scholarly journals Quantification of Total Phenolics, Flavonoids and Evaluation of in vitro Free Radical Scavenging Activities in Psidium guajava L.

2020 ◽  
Vol 82 (4) ◽  
Author(s):  
B. H. SOWMYA ◽  
D. USHA ANANDHI
Keyword(s):  
Free Radical ◽  
Total Phenolics ◽  
Radical Scavenging ◽  
Psidium Guajava ◽  
Free Radical Scavenging ◽  
Free Radical Scavenging Activities

scholarly journals ANTIOXIDANT ACTIVITIES OF ROPINIROLE AND PRAMIPEXOLE NOVEL DRUGS USED IN TREATMENT OF PARKINSONISM: AN IN VITRO APPROACH

2016 ◽  
Vol 9 (9) ◽  
pp. 105 ◽  
Author(s):  
Preetha Selva ◽  
Srinivasan Vengadassalapathy
Keyword(s):  
Free Radical ◽  
Dopamine Agonist ◽  
Antioxidant Activities ◽  
Radical Scavenging ◽  
Free Radical Scavenging ◽  
Novel Drugs ◽  
Dpph Method ◽  
Selective Dopamine ◽  
Free Radical Scavenging Activities

ABSTRACTObjective: The objective of this study is to evaluate and compare the free radical scavenging activities of selective dopamine agonist namely ropiniroleand pramipexole.Methods: The antioxidant activity of ropinirole and pramipexole at various concentrations was done by 1, 1-diphenyl-2picrylhydrazyl (DPPH) freeradical scavenging assay comparing it with ascorbic acid which was taken as standard.Results: The free radical scavenging property as measured by DPPH method showed that ropinirole and pramipexole have got a potent free radicalscavenging activity with that of ascorbic acid.Conclusion: Novel drugs such as pramipexole and ropinirole are promising molecules in the field of oxidative damage related neurodegenerativedisorders providing us an optimistic targeted approach toward neuroprotection.Keywords: Free radical scavenging, 1, 1-diphenyl-2picrylhydrazyl assay, Anti-Parkinson’s, Dopamine agonist.

Dithiols as more effective than monothiols in protecting biomacromolecules from free-radical-mediated damage: in vitro oxidative degradation of high-molar-mass hyaluronan

2014 ◽  
Vol 68 (10) ◽  
Author(s):  
Mária Baňasová ◽  
Katarína Valachová ◽  
Ivo Juránek ◽  
Ladislav Šoltés
Keyword(s):  
Free Radical ◽  
Molar Mass ◽  
Radical Scavenging ◽  
Oxidative Degradation ◽  
Free Radical Scavenging ◽  
Dpph Assay ◽  
High Molar Mass ◽  
High Concentrations ◽  
Free Radical Scavenging Activities

AbstractOxidative stress and the resulting damage to cellular and extracellular components has been observed in a variety of degenerative processes, including degenerative joint disorders, where high-molar-mass hyaluronan (HA) is often found to be massively degraded. The present study sought to test the hypothesis that dithiols are more effective in protecting biomacromolecules from free-radicalmediated damage than monothiols. The materials/thiols tested included bucillamine (BUC), dithioerythritol (DTE), dithiothreitol (DTT) and glutathione (GSH), as a reference, for their effectiveness in protecting HA from oxidative degradation induced in vitro. Since HA degradation results in a decrease in its dynamic viscosity, rotational viscometry was applied to follow HA oxidative degradation. The free-radical-scavenging activities of the thiols tested were determined by 2,2′-azino-bis(3-ethylbenzthiazoline-6-sulphonic acid) (ABTS) and di(phenyl)-(2,4,6-trinitrophenyl)iminoazanium (DPPH) assays. It was found that all the dithiols in the concentration range tested protected HA from the oxidative degradation. On the other hand, monothiol GSH exerted protection only at high concentrations (10 μmol L−1 and 100 μmol L−1) and 1 μmol L−1 of GSH even exhibited a prodegradative effect. The ABTS assay revealed free-radical scavenging activities in the following order: BUC, DTT, DTE, GSH, and that of the DPPH assay: BUC, DTE, DTT, GSH. In conclusion, it was demonstrated that dithiols may be more effective than monothiols in affording biomacromolecule protection from oxidative degradation.

scholarly journals Ethno-Pharmacological Survey, In Vitro Anti-Sickling and Free Radical Scavenging Activities of Carapa Procera DC. Stem Bark (Meliaceae)

2014 ◽  
Vol 03 (01) ◽  
pp. 1-10 ◽  
Author(s):  
Koto-te-Nyiwa Ngbolua ◽  
Tshitenge T. Bishola ◽  
Tshimankinda P. Mpiana ◽  
Virima Mudogo ◽  
Sha-Tshibey D. Tshibangu ◽  
...  
Keyword(s):  
Free Radical ◽  
Radical Scavenging ◽  
Stem Bark ◽  
Free Radical Scavenging ◽  
Carapa Procera ◽  
Free Radical Scavenging Activities
Sign in / Sign up

Export Citation Format

Share Document