Identification of phenotypic clusters of nonsteroidal anti-inflammatory drugs exacerbated respiratory disease

Allergy ◽  
2016 ◽  
Vol 72 (4) ◽  
pp. 616-626 ◽  
Author(s):  
H. Y. Lee ◽  
Y. M. Ye ◽  
S. H. Kim ◽  
G. Y. Ban ◽  
S. C. Kim ◽  
...  
Keyword(s):  
Respiratory Disease ◽  
Inflammatory Drugs ◽  
Anti Inflammatory

Nonsteroidal anti-inflammatory drugs-exacerbated respiratory disease in adolescents

2015 ◽  
Vol 5 (5) ◽  
pp. 392-398 ◽  
Author(s):  
Hacer Ilbilge Ertoy Karagol ◽  
Ozlem Yilmaz ◽  
Erdem Topal ◽  
Alper Ceylan ◽  
Arzu Bakirtas
Keyword(s):  
Respiratory Disease ◽  
Inflammatory Drugs ◽  
Anti Inflammatory

Non-steroidal anti-inflammatory drugs (NSAIDs) – exacerbated respiratory disease: epidemiology, pathogenesis, clinical findings and management

2020 ◽  
Vol 17 (3) ◽  
pp. 15-33
Author(s):  
Ksenia S. Pavlova ◽  
Miramgul E. Dyneva ◽  
Oksana M. Kurbacheva
Keyword(s):  
Respiratory Disease ◽  
Oral Corticosteroid ◽  
Nasal Congestion ◽  
Clinical Findings ◽  
Eosinophilic Inflammation ◽  
Disease Epidemiology ◽  
Eosinophilic Chronic Rhinosinusitis ◽  
Inflammatory Drugs ◽  
Anti Inflammatory ◽  
Oral Corticosteroid Therapy

Non-steroidal anti-inflammatory drugs (NSAIDs) exacerbated respiratory disease (N-ERD) are characterized by non-allergic hypersensitivity (intolerance) to NSAIDs and aspirin in patients with asthma and/or eosinophilic chronic rhinosinusitis with nasal polyps (CRSwNP). Asthma in N-ERD patients is usually characterized by eosinophilic inflammation, tends to become severe and intractable, and needs chronic oral corticosteroid therapy. For some patients recurrent CSwNP is more significant problem due to nasal congestion, anosmia, and multiple repeated surgeries. Intolerance to aspirin and other NSAIDs limits the choice of pain relievers and antipyretics. Accidental use of these medications can lead to dangerous consequences, including anaphylaxis. This review presents the current understanding of the N-ERD pathogenesis and perspective trends in therapy.

Can nasal acetylsalicylic acid challenge predict the severity of non-steroidal anti-inflammatory drugs (NSAIDs)-exacerbated respiratory disease (N-ERD)?

2020 ◽  
Vol 4 (01) ◽  
pp. 135-143
Author(s):  
Ulrike Förster-Ruhrmann ◽  
Anne-Kristin Tietz ◽  
Jonghui Kim ◽  
Uta Liebers ◽  
Agnieszka J. Szczepek ◽  
...  
Keyword(s):  
Acetylsalicylic Acid ◽  
Respiratory Disease ◽  
Inflammatory Drugs ◽  
Anti Inflammatory ◽  
Acid Challenge

scholarly journals Artificial neural network identifies nonsteroidal anti‐inflammatory drugs exacerbated respiratory disease (N‐ERD) cohort

Allergy ◽  
2020 ◽  
Vol 75 (7) ◽  
pp. 1649-1658
Author(s):  
Katarzyna Ewa Tyrak ◽  
Kinga Pajdzik ◽  
Ewa Konduracka ◽  
Adam Ćmiel ◽  
Bogdan Jakieła ◽  
...  
Keyword(s):  
Neural Network ◽  
Artificial Neural Network ◽  
Respiratory Disease ◽  
Inflammatory Drugs ◽  
Artificial Neural ◽  
Anti Inflammatory

scholarly journals Sputum biomarkers during aspirin desensitization in nonsteroidal anti-inflammatory drugs exacerbated respiratory disease

2019 ◽  
Vol 152 ◽  
pp. 51-59 ◽  
Author(s):  
Katarzyna Ewa Tyrak ◽  
Izabela Kupryś-Lipińska ◽  
Ewa Czarnobilska ◽  
Bogdan Jakieła ◽  
Kinga Pajdzik ◽  
...  
Keyword(s):  
Respiratory Disease ◽  
Aspirin Desensitization ◽  
Inflammatory Drugs ◽  
Anti Inflammatory

scholarly journals IL10 rs1800872 Is Associated with Non-Steroidal Anti-Inflammatory Drugs Exacerbated Respiratory Disease in Mexican-Mestizo Patients

Biomolecules ◽  
2020 ◽  
Vol 10 (1) ◽  
pp. 104
Author(s):  
Gandhi Fernando Pavón-Romero ◽  
Gloria Pérez-Rubio ◽  
Fernando Ramírez-Jiménez ◽  
Enrique Ambrocio-Ortiz ◽  
Cristian Rubén Merino-Camacho ◽  
...  
Keyword(s):  
Respiratory Disease ◽  
Association Studies ◽  
Genetic Association Studies ◽  
Control Group ◽  
Nucleotide Polymorphisms ◽  
Mexican Mestizo ◽  
Second Stage ◽  
Inflammatory Drugs ◽  
Anti Inflammatory ◽  
Two Stages

Non-steroidal anti-inflammatory drugs (NSAID) exacerbated respiratory disease (N-ERD) is a disease integrated by asthma, nasal polyps, and hypersensitivity to non-steroidal anti-inflammatory drugs (NSAID). Genetic association studies have explored single nucleotide polymorphisms (SNPs) in genes involved in theoretical pathophysiological mechanisms, but most of these lack replication of findings in second populations. Our objective was to evaluate the association of SNPs in candidate genomic regions described in Asian and European subjects with N-ERD in Mexican-mestizo patients. We designed a replicative study in two stages. We included 381 SNPs selected by fine mapping of associated genes in a microarray, which were tested in three groups: N-ERD (N), asthma (A), and control group (CG); by means of GoldenGate array, positive results by genetic models were validated in the second stage in another population through qPCR with the same methodology. In the allelic model, we identified 11 SNPs in N vs. CG comparison, and five in N vs. A and A vs. CG, respectively. By genetics models, all SNPs in PPARG, rs13239058 in TBXAS1, and rs1554286 and rs1800872 in IL10 were associated in both models. In the second stage, only rs1800872CC showed an association in the dominant model comparing N vs. GC, p = 0.004, OR = 0.44. In conclusion, rs1800872 in IL10 was the only associated with N-ERD in Mexican-mestizo patients.

Sign in / Sign up

Export Citation Format

Share Document