Non-steroidal anti-inflammatory drugs (NSAIDs) – exacerbated respiratory disease: epidemiology, pathogenesis, clinical findings and management

2020 ◽  
Vol 17 (3) ◽  
pp. 15-33
Author(s):  
Ksenia S. Pavlova ◽  
Miramgul E. Dyneva ◽  
Oksana M. Kurbacheva
Keyword(s):  
Respiratory Disease ◽  
Oral Corticosteroid ◽  
Nasal Congestion ◽  
Clinical Findings ◽  
Eosinophilic Inflammation ◽  
Disease Epidemiology ◽  
Eosinophilic Chronic Rhinosinusitis ◽  
Inflammatory Drugs ◽  
Anti Inflammatory ◽  
Oral Corticosteroid Therapy

Non-steroidal anti-inflammatory drugs (NSAIDs) exacerbated respiratory disease (N-ERD) are characterized by non-allergic hypersensitivity (intolerance) to NSAIDs and aspirin in patients with asthma and/or eosinophilic chronic rhinosinusitis with nasal polyps (CRSwNP). Asthma in N-ERD patients is usually characterized by eosinophilic inflammation, tends to become severe and intractable, and needs chronic oral corticosteroid therapy. For some patients recurrent CSwNP is more significant problem due to nasal congestion, anosmia, and multiple repeated surgeries. Intolerance to aspirin and other NSAIDs limits the choice of pain relievers and antipyretics. Accidental use of these medications can lead to dangerous consequences, including anaphylaxis. This review presents the current understanding of the N-ERD pathogenesis and perspective trends in therapy.

Colchicine Therapy in Sarcoid Arthropathy

PEDIATRICS ◽  
1986 ◽  
Vol 78 (4) ◽  
pp. 717-718
Author(s):  
ISRAEL RUBINSTEIN ◽  
GERALD L. BAUM
Keyword(s):  
Oral Corticosteroid ◽  
Bed Rest ◽  
Dramatic Improvement ◽  
Adequate Response ◽  
Limited Success ◽  
Inflammatory Drugs ◽  
Anti Inflammatory ◽  
Oral Corticosteroid Therapy ◽  
Low Dosage ◽  
Colchicine Therapy

To the Editor.— We read with great interest the article by Lindsley and Godfrey1 but wish to disagree with one of their conclusions. They suggested that oral corticosteroid therapy is the treatment of choice in sarcoid arthropathy because salicylate and other nonsteroidal anti-inflammatory drugs have only limited success in such cases. We believe, however, that this is not the case, because low-dosage colchicine therapy has provided good results in the agement of both the acute and chronic forms of sarcoid arthropathy when there was no adequate response to nonsteroidal anti-inflammatory agents and bed rest. Colchicine was first used in the treatment of sarcoid arthropathy by Kaplan,2,3 who reported a dramatic improvement, usually within a few days, with the use of 0.5 mg of oral colchicine daily. Subsequently, maintenance oral therapy with colchicine, 1 to 2 mg/d, was introduced to treat the chronic form of the disease, with similar beneficial results.3-7

Nonsteroidal anti-inflammatory drugs-exacerbated respiratory disease in adolescents

2015 ◽  
Vol 5 (5) ◽  
pp. 392-398 ◽  
Author(s):  
Hacer Ilbilge Ertoy Karagol ◽  
Ozlem Yilmaz ◽  
Erdem Topal ◽  
Alper Ceylan ◽  
Arzu Bakirtas
Keyword(s):  
Respiratory Disease ◽  
Inflammatory Drugs ◽  
Anti Inflammatory

Identification of phenotypic clusters of nonsteroidal anti-inflammatory drugs exacerbated respiratory disease

Allergy ◽  
2016 ◽  
Vol 72 (4) ◽  
pp. 616-626 ◽  
Author(s):  
H. Y. Lee ◽  
Y. M. Ye ◽  
S. H. Kim ◽  
G. Y. Ban ◽  
S. C. Kim ◽  
...  
Keyword(s):  
Respiratory Disease ◽  
Inflammatory Drugs ◽  
Anti Inflammatory

OUTCOMES OF SHORT-COURSE ORAL CORTICOSTEROID WITH NON-STEROIDAL ANTI-INFLAMMATORY DRUGS FOR EARLY STAGE OFFROZEN SHOULDER AT KOSHI ZONAL HOSPITAL

2018 ◽  
Vol 5 (3) ◽  
pp. 246
Author(s):  
Yagya RajKharel ◽  
Shambhu Sah ◽  
Rem Kumar Rai ◽  
Nabin Subedi ◽  
Anurag Raj Adhikari ◽  
...  
Keyword(s):  
Oral Corticosteroid ◽  
Early Stage ◽  
Short Course ◽  
Inflammatory Drugs ◽  
Anti Inflammatory

Can nasal acetylsalicylic acid challenge predict the severity of non-steroidal anti-inflammatory drugs (NSAIDs)-exacerbated respiratory disease (N-ERD)?

2020 ◽  
Vol 4 (01) ◽  
pp. 135-143
Author(s):  
Ulrike Förster-Ruhrmann ◽  
Anne-Kristin Tietz ◽  
Jonghui Kim ◽  
Uta Liebers ◽  
Agnieszka J. Szczepek ◽  
...  
Keyword(s):  
Acetylsalicylic Acid ◽  
Respiratory Disease ◽  
Inflammatory Drugs ◽  
Anti Inflammatory ◽  
Acid Challenge

scholarly journals Artificial neural network identifies nonsteroidal anti‐inflammatory drugs exacerbated respiratory disease (N‐ERD) cohort

Allergy ◽  
2020 ◽  
Vol 75 (7) ◽  
pp. 1649-1658
Author(s):  
Katarzyna Ewa Tyrak ◽  
Kinga Pajdzik ◽  
Ewa Konduracka ◽  
Adam Ćmiel ◽  
Bogdan Jakieła ◽  
...  
Keyword(s):  
Neural Network ◽  
Artificial Neural Network ◽  
Respiratory Disease ◽  
Inflammatory Drugs ◽  
Artificial Neural ◽  
Anti Inflammatory

scholarly journals Problems of prescribing nonsteroidal anti-inflammatory drugs for reproductive-aged women with ankylosing spondylitis

2020 ◽  
Vol 14 (3) ◽  
pp. 132-139
Author(s):  
O. A. Krichevskaya ◽  
T. V. Dubinina ◽  
A. E. Karateev
Keyword(s):  
Ankylosing Spondylitis ◽  
Reproductive System ◽  
Clinical Findings ◽  
Nsaid Therapy ◽  
Spontaneous Abortions ◽  
Female Reproductive System ◽  
First Line ◽  
Inflammatory Drugs ◽  
Anti Inflammatory ◽  
Reproductive Aged Women

Nonsteroidal anti-inflammatory drugs (NSAIDs) are the first-line medications for ankylosing spondylitis (AS); their action is associated with blockade of the enzyme cyclooxygenase 2 and with a mediated decrease in the synthesis of prostaglandins (PGs). However, PGs play an important role in regulating the functions of the female reproductive system. The paper presents an update on the participation of PG in folliculogenesis, ovulation, implantation, and development of the embryo, and labor activity. Based on experimental and clinical findings, the authors discuss whether due to inhibition of the synthesis of PGs, NSAIDs are able to cause ovulation failure, including luteinized unovulated follicle syndrome and spontaneous abortions. Further investigation is justified to determine the most optimal NSAID therapy regimens when planning pregnancy and during gestation in women with AS.

scholarly journals Sputum biomarkers during aspirin desensitization in nonsteroidal anti-inflammatory drugs exacerbated respiratory disease

2019 ◽  
Vol 152 ◽  
pp. 51-59 ◽  
Author(s):  
Katarzyna Ewa Tyrak ◽  
Izabela Kupryś-Lipińska ◽  
Ewa Czarnobilska ◽  
Bogdan Jakieła ◽  
Kinga Pajdzik ◽  
...  
Keyword(s):  
Respiratory Disease ◽  
Aspirin Desensitization ◽  
Inflammatory Drugs ◽  
Anti Inflammatory
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