scholarly journals Immunological biomarkers changes during diet therapy in children with food allergy

2015 ◽  
Vol 12 (1) ◽  
pp. 73-78
Author(s):  
I V Vorozhko ◽  
T B Sentsova ◽  
V A Revyakina ◽  
O O Chernyak ◽  
S N Denisova
Keyword(s):  
Food Allergy ◽  
Milk Protein ◽  
Goat Milk ◽  
Specific Ige ◽  
Diet Therapy ◽  
Cow’S Milk ◽  
Igg Antibodies ◽  
Cow's Milk ◽  
Cow’S Milk Protein ◽  
Different Sources

Immunological estimating of different diet therapy types became currently very important. The aim of this work was to study the changes of immunological biomarkers during usage of formulas based on different sources of protein in children with food allergy and to assess and predict the effectiveness of diet therapy. The study included 66 children with food allergy in age from 1,5 months to 1,5 years. Observed children were divided into three groups depending on the type of formulas used. The dynamics of immunoregulatory substances (IL-5, TGF β 1, IL-10, IL-4, IL-2, IL-13, Eotaxin3), and allergenspecific IgE and IgG antibodies to cow’s milk protein, α-lactoglobulin, β-laktoglobulin, casein, soy and goat’s milk during diet therapy were evaluated. Observation duration was 28-30 days. The differences in the dynamics of the investigated parameters depending on the type of formula were revealed. Thus, the use of formula based on cow’s milk hydrolysates revealed their primarily effect on cytokines IL-2, IL-5 and growth factor TGF β ; the use of formula based on soy protein revealed combined effect on humoral immunity (allergen specific IgE and IgG antibodies) and IL-5; the use of formula based on goat milk characterized decreased levels of allergenspecific IgG antibodies to the cow’s milk protein and its fractions, reduced allergen specific IgE antibody concentrations to cow’s milk protein and α-lactoglobulin, decreased levels of IL-5, and, exclusive for this formula - reduction of IL-4 level. Accordingly, the assessment of immunological biomarkers can be used to personalize diet therapy in children with food allergy.

scholarly journals Evaluation of the effectiveness of diet therapy in infants with gastrointestinal manifestations of food allergy

2014 ◽  
Vol 11 (1) ◽  
pp. 80-84
Author(s):  
T B Sentsova ◽  
O O Kirillova ◽  
I V Vorozhko ◽  
V A Revyakina ◽  
O Yu Monosova ◽  
...  
Keyword(s):  
Food Allergy ◽  
New Zealand ◽  
Mucosal Immunity ◽  
Goat Milk ◽  
Specific Ige ◽  
Diet Therapy ◽  
Cow’S Milk ◽  
Healthy Children ◽  
Gastrointestinal Manifestations ◽  
Cow's Milk

Background. The aim of the study was to evaluate the effectiveness of the diet therapy in infants with gastrointestinal manifestations of food allergy to cow’s milk protein. Materials and methods. 126 bottlefed infants aged from 1 to 12 months were examined for mucosal immunity and bowel microbiota parameters. Results. The changes of intestinal microbiota with in creased of conditionally pathogenic species (Klebsiella, Proteus, Citrobacter spp., etc.) with normal rates of anaerobic bacteria (bifido- and lactobacilli spp.) were revealed. sIgA levels in coprofiltrates in infants with gastrointestinal manifestations of food allergy were significantly reduced compared with the control group. Elevated C-reactive protein (CRP) levels compared with healthy children were obtained. Elevated levels of total IgE as well as allergen-specific IgE to cow’s milk proteins incoprofiltrates were estimated being the evidence of food sensitization. Using of adapted formulas based on the New Zealand goat milk with a complex of prebiotics in infants with gastrointestinal manifestations of food allergy led to normalization of intestinal microflora with reducing of Enterobacteriaceae spp. colonization. Positive changes in mucosal immunity were observed: increase of sIgA levels, decrease of total and allergen-specific IgE and CRP levels in coprofiltrates. Conclusion. The study demonstrated the usefulness of adapted formulas based on the New Zealand goat milk with a complex of prebiotics as diet therapy in infants with gastrointestinal manifestations of food allergy.

scholarly journals ASSESSMENT OF CLINICAL-IMMUNOLOGICAL EFFECTIVENESS OF COMPLEX THERAPY OF INFANT ATOPIC DERMATITIS

2013 ◽  
Vol 10 (5) ◽  
pp. 55-60
Author(s):  
S N Denisova ◽  
T B Sentsova ◽  
M Y Belitskaya
Keyword(s):  
Atopic Dermatitis ◽  
Milk Protein ◽  
Protein Hydrolysate ◽  
Blood Stream ◽  
Diet Therapy ◽  
Cow’S Milk ◽  
Cow's Milk ◽  
Complex Therapy ◽  
Specific Igg ◽  
Cow’S Milk Protein

The work is aimed at assessment of clinicalimmunological effectiveness of diet therapy based on hypoallergenic formula used for infants with atopic dermatitis. 167 infants with atopic dermatitis associated with cow’s milk protein allergy have been put included under outpatient observation. 52 infants of from the first group were being fed on whole goat milk’s formula, 56 infants of from the the second group — cows’ milk protein hydrolysate and 59 infants of the from the third groupsoy’s isolate formula. The age of infants was 2, 5—9 months. The duration of observation was 3—12 months. Complex therapy has been conducted over the infants and it contained antiallergenic treatment and diet therapy with hypoallergenic baby formula. The majority of patients showed improvement due to applied treatment. The first group’s infants with positive clinical dynamic showed decrease of specific IgG and IgE to cow’s milk protein, casein, β-LH and soy’s protein. The infants of the second and third groups also showed decrease of specific IgG and IgE to cow’s milk protein, casein, β-LH, soy’s protein and goat’s milk at clinical remission. All the infants with positive clinical effect showed trend to decrease of IL12, IL13, sICAM1 and sEselectin’s concentration in the blood stream, that can indicate on leukocyte adherence inhibition and cell migration to the area of inflammation. Based on the results of research, we can conclude that replacement of one product with another one by taking into account their clinicalimmunological effectiveness as the method of treatment the of atopic dermatitis patients let us optimize infant diet therapy.

scholarly journals Prevalence, Risk Factors, Clinical Manifestation, Diagnosis Aspects and Nutrition Therapy in Relation to both IgE and IgG Cow’s Milk Protein Allergies among a Population of Saudi Arabia: A Literature Review

2021 ◽  
Vol 9 (2) ◽  
pp. 375-389
Author(s):  
Mashail A Baghlaf ◽  
Noura M S Eid
Keyword(s):  
Risk Factors ◽  
Saudi Arabia ◽  
Food Allergy ◽  
Clinical Manifestation ◽  
Milk Protein ◽  
Immunoglobulin E ◽  
Cow Milk ◽  
Cow’S Milk ◽  
Cow's Milk ◽  
Cow’S Milk Protein

Cow milk protein allergy (CMPA) becoming a major public health issue that has attracted the attention of health professionals and researchers. This paper aimed to review the important aspects of both IgE and IgG types of cow’s milk protein allergy in terms of prevalence, clinical manifestation, risk factors, other health-related issues and nutritional therapy proposed for such allergies in the adult and pediatric population in Saudi Arabia. A search on “cow’s milk allergy” was done using PubMed, Google Scholar and Scopus Engine for published papers between 1993 and 2020 to find studies yielding knowledge on that context. The prevalence of cow’s milk protein allergy (CMPA) among infants is now in the range of 2–3%. This type of allergy is also detected in adulthood but less frequently. CMPA is defined as an immunological reaction to specific proteins in milk. CMPA is classified based on its type as an immunoglobulin E (IgE)-mediated form and an immunoglobulin G (IgG)-mediated form, each type representing different immunological pathways. The presence of Genetic aspects, family history and short duration of breastfeeding in the infant are among the risk factors contributing to this form of allergy. Its manifestations mainly present as skin presentation, followed by the gastrointestinal and respiratory presentation in most cases in addition to a life-threatening anaphylactic reaction that may occur in 12% of cases. food allergy committees have developed strict diagnosis criteria, including blood testing for food-specific immunoglobulin E (sIgE), a skin prick test and double-blind placebo-controlled food challenges (DBPCFC) as the gold standard. A diet free of cow’s milk protein (CMP) allergen and including the appropriate alternative milk formula is the first line of prevention recommended by many organizations and food allergy experts. As for Saudi Arabia, more research and clinical trials are required to discuss the various aspects of adult and pediatric CMPA and to provide a better understanding along with good control strategies implementation.

scholarly journals Microbiota and Derived Parameters in Fecal Samples of Infants with Non-IgE Cow’s Milk Protein Allergy under a Restricted Diet

Nutrients ◽  
2018 ◽  
Vol 10 (10) ◽  
pp. 1481 ◽  
Author(s):  
María Díaz ◽  
Lucía Guadamuro ◽  
Irene Espinosa-Martos ◽  
Leonardo Mancabelli ◽  
Santiago Jiménez ◽  
...  
Keyword(s):  
Food Allergy ◽  
Milk Protein ◽  
Transforming Growth Factor ◽  
Cow’S Milk ◽  
Control Group ◽  
Microbiota Composition ◽  
Fecal Samples ◽  
Cow's Milk ◽  
Healthy Infants ◽  
Cow’S Milk Protein

Cow’s milk protein allergy (CMPA) is the most common food allergy in infancy. Non-IgE mediated (NIM) forms are little studied and the responsible mechanisms of tolerance acquisition remain obscure. Our aim was to study the intestinal microbiota and related parameters in the fecal samples of infants with NIM-CMPA, to establish potential links between type of formula substitutes, microbiota, and desensitization. Seventeen infants between one and two years old, diagnosed with NIM-CMPA, were recruited. They were all on an exclusion diet for six months, consuming different therapeutic protein hydrolysates. After this period, stool samples were obtained and tolerance development was evaluated by oral challenges. A control group of 10 age-matched healthy infants on an unrestricted diet were included in the study. Microbiota composition, short-chain fatty acids, calprotectin, and transforming growth factor (TGF)-β1 levels were determined in fecal samples from both groups. Infants with NIM-CMPA that consumed vegetable protein-based formulas presented microbiota colonization patterns different from those fed with an extensively hydrolyzed formula. Differences in microbiota composition and fecal parameters between NIM-CMPA and healthy infants were observed. Non-allergic infants showed a significantly higher proportion of Bacteroides compared to infants with NIM-CMPA. The type of protein hydrolysate was found to determine gut microbiota colonization and influence food allergy resolution in NIM-CMPA cases.

scholarly journals Chemically Defined Formulas, Symbiotics and Cow’s Milk Protein Allergy

Nutrients ◽  
2022 ◽  
Vol 14 (2) ◽  
pp. 299
Author(s):  
Jean-Pascal De Bandt
Keyword(s):  
Food Allergy ◽  
Milk Protein ◽  
Cow’S Milk ◽  
Cow's Milk ◽  
Common Food ◽  
Cow’S Milk Protein

Cow’s milk protein (CMP) allergy (CMPA) is the earliest and most common food allergy in children [...]

scholarly journals The estimation of efficiency of diet therapy in atopic dermatitis and food allergy in children

2012 ◽  
Vol 9 (4) ◽  
pp. 72-78
Author(s):  
V A Revyakina ◽  
K G Sharapova ◽  
E YU Berezina ◽  
T B Sentsova ◽  
O YU Monosova ◽  
...  
Keyword(s):  
Atopic Dermatitis ◽  
Food Allergy ◽  
Milk Protein ◽  
Goat Milk ◽  
Serum Levels ◽  
Diet Therapy ◽  
Cow Milk ◽  
Milk Formula ◽  
Igg Antibodies ◽  
Positive Skin

Background. Clinical and immunological estimation of efficiency of different special formulas in children with atopic dermatitis due to food allergy. Methods. Fifty four children with atopic dermatitis aged 0,5—3 years old were examined. Children were divided into three groups on the base of their diet therapy. The 1 st group included 15 patients on the hypoallergenic milk-free diet, the 2 nd group (18 patients) was fed by goat milk formula, and the 3 rd group (21 children) was fed by special formula with high hydrolyzed protein. The dynamics of serum levels of IgE and IgG antibodies to cow milk protein and its fractions, and dynamics of cytokine levels (IL-4, IL-5, and IL-10) were measured during different types of diet therapy. Results. The positive skin changes during diet therapy included decrease of erythema, exudation and itching, gradual regression of rash. In 3 months of therapy complete clinical remission was achieved in 10 (66,7%) children in the 1 st group, in 14 (77,8%) children in the 2 nd group and in 15 (71,7%) children in the 3 rd group. The significant decrease of levels of IgG antibodies levels to cow milk protein and its fractions in children during different elimination diets was determined. The significant decrease of levels of specific IgE antibodies to cow milk protein (p

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