scholarly journals Dynamics of clinical symptoms and immunity local parametres during allergen - specific immunotherapy in patents with pollinosis and combined forms of sensibilization

2009 ◽  
Vol 7 (3) ◽  
pp. 14-18
Author(s):  
E V Bezrukova ◽  
B A Molotilov
Keyword(s):  
Czech Republic ◽  
Oral Cavity ◽  
Specific Immunotherapy ◽  
Sublingual Immunotherapy ◽  
Clinical Symptoms ◽  
Pollen Allergens ◽  
Local Immunity ◽  
Allergen Specific Immunotherapy ◽  
Made In

Background. To evaluate clinical and immunological efficiency of immunotherapy of pollinosis patients with combined forms of sensitization with «Sevapharma» allergens, Czech Republic. Materials and methods. 189 patients with pollinosis (age 18-55 years old) were examined during this study. Out of these 189 patients three groups were chosen to be treated with pollen allergens made in Czech Republic and domestic allergens from Russia. During the study slgA in saliva was examined and the efficiency of different AS IT methods with combined forms of sensitization was tested. Results. Patients with pollinosis had disruption in local immunity. slASIT increases slgA production in saliva. Treatment with interfacing allergens is most effective in combined forms of sensitization. Conclusion. The sensibilization to different kinds of pollen allergens was observed in 10- 15% of cases. Combined forms of sensitization are much more common. Moreover, combined forms of sensitization to pollen and domestic allergens predominate. Besides that, the study showed pollinosis patients have disruption of local immunity that appeared in slgA deficit in oral cavity. Sublingual immunotherapy is the most effective method of treatment. In case of combined forms of sensitization treatment with interfacing allergens is the most efficient.

scholarly journals Analysis of the dynamics of clinical indicators in patients with allergic rhinitis with sensitization to pollen and household allergens using combined allergen-specific immunotherapy

2021 ◽  
Vol 26 (4) ◽  
pp. 87-93
Author(s):  
S.V. Biletska ◽  
E.M. Dytyatkovska ◽  
M.A. Nikolaychuk
Keyword(s):  
Allergic Rhinitis ◽  
Specific Immunotherapy ◽  
High Efficiency ◽  
Comparison Group ◽  
Clinical Symptoms ◽  
Clinical Manifestations ◽  
House Dust Mites ◽  
Skin Tests ◽  
Pollen Allergens ◽  
Allergen Specific Immunotherapy

The aim of this study was to evaluate the clinical efficacy of combined allergen-specific immunotherapy (ASIT) in patients with allergic rhinitis (AR) with combined sensitization to pollen and household allergens. To achieve this goal, 49 patients with AR of working age were examined – 35.5±1.5 years with clinical manifestations of seasonal rhinoconjunctival syndrome with a long period of 9.2±1.1 years, among which there were 25 (51.0%) males and 24 (49%) females. All patients were divided into 2 homogeneous groups by age, sex, duration of the disease, the average number of etiologically significant allergens: the main one – 31 patients who received combined ASIT with solutions of pollen and household allergens and a comparison group – 18 patients for whom only pollen allergens were used. Allergological examination included anamnesis, skin tests with pollen allergens (wormwood, ragweed, quinoa, corn, etc.) and household (house dust, mites, epidermal agents) and / or molecular research methods using the ALEX technology. The quantitative integral assessment of the intensity of AR clinical symptoms was calculated as a total score for the main symptoms. The maximum score for the severity of nasal symptoms – 12, eye - 6, total – 18. The results obtained and their analysis indicate that under the influence of ASIT pollen and household allergens in patients there is a significant and reliable decrease in the intensity of clinical manifestations of seasonal rhinoconjunctive syndrome: nasal manifestations – by 52,2%, conjunctival – by 60%, integral – by 54.3% and an increase of 2.2 times in the percentage of patients in the main group with the disappearance or minimization of clinical symptoms of the disease after treatment compared with patients from the comparison group, which convincingly proves and confirms high efficiency of the selected type of therapy in patients with AR in combination with sensitization to pollen and household allergens.

Planning and approach to allergen-specific immunotherapy in polyallergic patients

Immunotherapy ◽  
2020 ◽  
Vol 12 (8) ◽  
pp. 577-585
Author(s):  
Nerin N Bahceciler ◽  
Ozel Yuruker
Keyword(s):  
Clinical Management ◽  
Respiratory Diseases ◽  
Specific Immunotherapy ◽  
Clinical Symptoms ◽  
Allergen Specific Immunotherapy ◽  
Stepwise Approach ◽  
Future Studies ◽  
Disease Modifying ◽  
Management Recommendations ◽  
Disease Modifying Treatment

Allergy immunotherapy (AIT) is currently the only disease-modifying treatment for allergic-respiratory diseases. Polysensitization may increase the severity of current disease resulting in subsequent asthma development in patients with allergic rhinitis. Due to the absence of general recommendations for the practical approach to polysensitized patients, clinical management is not standardized. The correlation between sensitizations and clinical symptoms, elimination of possible pollen cross-reactivities and principles of homologous allergen groups will guide the allergists to deduce the most relevant allergens for AIT. In the highlight of the previously proposed approach strategies to polyallergic patients, hereby we propose a revised practical stepwise approach based on the current European Medicine Agency (EMA) guidelines. However, more supporting data from well-designed, controlled, future studies are needed to improve clinical management recommendations for AIT in polyallergic patients.

scholarly journals COMPARATIVE CHARACTERISTICS OF SAFETY OF SUBLINGUAL AND PARENTERAL IMMUNOTHERAPY METHODS

2020 ◽  
Vol 17 (34) ◽  
pp. 736-744
Author(s):  
Ulbossyn SALTABAYEVA ◽  
Alexei YUMASHEV
Keyword(s):  
Adverse Reactions ◽  
Specific Immunotherapy ◽  
Sublingual Immunotherapy ◽  
Scientific Evidence ◽  
Adult Population ◽  
Pollen Allergy ◽  
Hay Fever ◽  
Sharp Drop ◽  
Allergen Specific Immunotherapy ◽  
Good Substitute

Among a significant number of allergies, the most common among children and adults is pollen allergy. Pollen allergies primarily lead to irritation of the nose and eyes, but can also cause headaches, weakness, fatigue, and decreased attention span. In an acute allergic reaction, anaphylactic shock can occur, that is, a lifethreatening sharp drop in blood pressure. These and many other consequences of allergic reactions imply the need to create drugs that could cure a person of allergies or stop the manifestation of allergen reactions. The aim of the article was to study the safety of allergen-specific immunotherapy. The research methods included an analysis of the comparison of the effectiveness of two immunotherapy methods, a comparison of the safety of sublingual and parenteral methods of administering allergic vaccines, a comparative assessment of the safety of types of allergen-specific immunotherapy. The study involved 228 patients with varying severity of hay fever, among whom were children from 5 to 18 years old and an adult population (113 patients were men, 115 were women). The study revealed that sublingual immunotherapy increases the safety of treatment and is a good substitute for parenteral immunotherapy, especially in children. The studies have also confirmed well-known scientific evidence on the safety of sublingual immunotherapy in patients with hay fever. It was concluded that sublingual immunotherapy increases the safety of treatment and is a good substitute for the parenteral allergenspecific immunotherapy method, especially in pediatric patients, while having several advantages, such as a significant reduction in adverse reactions, high potency, and a convenient mode of administration, greater patient commitment and trust in treatment, and the elimination of infection transmission.

scholarly journals DENTAL STATUS FEATURES OF PATIENTS WITH CHRONIC MYELOID LEUKEMIA

2021 ◽  
Vol 16 (4) ◽  
pp. 71-76
Author(s):  
Kamilla Yanbuhtina ◽  
Milyausha Kabirova ◽  
Bulat Kabirov
Keyword(s):  
Chronic Myeloid Leukemia ◽  
Oral Cavity ◽  
Myeloid Leukemia ◽  
Dental Treatment ◽  
Clinical Symptoms ◽  
The State ◽  
Dental Status ◽  
Malignant Neoplasms ◽  
Local Immunity ◽  
Oral Symptoms

Subject. At the present stage of society development cancer incidence remains among the most pressing medical and social problems. In the structure of oncopathology a special place is occupied by malignant neoplasms of lymphoid and hematopoietic tissues which include chronic myeloid leukemia (CML). In some patients, the disease can appear with dental symptoms associated with a decrease in local immunity of the oral cavity — the appearance of aphthae, plaque on the oral mucosa, angular cheilosis, bleeding gums, dry mouth. It is diagnostically significant that such oral symptoms may precede general clinical symptoms, that is, they can be considered as early symptoms of CML. In addition, their severity often prompts a patient with CML to see a dentist. Thus, the importance of the professional knowledge of the dentist in general clinical and dental symptomatology of CML, the correct routing of the patient for further clinical and laboratory examination, treatment and observation by a hematologist is undeniably high. The goal is to study and identify the features of the dental status of patients with chronic myeloid leukemia. Methodology. The work carried out a comprehensive assessment of the state of the oral cavity and the need for dental treatment of patients with chronic myeloid leukemia in which patients with preserved systemic status and patients with chronic myeloid leukemia took part. Results. According to the results of a complex dental examination and the calculation of the main dental indices, patients with CML were found to have serious disorders in the state of their oral health. Conclusions. Patients with CML showed a high need for various types of dental care, primarily in conservative oral cavity sanitation, periodontal treatment and rationalization of oral hygiene protocols (professional and individual).

Allergen-specific immunotherapy with recombinant grass pollen allergens

2005 ◽  
Vol 116 (3) ◽  
pp. 608-613 ◽  
Author(s):  
Marek Jutel ◽  
Lothar Jaeger ◽  
Roland Suck ◽  
Hanns Meyer ◽  
Helmut Fiebig ◽  
...  
Keyword(s):  
Grass Pollen ◽  
Specific Immunotherapy ◽  
Pollen Allergens ◽  
Allergen Specific Immunotherapy

scholarly journals Allergen-specific immunotherapy: an update on immunological mechanisms of action

2016 ◽  
Vol 65 (1) ◽  
Author(s):  
G. Ciprandi ◽  
G.L. Marseglia ◽  
M.A. Tosca
Keyword(s):  
Specific Immunotherapy ◽  
T Regulatory Cells ◽  
Sublingual Immunotherapy ◽  
Mechanisms Of Action ◽  
Regulatory Cells ◽  
Allergen Specific Immunotherapy ◽  
Specific Antibodies ◽  
Immunological Mechanisms ◽  
Specific Igg4 ◽  
History Of

Specific immunotherapy (SIT) is the only treatment able to modify the natural history of the allergic subjects. Several aspects of the immunopathological response modified by SIT have been investigated; the first parameter historically studied was the production of allergen-specific antibodies. An increase of allergen-specific IgG4 and a decrease of IgE appear after SIT. A shift from Th2-polarized immune response toward Th1-oriented pattern has been reported after SIT. More recently, a crucial role for a subpopulation of T cells has been evidenced: T regulatory cells (Treg). Allergic patients have a defect of Tregs. SIT is able of inducing a specific Treg response. Sublingual immunotherapy is an alternative route of administration for SIT. Recent evidence shows that SLIT is also able of inducing a Treg response as detected by IL- 10 production.

scholarly journals ASIT – A SOLUTION IN ALLERGY TREATMENT

2017 ◽  
pp. 116-119
Author(s):  
S. V. TSAREV
Keyword(s):  
Side Effects ◽  
Specific Immunotherapy ◽  
Sublingual Immunotherapy ◽  
Allergic Diseases ◽  
Action Mechanism ◽  
Allergen Specific Immunotherapy ◽  
Allergy Treatment ◽  
Paediatric Practice ◽  
Indications For Use

This article discusses the place and role of an allergen-specific immunotherapy in the treatment of allergic diseases. It provides an action mechanism, indications for use, contraindications, and side effects of an allergen-specific immunotherapy. A comparison of different methodologies for an allergen-specific immunotherapy was made. The advantages of sublingual allergen-specificimmunotherapy in paediatric practice were demonstrated. Provides data on the efficiency and safety of pollinosis sublingual immunotherapy with sensitization to grass

scholarly journals Dynamics of class E and G immunoglobulins under the influence of combined allergen-specific immunotherapy in patients with allergic rhinitis with combined sensitization to pollen and household allergens

2020 ◽  
pp. 42-48
Author(s):  
E.М Dityatkovska ◽  
S.V. Biletska
Keyword(s):  
Allergic Rhinitis ◽  
Specific Immunotherapy ◽  
Immunoglobulin E ◽  
Skin Tests ◽  
Total Serum ◽  
Combination Immunotherapy ◽  
Pollen Allergens ◽  
Allergen Specific Immunotherapy ◽  
Prick Test ◽  
Specific Combination

The aim of this study is to assess the dynamics of immunoglobulin E and G under the influence of combined allergen-specific immunotherapy (ASIT) in patients with allergic rhinitis with combined sensitization to pollen and household allergens. Materials and methods: The study involved 49 patients, residents of Dnipro city, of working age (35,5±1,5 years), of whom 24 (49,0%) - women and 25 (51,0%) - men. All patients were diagnosed with allergic rhinitis with average disease duration of 9,2 ±1,1 year, who underwent allergy examination - skin tests - prick test with pollen and household allergens and/or methods of allergy component diagnosis ALEX. The number of pollen allergens in one patient was 4,6±0,4 on average. All patients received one course of pre-season ASIT allergen according to the express scheme. Patients in the main group (31 patients) received a combined ASIT with solutions of pollen and household allergens. 18 patients in the comparison group received ASIT only with pollen allergens. Clinical groups were homogeneous in age, sex, duration of the disease, as well as the average number of pollen allergens. Results: The obtained results and their analysis show that the use of allergen-specific combination immunotherapy in patients with allergic rhinitis with combined sensitization to pollen allergens causes a more significant effect on the activation of the immune response, which was revealed by reduced relative to baseline lgE production by 41,9% (p<0,001) and an increase in lgG by 7,5% (p<0,05). The production of total serum in patients with allergic rhinitis before treatment and under the influence of ASIT was the opposite to the dynamics of lgG production. The positive results of immunological studies convincingly prove the benefits and effectiveness of allergen-specific combination immunotherapy in the treatment of patients with allergic rhinitis with combined sensitization to pollen and household allergens.

Dynamics of basophil reactivity in the patients with allergic rhinitis on the background of allergen-specific immunotherapy

2021 ◽  
Vol 17 (4) ◽  
pp. 75-84
Author(s):  
Liudmila Yu. Barycheva ◽  
Liudmila V Dushina ◽  
Marina V. Golubeva ◽  
Milana M. Minasyan ◽  
Yulia N. Medvedenko
Keyword(s):  
Allergic Rhinitis ◽  
Specific Immunotherapy ◽  
Clinical Symptoms ◽  
Stimulation Index ◽  
Basophil Activation Test ◽  
Basophil Activation ◽  
House Dust Mites ◽  
Allergen Specific Immunotherapy ◽  
Activation Test ◽  
Positive Treatment

BACKGROUND: Allergen-specific immunotherapy (ASIT) helps to reduce spontaneous and to induce basophil reactivity, which is one of the major mechanisms of its effectiveness. A number of studies, though, have not confirmed the informative value of the basophil activation test (BAT), in case of ASIT, with house dust mites, meadow grass pollen, and wasp venom. BAT outcomes are likely to be influenced by the properties of the sensitizing allergen, the duration of ASIT, and the BAT markers that are used. AIMS: To evaluate the basophils reactivity in the patients sensitized to weed pollen and treated with allergen-specific therapy. MATERIALS AND METHODS: The study involved 60 patients (aged 1655) with allergic rhinitis sensitized to weed pollen. The diagnosis was based on the skin test outcomes as well as on identifying specific antibodies to major allergens of ragweed, wormwood, timothy, and birch. The pre-seasonal ASIT involved water-salted extracts of pollen allergens during 2 years. Clinical symptoms and the immunotherapy effectiveness were evaluated 6 and 18 months after the ASIT started. BATs were made before the treatment, after the first and second courses of pre-seasonal ASIT, which corresponded to zero, the 3rd and the 15th months of the treatment. The activated basophils were identified based on the CRTH2pos CD203brightCD3neg phenotype. RESULTS: The first treatment course was completed by 52 patients, while the second one by 43 patients. A statistically significant decrease in spontaneous basophil reactivity was detected only after the second course of ASIT. The decrease in the allergen-induced basophil activation was identified in 67.4% of the samples obtained after the first ASIT course, and in 67.6% of samples taken after the second immunotherapy course. A decrease in the BAT stimulation index (BAT SI) was identified mainly in the patients featuring positive treatment outcomes. CONCLUSIONS: ASIT influences on the basophil reactivity indicators in the patients sensitized to weed pollen. The basophil activation test may be considered as a potential predictor of ASIT effectiveness.

scholarly journals Experienceof subcutaneous allergen-specific immunotherapy with «Phostal» in children.

2011 ◽  
Vol 8 (6) ◽  
pp. 28-32
Author(s):  
Natal'ya Viktorovna Shakhova ◽  
V V Gordeev ◽  
V P Tokarev ◽  
T Yu Borisenko ◽  
S S Kharchenko ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Specific Immunotherapy ◽  
Clinical Symptoms ◽  
Control Group ◽  
Tree Pollen ◽  
Allergen Specific Immunotherapy ◽  
Drug Load ◽  
Initial Stage ◽  
Local Reactions

Background. The purpose of the work is to investigate the effectiveness and safety of the subcutaneous allergenspecific immunotherapy (scIT ) using F ostal at pollinosis children. Methods. 31 patient (19 boys and 12 girls) at the age from 5 to 16 with pollinosis with sensibilization to tree pollen (birch, alder, hazel) allergens were observed. A ll patients were divided into 2 groups. T he first group consisted of 11 children, which were treated with F ostal. T he second group was a control group, consisted of 20 children, no treatment was assigned to them. A ll patients from both groups got the basis pollinosis therapy. Efficiency of the scIT using F ostal was estimated in terms of its influence on the childrens quality of life, clinical symptoms and drug load. Results. Good results demonstrated in terms of increased quality of life indexes were achieved after the initial stage of the scIT using F ostal. C ompared to the control group, the amount of needed drugs was significantly decreased, and the decrease in the severity of clinical symptoms of rhinitis (p=0,001) and conjunctivitis (p=0,002) was observed. During the scIT with the F ostal trees pollen some negligible local reactions were observed in all cases, in 7 of 11 patients marked local reactions appeared. O n the initial stage of the therapy no systemic allergic reaction was observed. Conclusion. On the basis of the results of the study, F ostal could be considered as a highly effective and safe for treatment of pollinosis children. S cIT with the F ostal leads to the improvement of childrens quality of life, decreasing of clinical symptoms severity as well as drug load.

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