scholarly journals Risk Factors and Outcomes of Carbapenem-Resistant Enterobacteriaceae Infection After Liver Transplantation: A Retrospective Study in a Chinese Population

2020 ◽  
Vol Volume 13 ◽  
pp. 4039-4045
Author(s):  
Ying Chen ◽  
Wei-li Wang ◽  
Wei Zhang ◽  
Yun-tao Zhang ◽  
Sa-xiao Tang ◽  
...  
Keyword(s):  
Risk Factors ◽  
Liver Transplantation ◽  
Retrospective Study ◽  
Chinese Population ◽  
Carbapenem Resistant ◽  
Carbapenem Resistant Enterobacteriaceae

Risk factors for mortality among carbapenem-resistant enterobacteriaceae carriers with focus on immunosuppression

2019 ◽  
Vol 78 (2) ◽  
pp. 101-105 ◽  
Author(s):  
Haggai Bar-Yoseph ◽  
Nadav Cohen ◽  
Alexander Korytny ◽  
Elias R. Andrawus ◽  
Razi Even Dar ◽  
...  
Keyword(s):  
Risk Factors ◽  
Carbapenem Resistant ◽  
Carbapenem Resistant Enterobacteriaceae

Epidemiology and risk factors for carbapenem-resistant Enterobacteriaceae colonisation and infections: case-controlled study from an academic medical center in a southern area of China

2019 ◽  
Vol 77 (4) ◽  
Author(s):  
Lili Fang ◽  
Xiaohui Lu ◽  
Heping Xu ◽  
Xiaobo Ma ◽  
Yilan Chen ◽  
...  
Keyword(s):  
Risk Factors ◽  
Medical Center ◽  
Academic Medical Center ◽  
Pulmonary Diseases ◽  
Controlled Study ◽  
Global Public Health ◽  
Detection Rates ◽  
Carbapenem Resistant ◽  
Associated Risk Factors ◽  
Carbapenem Resistant Enterobacteriaceae

ABSTRACT OBJECTIVE While the emergence and spread of carbapenem-resistant Enterobacteriaceae (CRE) and related infections pose serious threats to global public health, the epidemiology and associated risk factors remain poorly understood and vary by geography. METHODS In a case-controlled retrospective study, we examined the prevalence, patient background and risk factors for CRE colonisation and infections, and all patient-derived CRE from January 2015 to January 2017. Isolated carbapenem-susceptible Enterobacteriaceae (CSE) from 2875 enrolled patients were randomly selected during the study. RESULTS CRE colonisation and infections detection rates were 47/2875 (1.6%). Respiratory tract specimens were most frequently seen in 20/47 (42.6%) cases. Klebsiella pneumoniae was the main isolate in 35/47 (74.5%) CRE. As for carbapenemase, KPC-2-producing bacteria was most frequently detected in 38/47 (80.9%) Enterobacteriaceae. No underlying conditions (P = 0.004), pulmonary diseases (P = 0.018) and no antibiotics used prior to culture within 30 days (P < 0.001) were statistically significant between the CRE and CSE groups. CONCLUSION Klebsiellapneumoniae was the main isolate of CRE. The blaKPC-2 was the predominant CRE gene. Underlying conditions especially pulmonary diseases and antibiotics used prior to culture within 30 days represented key risk factors for acquisition of CRE.

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