Prevalence and risk factors of T-cell mediated rejection in patients after liver transplantation from deceased donors: a retrospective study over 10 years

2020 ◽  
Vol 66 (1) ◽  
pp. e4-e10
Author(s):  
Svetlana Adamcová-Selčanová ◽  
Ľubomír Skladaný ◽  
Tomáš Koller
Keyword(s):  
Risk Factors ◽  
Liver Transplantation ◽  
Retrospective Study ◽  
T Cell ◽  
Deceased Donors

scholarly journals Weight Gain and De Novo Metabolic Disorders after Liver Transplantation

Nutrients ◽  
2019 ◽  
Vol 11 (12) ◽  
pp. 3015 ◽  
Author(s):  
Barbara Lattanzi ◽  
Daria D’Ambrosio ◽  
Daniele Tavano ◽  
Demis Pitoni ◽  
Gianluca Mennini ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Risk Factors ◽  
Liver Transplantation ◽  
Retrospective Study ◽  
Liver Disease ◽  
Metabolic Disorders ◽  
De Novo ◽  
Metabolic Abnormalities ◽  
Single Center

The development of nutritional and metabolic abnormalities represents an important burden in patients after liver transplantation (LT). Our study aimed at evaluating the incidence, time of onset, and risk factors for nutritional and metabolic abnormalities in patients after LT. The study was a single-center retrospective study. Consecutive patients undergoing elective LT from 2000 to 2016 were enrolled. The presence of at least two among arterial hypertension (AH), diabetes mellitus (DM), dyslipidemia, and obesity (BMI ≥ 30 Kg/m2) was utilized to define patients with the metabolic disorder (MD). Three hundred and fifteen patients were enrolled; the median age was 56 years (68% males). Non-alcoholic steatohepatitis (NASH) was the origin of liver disease in 10% of patients. During follow-up, 39% of patients developed AH, 18% DM, and 17% dyslipidemia. Metabolic disorders were observed in 32% of patients. The NASH etiology (OR: 6.2; CI 95% 0.5–3; p = 0.003) and a longer follow-up (OR: 1.2; CI 95% 0.004–0.02; p = 0.002) were associated with de novo MD. In conclusion, nutritional and metabolic disorders are a frequent complication after LT, being present in up to one-third of patients. The NASH etiology and a longer distance from LT are associated with de novo MD after LT.

scholarly journals Renal damage after liver transplantation

2020 ◽  
Vol 40 (1) ◽  
Author(s):  
Thorsten Feldkamp ◽  
Anja Bienholz ◽  
Andreas Paul ◽  
Fuat H. Saner
Keyword(s):  
Risk Factors ◽  
Liver Transplantation ◽  
Acute Kidney Injury ◽  
Risk Factor ◽  
Retrospective Study ◽  
Survival Rate ◽  
Renal Damage ◽  
Kidney Injury ◽  
The Impact ◽  
Detrimental Impact

Abstract Background: Patients following liver transplantation are at risk to develop acute kidney injury (AKI). The aim of our study was to assess risk factors for the development of AKI and the impact of AKI on the outcome of patients after liver transplantation (OLT). Patients and methods: In this retrospective study, we analyzed 149 patients undergoing OLT from 1/2004 to 12/2007. AKI was defined according to the KDIGO definition representing the AKIN and the RIFLE classification, and according to the need for renal replacement therapy (RRT). Results: According to the AKIN criteria alone 14 patients, according to the RIFLE criteria alone no patient and according to both definitions 30 patients developed AKI. RRT was required in 54 patients experiencing AKI, whereas 51 patients did not develop AKI. Pre OLT serum creatinine (SCr) significantly predicted the development of AKI requiring RRT, but not AKI without RRT requirement. Survival rate was significantly inferior after 28 days, one or three years in patients with AKI requiring RRT (70.4, 46.4, 44.4% vs. 100, 92.2, 90.2%, P < 0.001). There was no difference in survival between patients experiencing AKI according to the RIFLE or AKIN criteria without RRT requirement and patients without AKI. Conclusion: Pre OLT renal dysfunction assessed by SCr was the most important risk factor predicting severe forms of AKI, but not milder forms of AKI. AKI requiring RRT had a detrimental impact on patients’ survival, whereas milder forms of AKI were not associated with a worse outcome.

scholarly journals Risk Factors Associated with Reoperation for Bleeding following Liver Transplantation

HPB Surgery ◽  
2014 ◽  
Vol 2014 ◽  
pp. 1-8 ◽  
Author(s):  
Maxwell A. Thompson ◽  
David T. Redden ◽  
Lindsey Glueckert ◽  
A. Blair Smith ◽  
Jack H. Crawford ◽  
...  
Keyword(s):  
Risk Factors ◽  
Liver Transplantation ◽  
Retrospective Study ◽  
Platelet Transfusion ◽  
Multivariable Analysis ◽  
Aminocaproic Acid ◽  
Meld Score ◽  
Single Institution ◽  
Factors Associated ◽  
Risk Of Death

Introduction. This study’s objective was to identify risk factors associated with reoperation for bleeding following liver transplantation (LTx). Methods. A retrospective study was performed at a single institution between 2001 and 2012. Operative reports were used to identify patients who underwent reoperation for bleeding within 2 weeks following LTx (operations for nonbleeding etiologies were excluded). Results. Reoperation for bleeding was observed in 101/928 (10.8%) of LTx patients. The following characteristics were associated with reoperation on multivariable analysis: recipient MELD score (OR 1.06/MELD unit, 95% CI 1.03, 1.09), number of platelets transfused (OR 0.73/platelet unit, 95% CI 0.58, 0.91), and aminocaproic acid utilization (OR 0.46, 95% CI 0.27, 0.80). LTx patients who underwent reoperation for bleeding had a longer ICU stay (5 days ± 7 versus 2 days ± 3, P<0.001) and hospitalization (18 days ± 9 versus 10 days ± 18, P<0.001). The risk of death increased in patients who underwent reoperation for bleeding (HR 1.89, 95% CI 1.26, 2.85). Conclusion. Reoperation for bleeding following LTx was associated with increased resource utilization and recipient mortality. A lower threshold for intraoperative platelet transfusion and antifibrinolytics, especially in patients with high lab-MELD score, may decrease the incidence of reoperation for bleeding following LTx.

Risk factors for mortality on the liver waiting list of cirrhotic patients listed for liver transplantation

2001 ◽  
Vol 120 (5) ◽  
pp. A77-A77
Author(s):  
D DELPHINE ◽  
F AGNESE ◽  
B NADINE ◽  
L OLIVIER ◽  
L HUBERT ◽  
...  
Keyword(s):  
Risk Factors ◽  
Liver Transplantation ◽  
Waiting List ◽  
Cirrhotic Patients

Biliary cast syndrome after orthotopic liver transplantation: risk factors and outcome

2013 ◽  
Vol 51 (01) ◽  
Author(s):  
T Voigtländer ◽  
AA Negm ◽  
CP Strassburg ◽  
F Lehner ◽  
MP Manns ◽  
...  
Keyword(s):  
Risk Factors ◽  
Liver Transplantation ◽  
Orthotopic Liver Transplantation ◽  
Cast Syndrome

Risk factors for primary poor function in liver transplantation: a retrospective single centre analysis

2019 ◽  
Author(s):  
M Fodor ◽  
A Woerdehoff ◽  
J Walte ◽  
S Neururer ◽  
H Esser ◽  
...  
Keyword(s):  
Risk Factors ◽  
Liver Transplantation ◽  
Single Centre
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