The features of the pollen sensitization in seasonal allergic rhinitis patients with gastrointestinal tract inflammatory diseases comorbidity

2020 ◽  
Vol 17 (3) ◽  
pp. 57-63
Author(s):  
Natalia S. Iraklionova ◽  
Eleonora B. Belan ◽  
Svetlana V. Turkina ◽  
Anna A. Panina ◽  
Tatiana L. Sadchikova ◽  
...  
Keyword(s):  
Allergic Rhinitis ◽  
Gastrointestinal Tract ◽  
Seasonal Allergic Rhinitis ◽  
Inflammatory Diseases ◽  
Skin Prick Testing ◽  
Birch Pollen ◽  
Gastrointestinal Diseases ◽  
Control Group ◽  
Pollen Allergens ◽  
H Pylori

BACKGROUND:Allergic diseases and gastrointestinal tract diseases can influence on the natural course of each other. AIM:To study the sensitization profile in patients with comorbidity of seasonal allergic rhinitis (SAR) and upper gastrointestinal tract inflammatory diseases (UGITID). MATERIALS AND METHODS:112 adult residents of Volgograd city suffering from SAR but without perennial symptoms and sensitization to indoor allergens have been included in the study. 31/112 patients hadH. pylori-negative and 38/112 H. pylori-positive UGITID. Control group consisted of 43/112 patients without gastrointestinal diseases. Skin prick-testing with 3 groups of pollen allergens have been carried out. RESULTS:75.9% of patients were sensitized to weed pollen; sensitization to grass pollen was in 1.53 times less, and 10.5% of patients (4/38) had positive tests with birch pollen. The sensitization to quinoa and ragweed in SAR and H. pylori-UGITID patients was comparable with control group but less common with wormwood, sumpfweed allergens. The sensitization in SAR patients andH. pylori+-UGITID was similar to the control group, but positive SPT with sunflower and corn allergens were rare then in control group. CONCLUSION:Weed pollen allergens prevail in sensitization spectrum of adult Volgograd residents with SAR. Sensitization to goose-foot and ragweed is common less in SAR patients andH. pylori-UGITID but to graminea grass and birch pollen is more often. It may be supposed that the UGITID are predisposing factors to the sensitization to cross-reacting plant food allergens. At the same time supposed immunomodulating action ofH. pylorimake the differences between AR patients withH. pylori+-UGITID orH. pylori-UGITID minor.

scholarly journals FEATURES OF PROINFLAMMATORY CYTOKINE PRODUCTION IN PATIENT WITH COMBINATION OF ALLERGIC RHINITIS AND HELICOBACTER PYLORI-ASSOCIATED PATHOLOGIES

2019 ◽  
Author(s):  
N. Iraklionova ◽  
E. Belan ◽  
S. Turkina ◽  
A. Dotsenko
Keyword(s):  
Allergic Rhinitis ◽  
Gastrointestinal Tract ◽  
Serum Level ◽  
Blood Cell ◽  
Inflammatory Diseases ◽  
Upper Gastrointestinal Tract ◽  
Area Of Interest ◽  
Cell Counts ◽  
H Pylori ◽  
Upper Gastrointestinal

One of the most relevant courses in modern immunology is studying of the importance of pro- and anti-inflammatory cytokines in an immune and inflammatory response. By this moment a lot of data regarding the cytokine status of certain inflammatory processes in gastrointestinal tract were received. But still many questions remain unanswered. Moreover, most of the research concern the studying of the level of cytokines in biopsy materials from different parts of gastrointestinal tract or from the gastric juice itself. This article presents the results of the study of the features of cytokines production in patients with combination of allergic rhinitis and H. pylori-associated diseases of the upper gastrointestinal tract. A total of 225 patients aged 18 to 40 years (mean age was 29,5 ± 6,74 years) were examined. The patients included into the research: 43 patients had allergic rhinitis, 66 patients had inflammatory diseases of the upper gastrointestinal tract (chronic gastritis/gastroduodenitis), 69 patients had allergic rhinitis with concominant inflammatory diseases of the upper gastrointestinal tract. Allocating patients to group was carried out depending on the presence of allergic rhinitis and H. pylori infection. Serum level of IL-6 and IL-8 and complete blood cell counts were evaluated. Statistical significance in difference of frequency in independent groups was determined by Fisher’s exact test or χ2 criteria. It was shown that serum values of IL-6 in H. pylori-negative patients were within the reference interval with single peaks, while the synthesis of this cytokine is significantly increased in patients with H. pylori infection regardless of the presence of allergic pathology. Frequency of elevated serum values of IL-8 were comparable in groups of patients with gastrointestinal diseases, but it was significantly higher than in group of healthy individuals. Interdependence between serum level of IL-8 and white blood cell count was found. This fact is an area of interest for prognosis of development of the inflammatory process. As a result, the serum level of IL-8 in inflammatory diseases of the upper gastrointestinal tract increased regardless of the presence of H. pylori infection and allergic rhinitis, and increase of serum IL-6 level was observed only in H. pylori-positive patients.

ANTICYTOKINE ACTIVITY OF THE PROTOZOA BLASTOCYSTIS SPP

2020 ◽  
pp. 44-48
Author(s):  
Bugero N.V. ◽  
Ilyina N.A. ◽  
Aleksandrova S.M.
Keyword(s):  
Gastrointestinal Tract ◽  
Gastrointestinal Diseases ◽  
Control Group ◽  
Ulcer Disease ◽  
Cytokine Balance ◽  
High Prevalence ◽  
Blastocystis Spp ◽  
High Level ◽  
Eukaryotic Organisms ◽  
High Degree

In addition to the classical pathogens, which are well understood and well identified, new pathogens with the potential to spread epidemiologically are being identified. Some of these little-known organisms are the simplest Blastocystis spp. blastocystostosis. The clinical significance of Blastocystis spp. and its pathogenicity are still under discussion. This parasite belongs to a group of single-celled eukaryotic organisms living in the colon of the human intestine. Blastocystis spp. is known to be found both in people with reduced immune status and in individuals without any clinical manifestation. It has been established that a sufficiently high degree of invasiveness is observed in persons with gastrointestinal tract diseases, dermatosis, allergic reactions, in patients with carriers of the human immunodeficiency virus, etc. Possessing persistence factors, protozoa blastocysts contribute to the inactivation of host defensive mechanisms, providing a stable anthogonistic effect. In recent years, many works have been devoted to the characteristics of the persistent properties of Blastocystis spr., however, individual properties of blastocysts, in particular, anticytokine activity (ACA), have not yet been studied. In this regard, the work studied the anticytokine activity of microorganisms isolated from healthy subjects and patients with gastrointestinal tract diseases. A high prevalence of the studied characteristic in the subjects was shown. The expression of anticytokine activity in the obtained isolates of blastocysts was the highest in the group of persons with gastric ulcer disease, which decreased in the order of duodenal ulcer, chronic cholecystitis, chronic gastritis, etc. The data obtained in this work on the high level of ACA expression in blastocyst isolates obtained from individuals with gastrointestinal diseases as compared with the control group enables to conclude that their exometabolites may influence the local cytokine balance [1], which supports the inflammatory process.

scholarly journals Comparison of Intranasal Hypertonic Dead Sea Saline Spray and Intranasal Aqueous Triamcinolone Spray in Seasonal Allergic Rhinitis

2005 ◽  
Vol 84 (7) ◽  
pp. 426-430 ◽  
Author(s):  
Scott Cordray ◽  
Jim B. Harjo ◽  
Linda Miner
Keyword(s):  
Allergic Rhinitis ◽  
Nasal Mucosa ◽  
Seasonal Allergic Rhinitis ◽  
Dead Sea ◽  
Control Group ◽  
Life Questionnaire ◽  
Intranasal Corticosteroids ◽  
Eye Symptoms ◽  
The Dead ◽  
Positive Effect

Intranasal corticosteroids are well known to be efficacious in the treatment of allergic rhinitis. Nasal irrigation with saline, including hypertonic saline, has long been recommended for the treatment of sinonasal disease, and it has been shown to have a positive effect on the physiology of the nasal mucosa. Until now, no study of the clinical efficacy of intranasal hypertonic Dead Sea saline as a monotherapy for seasonal allergic rhinitis has been reported. We conducted a prospective, randomized, single-blind, placebo-controlled comparison of intranasal hypertonic Dead Sea saline spray and intranasal aqueous triamcinolone spray in 15 patients with seasonal allergic rhinitis. Results were based on a 7-day regimen. Based on Rhinoconjunctivitis Quality of Life Questionnaire scores, clinically and statistically significant (p < 0.0001) improvements were seen in both active-treatment groups; as expected, the corticosteroid spray was the more effective of the two treatments. No significant improvement occurred in the control group. Our preliminary results not only confirm the efficacy of intranasal corticosteroid therapy in moderate-to-severe allergic rhinitis, they also suggest that the Dead Sea saline solution can be an effective alternative in mild-to-moderate allergic rhinitis, particularly with respect to nasal and eye symptoms. The hypertonicity of the Dead Sea solution may have a positive effect on the physiology of the nasal mucosa by improving mucociliary clearance. In addition, the dominant cation in the Dead Sea solution— magnesium— probably exerts anti-inflammatory effects on the nasal mucosa and on the systemic immune response.

scholarly journals Management of patients with seasonal allergic rhinitis: Diagnostic consideration of sensitization to non‐frequent pollen allergens

2021 ◽  
Vol 11 (8) ◽  
Author(s):  
Conny Höflich ◽  
Galina Balakirski ◽  
Zuzanna Hajdu ◽  
Jens Malte Baron ◽  
Katharina Fietkau ◽  
...  
Keyword(s):  
Allergic Rhinitis ◽  
Seasonal Allergic Rhinitis ◽  
Pollen Allergens

scholarly journals The Association between Helicobacter Pylori Infection and Abdominal Pain in Children Aged 2-10 Years

2016 ◽  
Vol 5 (1) ◽  
pp. 19-24
Author(s):  
Dariush Zohoori ◽  
Omid Sadeghi Ardakani
Keyword(s):  
Helicobacter Pylori ◽  
Abdominal Pain ◽  
Demographic Data ◽  
Positive Association ◽  
Recurrent Abdominal Pain ◽  
Gastrointestinal Diseases ◽  
Control Group ◽  
Case Group ◽  
The Mean ◽  
H Pylori

Background: Helicobacter pylori (H. Pylori) is a common infection in children, especially in the developing countries. The infection is usually asymptomatic but it may cause gastrointestinal diseases. In children, the symptoms include abdominal pain, vomiting and anemia. Recurrent abdominal pain (RAP) is a common cause of children’s referral. But, whether H. Pylori causes RAP in children has to be scrutinized to prevent further complications by proper diagnosis and treatment. However, there is still controversy in the literature regarding this issue. Therefore, we aimed to assess the association between H. Pylori and RAP in children. Materials and Methods: In this case-control study, the children with RAP aged 2-10 years who referred to a private pediatric clinic in Marvdasht, Iran, were compared to other children without RAP, during 2015. The sample size was calculated to be 70 for each case and the control group. The patients were visited by a gastro-enterologist who recorded the demographic data of all the patients and the findings of stool test for H. Pylori. To assess the association of RAP with H. Pylori, the odds ratio was calculated. The statistical analysis was performed using SPSS 20.0 software. The P-values less than 0.05 were considered as statistically significant. Results: The mean age of the participants was 7.35±3.11 (with a range of 2-10). In the case group, 41/70 and 69/70 of the control group were girls. H. Pylori was found positive in 37 cases (52.9%) of the case group and 11 (15.7%) in the control group (P<0.001, OR=6.01, 95% CI=2.71-13.34). Logistic regression with adjustment for age indicated that there was a positive association between positive H. Pylori and abdominal pain (OR=16.69, 95% CI=4.71-59.18). This model also showed that by adjusting the H. Pylori test result, age was also positively associated with abdominal pain (OR=0.27, 95% CI=0.18-0.45). A T-test also indicated that the mean titer of H. Pylori was significantly higher in case group (1.42±1.29) than the control group (0.86±1.52) (P=0.020). Conclusion: There was a statistically significant correlation between H. Pylori and RAP. [GMJ. 2016;5(1):19-24]

scholarly journals From clinical guidelines to practice. Clinical experience in treatment of patients with allergic rhinitis

2021 ◽  
pp. 62-67
Author(s):  
A. Y. Ovchinnikov ◽  
N. A. Miroshnichenko ◽  
E. M. Khon ◽  
N. P. Jimsheleishvili ◽  
V. A. Simsovа ◽  
...  
Keyword(s):  
Allergic Rhinitis ◽  
Seasonal Allergic Rhinitis ◽  
Inflammatory Diseases ◽  
Nasal Congestion ◽  
Controlled Study ◽  
Double Blind ◽  
Entire Treatment Period ◽  
Treatment Groups ◽  
Histamine H1 Receptors ◽  
To Receive

Introduction. Antihistamines are the most commonly prescribed class of medications for the treatment of allergic rhinitis (AR). However, they are also widely used in the treatment of inflammatory diseases of the ENT organs. One such drug is levocytirizine, (R) an enantiomer of cetirizine, which is a selective antagonist of peripheral histamine H1-receptors. This article analyzes the properties of levocytirizine in terms of safety and efficacy in allergic rhinitis.Aim of the study is to assess the efficacy of levocetirizine in patients with seasonal allergic rhinitis (SAR) and perennial allergic rhinitis (PAR) versus placebo, and safety for patients with allergic rhinitis.Materials and methods. In this, double-blind, placebo-controlled study, 52 patients with year-round allergic rhinitis and 28 patients with seasonal allergic rhinitis were randomized to receive levocetirizine 5 mg/day once or placebo. Mean overall measures of five symptoms (nasal congestion, nasal itching, itchy eyes, rhinorrhea, and sneezing) were compared between treatment groups at 1, 2, and 4 weeks. All individual symptom scores were also examined.Results. Levocetirizine showed a significant improvement in the condition of patients with CAR and SAR over the entire treatment period compared to placebo. Assessment of individual symptoms showed statistically significant differences in favor of levocetirizine. Conclusion. Levocetirizine is an effective, safe, and well-tolerated drug for the treatment of allergic rhinitis.

scholarly journals CLINICAL CHARACTERISTICS OF PATIENTS WITH SEASONAL ALLERGIC RHINOCONJUNCTIVITIS (SARK). ANAMNESTIC DATA AND THE STRUCTURE OF COMORBIDITY

2020 ◽  
pp. 72-81
Author(s):  
Олексій Кузнєцов
Keyword(s):  
Allergic Rhinitis ◽  
Infectious Diseases ◽  
Viral Hepatitis ◽  
Scarlet Fever ◽  
Seasonal Allergic Rhinitis ◽  
Acute Bronchitis ◽  
Control Group ◽  
Upper Respiratory Tract ◽  
Intestinal Infection ◽  
Nasal Symptoms

Introduction. Seasonal allergic rhinitis is AZ of mucous membranes (primarily the conjunctiva of the eye and nasal mucosa), due to hypersensitivity to aerosol allergens of plant pollen and fungi spores, the concentration of which in the air periodically becomes prijenosnog. The leading clinical manifestation of SAR is considered as allergic conjunctivitis. According to statistics, about 70-90% of patients with SAR develops Pulawy conjunctivitis, characterized by itching of eyes, eyelids, their redness, photophobia, lacrimation. Clinically important is the combination of SAR and conjunctivitis. Although the SAR attention usually emphasize on nasal symptoms, more than 80% of patients, as practice shows, suffer from symptoms from the eyes. According to the European and North American researchers, more than 70% of patients with SAR suffer from eye and nasal symptoms, and their severity the majority of patients assessed asmoderate or severe.Materials and methods. Clinical and anamnestic study was done in 120 patients aged from 19 to 45 years. All the studied patients were divided according to the degree of severity of the disease: 58 patients with moderate course of seasonal allergic rhinitis and conjunctivitis (EYE), which caused Pilica ambrosia and 62 patients with severe SARK, which pilca caused by ragweed. Of these, 43 (35,8%) women, 77 (64.1%) of men aged 19 to 25 years – 76 (63.3 per cent), from 25 to 45 years – 44 (36.6%) patients. The control group consisted of 30 healthy people.Research results. The differentiation of the history of infectious diseases patients. In the studied patients SARK with moderate current, acute respiratory illness (ARI) was observed in 54 (26,9%) patients, varicella – 16 (8,0%), mumps – 12 (6,0%), measles in 11 (5,5%), viral hepatitis in 4 (1,9%) patients, acute bronchitis 36 (17,9%), pneumonia – 17 (8,5%), the scarlet fever in 6 (2.9%) and intestinal infection in 7 (3,5%), sore throat – 25 (12,4%), otitis in 13 (6,5%) patients. In patients with severe SARK, ARI was observed in 59 (23,3%) patients, varicella – 24 (9,5%), mumps – in 18 (7.1 percent), measles – in 16 (6.3 percent), viral hepatitis in 7 (2.8%) and acute bronchitis – in 43 (17%), pneumonia in 19 (7,5%), scarlet fever in 8 (3,2%), intestinal infection in 9 (3,6%), angina 32 (12,6%), otitis media – in 18 (7.1 per cent) patients.Analyzing the structure of infectious diseases in the anamnesis in the studied patients SARK need to emphasize that their structure is dominated infection in the upper respiratory tract and broncho-pulmonary system that leads to depletion of nonspecific and specific immunity factors, formation of secondary immunodeficiency in these systems.Discussion of research. In the study of biochemical parameters of blood in patients with SARK in the period of aggravation established that the greatest changes are observed from endogenous cholesterol and phospholipids, which may indicate the failure of the macrophage link of immunity. At the same time, β-lipoproteins and NIK was increased only in the group of patients with severe SARK. The increase of phospholipids in serum of patients with severe SARK can point to the implementation of late phase allergic inflammation in cellular tissue structure of the nasal mucosa.Conclusions. Conducted research of history data, the structure of comorbidity, laboratory parameters allergological studies have shown that SARK is formed on the background of progressive sensitization and allergization of the organism, which is implemented in the manifestation of allergic reactions, forming the severity of SARK, and on the strength of the immune response to a variety of ecoalign that define the types of immunopathological reactions in this cohort of patients.

scholarly journals H. pyloriMay Not Be Associated with Iron Deficiency Anemia in Patients with Normal Gastrointestinal Tract Endoscopy Results

2014 ◽  
Vol 2014 ◽  
pp. 1-4 ◽  
Author(s):  
Tayyibe Saler ◽  
Şakir Özgür Keşkek ◽  
Sibel Kırk ◽  
Süleyman Ahbab ◽  
Gülay Ortoğlu
Keyword(s):  
Gastrointestinal Tract ◽  
Iron Deficiency ◽  
Iron Deficiency Anemia ◽  
Deficiency Anemia ◽  
Control Group ◽  
Control Groups ◽  
Significant Difference ◽  
Male Patients ◽  
H Pylori ◽  
And Control

Background. The aim of this study was to investigate the association between iron deficiency anemia andH. pyloriin patients with normal gastrointestinal tract endoscopy results.Materials and Methods. A total of 117 male patients with normal gastrointestinal tract endoscopy results were included in this retrospective study. The study and control groups included 69 and 48 patients with and without iron deficiency anemia, respectively. The prevalence ofH. pylori, the number of RBCs, and the levels of HGB, HTC, MCV, iron, and ferritin were calculated and compared.Results. There was no statistically significant difference found between the groups according to the prevalence ofH. pylori(65.2% versus 64.6%,P=0.896). Additionally, the levels of RBCs, HGB, HTC, MCV, iron, and ferritin in the patients in the study group were lower than those in the control group (P<0.05). Finally, there was no association between iron deficiency anemia andH. pylori(OR 1.02, Cl 95% 0.47–2.22, andP=0.943).Conclusion.H. pyloriis not associated with iron deficiency anemia in male patients with normal gastrointestinal tract endoscopy results.

scholarly journals The features of mucosal immunity and microbiota at different forms of allergic rhinitis

2013 ◽  
Vol 94 (5) ◽  
pp. 766-770
Author(s):  
Yu A Tyurin ◽  
E I Shapkina ◽  
I G Mustafin ◽  
R S Fassakhov
Keyword(s):  
Allergic Rhinitis ◽  
Seasonal Allergic Rhinitis ◽  
Interleukin 10 ◽  
Control Group ◽  
Healthy Controls ◽  
Toll Like Receptors ◽  
Persistent Allergic Rhinitis ◽  
Nasal Swabs ◽  
Blue Solution ◽  
And Gender

Aim. To assess the parameters of local immune response in patients with different forms of allergic rhinitis, associated with nasal bacterial infection. Methods. Nasal swabs and nasal epithelium samples obtained from 10 patients with seasonal allergic rhinitis aged 12 to 32 years and from 15 patients with persistent allergic rhinitis aged 18 to 45 years, as well as form the 20 healthy subjects aged 18 to 45 years without signs of allergy who were age and gender-comparable, were examined. Swabs were prepared from cell suspension, stained with 0.04% trypan blue solution, and a microscopy with the count of non-stained cells was performed. Epitheliocytes expressing toll-like receptors-2, were determined by flow cytometry. Interleukin-10 concentration in swabs was assessed by ELISA. Results. The number of epitheliocytes expressing toll-like receptors-2 was by 1.9 times lower in patients with seasonal allergic rhinitis and by 1.7 times lower in patients with persistent allergic rhinitis compared to control group. There was a reverse correlation found between the number of epitheliocytes expressing toll-like receptors-2 and interleukin-10 level in nasal swabs of healthy controls, while in patients with allergic rhinitis a it was a direct correlation. In patients with persistent allergic rhinitis S. aureus was a part of microbiota in 100% of cases and was associated with other bacteria (Str. pyogenes - 33.3%, Neisseria spp. - 66.7%). In patients with seasonal allergic rhinitis the association of S. aureus and S. hemolyticus (70.0%) was the most frequent one. In the control group, S. epidermidis (50.0%), Str. viridians (25.0%), S. hominis (25.0%) were among the nasal microbiota. There were no differences revealed between the mean levels of interleukin-10 in patients with allergic rhinitis and healthy controls. Conclusion. The number of epitheliocytes expressing toll-like receptors-2 was significantly reduced by almost 2 times in patients with persistent allergic rhinitis compared to control group. Colonization of nasal mucosa by S. aureus in patients with allergic rhinitis leads to an increase of epithelial cells expressing toll-like receptors-2.

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