scholarly journals Experienceof subcutaneous allergen-specific immunotherapy with «Phostal» in children.

2011 ◽  
Vol 8 (6) ◽  
pp. 28-32
Author(s):  
Natal'ya Viktorovna Shakhova ◽  
V V Gordeev ◽  
V P Tokarev ◽  
T Yu Borisenko ◽  
S S Kharchenko ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Specific Immunotherapy ◽  
Clinical Symptoms ◽  
Control Group ◽  
Tree Pollen ◽  
Allergen Specific Immunotherapy ◽  
Drug Load ◽  
Initial Stage ◽  
Local Reactions

Background. The purpose of the work is to investigate the effectiveness and safety of the subcutaneous allergenspecific immunotherapy (scIT ) using F ostal at pollinosis children. Methods. 31 patient (19 boys and 12 girls) at the age from 5 to 16 with pollinosis with sensibilization to tree pollen (birch, alder, hazel) allergens were observed. A ll patients were divided into 2 groups. T he first group consisted of 11 children, which were treated with F ostal. T he second group was a control group, consisted of 20 children, no treatment was assigned to them. A ll patients from both groups got the basis pollinosis therapy. Efficiency of the scIT using F ostal was estimated in terms of its influence on the childrens quality of life, clinical symptoms and drug load. Results. Good results demonstrated in terms of increased quality of life indexes were achieved after the initial stage of the scIT using F ostal. C ompared to the control group, the amount of needed drugs was significantly decreased, and the decrease in the severity of clinical symptoms of rhinitis (p=0,001) and conjunctivitis (p=0,002) was observed. During the scIT with the F ostal trees pollen some negligible local reactions were observed in all cases, in 7 of 11 patients marked local reactions appeared. O n the initial stage of the therapy no systemic allergic reaction was observed. Conclusion. On the basis of the results of the study, F ostal could be considered as a highly effective and safe for treatment of pollinosis children. S cIT with the F ostal leads to the improvement of childrens quality of life, decreasing of clinical symptoms severity as well as drug load.

scholarly journals The influence of subcutaneous allergen-specific immunotherapy with birch extract absorbed onto calcium phosphate on quality of life of children with allergic rhinoconjunctivitis: 2-years follow-up results

2014 ◽  
Vol 11 (1) ◽  
pp. 33-38
Author(s):  
N V Shakhova ◽  
U F Lobanov ◽  
V V Gordeev ◽  
V P Tokarev ◽  
M V Surkova
Keyword(s):  
Quality Of Life ◽  
Calcium Phosphate ◽  
Specific Immunotherapy ◽  
Systemic Reaction ◽  
Allergic Rhinoconjunctivitis ◽  
Control Group ◽  
Allergen Specific Immunotherapy ◽  
Local Reactions

Background. The purpose of the study was to investigate the influence of subcutaneous allergenspecific immunotherapy with birch extract absorbed onto calcium phosphate on quality of life of children with allergic rhinoconjunctivitis Methods. 50 patients at the age from 5 to17 years old with allergic rhinoconjunctivitis sensitized to trees pollen (birch, alder, hazel) were observed. All the patients were divided into 2 groups. The first group consisted of 23 children, who were treated with birch extract («Phostal») subcutaneous allergen-specific immunotherapy (SCIT). The second group was a control group, consisted of 27 children, no treatment was assigned to them. Results. Statistically significant increase of all quality of life indexes in the group which was treated with SCIT using «Phostal» was observed. Statistically valid decrease of severity of rhinoconjunctivitis symptoms in the 1 group was shown (6,1±3,1; 11,8±4,5; p=0,00002). Total number of Phostal injections was 990, 227 (23%) local reactions and no one systemic reaction have been observed during the study. Conclusion. SCIT with birch extract absorbed onto calcium phosphate could be considered as a highly effective and safe method of treatment of pollinosis in children.

scholarly journals Efektivitas imunoterapi terhadap gejala, temuan nasoendoskopik dan kualitas hidup pasien rinosinusitis alergi

2012 ◽  
Vol 42 (2) ◽  
Author(s):  
Yuwan Pradana ◽  
Teti Madiadipoera ◽  
Melati Sudiro ◽  
Arif Dermawan
Keyword(s):  
Quality Of Life ◽  
Visual Analogue Scale ◽  
Disease Severity ◽  
Analogue Scale ◽  
Specific Immunotherapy ◽  
Drug Intake ◽  
Allergen Specific Immunotherapy ◽  
Nasal Symptoms ◽  
Severity Of The Disease

Background: Rhinosinusitis is one of major health problems which increased the economic burden. With symptoms include nasal congestion, rhinorrhea, facial pain, and sometimes reduced or loss of smell, this condition may impair work productivity and quality of life (QOL). Rhinosinusitis is one of the comorbidity of allergic rhinitis. Allergen specific immunotherapy provides protection against the occurence of allergic symptoms and inflammatory reactions due to allergen exposure, that results in improvement  of QOL of allergic rhinosinusitis patients.   To assess the effectiveness of immunotherapy in the  severity of the disease, nasal symptoms, nasoendoscopic findings, drugs intake, and the QOL in allergic rhinosinusitis patients treated with specific immunotherapy. Methods: A retrospective descriptive study conducted at the Rhinology-Allergy Clinic of ORL-HNS Department, Dr.Hasan Sadikin General Hospital, Bandung, on January - December 2011, towards 25 patients, by anamnesis, severity of the disease using Visual Analogue Scale (VAS), nasal symptoms from Weeke, Davis and Okuda, nasoendoscopic findings from Lund-Kennedy, drug intake score, and QOL assesment using Rhinoconjuctivitis Quality of Life Questionaire. Results: There was a significant correlation (p<0,05) between specific immunotherapy for 1 year observed by reduced disease severity, reduced nasal symptoms, nasoendoscopic findings improvement, reduced drug intake, and increased Quality of Life which shows significant results from 3 months after immunotherapy using Wilcoxon differential test (p<0,001). Conclusion: Immunotherapy for 1 year was significantly reduced disease severity, reduced nasal symptoms, improved nasoendoscopic findings, reduced drug intake, and improvement of QOL in patients with allergic rhinosinusitis began from 3 months after immunotherapy and maintained afterwards. Key words: allergic rhinosinusitis, nasal symptoms, nasoendoscopy, specific immunotherapy, quality of life    Abstrak :  Latar belakang: Rinosinusitis merupakan salah satu masalah kesehatan yang semakin meningkat sehingga menjadi beban besar terhadap perekonomian masyarakat. Dengan gejala berupa hidung tersumbat, rinore, nyeri pada wajah dan dapat disertai berkurang atau hilangnya penciuman, kondisi ini dapat menurunkan produktivitas kerja dan kualitas hidup. Rinosinusitis merupakan salah satu komorbiditas dari rinitis alergi. Imunoterapi alergen spesifik bertujuan untuk memberikan perlindungan terhadap timbulnya gejala alergi dan reaksi inflamasi akibat pajanan alergen, sehingga dapat meningkatkan kualitas hidup pasien rinosinusitis. Tujuan: Membuktikan efektivitas imunoterapi terhadap tingkat beratnya penyakit, gejala hidung, nasoendoskopi, penggunaan obat dan kualitas hidup pasien rinosinusitis alergi yang diberikan pengobatan imunoterapi selama 3, 6, dan 12 bulan. Metode: Dilakukan penelitian deskriptif retrospektif, di Poliklinik Rinologi Alergi Ilmu Kesehatan THT-KL RSHS Bandung, dalam periode JanuariDesember 2011 pada 25 pasien, menggunakan anamnesis, tingkat berat penyakit berdasarkan Visual Analogue Scale (VAS), gejala hidung  berdasarkan Weeke, Davis dan Okuda, pemeriksaan nasoendoskopi berdasarkan Lund-Kennedy, penggunaan obat dan penilaian kualitas hidup dengan Rhinoconjuctivitis Quality of Life Questionaire. Hasil: Didapatkan hubungan bermakna berdasarkan uji chi-kuadrat-Friedman   antara imunoterapi selama 1 tahun (p<0,05) terhadap penurunan tingkat berat penyakit, penurunan gejala hidung, perbaikan temuan nasoendoskopi, penurunan penggunaan obat, serta peningkatan kualitas hidup. Didapat perbaikan secara bermakna sejak 3 bulan pasca imunoterapi (p<0,001) berdasarkan uji beda Wilcoxon. Kesimpulan: Imunoterapi selama 1 tahun efektif terhadap penurunan tingkat berat penyakit, penurunan gejala hidung, perbaikan temuan nasoendoskopi, penurunan penggunaan obat, serta peningkatan kualitas hidup pada pasien rinosinusitis alergi, dengan perbaikan sejak 3 bulan dan bertahan hingga 1 tahun pasca-imunoterapi. Kata kunci: rinosinusitis alergi, gejala hidung, nasoendoskopi, imunoterapi, kualitas hidup 

scholarly journals Effect of unicornuate uterus on women's reproductive health

2019 ◽  
Keyword(s):  
Quality Of Life ◽  
Reproductive Health ◽  
Clinical Symptoms ◽  
Normal Karyotype ◽  
Pain Scale ◽  
Control Group ◽  
Visual Analogue Pain Scale ◽  
Visual Analogue Pain ◽  
Unicornuate Uterus

Objectives. The effect of the unicornuate uterus on the reproductive health and quality of life of woman has been analyzed. Materials and methods. The study included 26 patients with unicornuate uterus aged 25 to 42 years and 20 women without gynecological pathology. Diagnosis of uterine abnomalies was based on patient complaints, medical history and life history, as well as clinical and laboratory and instrumental examinations. The severity of dysmenorrhea was determined using a visual analogue pain scale, women's quality of life was assessed using a short SF-12 health questionnaire. Results. The average age of the surveyed women was 30.2 ± 3.9 years. All patients with unicornuete uterus by subclasses were distributed as follows: subclass U4a (unicornuate uterus with rudimentary cavity) – 69.2% of patients, subclass U4b (unicornuate uterus without rudimentary cavity in the contralateral horn or with its aplasia) – 30.8%. In all patients was confirmed normal karyotype – 46XX. The combination of a unicornuate uterus with a defect of the urinary system (aplasia, doubling, or kidney dystopia) occurred in 23.1% of women. It has been found that in women with unicornuate uterus, clinical symptoms in 76.9% of cases are accompanied by dysmenorrhea. The unicornuate uterus in 69.2% of cases causes negative reproductive outcomes, among which 26.9% – early spontaneous abortions, 11.5% – ectopic pregnancy. In 46.2% of cases the unicornuate uterus is combined with other gynecological pathology, whereby the incidence of concomitant gynecologic pathology is significantly more frequent in U4a patients than in the U4b subclass (˂0.01). The severity of dysmenorrhea in the main group was 5.8 ± 1.8 points (the difference was significant compared with the control group, p = 0.0032). Conclusions. Due to the low physical subunit, the unicornuate uterus significantly impairs the quality of life of women, which was significantly lower in the group of patients with unicornuate uterus compared to the control group (total SF-12 score: 85.4 ± 11.2 vs. 95.8 ± 12.1; p = 0.002).

scholarly journals Effect of a Smartphone-Based App on the Quality of Life of Patients With Heart Failure: Randomized Controlled Trial

JMIR Nursing ◽  
10.2196/20747 ◽  
2020 ◽  
Vol 3 (1) ◽  
pp. e20747
Author(s):  
Mahboube Davoudi ◽  
Tahereh Najafi Ghezeljeh ◽  
Farveh Vakilian Aghouee
Keyword(s):  
Quality Of Life ◽  
Heart Failure ◽  
Clinical Symptoms ◽  
Controlled Trial ◽  
Intervention Group ◽  
Control Group ◽  
Controlled Clinical Trial ◽  
Randomized Controlled ◽  
Patients With Heart Failure

Background Patients with heart failure have low quality of life because of physical impairments and advanced clinical symptoms. One of the main goals of caring for patients with heart failure is to improve their quality of life. Objective The aim of this study was to investigate the effect of the use of a smartphone-based app on the quality of life of patients with heart failure. Methods This randomized controlled clinical trial with a control group was conducted from June to October 2018 in an urban hospital. In this study, 120 patients with heart failure hospitalized in cardiac care units were randomly allocated to control and intervention groups. Besides routine care, patients in the intervention group received a smartphone-based app and used it every day for 3 months. Both the groups completed the Minnesota Living with Heart Failure Questionnaire before entering the study and at 3 months after entering the study. Data were analyzed using the SPSS software V.16. Results The groups showed statistically significant differences in the mean scores of quality of life and its dimensions after the intervention, thereby indicating a better quality of life in the intervention group (P<.001). The effect size of the intervention on the quality of life was 1.85 (95% CI 1.41-2.3). Moreover, the groups showed statistically significant differences in the changes in the quality of life scores and its dimensions (P<.001). Conclusions Use of a smartphone-based app can improve the quality of life in patients with heart failure. The results of our study recommend that digital apps be used for improving the management of patients with heart failure. Trial Registration Iranian Registry of Clinical Trials IRCT2017061934647N1; https://www.irct.ir/trial/26434

Effects of health education based on mobile platform on cognitive function and quality of life of children with pneumonia

2021 ◽  
Vol 7 (6) ◽  
pp. 6529-6539
Author(s):  
Yang Lu ◽  
Xi Ying
Keyword(s):  
Quality Of Life ◽  
Cognitive Function ◽  
Health Education ◽  
Clinical Symptoms ◽  
Nursing Intervention ◽  
Mobile Platform ◽  
Control Group ◽  
Observation Group ◽  
Early Recovery

Objective: To explore the effects of health education based on mobile platform on cognitive function and quality of life of children with pneumonia. Methods: Eighty parents with pneumonia admitted to our hospital from March 2018 to March 2020 were selected as the research subjects. The parents of the control group received routine nursing intervention, and the parents of the observation group received health education intervention based on the mobile platform. After nursing, the nursing effect of the two groups was compared. The cognitive function and quality of life of the two groups were compared after nursing. The time of cough, dyspnea, shortness of breath and lung rales were compared between the two groups. The incidence of rash, abdominal pain, dizziness and headache and parents' satisfaction with nursing were compared between the two groups. Results: Compared with the control group, the nursing effective rate of the observation group was significantly increased (P<0.05). The scores of cognitive function and quality of life in observation group were significantly higher than those in control group (P<0.05). Compared with the control group, the disappearance time of clinical symptoms in the observation group was significantly decreased (P<0.05). The satisfaction of parents in the observation group was significantly higher than that in the control group (P<0.05). Conclusion: Health education based on mobile platform can effectively improve the cognitive function and quality of life of children with pneumonia, contribute to the early recovery of children, and has high clinical application value.

scholarly journals Safety, effect anti tolerance of metoprolol in the treatment of elderly and old patients of cardiological profile

2006 ◽  
Vol 12 (1) ◽  
pp. 52-55
Author(s):  
I. .. Vologdina
Keyword(s):  
Quality Of Life ◽  
Treatment Period ◽  
Clinical Symptoms ◽  
Control Group ◽  
Pronounced Increase ◽  
Old Patients ◽  
Sf 36 ◽  
Depression Level ◽  
Safety Effect

76 elderly patients with cardiac heart disease (CHD) (31 male and 45 female) were included in the study. Mean age was 81.6 ± 3.4 (from 76 to 89) years. All investigated patients had stable angina pectoris (I-III class). The duration of disease was 8-15 years. The patients were hypertensive (mean arterial pressure 164.5 ± 5.8 / 100 ± 4.3 mm Hg) and had clinical symptoms of heart failure (II class by NYHA). The mental status was evaluated by variety specific tests. The quality of life was assessed by using questionnaire scale SF-36 Health Stains Survey. All subjects were treated by nitrates. ACE-inhibitors and diuretics. Patienis were divided into 2 groups, clinical data and demographies signs of witch, were comparable. 29 patients (1 group) received Metocard 25-100 mg per day. 27 patients were included in control group. Patients of 1 group demonstrated more pronounced increase of distance in test with 6-minutes walking. The depression level after treatment period was significantly reduced in patients of 1 group compare with control group and it's precede level (Camilton scale). Evaluation of quality of life following treatment period shewed statistically significant improvement of number indexes of scale SF-36 Health Status Survey.

scholarly journals Clinical Effect of Buyang Huanwu Decoction in Treating Sequelae of Stroke

2020 ◽  
Vol 218 ◽  
pp. 03012
Author(s):  
Yujin Hou ◽  
Xiaosu Jie ◽  
Xin Guo ◽  
Yingying Zhang ◽  
Hua Shi ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Clinical Effect ◽  
Clinical Symptoms ◽  
Research Work ◽  
Test Group ◽  
Control Group ◽  
Clinical Effects ◽  
Buyang Huanwu Decoction ◽  
Positive Meaning

Objective: To explore the clinical effect of applying Buyang Huanwu Decoction in the treatment of sequelae of stroke. Methods: The research work was carried out in our hospital, which was from November 2018 to November 2019. A total of 200 patients were selected for treatment during this period, all of whom were patients with sequelae of stroke, and 100 patients were grouped randomly. One group was given conventional acupuncture treatment as the control group, and the other group was given acupuncture combined with Buyang Huanwu Decoction treatment as the test group. The clinical effects of the two groups of patients were evaluated. Results: After treatment intervention, the treatment rates of the test group and the control group were 94.00% and 78.00%, respectively. The Fahl-Meyer score and Barthel index score of the test group were significantly higher than those of the control group, and the quality of life score was higher. There are significant data differences, which was statistically meaningful (P<0.05), and the test group has a better effect. Conclusion: The clinical effect of applying Buyang Huanwu Decoction in stroke patients is significant, which can improve the clinical symptoms and quality of life of patients, which has positive meaning for clinical development.

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