scholarly journals ATOPIC DISEASES WITHOUT SYSTEMIC SENSIBILIZATION

2014 ◽  
Vol 11 (5) ◽  
pp. 14-20
Author(s):  
D S Korostovtsev ◽  
L A Galenko ◽  
O V Trusova ◽  
A V Kamaev ◽  
I V Makarova
Keyword(s):  
Specific Ige ◽  
Systemic Circulation ◽  
Atopic Asthma ◽  
Skin Tests ◽  
Lymphoid Tissues ◽  
Esophageal Mucosa ◽  
Therapeutic Approaches ◽  
Positive Skin ◽  
Ige Synthesis ◽  
Non Allergic Rhinitis

The diagnosis of allergic disease related to the group of immediate hypersensitivity involves confirmation of IgE sensitization: positive skin tests with the suspected allergen and/or detection of allergen-specific IgE. Research over the past decades showed that IgE synthesis may occur exclusively in the tissues of the affected organ and derived allergen-specific antibodies may not enter the systemic circulation. In contrast to «atopy», this concept of local sensitization was termed «entopy». local production of IgE was detected in more then 47% of adults previously diagnosed as having non-allergic rhinitis. besides the nasal mucosa, local sensitization was found in lymphoid tissues of nasopharyngeal ring, bronchial mucosa in some patients with non-atopic asthma, esophageal mucosa in patients with eosinophilic esophagitis. The processes of local immune response is currently studied and probably one day the accumulated data will swing our understanding of atopic sensitization, that will be reflected in classification and therapeutic approaches.

Neue Charakteristika klinisch manifester Latexallergiker

2019 ◽  
Vol 7 (1) ◽  
pp. 29-31
Author(s):  
Vera Mahler
Keyword(s):  
Medical History ◽  
Skin Test ◽  
Correct Diagnosis ◽  
Natural Rubber Latex ◽  
Specific Ige ◽  
Latex Allergy ◽  
Skin Tests ◽  
Diagnostic Challenge ◽  
Positive Skin ◽  
Significant Difference

Background: Natural rubber latex (NRL) allergy is commonly diagnosed according to medical history, skin allergy tests, and serological analyses. However, skin tests are increasingly being abandoned because of (i) their time-consuming nature, (ii) latex preparations for skin tests being not commercially available, and (iii) the use of in-house prepared test solutions is becoming ever more difficult due to increasing regulatory hurdles. In this light, we have evaluated differences in the profiles of current and former patients with suspected latex allergy. Methods: Sera of skin test-positive patients from a historic cohort (1995-2001, n = 149 patients) and currently (2014-2015, n = 48 patients) were simultaneously analyzed for specific IgE to latex by ImmunoCAP. If the serological screening was positive (≥ 0.35 kU/l), component-resolved diagnostics including profilins and cross-reactive carbohydrate determinants (CCDs) were performed. Results: In contrast to 88% (131/149) of the skin test-positive patients from the 1990s, only 51.1% (24/47) of the current cohort were found positive for specific IgE to latex. While 48.3% (72/149) of the patients had a convincing positive history in the 1990s, current skin test-positive patients rarely reported a relevant medical history (8.5%, 4/47). Specific IgE levels to latex were significantly higher in former patients with suspected latex allergy (p < 0.001) than in former sensitized individuals without allergy. However, this significant difference was lost in current allergic and sensitized patients with positive skin tests. Conclusion: Sensitization profiles in patients with latex allergy have changed significantly over the last 2 decades. Discrimination between NRL sensitization and clinical allergy remains a diagnostic challenge. Our data highlight the need for a combination of all 3 criteria, i.e., patient history, skin test, and analysis of specific IgE, for a correct diagnosis of latex allergy.

Allergic Fungal Sinusitis Associated with Allergic Bronchopulmonary Aspergillosis: An Uncommon Sinobronchial Allergic Mycosis

2007 ◽  
Vol 21 (4) ◽  
pp. 412-416 ◽  
Author(s):  
Jean Jacques Braun ◽  
Gabrielle Pauli ◽  
Philippe Schultz ◽  
André Gentine ◽  
David Ebbo ◽  
...  
Keyword(s):  
Allergic Bronchopulmonary Aspergillosis ◽  
Specific Ige ◽  
Antifungal Drugs ◽  
Sinus Surgery ◽  
Skin Tests ◽  
Fungal Sinusitis ◽  
Allergic Fungal Sinusitis ◽  
Positive Skin ◽  
Oral Corticosteroids ◽  
Blood Eosinophils

Background The identification of allergic fungal sinusitis (AFS) is still controversial and much more recent than that of allergic bronchopulmonary aspergillosis (ABPA). Their association has been reported very rarely in the literature. Methods The aim of this study was to present a review of 6 cases of AFS associated with ABPA from a series of 12 cases of AFS and to compare AFS associated with ABPA and isolated AFS. Results All cases of AFS presented with chronic rhinosinusitis. The six cases with AFS and ABPA were atopic, asthmatic, with pulmonary infiltrates (five cases), central bronchiectasis (four cases), and both (three cases). The mycological and immunoallergological features of isolated AFS and AFS associated with ABPA were similar: eosinophilic allergic mucin with noninvasive fungi hyphae, high levels of blood eosinophils, total IgE, specific IgE, IgG, and positive skin tests to Aspergillus. The association of AFS and ABPA was concomitant (two cases) or remote in time (four cases). The treatment with oral corticosteroids and sinus surgery (six cases) associated with antifungal drugs (four cases) led to resolution in three cases, considerable improvement in one case, and therapeutic failure in two cases (follow-up longer than 5 years in all cases). Conclusion Independently of the signs linked to the organs involved (sinuses and bronchi) the mycological and immunoallergological features were similar for AFS and AFS associated with ABPA. AFS and ABPA can be isolated or associated in a sinobronchial allergic mycosis.

Lipid Transfer Protein Sensitization: Risk of Anaphylaxis and Molecular Sensitization Profile in Pru p 3-Sensitized Patients

2020 ◽  
pp. 1-8
Author(s):  
Maria Ruano-Zaragoza ◽  
Maria Luisa Somoza ◽  
Teodorikez Wilfox Jiménez-Rodriguez ◽  
Victor Soriano-Gomis ◽  
Purificación González-Delgado ◽  
...  
Keyword(s):  
Lipid Transfer Protein ◽  
Allergic Diseases ◽  
Specific Ige ◽  
Oral Allergy Syndrome ◽  
Skin Tests ◽  
Food Allergies ◽  
Lipid Transfer ◽  
Cross Sectional ◽  
Positive Skin ◽  
Pru P 3

<b><i>Background:</i></b> Component-resolved diagnosis reveals the IgE response to many inhaled, food, and other allergens, improving the understanding and diagnosis of allergic diseases. <b><i>Objective:</i></b> The aims of the study are to study the recognition of different lipid transfer proteins (LTPs) and other allergen families in a large group of people sensitized to Pru p 3 and to analyze the relationship between the clinical entities and the allergens. <b><i>Methods:</i></b> This cross-sectional study included a large cohort of patients with positive skin tests to peach fruit and Pru p 3 specific IgE antibodies. Respiratory and food allergy symptoms were collected, and we performed prick tests with pollen, plant food, and other allergens plus the ImmunoCAP ISAC assay. <b><i>Results:</i></b> Our sample consisted of 421 people with a mean age of 33.25 years (range 16–68); 54.6% were women. Clinical entities included anaphylaxis (37.1%), urticaria (67.9%), and oral allergy syndrome (59.1%). Rhinitis, rhinoconjunctivitis, and/or asthma were diagnosed in 71.8% of the participants. The most pronounced correlation existed between sensitization to Pru p 3 and to Jug r 3, Pla a 3, Ara h 9, and Cor a 8. We found a higher incidence of anaphylaxis in people with 5 or more recognized LTPs. No association was observed between inhaled and food allergies. <b><i>Conclusion:</i></b> Most Pru p 3-sensitized participants were sensitized to additional allergens from the same family and, to a lesser extent, to other allergens, mainly in the profilin and PR-10 protein families. Anaphylaxis occurred in more than a third of the cases evaluated, and almost three-quarters of them had respiratory symptoms. Respiratory and food allergies involving LTPs do not seem to be associated.

scholarly journals Peculiarities of non-allergic rhinitis with eosinophilia syndrome

2015 ◽  
Vol 12 (4) ◽  
pp. 3-7
Author(s):  
V A Utesheva ◽  
G P Bondareva ◽  
A I Kryukov ◽  
T G Barkhina
Keyword(s):  
Allergic Rhinitis ◽  
Nasal Mucosa ◽  
Specific Ige ◽  
Skin Tests ◽  
Eosinophilic Infiltration ◽  
Eosinophilic Inflammation ◽  
Nonallergic Rhinitis ◽  
Provocation Tests ◽  
Nasal Provocation ◽  
Non Allergic Rhinitis

Nonallergic rhinitis with eosinophilia syndrome (NARES) is a syndrome containing the symptoms similar to allergic rhinitis, with absence of atopy and the presence of eosinophila more than 20% in smears from nasal mucosa. Pathophysiology of NARES has not been studied completely, but permanent eosinophilic inflammation is the keystone of NARES pathogenesis. This disease is marked by local eosinophilic infiltration without atopy, confirmed by negative skin tests, normal levels of total and specific IgE in serum, negative nasal provocation tests with allergens. Nowadays this nosology is considered to be poorly understood.

scholarly journals Diseases connected with work in hay in Iceland. Causes and scientific studies

2021 ◽  
Vol 107 (03) ◽  
pp. 130-136
Author(s):  
Davíð Gíslason ◽  
◽  
Tryggvi Ásmundsson ◽  
Þórarinn Gíslason ◽  
◽  
...  
Keyword(s):  
Specific Ige ◽  
House Dust Mites ◽  
Skin Tests ◽  
Dust Mites ◽  
Storage Mites ◽  
Thermophilic Actinomycetes ◽  
Positive Skin ◽  
Long Time ◽  
Precipitin Test ◽  
Farming Families

Diseases connected with work in hay have been known in Iceland for a long time. In 1981 scientific studies of these diseases were started in Iceland at the request of the Farmers Union. The results of these studies are summarized in this article. In studies of hay a great amount of storage mites, moulds and thermophilic actinomycetes (microlyspora faeni) were found in addition to allergens from mice and pollen. Symptoms caused by hay dust were mainly from nose and eyes in people with positive skin tests, but cough, dyspnea and fever were equally common in those with negative skin tests. The most common causes of allergy in farming families were storage mites and cattle, but allergy to cats, dogs and grass pollen were less common rurally than in the Reykjavik area. When comparing individuals working in heavy hay dust with those working in cleaner air, the former group had a higher likelihood of having a positive precipitin test against micropolyspora faeni, fever after work in hay and airway obstruction. It was shown that Icelandic farmers were more likely to get emphysema than other people irrespective of smoking. In a large study of homes in the Reykjavik area almost no mites were found. In spite of this, positive specific IgE tests against dust mites were equally common as in Uppsala, Sweden, where dust mites were found in 16% of homes. In further studies it was found, that 57% of people in the study had been more and less exposed to hay dust. They had either been raised on a farm, been on a farm in the summer during childhood or owned horses and fed them with hay. We have argued that cross allergy to storage mites may be the cause of a rather common allergy to house dust mites. A new study of middle-aged individuals has shown that allergy to storage mites is a little more common in the Reykjavik area than in Aarhus, Bergen or Uppsala. The most likely explanation is that they have more often been exposed to hay dust.

Significance of Borderline Levels of Specific IgE obtained by FAST-Plus Assay

1992 ◽  
Vol 106 (3) ◽  
pp. 250-253 ◽  
Author(s):  
Richard L. Mabry ◽  
Cynthia S. Mabry
Keyword(s):  
Skin Test ◽  
Specific Ige ◽  
Skin Tests ◽  
In Vitro Assays ◽  
Test Results ◽  
Positive Skin ◽  
Glycerine Concentration ◽  
Current Standards

The significance of “borderline” levels of allergen-specific IgE as measured by in vitro assays has been questioned. Patients whose specific IgE tests Patients were tested for twelve antigens using the FAST-Plus methodology. All 0/1 results were checked using skin tests at a 1:500 concentration. Positive (histamine) and negative (diluent) controls were used. The antigen-induced wheals were compared with those produced by a control wheal of 2% glycerine (the glycerine concentration in a 1:500 dilution). Positive wheals were arbitrarily considered to be those whose diameter after 10 minutes exceeded that of the glycerine control wheal by 2 mm or more. Using the limits of calibrator fluorescence for the FAST-Plus test in effect before 1990, a significant discordance between skin test results and the class 0/1 in vitro readings was evident. Using the standards in effect since 1990, marked concordance between class 0/1 results and positive skin tests was noted. This was most marked for pollens, less so for molds. Using current standards, FAST-Plus class 0/1 results are best considered positive (pending clinical confirmation), rather than negative.

scholarly journals Detection of IgE-antibodies to recombinant birch allergens rBet v 1 and rBet v 2 in patients withsensitization to birch pollen

2011 ◽  
Vol 8 (4) ◽  
pp. 45-48
Author(s):  
M A Mokronosova ◽  
A V Sergeev ◽  
E S Korovkina ◽  
N G Konyukova ◽  
M A Mokronosova ◽  
...  
Keyword(s):  
Birch Pollen ◽  
Clinical History ◽  
Specific Ige ◽  
Skin Tests ◽  
Recombinant Allergen ◽  
Antibody Testing ◽  
Positive Skin ◽  
Ige Antibodies ◽  
Birch Tree ◽  
Skin Prick Tests

Background. Allergic diagnosis is based on accurate clinical history and conducting of skin prick tests (sPt) and specific IgE determination. the past decade recombinant allergen components from pollen of birch are available for allergen-specific IgE antibody testing. the major allergen of birch tree pollen is Bet v 1; Bet v 2 is a well described minor allergen. Methods. 83 patients with birch pollinosis (55 male/28 female, age 4-35 years, mean 15,5) were observed. specific IgE levels were determined by using the ImmunoCap (Phadia, sweden); skin prick tests with standard aeroallergens panel was used. Results. All 83 patients had positive skin tests to birch pollen. the levels of specific IgE to rBet v1 had 87,9% of patients, sIgE to rBet v 2 (profilin) 14,5% of patients, sIgE to rBet v 1 and rBet v 2 13,3% of patients. Conclusion. the prevalence of the patients with presence of IgE - antibodies to profiling Bet v2 among citizens of moscow region, sensitized to birch, accounts 14,5%.

Penicillin Hypersensitivity

1979 ◽  
Vol 1 (5) ◽  
pp. 132-158
Keyword(s):  
Skin Test ◽  
Multicenter Study ◽  
Positive Skin Test ◽  
Penicillin Allergy ◽  
Skin Tests ◽  
Penicillin G ◽  
Positive Skin ◽  
Positive History ◽  
History Of

A (massive) multicenter study of 3,000 patients has demonstrated that skin tests to penicillin G and penicilloyl-polylysine (PPL-now commercially available) predict and confirm penicillin allergy. Of patients with a history of penicillin reaction, 19% were positive to either, compared to 7% of controls. A history of anaphylaxis led to 46% positive. Of those with a history of urticaria 17% were positive, and those with maculopapular eruptions did not differ from controls (7% positive). Challenge with penicillin led to a reaction in 6% with a positive history (compared to 2% with a negative) and 67% with a combined positive history and positive skin test (to either).

Anaphylaxis to the 23-valent pneumococcal vaccine in child: a case-control study based on immediate responses in skin tests and specific IgE determination

Vaccine ◽  
2001 ◽  
Vol 19 (32) ◽  
pp. 4588-4591 ◽  
Author(s):  
Claude Ponvert ◽  
Delia Ardelean-Jaby ◽  
Anne-Marie Colin-Gorski ◽  
Bruno Soufflet ◽  
Christine Hamberger ◽  
...  
Keyword(s):  
Pneumococcal Vaccine ◽  
Case Control Study ◽  
Specific Ige ◽  
Case Control ◽  
Skin Tests ◽  
Ige Determination ◽  
Control Study
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