◽  
Definition Of ◽  
D Antigen ◽  
Work Up

The purpose of the study was to assess the role of arterial hypertension (AH) in the development of immunization in women with Rh-negative blood to optimize perinatal outcomes. Subject and methods. A prospective comparatively study was conducted in 3 groups of pregnant women with Rh-negative blood. The 1-st group (n=148) was with hypertensive disease (HD), the 2-nd group (n=144) - with gestational arterial hypertension (GAH); the 3-rd group (n=110) - without somatic pathology. The immune-hematological studies included a definition of the partial D antigen using gel method. Results. It was definited that the pregnancy of these patients accompanied by the high frequency of early gestational toxicosis, threatened premature birth, preeclampsia, placental insufficiency as well as expressed changes immu-nological properties of blood, which are pathogenetic basis of fetal and neonatal rhesus hemolytic disease. Antibodies (AB) in the blood serum of patients with hypertension were detected in the first half of pregnancy (up to 20 weeks) in 1.2-1.4 times more often than in healthy women, high titer of AB rate in patients with HD was significantly higher compared to other groups. Disadvantageous combination of immunoglobulins subclasses Gl and G3 was found in the group of pregnant women with HD (11.4%) and GAH (10,8%), significantly less frequently (6,45%) in the control group. Conclusion. To improve maternal, fetal and neonatal gestation outcomes the authors justified the necessity of prenatal work-up and delivery of these women.

scholarly journals КОМПЛЕКС ПРОФІЛАКТИЧНИХ ЗАХОДІВ ДЛЯ ВАГІТНИХ ПІСЛЯ ДРТ З ВИСОКИМ РИЗИКОМ ПРЕЕКЛАМПСІЇ

World Science ◽  
2020 ◽  
pp. 1-6
Author(s):  
Камінський В’ячеслав Володимирович ◽  
Коломійченко Тетяна Василівна ◽  
Жданович Олексій Ігоревич ◽  
Рогава Ірина Володимирівна
Keyword(s):  
Pregnant Women ◽  
Perinatal Outcomes ◽  
Fetal Distress ◽  
Pregnancy And Childbirth ◽  
System Reduction ◽  
Vascular Regulation ◽  
Prophylactic Measures ◽  
Neonatal Adaptation ◽  
Gynecological Care

The purpose of the study: to evaluate the effectiveness of the proposed set of preventive measures for pregnant women after ART with a high risk of preeclampsia. Material and methods. To test the effectiveness of the proposed set of prophylactic measures, 60 pregnant women after ART were selected, which were randomly divided into 2 groups: 30 women who received the recommended complex (main group) and 30 women (comparison group), whose preeclampsia was prevented by order of the Ministry of Health. № 417 "Guidelines for the provision of outpatient obstetric and gynecological care." Results. The use of the recommended measures improves lipid metabolism (significant reduction of triglycerides and low density cholesterol), eliminates vitamin D deficiency, balances the cytokine profile (reduction of proinflammatory focus), reduces the prothrombotic potential of the hemostasis system (reduction of D-dimer and background marker damage). Improving the general condition and the use of psychotherapy can reduce the manifestations of vegetative-vascular dystonia, anxiety and improve quality of life. Such changes provide a more favorable background for the development of gestation. The incidence of preeclampsia decreased by 43.8% (from 26.7 to 15.0%), and mainly due to early preeclampsia, the incidence of which decreased by 78%, no cases of severe preeclampsia were reported. The frequency of placental insufficiency, fetal distress and growth retardation is reduced. The frequency of birth of children in a state of asphyxia is reduced by 2 times (up to 20.0 vs. 46.7%), severe asphyxia is not observed. Significantly lower and the frequency of violations of the period of neonatal adaptation (30.0 vs. 53.3%). Conclusions. The use of treatment and prophylactic complex to prevent preeclampsia in pregnant women after ART can improve a woman's homeostasis, balance vegetative-vascular regulation, reduce the incidence of preeclampsia by 43.8% (from 26.7 to 15.0%) and other complications of pregnancy and childbirth, improve perinatal outcomes. Proven medical, social and economic efficiency of the developed complex allows to recommend it for implementation in medical practice.

Topical issues of midwifery services under coronavirus pandemic in the area with low population density

2021 ◽  
Vol 19 (1) ◽  
pp. 110-114
Author(s):  
M. B Ovchinnikova ◽  
◽  
A. G. Arutyunyants ◽  
Keyword(s):  
Preterm Birth ◽  
Population Density ◽  
Pregnant Women ◽  
Critical Condition ◽  
Perinatal Outcomes ◽  
Gestation Period ◽  
Published Data ◽  
Third Wave ◽  
Pregnancy And Childbirth ◽  
The Third

The purpose was to describe the algorithms of midwifery services in the area with low population density under the coronavirus pandemic and to evaluate SARS-Cov-2 as a threatening factor for pregnancy and childbirth. Material and methods. 205 pregnant women aged from 16 to 42 y. o., with virusologically conformed presence of SARS-Cov-2, in the gestation period from 5 to 40 weeks were explored. Of them, 126 pregnant patients were hospitalized and monitored up to the recovery from COVID-19 or delivery. The features of pregnancy and childbirth, perinatal outcomes were studied. The obtained data were compared with the published data to identify the true and false threats of COVID-19 to a mother and a baby in case of the «third wave» of the pandemic. Results. Observation showed that pregnant women tend to have a lighter course of SARS-Cov-2 compared to the population and the frequency of critical condition is no more that 0.8%. The frequency of preterm birth is 1.5 % of all births of COVID-19 infected pregnant women, and the frequency of miscarriage is 0.58 % of all COVID-19 infected pregnant women. This does not confirm the published data of high proportion of preterm birth and misbirth (18-19%). Conclusion. Our investigation does not confirm that COVID-19 adds the complexity of the course of pregnancy and makes its outcomes worse.

Obstetric and perinatal outcomes in women with threatened interruption of pregnancy, living in the armed conflict zone

2020 ◽  
pp. 21-24
Author(s):  
I.Yu. Romanenko ◽  
Keyword(s):  
Pregnant Women ◽  
Inflammatory Diseases ◽  
Perinatal Outcomes ◽  
Control Group ◽  
Operative Delivery ◽  
Pregnancy And Childbirth ◽  
Group I ◽  
History Of ◽  
Complicated Course ◽  
Female Genital

The objective: was to evaluate the course of pregnancy, childbirth and perinatal outcomes of delivery of women with threatened interruption of pregnancy (TIP), living in the Lugansk region, to improve treatment and preventive measures and prevent obstetric and perinatal complications in such women. Materials and methods. A prospective clinical and statistical analysis of the course of pregnancy and childbirth of 86 pregnant women in first and second trimesters of pregnancy were hospitalized regarding TIP in the hospitals located in the Luhansk region was performed (group I). The control group consisted of 64 pregnant women with non-complicated obstetric anamnesis and physiological course of pregnancy with similar gestational period of pregnancy and place of residence (group II). Results. In women of group I, a history of female genital inflammatory diseases was significantly more frequent, and a complicated course of pregnancy and childbirth was registered. The number of cases of acute respiratory viral infection (ARVI) was in 4, isthmic-cervical insufficiency (ICI) was in 3 times more often than in healthy pregnant women, asymptomatic bacteriuria, recurring TIP, gestational pyelonephritis and ureaplasma infection were found only in pregnant women of group I, the number of cases of anemia there was no significant difference. 13 (15.12%) of women of group I and 3 (4.69%) of group II (p=0.041) had spontaneous preterm birth at 33–37 weeks of gestation; operative delivery was registered in 23 (26.74%) and 8 (12.50%) cases, respectively (p=0.033). It was established that recurrent TIP, ARVI during this pregnancy, ICI, gestational pyelonephritis are statistically significant risk factors for preterm delivery and operative delivery. Premature rupture of the membranes was found in 1.58, weakness of labor – in 2.2, premature detachment of a normally located placenta – in 6, fetal distress – in 1.9 times more often in women of group I, central placenta previa was noted only in group I. Conclusions. The complicated course of the first and second trimesters of pregnancy, in particular, recurrent TIP, ARVI during this pregnancy, ICI, gestational pyelonephritis, had a direct effect on frequency increase of premature termination of pregnancy and operative delivery in patients of the main group compared with women of the control group. The presence of a history of chronic female genital inflammatory diseases, sexually transmitted infections, ARVI during this pregnancy, TIP in the first and second trimesters, allows pregnant women to be at high risk of developing gestational complications in order to conduct timely treatment. Key words: pregnancy, the threat of abortion, childbirth, the condition of newborns.

scholarly journals Role of sildenafil citrate therapy in pregnant women with foetal growth restriction and oligohydrominos from Northern India

2018 ◽  
Vol 8 (1) ◽  
pp. 165
Author(s):  
Priyanka Joshi ◽  
Madhubala Chouhan ◽  
Nidhi Choudhary ◽  
Abhishek Singh
Keyword(s):  
Pregnant Women ◽  
Early Onset ◽  
Specific Treatment ◽  
Perinatal Outcomes ◽  
Growth Restriction ◽  
Sildenafil Citrate ◽  
Premature Delivery ◽  
Foetal Growth ◽  
Northern India ◽  
Foetal Growth Restriction

Background: No specific treatment is available for severe early-onset IUGR. To best of my knowledge, very few studies have assessed the potential benefit of Sildenafil therapy targeted to improve perinatal outcomes in pregnancies complicated by severe early-onset IUGR in Indian pregnant women.Methods: The present hospital based prospective study was carried out on one hundred ANC pregnant women with early and late fetal growth restriction and oligohydrominos at Pannadhai Mahila Chikatsalya, Rabindra Nath Tagore (RNT) Medical College, Udaipur, during Jan to Dec 2017. Sildenafil citrate 25 mg three times in a day was  administered until delivery. Study subjects were subjected to fetal Doppler and ultrasound twice a week after the Sildenafil administration.Results: After sildenafil therapy, out of total 45 cases of IUGR alone, 39 cases (86.66 %) had improvement. Out of 35 cases of oligohydramnios alone, 28 cases (80 %) had improvement.  Out of 20 cases having both IUGR and Oligohydramnios 16 had improvement (80 %) and only 4 cases did not show any improvement. Among gestation age 27-30 weeks group at the time of admission, there were total 10 cases out of which 5 (50 %) had early premature delivery (32-34 weeks), 3 (30 %) had late premature delivery (34-37 weeks) and 2 cases (2 %) had term delivery i.e. between 37-39 weeks after giving sildenafil treatment.Conclusions: The findings of the present study indicate that sildenafil citrate may offer a potential therapeutic strategy to improve outcomes in pregnant women facing foetal growth restriction and oligohydrominos.

scholarly journals Pregnancy and Childbirth in the COVID-19 Era—The Course of Disease and Maternal–Fetal Transmission

2020 ◽  
Vol 9 (11) ◽  
pp. 3749
Author(s):  
Agnieszka Irena Mazur-Bialy ◽  
Daria Kołomańska-Bogucka ◽  
Sabina Tim ◽  
Marcin Opławski
Keyword(s):  
Mechanical Ventilation ◽  
Intensive Care ◽  
Severe Acute Respiratory Syndrome ◽  
Pregnant Women ◽  
Premature Delivery ◽  
Course Of Disease ◽  
Pregnancy And Childbirth ◽  
Risk Of Disease ◽  
Maternal Fetal Transmission ◽  
The Moment

From the beginning of the Coronavirus Disease 2019 (COVID-19) pandemic, special attention has been paid to pregnant women and to monitoring comorbidities, such as gestational diabetes and hypertension, which could increase their risk of disease and death. The purpose of this review is to synthesize the available knowledge on the course of COVID-19 in pregnant women as well as the risk of maternal–fetal transmission. The study indicated that the course of COVID-19 is worse in pregnant women who are more often admitted to intensive care units or who require mechanical ventilation than nonpregnant women with COVID-19. Some symptoms, such as dyspnea and cough, were similar to those observed in nonpregnant women, but fever, headache, muscle aches, chills, and diarrhea were less frequent. A study revealed that premature delivery and cesarean section were more common in pregnant women diagnosed with COVID-19. In addition, recent studies confirm the possibility of intrauterine maternal–fetal transmission by positive genetic tests and the presence of IgM in newborns just after delivery; at the moment, the probability of transmission through mother’s milk is inconclusive. Considering all the above, a severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infection is an important factor that threatens the health and life of both the mother and the fetus, but further studies are still needed.

scholarly journals EARLY PREGNANCY AND ENDOTHELIAL DYSFUNCTION

2020 ◽  
Vol 73 (4) ◽  
pp. 743-745
Author(s):  
Lyudmyla V. Dubyk ◽  
Oleksandr M. Yuzko ◽  
Nataliia V. Chernetska ◽  
Tetiana R. Kolotylo
Keyword(s):  
Endothelial Dysfunction ◽  
Pregnant Women ◽  
Nitrogen Oxide ◽  
Functional State ◽  
Early Pregnancy ◽  
Prognostic Value ◽  
Opposite Pattern ◽  
Endothelin 1 ◽  
Definition Of ◽  
Complicated Pregnancy

The aim is to analyze the value of endothelial dysfunction markers during pregnancy. Materials and methods: We have examined 153 pregnant women to identify endothelial dysfunction markers of endothelin-1, nitrogen oxide (NO) that have been studied using immunoenzymometric sets for an uncomplicated and complicated pregnancy. Results: We found that the concentration of endothelin-1 repeatedly exceeded the rates in pregnant women with miscarriages than during physiological pregnancy. The diametrically opposite pattern concerns the level of nitrogen oxide. These changes in the markers of the functional state of the endothelin indicate the development of the dysfunction of this system in women with the pathology of pregnancy. Conclusions: Consequently, endothelial dysfunction can be considered to be one of the reasons for miscarriage in the examined women. Therefore, the definition of markers of endothelial dysfunction has prognostic value.

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