scholarly journals Clinical and laboratory features in young patients with bronchial asthma and obesity

2015 ◽  
Vol 12 (5) ◽  
pp. 9-16
Author(s):  
I V Demko ◽  
E A Sobko ◽  
I A Soloveva ◽  
A Yu Kraposhina ◽  
O P Ishenko ◽  
...  
Keyword(s):  
Bronchial Asthma ◽  
Cellular Structure ◽  
Young Patients ◽  
External Respiration ◽  
Laboratory Features ◽  
Alimentary Obesity ◽  
Functional Features ◽  
Body Weight Index ◽  
Respiration Function ◽  
Healthy Persons

Background. To study the clinical and functional features in interrelationship between the level of proinflammatory and antiinflammatory cytokines in young patients with bronchial asthma and alimentary obesity for optimization of therapy. Methods. 133 persons were examined: 93 patients with bronchial asthma were divided into 2 groups depending on body weight index (BWI): the 1st group included patients with bronchial asthma with BWI less than 25 kg/m2, the 2nd group included patients with bronchial asthma with BWI 30 kg/m2 and more. The group of control included 40 almost healthy persons. We studied external respiration function, cellular structure of the induced sputum, the level of TNFα, IL-2, IL-4, IL-6, IL-15, Creactive protein in blood. Results. The results of cytokines at patients with bronchial asthma depending on BWI out of an exacerbation of the disease within the last 2 months. We found the signs of more significant systemic inflammation in the group with obesity the increasing of the level of IL2, IL6, TNFa and Creactive protein in plasma was found. Conclusion. We found that there was more sever course of bronchial asthma in young patients with obesity, decreased external respiration functions, increased level of proinflammatory cytokines and proteins of acute phase in peripheral blood.

External respiration function in children with atopic dermatitis

1998 ◽  
Vol 79 (4) ◽  
pp. 282-285
Author(s):  
A. M. Potemkin ◽  
T. V. Klykova ◽  
I. A. Blonde
Keyword(s):  
Risk Factors ◽  
Atopic Dermatitis ◽  
Bronchial Asthma ◽  
Preventive Measures ◽  
External Respiration ◽  
Respiration Function

The data on the frequency of revealing the bronchial permeability disorders are presented and the mechanisms of its development in children with atopic dermatitis not having clinically bronchoobstructive syndrome in anamnesis are studied. In children with atopic dermatitis the main risk factors of the bronchial asthma development are shown and the possibilities of revealing its early preclinical signs are determined. It is significant in prevention of the bronchial asthma development in timely performance of specific preventive measures.

scholarly journals Features of cellular structure of the induced sputum and profile of cytokines at sintropiya of bronchial asthma and obesity at young patients

2018 ◽  
Vol 90 (3) ◽  
pp. 25-32
Author(s):  
I A Soloveva ◽  
E A Sobko ◽  
I V Demko ◽  
A Yu Kraposhina ◽  
M M Loktionova ◽  
...  
Keyword(s):  
Bronchial Asthma ◽  
Cellular Structure ◽  
Young Patients ◽  
Induced Sputum ◽  
World Health ◽  
Specific Patient ◽  
Antiinflammatory Therapy ◽  
Tnf Α ◽  
Severity Of The Disease ◽  
Health Organization

Aim. To estimate changes of cellular structure of the induced sputum at young patients with bronchial asthma at interrelations with BMI and level of cytokines in blood plasma. Materials and methods. 164 patients with bronchial asthma were divided into 2 groups taking into BMI: the 1st group included patients with bronchial asthma and BMI from 18 to 25 kg/m2, patients with bronchial asthma and BMI from 30 to 40 kg/m2 entered into the 2nd group. The group of control was made by 40 almost healthy volunteers. Estimated existence of excess weight and defined obesity degree according to recommendations of World Health Organization. Studied the level of control of bronchial asthma, cellular structure of the induced sputum, the IL-2, IL-4, IL-6, IL-8, IL-10, IL-12, IL-15, IL-17, TNF-α, INF-γ levels in plasma of peripheral blood. Results. There are presented the results of the research of cellular profile of the induced sputum and profile of cytokines at patients with bronchial asthma depending on BMI and severity of the disease. The received results testify to prevalence of eosinophilic type of an inflammation in the group of patients with BMI less than 25 kg/m2 whereas at patients mainly paucigranulation inflammation decided on obesity. The highest content of the Il-17 was registered at patients with bronchial asthma and obesity as in comparison with indicators of patients with normal BMI, and with almost healthy that, perhaps, is the reason of low effect of steroid therapy at these patients. Conclusion. Endotype assessment before basic antiinflammatory therapy at patients with the first time diagnosed bronchial asthma, will be able to help with selection of the most optimum treatment to each specific patient.

Clinical and functional peculiarities at patients with bronchial asthma, chronic obstructive pulmonary disease and overlap of asthma-chronic obstructive pulmonary disease

2020 ◽  
Vol 24 (4) ◽  
pp. 80-86
Author(s):  
V. I. Trofimov ◽  
D. Z. Baranov
Keyword(s):  
Chronic Obstructive Pulmonary Disease ◽  
Pulmonary Disease ◽  
Bronchial Asthma ◽  
Blood Test ◽  
Chronic Obstructive ◽  
Inflammation Markers ◽  
Obstructive Pulmonary Disease ◽  
Copd Patients ◽  
Functional Features ◽  
Lower Airways

BACKGROUND: a comparative analysis of laboratory and instrumental tests at patients with bronchial obstructive diseases seems very actual due to the wide prevalence of these diseases. THE AIM: to evaluate characteristics of spirometry as well as allergic (total IgE, sputum eosinophils) and infectious (blood and sputum leucocytes, ESR, CRP, fibrinogen) inflammation markers at patients with bronchial obstructive diseases. PATIENTS AND METHODS: 104 case histories of patients with bronchial asthma, chronic obstructive pulmonary disease and overlap were analyzed including age, duration of smoking (pack-years), laboratory (clinical blood test, biochemical blood test, general sputum analysis, sputum culture) and instrumental (spirometry, body plethysmography, echocardiography) tests. Data were processed statistically with non-parametric methods. RESULTS: COPD patients were older than other groups’ patients, had the highest pack-years index. ACO patients were marked with maximal TLC and Raw, minimal FEV1, FEF25-75, FEV1/FVC. Patients with COPD had the highest inflammation markers (leucocyte count, CRP, fibrinogen). CONCLUSION: high active inflammation may cause severe lower airways possibility disorders at patients with COPD. Data related to a possible role of K. pneumoniaе in the pathogenesis of eosinophilic inflammation in lower airways are of significant interest. Patients with ACO occupy an intermediate position between asthma and COPD patients based on clinical and functional features.

scholarly journals ANALYSIS OF DIAGNOSTIC PARAMETERS OF RESPIRATORY FAILURE IN PATIENTS WITH BRONCHIAL ASTHMA

2015 ◽  
Vol 4 (2) ◽  
pp. 10-12
Author(s):  
Dmitry Alexandrovich Anisimov ◽  
Lyudmila Nikitichna Goncharov ◽  
Anna Albertovna Dyachkova
Keyword(s):  
Respiratory Failure ◽  
Bronchial Asthma ◽  
Clinical Laboratory ◽  
Pathological Condition ◽  
External Respiration ◽  
Clinical Parameters ◽  
Arterial Blood ◽  
Criteria For Diagnosis ◽  
Invasive Techniques ◽  
Instrumental Methods

Respiratory failure (NAM)-a pathological condition in which there is provided the maintenance of normal blood gas or it is achieved through more intensive operation of external respiration and heart, resulting in decreased functional capacity of the organism [1,2]. The main method of diagnosis of DN is the study of the gas composition of the arterial blood, but because of the complexity of the analysis, which involves complex invasive techniques for obtaining arterial blood by puncture of a major artery in the therapeutic Department is not carried out [1,3]. A plurality of classifications days, the lack of clear criteria for diagnosis was to analyze assessment days by a combination of clinical, laboratory and instrumental methods patient days. As a model of acute respiratory failure were selected from patients with mild intermittent and persistent severity of asthma, which bore a slight aggravation, burdened days 1 severity, number of 30 people. SatO2 blood was the criterion for assessing the severity of DN. In the evaluation of clinical parameters, such as shortness of breath and respiratory rate, it was revealed that the values of these parameters increase is inversely proportional to the drop SatO2 blood. In assessing such clinical parameters as the rate of breathing and instrumental measure FEV1 did not find such dependence. Thus, to assess the severity of DN in patients with bronchial asthma it is necessary to conduct a comprehensive analysis of the clinical and instrumental methods.

scholarly journals Peculiarities of Carbohydrate Exchange in Patients with Generalized Periodontitis of Young Age Persons

2018 ◽  
Vol 25 (2) ◽  
Author(s):  
Halyna Kimak ◽  
Halyna Melnychuk ◽  
Hanna Ersteniuk
Keyword(s):  
Lactic Acid ◽  
Lactate Dehydrogenase ◽  
Carbohydrate Metabolism ◽  
Young Patients ◽  
Young Age ◽  
Lactate Dehydrogenase Activity ◽  
Significant Difference ◽  
Oral Liquid ◽  
Lactate Levels ◽  
Healthy Persons

There were studied 92 somatically healthy persons of young age (18-25 years old), with generalized periodontitis (GP) of initial-I degree of development, among them: 30 patients with chronic generalized periodontitis (CGP), who were included into group І; and 32 patients with exacerbation of the chronic generalized periodontitis (ECGP) – into group II; and 30 healthy patients. The carbohydrate metabolism indexes were studied, namely: the content of glucose, pyruvate (pyruvic acid) and lactate (lactic acid) and lactate dehydrogenase activity (LDG) in the oral liquid.We have determined that in the presence of CGP of the initial-I degree of development, and especially in its exacerbation, there is a significant increase of indicators of carbohydrate metabolism. In young patients with CGP indicators of glucose, pyruvate, lactate and LDG activity in the oral liquid increased by 2.0, 1.34, 1.58 and 1.37 (p<0.001, p<0.01) times respectively, and in case of ECGP they grew even more: by 2.71, 1.98, 1.76 and 2.07 (p<0.001) times, respectively.Among all the indicators, that characterize the carbohydrate metabolism, in addition to the level of pyruvate, in case of different course of GP a significant difference was revealed: in patients with ECGP compared with the data in CGP, glucose and lactate levels and LDG activity in the oral liquid were significantly higher - at 35.75% (p<0.05), 34.29% (p<0.01) and 36.59% (p<0.001) respectively.Detected violations of carbohydrate metabolism indeces in the oral liquid indicate the involvement of these processes in the pathogenesis of GP and the necessity of their correction. 

scholarly journals The role of integrated assessment of the indicators of external respiration function in cardiac surgical patients

2017 ◽  
Vol 89 (9) ◽  
pp. 109-114
Author(s):  
O V Kamenskaja ◽  
A S Klinkova ◽  
I Ju Loginova ◽  
V V Lomivorotov ◽  
D N Ponomarev ◽  
...  
Keyword(s):  
Integrated Assessment ◽  
Pulmonary Ventilation ◽  
Surgical Patients ◽  
External Respiration ◽  
Diffusing Capacity ◽  
Body Plethysmography ◽  
Operational Risks ◽  
Respiration Function

This literature review dedicated to the importance of an integrated assessment of external respiratory function in cardiovascular diseases (CVDs), including an analysis of up-to-date techniques, such as spirometry, body plethysmography, examination of the diffusing capacity of the lung, determination of O2 consumption with evaluation of the effectiveness of pulmonary ventilation. It considers the pathogenetic components of impairments in pulmonary ventilation and gas exchange, which develop in different CVDs, as well as during and after cardiac surgery. The authors analyze the results of international investigations and their own experience, which emphasize the prognostic value of lung function tests and suggest that there is a need for a comprehensive functional assessment of the respiratory system in cardiac surgical patients for their effective preoperative preparation, assessment and reduction of operational risks, and improvement of the prognosis of surgical treatment.

Correction of pyrimidine derivatives of immunologic activity of the organism and external respiration function for prevention of the lingering course of acute pneumonia

1993 ◽  
Vol 74 (3) ◽  
pp. 193-197
Author(s):  
Yu. D. Slabnov ◽  
D. A. Valimukhametova ◽  
A. P. Tsibulkin ◽  
R. F. Khamitov
Keyword(s):  
Side Effects ◽  
Combined Treatment ◽  
External Respiration ◽  
Pyrimidine Derivatives ◽  
Acute Pneumonia ◽  
Cellular And Humoral Immunity ◽  
Immunologic Activity ◽  
Derivatives Of ◽  
Respiration Function ◽  
Stabilization Period

The effect of xymedon on immunologic indices and external respiration function in combined treatment of patients with acute pnemonia is studied. The use of xymedon in the presence of basis therapy in patients with lingering pneumonia with reduced immunologic reactivity exerts a stimulating effect on the indices of cellular and humoral immunity. This effect is revealed in the stabilization period of pneumonia accompanied by positive clinicoroentgenologic shifts, provides a higher increase of the indices of external respiration function, reduces the terms of recovery of patients. Xymedon does not cause side effects. The drug may be recommended for a wider use in the clinic in patients with unspecific diseases of the lungs.

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