scholarly journals Renal dysfunction among HIV patients under highly active antiretroviral therapy attending Kibagabaga district

2021 ◽  
Vol 4 ◽  
Author(s):  
Munyandamutsa Fulgence ◽  
Mucumbitsi Joseph ◽  
Yadufashije Callixte ◽  
Niyonzima William
Keyword(s):  
Renal Function ◽  
Antiretroviral Therapy ◽  
Data Collection ◽  
Renal Dysfunction ◽  
Highly Active Antiretroviral Therapy ◽  
Function Analysis ◽  
Primary Data ◽  
Hiv Patients ◽  
Blood Samples ◽  
Highly Active

Antiretroviral therapy is used for the suppression of the HIV virus and stops its progression to cause disease. Despite its role, it has the pathophysiologic effect to kidney function for users. The study was conducted to evaluate the renal function for HIV patients under highly active antiretroviral therapy at Kibagabaga District Hospital. Venous blood samples (4mL) were collected by vein puncture in phlebotomy services by means of the dry tubes from 170 patients under antiretroviral therapy. Blood samples were transported to clinical biochemistry department for analysis. Rotor centrifuge was used to separate the serum and other blood components; creatinine level was analysed for renal function analysis. The total of 170 HIV patients were considered in the study. Of the 170, 50 HIV patients were used for primary data collection, while 120 HIV patients who previously received antiretroviral therapy were considered as secondary data collection source. The patients between 25-45 years old have experienced the highest level of abnormal concentration of renal tests 25%, patients with above 45 years old was ranked the second to have the abnormal level (14.2%). Females were 59% and have experienced the high risk of renal dysfunction than males, the level of glomerular filtration rate was 67 (39.4%), and was higher than creatinine 42 (24.7%). Antiretroviral therapy has a negative effect on kidneys. Abnormalities of the kidney parameters were prevalently high among both male and female. The serious follow is needed for this vulnerable population.

scholarly journals Renal dysfunction among HIV patients under highly active antiretroviral therapy attending Kibagabaga district

2021 ◽  
pp. bs20212
Author(s):  
Munyandamutsa Fulgence ◽  
Mucumbitsi Joseph ◽  
Yadufashije Callixte ◽  
Niyonzima William
Keyword(s):  
Renal Function ◽  
Antiretroviral Therapy ◽  
Data Collection ◽  
Renal Dysfunction ◽  
Highly Active Antiretroviral Therapy ◽  
Function Analysis ◽  
Primary Data ◽  
Hiv Patients ◽  
Blood Samples ◽  
Highly Active

Antiretroviral therapy is used for the suppression of the HIV virus and stops its progression to cause disease. Despite its role, it has the pathophysiologic effect to kidney function for users. The study was conducted to evaluate the renal function for HIV patients under highly active antiretroviral therapy at Kibagabaga District Hospital. Venous blood samples (4mL) were collected by vein puncture in phlebotomy services by means of the dry tubes from 170 patients under antiretroviral therapy. Blood samples were transported to clinical biochemistry department for analysis. Rotor centrifuge was used to separate the serum and other blood components; creatinine level was analysed for renal function analysis. The total of 170 HIV patients were considered in the study. Of the 170, 50 HIV patients were used for primary data collection, while 120 HIV patients who previously received antiretroviral therapy were considered as secondary data collection source. The patients between 25-45 years old have experienced the highest level of abnormal concentration of renal tests 25%, patients with above 45 years old was ranked the second to have the abnormal level (14.2%). Females were 59% and have experienced the high risk of renal dysfunction than males, the level of glomerular filtration rate was 67 (39.4%), and was higher than creatinine 42 (24.7%). Antiretroviral therapy has a negative effect on kidneys. Abnormalities of the kidney parameters were prevalently high among both male and female. The serious follow is needed for this vulnerable population.

scholarly journals Hematological Profile of HIV-Infected Patients on First-Line Highly Active Antiretroviral Therapy and Its Correlation With CD4 Count

2021 ◽  
Author(s):  
John Jospeh Diamond Princy ◽  
Kshetrimayum Birendra Singh ◽  
Ningthoujam Biplab ◽  
Ningthoukhongjam Reema ◽  
Rajesh Boini ◽  
...  
Keyword(s):  
Platelet Count ◽  
Antiretroviral Therapy ◽  
Hiv Infection ◽  
Highly Active Antiretroviral Therapy ◽  
Cd4 Count ◽  
Total Leukocyte Count ◽  
Hiv Patients ◽  
Positive Correlation ◽  
Highly Active ◽  
The Mean

Abstract Introduction Human immunodeficiency virus (HIV) infection is a state of profound immunodeficiency. Disorders of hematopoietic system are a common but often overlooked complication of HIV infection. This can manifest at any stage of the disease but more commonly in the advanced stage with low CD4 count. Anemia is the most common hematological abnormality in HIV patients and prevalence ranges from 1.3 to 95%. As HIV disease progresses, the prevalence and severity of anemia also increase. Hence, this study was undertaken to assess the hematological parameters of HIV-infected patients on highly active antiretroviral therapy (HAART) at different treatment durations with the hope to improve the HAART outcome in HIV patients and its correlation with CD4 count. Methods This prospective longitudinal study enrolled 134 HIV-infected patients admitted to or attending the OPD in the Department of Medicine or Antiretroviral Therapy (ART) Center (Center of Excellence), Regional Institute of Medical Sciences (RIMS), Imphal, Manipur, from 2018 to 2020. Complete hemogram, CD4 count, and other related-blood investigations were studied. Results The mean age of the study population was 39.9 ± 11.04 years. Of the 134 patients, 75 (56%) were males and 59 (44%) were females. Twelve (9%) patients had a history of injecting drug use (IDU). TLE (tenofovir, lamivudine, efavirenz) regimen was started on 112 (83.6%) patients and the majority of them (69/134 [51.5%]) had a CD4 count of 200 to 499 cells/mm3, which increased significantly 6 months after HAART to 99 to 1,149 cells/mm3, with a mean of 445 ± 217 cells/mm3. There were significant improvements in hemoglobin (Hb) levels, total leukocyte count (TLC), absolute neutrophil count (ANC), and absolute lymphocyte count (ALC) after HAART indicating a positive correlation with CD4 count (p < 0.05). Thrombocytopenia was observed higher after HAART when compared to baseline. There was a positive correlation between platelet count and CD4 count. However, the mean corpuscular volume (MCV) and erythrocyte sedimentation rate (ESR) had a negative correlation with CD4 count. Conclusion The study inferred a strong positive correlation between CD4 and Hb levels, TLC, ANC, ALC, and platelet count after HAART with improvement in these values as CD4 count increases. Specific treatment intervention based on the changes in the immunohematological profile trends can help prevent most of the adverse effects on HIV patients in our community.

scholarly journals Langerhans cells in periodontal disease of HIV- and HIV+ patients undergoing highly active antiretroviral therapy

2011 ◽  
Vol 25 (3) ◽  
pp. 255-260 ◽  
Author(s):  
Takeshi Kato Segundo ◽  
Giovanna Ribeiro Souto ◽  
Ricardo Alves Mesquita ◽  
Fernando Oliveira Costa
Keyword(s):  
Antiretroviral Therapy ◽  
Periodontal Disease ◽  
Highly Active Antiretroviral Therapy ◽  
Langerhans Cells ◽  
Hiv Patients ◽  
Highly Active

Mitochondrial Damage in HIV Patients treated with Highly Active Antiretroviral Therapy

2002 ◽  
pp. 141-152
Author(s):  
A. Lombès ◽  
C. Barthélémy ◽  
C. Jardel ◽  
E. Teicher ◽  
T. Maisonobe ◽  
...  
Keyword(s):  
Antiretroviral Therapy ◽  
Highly Active Antiretroviral Therapy ◽  
Mitochondrial Damage ◽  
Hiv Patients ◽  
Highly Active
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