scholarly journals PRIMARY IMMUNODEFICIENCIES - NOT A RARE DISEASE, BUT A DIFFICULT DIAGNOSIS. COMMON VARIABLE IMMUNODEFICIENCY (ANALYSIS OF CLINICAL CASES)

2013 ◽  
Vol 10 (1) ◽  
pp. 58-61
Author(s):  
E A Latysheva
Keyword(s):  
Immune Deficiency ◽  
Brain Tumor ◽  
Humoral Immunity ◽  
Common Variable Immunodeficiency ◽  
Primary Immunodeficiencies ◽  
Common Variable Immune Deficiency ◽  
Difficult Diagnosis ◽  
Wide Range ◽  
The Brain ◽  
Common Variable

Primary immunodeficiencies (PID) occur more often than we used to think. Due to the low awareness of physicians about this disease, from the onset of symptoms to diagnosis patients are difficult path, often measured in years. In PID adults the most common is humoral immunity disorder. Given the wide range of clinical phenotypes of the disease, immunologist may be far from the GP during diagnosis. The article presents a case of a patient with common variable immune deficiency, that was masked under the brain tumor.

scholarly journals Common variable immune deficiency: case studies

Blood ◽  
2019 ◽  
Vol 134 (21) ◽  
pp. 1787-1795 ◽  
Author(s):  
Charlotte Cunningham-Rundles
Keyword(s):  
Immune Deficiency ◽  
Case Studies ◽  
Common Variable Immunodeficiency ◽  
Common Variable Immune Deficiency ◽  
Granulomatous Disease ◽  
Autoimmune Cytopenias ◽  
Common Variable

In this review, the authors describe 3 patients with common variable immunodeficiency (CVID), noting the disease manifestations most relevant to the practicing hematologist, especially autoimmune cytopenias, benign lymphoproliferation, granulomatous disease, and lymphomas such as common noninfectious complications of CVID.

scholarly journals Common variable immune deficiency in adults: focus on pulmonary complications

2017 ◽  
Vol 89 (12-2) ◽  
pp. 211-215
Author(s):  
D S Fomina ◽  
E N Bobrikova ◽  
D O Sinyavkin ◽  
V V Parshin
Keyword(s):  
Immune Deficiency ◽  
Causes Of Death ◽  
Inflammatory Diseases ◽  
Pulmonary Complications ◽  
Adult Patients ◽  
Primary Immunodeficiencies ◽  
Common Variable Immune Deficiency ◽  
Diagnostic Delays ◽  
Common Variable ◽  
Clinical Cases

Common variable immune deficiency is the most common form of a group of primary immunodeficiencies in adult patients. Pulmonary complications occupy leading positions. It is the development of recurrent bronchopulmonary inflammatory diseases that is considered to be one of the main causes of death and disability in patients with this disease. By presenting two clinical cases with long diagnostic delays, the authors try to attract the attention of specialists of related professions, which will minimize the development of irreversible complications in the patients.

scholarly journals Common variable immune deficiency in clinical practice

2015 ◽  
Vol 96 (2) ◽  
pp. 249-252
Author(s):  
L A Yagudina ◽  
D M Khakimova
Keyword(s):  
Immune Deficiency ◽  
Clinical Symptoms ◽  
Disease Onset ◽  
Clinical Manifestations ◽  
Primary Immunodeficiencies ◽  
Common Variable Immune Deficiency ◽  
Immune Deficiencies ◽  
Inflammatory Processes ◽  
Genetically Determined ◽  
Common Variable

Primary immunodeficiencies are rare but severe diseases. Out of all primary immunodeficiencies, most commonly diagnosed conditions belong to the group of common variable immune deficiencies. According to criteria of European Society for Immunodeficiencies (ESID) the diagnosis of common variable immune deficiency is extremely likely at considerable decrease (over 2 standard deviation values compared to median value) of two or three main isotypes of immunoglobulins (classes A, G, M). The mean prevalence of variable immune deficiency in general population ranges from 1:50 000 to 1:70 000. This disease has two age peaks of onset: the first peak is between the age of 6 and 10 years; the second peak - between the age of 26-30 years. Moreover, before the disease onset patients are considered as healthy. The range of clinical manifestations, which may help to suspect common variable immune deficiency, is very wide: some patients have repeated pneumonia, others have thrombocytopenic purpura, autoimmune hemolytic anemia or colitis. Low prevalence of primary immunodeficiency in population, a variety of its clinical forms, insufficient awareness of practical doctors dictate the need for detailed description of this pathology on a clinical example. The article presents a case of firstly diagnosed case of common variable immune deficiency in a 26 years old female. Issues of epidemiology, etiology, pathogenesis, clinical symptoms and diagnosis of this disease are described. It is necessary to draw the attention of doctors of various specialties to the fact that changes in the immune system, up to hereditary, genetically determined immunodeficiencies can often be the cause of recurrent inflammatory processes of different localization with a low response to conventional therapy.

Vedolizumab Induced Clinical, Endoscopic, and Histological Improvement in Common Variable Immunodeficiency Disease–associated Intestinal Enteropathy

2020 ◽  
Vol 26 (4) ◽  
pp. e22-e23 ◽  
Author(s):  
Hisham Javed Akhtar ◽  
Bharat Markandey ◽  
Christopher Ma ◽  
Darryl Ramsewak ◽  
Joanna C Walsh ◽  
...  
Keyword(s):  
Immune Deficiency ◽  
Treatment Option ◽  
Common Variable Immunodeficiency ◽  
Common Variable Immune Deficiency ◽  
Histological Improvement ◽  
Immunodeficiency Disease ◽  
Common Variable

After treatment with vedolizumab, a patient with diarrhea and malnutrition secondary to common variable immune deficiency (CVID)–related enteropathy was able to achieve clinical, endoscopic, and histological improvement. Vedolizumab may be a treatment option for patients with CVID-associated enteropathy.

Cancer and autoimmune disease in families with common variable immune deficiency

1986 ◽  
Vol 3 (1) ◽  
pp. 17-26 ◽  
Author(s):  
Daphne Morrell ◽  
Charles L. Chase ◽  
Michael Swift ◽  
D. C. Rao
Keyword(s):  
Immune Deficiency ◽  
Autoimmune Disease ◽  
Common Variable Immune Deficiency ◽  
Common Variable
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