scholarly journals THE LEVEL OF SOME HORMONES IN THE BLOOD WOMEN WITH ENDOMETRIOSIS WHICH ASSOCIATED WITH INFERTILITY

2019 ◽  
Vol 72 (4) ◽  
pp. 654-656
Author(s):  
Oksana V. Bakun ◽  
Oksana I. Yurkiv ◽  
Ksenia V. Slobodian ◽  
Oksana V. Kolesnik ◽  
Aliona V. Maruschak
Keyword(s):  
Menstrual Cycle ◽  
Reproductive Function ◽  
Pituitary Hormones ◽  
Main Group ◽  
Endocrine Function ◽  
Control Group ◽  
Pituitary Hormone ◽  
Hormone Concentration ◽  
Severity Of The Disease ◽  
Degree Of Severity

Introduction: The work has been dedicated the study of pituitary hormone concentration in the blood of women with endometriosis-associated infertility on 2-3 days of the menstrual cycle and the day of the puncture of ovarian stimulation superovulation in the cycle. The aim of our study was to examine the concentration of pituitary hormones in the blood of women with endometriosis associated with infertility. Materials and methods: For the purpose of the research we have conducted a special study of protein (lutropin - LH, folitropin -FSH) hormones level in the blood plasma of women with endometriosis associated with infertility, which formed the main group of 20 people. Similar studies of protein hormones level were performed in the control group, which made somatically healthy women of reproductive function preserved, whose age corresponded to the age of patients of the main group. The value of p (authenticity difference) was determined by Student’s table-Fischer. Differences between contrasting averages were considered significant at p <0.05. Results and conclusions: Analized the results of our research stated that women with endometriosis associated with infertility 2-3 days of the menstrual cycle endocrine function of gonadotropocites anterior pituitary did not differ from that of the control group. This fact appeared to have an additional criteria for the formation of a main group. In patients with endometriosis associated with infertility found significant violation of rhythm and secretion of blood gonadotropin hormones that are proportionate to the degree of severity of the disease.

scholarly journals Analysis of menstrual and reproductive function in women with infertility and varicose gonadic veins

2018 ◽  
Vol 22 (4) ◽  
pp. 660-665
Author(s):  
O.V. Astakhova ◽  
O.B. Malinina ◽  
A.M. Grigorenko
Keyword(s):  
Menstrual Cycle ◽  
Functional Properties ◽  
Structural Changes ◽  
Varicose Veins ◽  
Venous Blood ◽  
Reproductive Function ◽  
Uterine Bleeding ◽  
Endocrine Function ◽  
Venous Blood Flow ◽  
Significant Percentage

The problem of reproductive health in Ukraine over the last decade has become very important. The greatest clinical interest is infertility, which is accompanied by a violation of the ovulatory function of the ovaries due to hypothalamic-pituitary-ovarian failure. Sustained anovulation for a long time, as well as the lack of adequate correction of menstrual disorders, lead to the development of endocrine-dependent gynecological diseases, the manifestation of which is primary or secondary infertility. Increased flow of venous blood through the ovarian veins is accompanied by phlebostasis and phlebohypertension in the venous sector of the internal genital organs. Increasing the viscosity and rheological properties of blood that occurs at the same time leads to a deterioration of transcapillary metabolism and transport of oxygen to tissues. In the ischemic ovary, degenerative changes in the follicular apparatus, yellow bodies, followed by spreading to all the ovarian structural elements, which leads to its atrophy and reduced functional properties. Considering the importance of venous blood flow in the development of hormonal imbalance as a result of a violation of the endocrine function of the ovaries, the purpose of our study was to assess the menstrual and reproductive function of infertile women against the background of varicose veins. The reproductive function of women with infertility and varicose changes in ovarian veins is represented by a significant percentage of unauthorized miscarriages (41.9%) in the period of pregnancy after 6 weeks (30.6%). In patients with varicose veins in the ovaries, there was a tendency to increase the duration of infertility compared with patients without varicose dilatation of ovarian veins, which may indirectly indicate more significant functional and structural changes in the reproductive organs. In women, both the primary and the comparator groups are predominantly the late and early menarche, but the rates in groups differ slightly in their direction in women with infertility and varicose veins in the ovaries, although they do not reach statistically significant values. The menstrual function of women in the main group is characterized by a regular menstrual cycle (77.5%), regular duration (43.6%) with excessive blood loss during menstruation (54.8%) and a duration of more than 6 days (50.1%) with acyclic uterine bleeding (37.1%), dysmenorrhea (56.4%) and premenstrual disorders (51.6%), which significantly impairs the quality of life of women. At the same time, the violation of the menstrual cycle in the form of its shortening of 16,1% and acyclic uterine bleeding — 6,5%, was gradually increasing with age and was statistically significant against women from the comparison group. Conclusion in the analysis of clinical characteristics, the more significant percentage of changes in the menstrual cycle, reproductive function in women with functional infertility and varicose veins of the ovary compared with patients with infertility without structural changes in ovarian veins indicates the significant importance of venous hemodynamics in the functional properties of the ovary.

scholarly journals CHARACTERISTICS OF METABOLIC PROCESSES IN THE FORMATION OF MENSTRUAL FUNCTION DISORDERS IN ADOLESCENT GIRLS WITH OBESITY

2021 ◽  
Vol 11 (4(42)) ◽  
pp. 28-33
Author(s):  
A. Borshuliak ◽  
O. Andriets ◽  
A. Andriets ◽  
A. Semeniak
Keyword(s):  
Insulin Resistance ◽  
Body Mass Index ◽  
Body Weight ◽  
Menstrual Cycle ◽  
Body Mass ◽  
Adolescent Girls ◽  
Main Group ◽  
Leptin Resistance ◽  
Control Group ◽  
Menstrual Dysfunction

Іntroduction. Today, a quarter of the population of economically developed countries has a body weight that is 15% larger than the norm. According to various authors, the timely onset of menarche in women with various forms of obesity and reproductive dysfunction is observed in 31% of cases only. Obesity results in insulin resistance, which in its turn results in hyperinsulinemia. The main reason of the connection of insulin resistance with reproductive function disorders consists in the specific influence of insulin on ovaries. Insulin suppresses apoptosis, binding to receptors of various growth factors that promotes long existence of atresizing follicles. In the pathogenesis of the metabolic syndrome, along with the development of hyperinsulinemia and insulin resistance, a significant role belongs to the imbalance of adipocytokines, one of which is adiponectin. The aim is to analyze metabolic processes in the formation of menstrual dysfunction in adolescent girls with obesity to improve diagnostic methods of menstrual disorders. Material and methods. Clinical and laboratory examination of adolescent girls aged 12-18 years was held, among which 79 had obesity and complaints about menstrual dysfunction (the main group); 31 with normal body weight and regular menstrual cycle (the control group). Research methods: general clinical, biochemical (indicators of lipid and carbohydrate metabolism were determined), instrumental (ultrasound), statistical. Results. It was found that 53.3% of the girls from the main group had the beginning of the first menstruation after 14 years, delayed menstruation from 42 days to 6 days, duration 2.1 ± 0.05 days, which was significantly shorter, the volume of 10.2 ± 0.05; 0.4 points (average 1-2 pads per day) was significantly lower (p <0.05). Ultrasound showed uterine hypoplasia in almost every second girl in the main group - 36 (45.46%). Hyperleptinemia and leptin resistance was found in obesity of the first degree 34.8 ± 1.75, in obesity of the second degree 37.15 ± 2.12, in obesity of the third degree 40.64 ± 2.0. It was 14.35 ng / ml in the control group, p<0,01. Hyperleptinemia in the main group was accompanied by hyperinsulinemia in 26% of cases and insulin resistance. The relationship between low values of adiponectin and elevated body mass index in patients of the main group was established, which was confirmed by the results of correlation analysis (adiponectin & body mass index: ρ = -0.74). Analysis of the results revealed a decrease of A/L level in the main group by 4.3 times. Based on our own results, the A/L and HOMA-AD models can be considered more accurate for determining insulin resistance. Conclusions. 1. Changes of the menstrual cycle in overweight girls were found. The association of adipokines secretion disorders is characterized by hyperleptinemia, leptin resistance, decreased Adiponectin / Leptin index and hypoadiponectinemia, which, in combination with insulin resistance, indicates the participation of adipokines in the genesis of oligomenorrhea. The algorithm of adolescents’ treatment with menstrual dysfunction on the background of obesity must include the calculation of Adiponectin/Leptin and HOMA-AD, which will make it possible to avoid overdiagnosis of insulin resistance.

scholarly journals Endometrial E-cadgerin Expression in Women with Reproductive Dysfunctions and Healthy Fertile Women with Ovulatory Menstrual Cycle

2019 ◽  
Vol 6 (3) ◽  
pp. 44-52 ◽  
Author(s):  
S. S. Aganezov ◽  
V. N. Ellinidi ◽  
A. V. Morotskaya ◽  
A. S. Artemyeva ◽  
A. O. Nuganen ◽  
...  
Keyword(s):  
Menstrual Cycle ◽  
Endometrial Biopsy ◽  
Main Group ◽  
Control Group ◽  
Luminal Epithelium ◽  
History Of ◽  
Design And Methods ◽  
To Receive ◽  
Fertile Women ◽  
E Cadherin

Background. E-cadherin is known as one of the endometrial receptivity biomarkers.Objective: to conduct a comparative analysis of the endometrial E-cadherin expression in healthy fertile women and patients with reproductive dysfunctions with the ovulatory menstrual cycle.Design and methods. The main group consisted of patients with infertility (n = 81) and early pregnancy loss (n = 40), the control group — of 16 healthy fertile women. All subjects underwent endometrial biopsy and venipuncture to receive peripheral blood sample (to determine estradiol and progesterone levels) at 6–8 days after ovulation. Endometrial specimens were assessed by histological and immunohistochemical (evaluation of e-cadherin expression) methods.Results. In patients with reproductive failure, the frequency of apparent E-cadherin expression in the luminal (89 %, n = 84 out of 94) and glandular (74 %, n = 89 out of 121) epithelium did not differ from the corresponding indicators in fertile women (luminal epithelium — 94 %, n = 15 out of 16, gland — 88 %, n = 14 out of 16) (p > 0.05 for all indicators). The frequency of reduced E-cadherin endometrial expression was similar in patients of the main group with complete secretory transformation of the endometrium (1), incomplete secretory transformations (2) and in healthy women (3): respectively in the luminal epithelium — 7 % (n = 3 out of 43) (1), 14 % (n = 7 out of 52) (2), 6 % (n = 1 out of 16) (p > 0.05); in the glands — 20 % (n = 10 out of 51) (1), 31 % (n = 22 out of 70) (2), 13 % (n = 2 out of 16) (3) (p > 0.05).Conclusion. In patients with the history of reproductive disfunctions freaquency of lower/higher E-cadherin expression was similar to those in healthy fertile women.

scholarly journals Prolactin level correction in restoration of menstrual cycle in obese women

2021 ◽  
pp. 53-58
Author(s):  
T.F. Tatarchuk ◽  
N.V. Kosei ◽  
S.I. Reheda ◽  
M.I. Hlamazda ◽  
I.M. Shakalo
Keyword(s):  
Metabolic Syndrome ◽  
Menstrual Cycle ◽  
Reference Values ◽  
Prolactin Level ◽  
Experimental Studies ◽  
Main Group ◽  
Reproductive Age ◽  
Control Group ◽  
Upper Limit ◽  
Cycle Disorders

Obesity is a common problem among women of reproductive age. There are data from clinical and experimental studies indicating the role of hyperprolactinemia in the development of metabolic syndrome, as well as the metabolic benefits of treating hyperprolactinemia.Research objective: to evaluate the clinical efficacy of Vitex Agnus Castus standardized extract on hormonal and metabolic status in women with menstrual cycle disorders and obesity.Materials and methods. 60 women aged 19 to 35 years with obesity and menstrual cycle disorders with laboratory-confirmed insulin resistance and prolactin near the upper limit of the reference values or was slight increase were examined. All the patients were given recommendations for lifestyle modification. 30 of them, who formed the main group, received Cyclodynon. 30 patients of the control group were not prescribed Cyclodynon therapy.Results. At the end of the treatment, the menstrual cycle was normalized in 93.3% patients of the main group, and in 66.3% patients of the control group (p < 0.05). Ovulation signs were detected in 86.67% women of the main group and only in 30.0% women of the control group (p < 0.05). The mean prolactin value and the HOMA index were significantly lower in the main group; prolactin level did not exceed the physiological values in 86.67% women in the main group after 6 months, and in 40.0% of the control group, p < 0.05. There was a decrease in body mass index and waist/hip circumference ratio in patients of the studied groups; the dynamics was slightly higher in the main group but did not differ significantly. Conclusions. Cyclodynon is effective for the treatment of menstrual cycle disorders and metabolic disorders in women with obesity and metabolic syndrome. Good tolerability, absence of side effects, and sufficient efficacy of Cyclodynon allow it to be recommended as the drug of choice in patients with prolactin levels near the upper limit of the reference values or a slight increase of it and in patients with intolerance to synthetic dopamine agonists.

Safety assessment of preoperative oil chemoembolization with nanoparticle albumin-bound paclitaxel in patients with pancreatic head adenocarcinoma

2020 ◽  
Vol 22 (4) ◽  
pp. 67-71
Author(s):  
A. V. Pavlovskii ◽  
A. A. Statsenko ◽  
S. A. Popov ◽  
V. E. Moiseenko ◽  
A. A. Polikarpov
Keyword(s):  
Preoperative Chemotherapy ◽  
Combined Treatment ◽  
Pancreatic Head ◽  
Main Group ◽  
Ductal Adenocarcinoma ◽  
Control Group ◽  
Postoperative Pancreatitis ◽  
Body Level ◽  
Degree Of Severity ◽  
Group Grade

Results of combined treatment of 36 patients suffering from pancreatic head ductal adenocarcinoma are evaluated, including preoperative chemotherapy using nanodispersed albumin-stabilized paclitaxel (nab-paclitaxel) in intraarterial oil chemoembolization or intravenous administration and radical surgical treatment. Intraarterial oily chemoembolization of the pancreatic head consisted of the introduction of 17 patients (main group) into the gastroduodenal artery of an emulsion of super-liquid lipiodol (Lipiodol Ultra Fluid) in an aqueous solution of nab-pacliaxel 50 mg/m2 and gemcitabine 400 mg/m2. 19 patients (control group) were administered nab-paclitaxel 100 mg/m2 and gemcitabine 1000 mg/m2 intravenously according to standard guidelines. Safety and tolerability assessment of combined treatment with preoperative application of nab-paclitaxel was carried out in advance. Pil-preserving pancreatoduodenal resection is considered safe on day 710, after completion of preoperative chemotherapy with nab-paclitaxel. The use of nab-paclitaxel in preoperative intraarterial oily chemoembolization of the pancreatic head requires extension of the pancreatic crossing boundary to body level. Postoperative lethality and 4th degree complications according to the Clavien-Dindo classification were not observed. In the main group, grade 3a complication was observed in 2 (12%) patients and was represented by bleeding from acute gastric erosions resolved endoscopically. In the control group, complications of degree 3 were also noted in 2 (11%) patients and were represented by: one bleeding from acute stomach erosions that required endoscopic hemostasis and an intraabdominal abscess allowed by percutaneous drainage. In the main group, complications of the 2nd degree were recorded in 8 (47%) patients: in 3 (17%) patients the formation of pancreatic fistula was noted, in 4 (23%) postoperative pancreatitis was detected, and in 1 (6%) gastrostasis phenomena that required conservative therapy. In the control group, complications of the 2nd degree were observed in 11 (58%) patients and were presented: pancreatic fistulae in 2 (10%) patients, postoperative pancreatitis in 6 (31%) and gastrostasis in 3 (16%) patients. The most common complication observed in both groups was the suppression of a postoperative wound, corresponding to the 1st degree of severity: in the main group in 5 (29%) patients, in the control group in 7 (37%) patients. Thus, the use of intraarterial oil chemoembolization with nab-paclitaxel as a preoperative antitumor treatment can be considered safe.

scholarly journals MICROBIOTA OF VAGINA AND MAMMARY GLANDS SKIN IN THE PREGNANT WOMEN WITH PREECLAMPSIA

2019 ◽  
Vol 4 (2) ◽  
pp. 44-49
Author(s):  
V. Ya. Ivankiv ◽  
I. M. Malanchyn ◽  
N. I. Tkachuk
Keyword(s):  
Pregnant Women ◽  
Mammary Glands ◽  
Main Group ◽  
Control Group ◽  
Quantitative Composition ◽  
Clinical Knowledge ◽  
Normal Microflora ◽  
Mother And Child ◽  
Perinatal Center ◽  
Severity Of The Disease

Background. Timely prediction, diagnosis and prevention of complications during the gestational period leading to perinatal loss and maternal mortality are the main tasks of contemporary obstetrics. About 50,000 women die from preeclampsia and eclampsia every year and perinatal mortality ranges from 15 to 25%. Objective. The aim of the research was to study and analyze the microecology of vagina and mammary glands skin in the pregnant women with underlying preeclampsia. Methods. The pregnancy examination was conducted at the Ternopil Regional Clinical Perinatal Center “Mother and Child”. The research involved 25 pregnant women with preeclampsia (the main group) and 15 healthy women with a physiological course of pregnancy (the control group). Material from the pregnant women was taken out of the skin of mammary glands and mucous membrane of vagina, then it was plated out in the nutrient medium for the cultivation and the microorganisms were defined. Results. The quantitative composition of a normal microflora of vagina and mammary glands skin in the control group was within the normal range. The quantitative composition of a normal microflora of vagina and mammary glands skin in the pregnant women of the main group decreased, the representatives of opportunistic and pathogenic flora were found. Conclusions. In the pregnant women with preeclampsia, abnormal microbiocenosis of vagina and breast skin was revealed, the degree of abnormality correlated with the severity of the disease. Our results may provide useful clinical knowledge to a broader understanding of microbiota role in pregnancy complications.

Clinical experience of non-hormonal correction of the luteal phase deficiency in women of reproductive age

2019 ◽  
pp. 24-26
Author(s):  
T.R. Streltsova ◽  
◽  
N.R. Simonov ◽  
Keyword(s):  
Menstrual Cycle ◽  
Blood Loss ◽  
Luteal Phase ◽  
Main Group ◽  
Reproductive Age ◽  
Control Group ◽  
Second Phase ◽  
Menstrual Disorders ◽  
Women Of Reproductive Age ◽  
Cycle Disorders

The objective: to study the clinical efficacy of two schemes of using the monocomponent herbal preparation Cyclodynon® in women of reproductive age with complaints of various menstrual cycle disorders diagnosed with latent hyperprolactinemia and second phase failure of the menstrual cycle based on the results of clinical and hormonal studies. Materials and methods. The study included 60 patients aged 25–38 years suffering from PMS. The main group (n = 30) received Cyclodynon® in an ascending pattern: from 1 to the 14th day of the menstrual cycle – 40 drops 1 time a day and from the 15th day to the end of the cycle – 40 drops 2 times a day. The control group (n = 30) – 40 drops 1 time per day until the end of the cycle for three menstrual cycles. Results. After 3 months in the main group there was a more significant decrease in the level of prolactin (from 28.3 to 18.4 ng / ml) as compared with the control (from 27.8 to 23.1 ng / ml). Increased progesterone and estradiol production was also more significantly observed in the main group. The dynamics of normalization of the duration of the menstrual cycle and the volume of blood loss was also more significant in the main group and amounted to 93.3%. Conclusion. The use of an increasing treatment regimen with Cyclodynon® in women with a luteal phase deficiency on the background of hyperprolactinemia has advantages over the use of a standard continuous regimen with respect to a more rapid normalization of hormonal homeostasis, the duration of the menstrual cycle and blood loss. Key words: luteal phase deficiency, hyperprolactinemia, menstrual disorders, Cyclodynon®.

Medico-social factors influencing the menstrual function in adolescents with overweight

2015 ◽  
Vol 6 (1) ◽  
pp. 71-75
Author(s):  
Elena Anatol’yevna Yalfimova ◽  
Galiya Fettyakhovna Kutusheva
Keyword(s):  
Blood Flow ◽  
Body Weight ◽  
Menstrual Cycle ◽  
Adolescent Girls ◽  
Social Factors ◽  
Main Group ◽  
Control Group ◽  
Normal Body ◽  
Factors Influencing ◽  
Normal Body Weight

Obesity is a serious medical, social and economic issue in modern society. Relevance it is determined primarily by the high prevalence of obesity. Objective: identify medical and social factors influencing the development of obesity in adolescent girls with menstrual cycle. Materials and methods: questionnaires, analysis of medical records, clinical, laboratory and instrumental examination 167 girls from 14 to 18 years with obesity I degree (28,7 %), obesity degree II (58,1 %), obesity III degree (13.2 %) and their parents, and 211 girls with normal body weight and their parents. Results: artificial feeding from birth had 23,2% of the young women of the main group, in the control group the rate was 7.4 %. The regularity of meals keep 12.5 % of adolescents in primary and 27.1 % of adolescents in the control groups. The prevalence of high-calorie foods noted 21.1 % of girls are obese and only 4.9 % of normal body weight. The average age at onset of menarche in girls with obesity was 10 years and 9 months, which is 11 months earlier than in the con-control group girls. Girls with overweight significantly more often in 80.6 % of identified disorders of lipid compared with a group of girls with normal body weight, in 13.9 % of cases respectively. In the main group was observed hormonal changes, talking about changing the gonadotropic function of the pituitary gland, disorders of the cyclical release of gonadotropins, the absence of physiological “ovulatory peak”, a chaotic secretion of FSH and LH, the violation of physiological ratio of FSH/LH. When conducting USDG in the first group identified dyscirculatory violations arterial bed, in the form of the asymmetry of the flow and signs of venous degenii in the form of increased speed of blood flow in the jugular veins, monophasic flow in the veins, the blood flow in the vertebral veins in a horizontal position. Conclusions: the menstrual cycle occurs under the action of complex factors, such as physical illness, unbalanced diet, chronic stress, bad habits, poor physical living conditions. A survey of adolescent girls who turned over the menstrual cycle and with obesity should be integrated and include in addition to the laboratory, instrumentaltion survey joint management of such patients related-governmental experts.

scholarly journals Neuroendocrine disorders in women with epilepsy depending on anticonvulsants intake

2013 ◽  
Vol 94 (1) ◽  
pp. 63-67
Author(s):  
S N Mekhtieva
Keyword(s):  
Menstrual Cycle ◽  
Serum Level ◽  
Serum Levels ◽  
Reproductive Age ◽  
Endocrine Function ◽  
Control Group ◽  
Reference Ranges ◽  
Hormone Release ◽  
Female Patients ◽  
Patients With Epilepsy

Aim. To assess the influence of epilepsy and anticonvulsants on central control of hormone release and ovarian function in women of reproductive age. Methods. The reproductive and endocrine functions were assessed in 82 female patients with epilepsy, of whom 37 did not receive anticonvulsants (first group), 45 patients were on anticonvulsant treatment (second group). 17 healthy females (control group) were also assessed. Serum levels of estradiol, progesterone, prolactin, luteinizing hormone, follicle-stimulating hormone and dehydroepiandrosterone were estimated during follicular (n=48) and luteal (n=34) stages of menstrual cycle. Results. Estradiol serum level was below normal ranges, and prolactin serum level - above normal limits at follicular stage of menstrual cycle in female patients not treated with anticonvulsants. In luteal phase serum levels of estradiol, progesterone, dehydroepiandrosterone exceeded the reference ranges, and testosterone levels were lower than normal in both patients treated and not treated with anticonvulsants. Comparison of two groups showed that estradiol serum level was lower in untreated patients in both stages of menstrual cycle compared to patients treated with anticonvulsants. There was a marked difference in endocrine function at all levels of reproductive neuroendocrine regulation in untreated female patients compared to female patients treated with anticonvulsants with major transformations in female patients with epilepsy not treated with anticonvulsants. Conclision. Epilepsy and treatment with anticonvulsants can influence the central regulation of hormone release in females.

scholarly journals The Effect of Increased Female Sex Hormone Concentration on Movement Proprioception

2018 ◽  
Vol 3 (86) ◽  
Author(s):  
Laura Daniusevičiūtė ◽  
Vitas Linonis ◽  
Lina Barsienė
Keyword(s):  
Menstrual Cycle ◽  
Knee Joint ◽  
Luteal Phase ◽  
Follicular Phase ◽  
Sex Hormone ◽  
Control Group ◽  
Hormone Concentration ◽  
Basketball Players ◽  
Female Sex ◽  
Normal Menstrual Cycle

Research background and hypothesis. Over the last years, basic research on the effect of different hormones on tendons and ligaments has been initiated. Regarding oestrogen receptor localization in brain and their interaction with neurotransmitters (Maki et al., 2002; Friden et al., 2003; Farage et al., 2008), we speculate that the increase in the level of female sex hormone concentration will improve the sense of movement. Research aim was to study the effect of increased female sex hormone concentration on movement proprioception. Research methods. Subjects were healthy and physically active women (n = 15) with normal menstrual cycle, aged 19–23 years, body weight – 58.2 ± 6.1 kg, height – 168.4 ± 5.6 cm as well as female basketball players  (n = 15) with normal menstrual cycle, aged 19–23 years, body weight – 78.31 ± 2.81 kg, height – 182.40 ± 4.71 cm. We performed three experiments with each participant: in follicular phase, ovulation and luteal phase. The samples of 5 ml venom blood were taken to establish the amount of estradio17β-estradiol and progesterone concentration. The sense of knee joint position was evaluated using isokinetic dynamometer (System 3; Biodex Medical Systems, Shirley, New York, USA). During a training session, a subject’s right leg was flexed at the knee joint and fixed at the angle of 90°. Prior to each test, the researcher demonstrated the target angle of 60° by stretching subject’s leg. In order to train the flexion of the knee joint, a subject’s right leg was extended at the knee joint and fixed at the angle of 0°. The researcher demonstrated the target angle of 50° by flexing subject’s leg. The subjects had to perform three tests at the velocity of 2°/s, 5°/s and 10°/s with their eyes open and closed. Research results.  Females in the control group performed knee joint proprioception task better with an extended knee at velocity of 2°/s with open eyes during the follicular phase, but at the velocity of 10°/s the values were better during ovulation. Basketball players performed the same task better at velocity of 5°/s during ovulation, but at velocity of 10°/s the values were better during the luteal phase. Females in control group performed knee joint proprioception task with an extended knee at the velocity of 5°/s with closed eyes better during the luteal phase. No statistical difference between control group and basketball player indices of knee joint position proprioception task with a flexed knee at velocity of 2°/s, 5°/s and 10 °/s with closed eyes during the menstrual cycle was found.Discussion and conclusion. Knee joint proprioception indices were better during ovulation phase in control group and basketball players.Keywords: knee joint proprioception, follicular phase, ovulation, luteal phase.

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