Renal Function in Patients with Preexisting Renal Disease Receiving Tenofovir-Containing Highly Active Antiretroviral Therapy in the HIV Outpatient Study

2009 ◽  
Vol 23 (8) ◽  
pp. 589-592 ◽  
Author(s):  
Benjamin Young ◽  
Kate Buchacz ◽  
Anne Moorman ◽  
Kathy C. Wood ◽  
John T. Brooks
Keyword(s):  
Renal Function ◽  
Antiretroviral Therapy ◽  
Renal Disease ◽  
Highly Active Antiretroviral Therapy ◽  
Highly Active ◽  
Outpatient Study

scholarly journals Predictors of impaired renal function among HIV infected patients commencing highly active antiretroviral therapy in Jos, Nigeria

2011 ◽  
Vol 52 (3) ◽  
pp. 182 ◽  
Author(s):  
OcheO Agbaji ◽  
PatriciaE Agaba ◽  
KakjingD Falang ◽  
Adamu Onu ◽  
MuhammadA Muazu ◽  
...  
Keyword(s):  
Renal Function ◽  
Antiretroviral Therapy ◽  
Highly Active Antiretroviral Therapy ◽  
Impaired Renal Function ◽  
Highly Active

Effects of Highly Active Antiretroviral Therapy on Renal Function and Renal Phosphate Handling in African Adults with Advanced HIV and CKD

2019 ◽  
Vol 19 (1) ◽  
pp. 88-100 ◽  
Author(s):  
Tewogbade A. Adedeji ◽  
Simeon A. Adebisi ◽  
Nife O. Adedeji ◽  
Sikiru A. Biliaminu ◽  
Timothy O. Olanrewaju
Keyword(s):  
Renal Function ◽  
Antiretroviral Therapy ◽  
Tenofovir Disoproxil Fumarate ◽  
Highly Active Antiretroviral Therapy ◽  
Fractional Excretion ◽  
Plasma Phosphate ◽  
Phosphate Excretion ◽  
Highly Active ◽  
Immunodeficiency Virus ◽  
Moderate Chronic Kidney Disease

Background: Highly Active Antiretroviral Therapy (HAART) has been implicated in renal dysfunction with hypophosphataemia. Objective: We prospectively evaluated renal phosphate excretion during HAART use. Method: Newly diagnosed human immunodeficiency virus (HIV)-infected individuals were treated with Tenofovir disoproxil fumarate/Emtricitabine/Efavirenz (TDF/FTC/EFV), n=33; Zidovudine/Lamivudine/Nevirapine (ZDV/3TC/NVP), n=53; and Zidovudine/Lamivudine/Efavirenz (ZDV/3TC/EFV), n=16. Creatinine and phosphate were assayed in blood and urine simultaneously at baseline, 1, 3, 6 and 9 months. Glomerular filtration rate (eGFR), fractional phosphate excretion and reabsorption (FEPi % and TRP), and the ratio of tubular maximum reabsorption of phosphate (TmP) to GFR (TmP/GFR) were estimated. Results: At baseline, eGFR showed moderate chronic kidney disease (mean: 35.50 ± 2.02, 33.14 ± 1.63, and 39.97±1.84 ml/min/1.73m2 in the 3 groups respectively); 54 (52.9%) patients had hyperphosphataemia (1.4mmo/L); 43 (42.2%) had normophosphataemia (0.6-1.4mmol/L); 5 (4.9%) had hypophosphataemia (<0.6mmol/L). eGFR improved significantly from 1 month (≥60, 58.65 ± 1.11, and 51.76 ±1.59 ml/min/1.73m2; p=0.04, <0.001, 0.67 respectively), with a relapse at 9 months in TDFtreated subjects (50.10 ± 1.89 ml/min/1.73m2). TDF/FTC/EFV resulted in< significantly greater reduction in plasma phosphate than ZDV/3TC/NVP (p=0.031), but not significantly different from ZDV/3TC/EFV (p=0.968). Similarly, ZDV/3TC/EFV resulted in significantly greater reduction in plasma phosphate than ZDV/3TC/NVP (p=0.036). FEP% progressively increased with HAART duration, more in TDF-treated and ZDV/3TC/EFV-treated groups than ZDV/3TC/NVP (p=0.014); TRP was elevated (<0.86), implying non-maximal phosphate reabsorption. TmP/GFR values were elevated, (<1.35mmol/l). Conclusion: HIV causes kidney dysfunction with reduced phosphate excretion resulting in hyperphosphataemia but HAART improves renal function. Prolonged use of TDF can cause renal toxicity with hypophosphataemia as fractional excretion progressively increased with duration of therapy unlike ZDV/3TC/NVP. The use of different third agents (either NVP or EFV) in zidovudine-based therapy results in significantly different plasma phosphate levels; ZDV/3TC/EFV, like TDF/FTC/EFV, resulted in significantly greater decline in plasma phosphate than ZDV/3TC/NVP. Thus, Evafirenz (EVF) may have similar or synergistic adverse effects with tenofovir disoproxil fumarate (TDF).

scholarly journals Renal Function in Ghanaian HIV-Infected Patients on Highly Active Antiretroviral Therapy: A Case-Control Study

PLoS ONE ◽  
2014 ◽  
Vol 9 (6) ◽  
pp. e99469 ◽  
Author(s):  
Christian Obirikorang ◽  
Derick Nii Mensah Osakunor ◽  
Benedict Ntaadu ◽  
Opei Kwafo Adarkwa
Keyword(s):  
Renal Function ◽  
Antiretroviral Therapy ◽  
Highly Active Antiretroviral Therapy ◽  
Case Control Study ◽  
Case Control ◽  
Highly Active ◽  
Control Study

scholarly journals Renal dysfunction among HIV patients under highly active antiretroviral therapy attending Kibagabaga district

2021 ◽  
pp. bs20212
Author(s):  
Munyandamutsa Fulgence ◽  
Mucumbitsi Joseph ◽  
Yadufashije Callixte ◽  
Niyonzima William
Keyword(s):  
Renal Function ◽  
Antiretroviral Therapy ◽  
Data Collection ◽  
Renal Dysfunction ◽  
Highly Active Antiretroviral Therapy ◽  
Function Analysis ◽  
Primary Data ◽  
Hiv Patients ◽  
Blood Samples ◽  
Highly Active

Antiretroviral therapy is used for the suppression of the HIV virus and stops its progression to cause disease. Despite its role, it has the pathophysiologic effect to kidney function for users. The study was conducted to evaluate the renal function for HIV patients under highly active antiretroviral therapy at Kibagabaga District Hospital. Venous blood samples (4mL) were collected by vein puncture in phlebotomy services by means of the dry tubes from 170 patients under antiretroviral therapy. Blood samples were transported to clinical biochemistry department for analysis. Rotor centrifuge was used to separate the serum and other blood components; creatinine level was analysed for renal function analysis. The total of 170 HIV patients were considered in the study. Of the 170, 50 HIV patients were used for primary data collection, while 120 HIV patients who previously received antiretroviral therapy were considered as secondary data collection source. The patients between 25-45 years old have experienced the highest level of abnormal concentration of renal tests 25%, patients with above 45 years old was ranked the second to have the abnormal level (14.2%). Females were 59% and have experienced the high risk of renal dysfunction than males, the level of glomerular filtration rate was 67 (39.4%), and was higher than creatinine 42 (24.7%). Antiretroviral therapy has a negative effect on kidneys. Abnormalities of the kidney parameters were prevalently high among both male and female. The serious follow is needed for this vulnerable population.

scholarly journals Renal dysfunction among HIV patients under highly active antiretroviral therapy attending Kibagabaga district

2021 ◽  
Vol 4 ◽  
Author(s):  
Munyandamutsa Fulgence ◽  
Mucumbitsi Joseph ◽  
Yadufashije Callixte ◽  
Niyonzima William
Keyword(s):  
Renal Function ◽  
Antiretroviral Therapy ◽  
Data Collection ◽  
Renal Dysfunction ◽  
Highly Active Antiretroviral Therapy ◽  
Function Analysis ◽  
Primary Data ◽  
Hiv Patients ◽  
Blood Samples ◽  
Highly Active

Antiretroviral therapy is used for the suppression of the HIV virus and stops its progression to cause disease. Despite its role, it has the pathophysiologic effect to kidney function for users. The study was conducted to evaluate the renal function for HIV patients under highly active antiretroviral therapy at Kibagabaga District Hospital. Venous blood samples (4mL) were collected by vein puncture in phlebotomy services by means of the dry tubes from 170 patients under antiretroviral therapy. Blood samples were transported to clinical biochemistry department for analysis. Rotor centrifuge was used to separate the serum and other blood components; creatinine level was analysed for renal function analysis. The total of 170 HIV patients were considered in the study. Of the 170, 50 HIV patients were used for primary data collection, while 120 HIV patients who previously received antiretroviral therapy were considered as secondary data collection source. The patients between 25-45 years old have experienced the highest level of abnormal concentration of renal tests 25%, patients with above 45 years old was ranked the second to have the abnormal level (14.2%). Females were 59% and have experienced the high risk of renal dysfunction than males, the level of glomerular filtration rate was 67 (39.4%), and was higher than creatinine 42 (24.7%). Antiretroviral therapy has a negative effect on kidneys. Abnormalities of the kidney parameters were prevalently high among both male and female. The serious follow is needed for this vulnerable population.

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