A CLINICAL STUDY SHOWING ASSOCIATION OF SERUM LIPIDS WITH PRIMARY OPEN ANGLE GLAUCOMA

2021 ◽  
pp. 63-64
Author(s):  
Sudeshna Roy ◽  
Debalina Ghanta
Keyword(s):  
Total Cholesterol ◽  
Serum Lipids ◽  
Open Angle Glaucoma ◽  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
Good Control ◽  
High Serum ◽  
High Serum Cholesterol ◽  
Independent Risk Factors ◽  
Total Triglyceride

Introduction: Glaucoma, a multifactorial condition characterized by progressive optic neuropathy and distinctive visual eld loss, has become the most common cause of irreversible blindness worldwide. Many cases have shown progress despite of good control of IOP, strengthening the view that other independent risk factors play role in pathogenesis of glaucoma. Few studies have shown association of serum lipids to glaucoma. The objective of the study is to nd relation between serum lipid and POAG. Materials and Method: The study was conducted on 50 cases of glaucoma and 50 age matched controls. Detailed ophthalmic examinations were performed in all patients. Fasting lipid prole including total cholesterol, triglyceride, Low density lipoprotein(LDL),and high density lipoprotein (HDL) were measured and analyzed between the cases and controls. Result: Level of total cholesterol, total triglyceride, and LDLwere signicantly higher in cases than in contacts with Pvalue <0.05.Level of HDL was lowered in cases than in controls but it was not statistically signicant. Conclusion: Dyslipidemia is an independent risk factor for POAG. High serum Cholesterol, high triglyceride and high serum LDLcorrelate signicantly with POAG.

scholarly journals High serum cholesterol levels in persons with 'high-normal' TSH levels: should one extend the definition of subclinical hypothyroidism?

1998 ◽  
pp. 141-145 ◽  
Author(s):  
G Michalopoulou ◽  
M Alevizaki ◽  
G Piperingos ◽  
D Mitsibounas ◽  
E Mantzos ◽  
...  
Keyword(s):  
Total Cholesterol ◽  
Serum Cholesterol ◽  
Subclinical Hypothyroidism ◽  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
High Serum ◽  
High Serum Cholesterol ◽  
Cholesterol Levels ◽  
Group D ◽  
Tsh Levels

OBJECTIVE: The association between established hypothyroidism and high cholesterol levels is well known. The aim of the present study was to investigate the effect of thyroxine (T4) administration on cholesterol levels in hypercholesterolemic subjects with TSH levels within the normal range ('high-normal' TSH compared with 'low-normal' TSH). DESIGN AND METHODS: We determined TSH levels in 110 consecutive patients referred for hypercholesterolemia (serum cholesterol >7.5 mmol/l). Those with 'high-normal' TSH (2.0-4.0 microU/ml) as well as those with 'low-normal' TSH (0.40-1.99 microU/ml) were randomly assigned to receive either 25 or 50 microg T4 daily for two months. Thus, groups A and B (low-normal TSH) received 25 and 50 microg T4 respectively and groups C and D (high-normal TSH) received 25 and 50 microg T4 respectively. Serum T4, tri-iodothyronine (T3), TSH, free thyroxine index, resin T3 uptake and thyroid autoantibodies (ThAab) as well as total cholesterol, high and low density lipoprotein cholesterol (HDL, LDL), and triglycerides were determined before and at the end of the two-month treatment period. RESULTS: TSH levels were reduced in all groups. The most striking effect was observed in group D (TSH levels before: 2.77+/-0.55, after: 1.41+/-0.85 microU/ml, P < 0.01). Subjects in groups C and D had a higher probability of having positive ThAabs. A significant reduction in total cholesterol (P < 0.01) and LDL (P < 0.01) was observed after treatment only in group D. In those subjects in group D who were ThAab negative, there was no significant effect of thyroxine on cholesterol levels. CONCLUSIONS: Subjects with high-normal TSH levels combined with ThAabs may, in fact, have subclinical hypothyroidism presenting with elevated cholesterol levels. It is possible that these patients might benefit from thyroxine administration.

Apolipoprotein E Phenotypes and Serum Lipids in Newborns and 3-Year-Old Children: The Cardiovascular Risk in Young Finns Study

PEDIATRICS ◽  
1994 ◽  
Vol 94 (4) ◽  
pp. 489-493 ◽  
Author(s):  
Terho Lehtimäki ◽  
Tapio Nikkari ◽  
Kimmo Porkka ◽  
Jorma Viikari ◽  
Christian Ehnholm ◽  
...  
Keyword(s):  
Apolipoprotein E ◽  
Total Cholesterol ◽  
Serum Lipids ◽  
Ldl Cholesterol ◽  
Disease Risk ◽  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
Serum Levels ◽  
Heart Disease Risk Factors ◽  
Apoe Phenotype

Background. Apolipoprotein E (apoE) phenotype is a genetic determinant of plasma total cholesterol and low density lipoprotein (LDL) cholesterol concentrations, that are classical coronary heart disease risk factors. ApoE appears in three major isoforms E2, E3, and E4, coded by corresponding alleles ∈2, ∈3, and ∈4. These give rise to six different phenotypes. Objective. To study the associations of apoE phenotype with cord serum lipids (during minimal enteral nutrition), and with serum lipids of 3-year-old children. Subjects and methods. We determined serum lipid levels and apoE phenotypes in 206 newborns and 259 3-year-old children in connection with a larger follow-up study of atherosclerosis precursors in children and young adults. ApoE phenotyping was done directly from plasma by isoelectric focusing followed by immunoblotting. Results. The effect of apoE phenotype on serum total and LDL cholesterol was significantly different in newborns and 3-year-old children (two-way ANOVA, interaction between apoE phenotype and age group: P &lt; .001 for both). In 3-year-old children, the concentrations of serum total cholesterol and LDL cholesterol increased with apoE phenotype in the order of E3/2, E3/3, E4/3, and E4/4, in both males and females (P &lt; .0001). On the contrary, in neonates total cholesterol and LDL cholesterol concentrations were low and did not differ significantly between apoE phenotypes (P &gt; .05) either in males or in females. The mean serum levels of triglycerides and high density lipoprotein cholesterol did not differ between apoE phenotypes either in 3-year-old children or newborns. Conclusions. The results show that the differences in serum total and LDL cholesterol levels between apoE phenotypes are formed after birth by the influence of environmental factors and suggest that both genetic and external factors influence the levels of serum cholesterol concentrations during the first years of life.

Genetic Variance and Heritability of Serum Cholesterol and Triglycerides Among Chinese Twin Neonates

1990 ◽  
Vol 39 (1) ◽  
pp. 123-131 ◽  
Author(s):  
C.-J. Chen ◽  
M.-W. Yu ◽  
C.-J. Wang ◽  
S.-L. Tong ◽  
M. Tien ◽  
...  
Keyword(s):  
Total Cholesterol ◽  
Serum Lipids ◽  
Genetic Variance ◽  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
Lipoprotein Cholesterol ◽  
Teaching Hospitals ◽  
Low Density Lipoprotein Cholesterol ◽  
Taipei City ◽  
Mz Twins

AbstractIn order to examine the genetic variance and heritability of serum total cholesterol, high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C) and triglycerides, a total of 349 pairs of same-sexed twin neonates born in four major general teaching hospitals in Taipei City were studied. Based on the placental pattern and 12 red blood cell antigens, 271 monozygotic (MZ) and 78 dizygotic (DZ) twin pairs were identified. There was a significant genetic variance for total cholesterol, HDL-C, LDL-C, and triglycerides both unadjusted and adjusted for sex, gestational age and placentation. The unadjusted heritability of total cholesterol, HDL-C, LDL-C, and triglycerides was 0.59, 0.30, 0.25 and 0.75, respectively; while the corresponding adjusted heritability was 0.74, 0.38, 0.31, and 0.49, respectively. Intrapair variance of serum lipids was not significantly different between monochorionic and dichorionic MZ twins.

Hypolipidemic Effect ofGlycine tomentellaRoot Extract in Hamsters

2004 ◽  
Vol 32 (01) ◽  
pp. 57-63 ◽  
Author(s):  
Yu-Jen Ko ◽  
Yueh-Wern Wu ◽  
Wen-Chuan Lin
Keyword(s):  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
Serum Triglyceride ◽  
Hdl Cholesterol ◽  
Cholesterol Content ◽  
High Serum ◽  
Hypolipidemic Effect ◽  
High Serum Cholesterol ◽  
Glycine Tomentella ◽  
Triglyceride Content

The influence of the aqueous crude extract of Glycine tomentella root (Leguminosae) on lipid metabolism was investigated in hyperlipidemic hamsters. It was found that the administration of the G. tomentella extract (GTE) leads to a decrease of high serum cholesterol and triglyceride levels induced by high-fat diet. The GTE also increased serum high-density lipoprotein (HDL) cholesterol and decreased serum low-density lipoprotein (LDL) cholesterol. The reduction of serum triglyceride levels was accompanied by a significant decrease in the hepatic triglyceride content, while the cholesterol content was not changed. The results indicate that GTE is definitely an anti-hyperlipidemic agent, at least, in animals.

scholarly journals INCREASE OF LIPIDS DURING HCV TREATMENT: VIRUS ACTION OR MEDICATION?

2018 ◽  
Vol 55 (2) ◽  
pp. 184-187 ◽  
Author(s):  
Vanessa Gutierrez de ANDRADE ◽  
Fabio da Silva YAMASHIRO ◽  
Cassio Vieira OLIVEIRA ◽  
Leticia Lastória KUROZAWA ◽  
Alecsandro MOREIRA ◽  
...  
Keyword(s):  
Prospective Study ◽  
Total Cholesterol ◽  
Serum Lipids ◽  
Lipid Analysis ◽  
Direct Action ◽  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
Serum Levels ◽  
P Value ◽  
Significant Difference

ABSTRACT BACKGROUND: The interaction between serum lipids and C virus infection is well known, as are serum lipid levels in the Peg-IFN / RBV-based treatment. However, with direct action antivirals (DAAs) this behavior is still unclear. OBJECTIVE: To compare serum lipids levels between patients treated with Peg-IFN/RBV and DAAs and to evaluate lipids in sustained virological response (SVR) with DAAs. METHODS: Retro prospective study comparing the behavior of total cholesterol (TC), low-density lipoprotein (LDL) and triglycerides (TG) serum levels during treatment with DAAs (G-DAAs) and a control historic group Peg-IFN/RBV (G-PR). Coorte, prospective study, to study the behavior of lipids in the SVR with DAAs. Data were collected at the beginning of treatment (baseline: t-base) and at week 12 of treatment (t-12) for G-DAAs and at week 24 (t-24) for G-PR, groups. In the cohort evaluation, the samples at t-base and at week 12 after the end of treatment (t-SVR). Delta lipids: difference between lipids in t-12 / t-24 minus t-base for comparison between G-PR and G-AADs groups and t-SVR minus t-base for lipid analysis in SVR. Analysis with Kruskal Wallis and Wilcoxon tests to compare the delta lipids of the groups. The P value was 0.05. RESULTS: In the assessment between G-PR and G-DAAs groups, we included 63 and 121 patients, respectively. The groups did not differ one from the other (BMI, sex, genotype, fibrosis, total cholesterol, LDL, and TG) except by age (50.38±10.44 vs 56±9.69, P=0.0006). We observed a decrease in levels of TC and LDL and an increase in TG, in G-PR, and in G-DAAs the opposite (Δ TC -13.9±34.5 vs 4.12±34.3 P=0.0005, Δ LDL -7.16±32 vs 10.13±29.92, P=0.003, Δ TG 4.51±53.7 vs -8.24±49.93, P=0.0025). In the coorte analysis, we included 102 patients, 70% men and 56% F4, 95 of them reached SVR. We observed an increase of TC and LDL and a decrease of TG in both groups (SVR and non SVR), with no statistical difference (Δ TC P=0.68; Δ LDL P=0.69; Δ TG P=0.43). We did not find significant difference in delta evaluation by genotype 1 and 3 (Δ TC +29.7±40.2 vs +13.4±30.3, P=0.06; Δ LDL +21.4±28.6 vs +16.6±31.3, P=0.41; Δ TG -3.6±60.6 vs -0.7±40, P=0.91). CONCLUSION: Serum lipids level differed during treatment with Peg-IFN and DAAs. Treatment with DAAs was associated with an increase of TC and LDL and a decrease of TG, independently of SVR.

scholarly journals The Effects of Pilates and Aerobic Exercise on Blood Pressure, Heart Rates, and Blood Serum Lipids in Sedentary Females

2019 ◽  
Vol 7 (4) ◽  
pp. 229 ◽  
Author(s):  
Semra Çetin ◽  
Cuma Ece ◽  
Murat Şen ◽  
H. Nedim Çetin ◽  
Alaeddin Aydoğan
Keyword(s):  
Blood Pressure ◽  
Body Weight ◽  
Aerobic Exercise ◽  
Total Cholesterol ◽  
Serum Lipids ◽  
Low Density Lipoprotein ◽  
Exercise Program ◽  
Density Lipoprotein ◽  
Waist To Hip Ratio ◽  
Sedentary Women

The aim of this study was to determinate the effects of 12 weeks pilates and aerobic exercise on blood pressure, heart rates, and blood serum lipids in sedentary females. 18 sedentary women with an average age of 45.52 years, height of 161.14 cm and weight of 72.5 kg have been selected and put through a plates and aerobic exercise programmer one hour a day for three days a week. Exercises in each training session were arranged in such a way as to make each woman’s heart rate to reach a level of 130-140 a minute. The waist and hip circumferences were measured using a measuring tape. BMI and waist hip ratio were calculated by standard formulas. Triglyceride (TG), Total Cholesterol (TC), High density lipoprotein (HDL-C) and Low density lipoprotein (LDL-C) levels were determined by Hitachi 717 auto analyzer. Analysis was performed on SPSS 21 version. Paired-t tests were done statistical analysis. Body Weight found before 12 weeks plates and aerobic exercise 72.5 kg and after 63.8 kg. At the end of the 12 weeks exercise program, a decrease of %12.00 in body weight, %14.03 in systolic, %3.96 in diastolic, %13.85 in cholesterol, %25.30 in Triglyceride, and %22.33 in LDL-C have been registered. However, there were increases of %16.34 in HDL-C. The effects of aerobic exercise is on Triglyceride, HDL-C, LDL-C and total cholesterol since (p<0.01). At the end of the 12 weeks exercise program, a decrease %13.34 hip circumference and %4.19 waist circumference. Waist to hip ratio found before 12 weeks plates and aerobic exercise 0.87 cm and after 0.78 cm. The effects of aerobic exercise is on Body weight, Systolic blood pressure, Heart rate, hip and waist circumference since (p<0.05; p<0.01). In this study, together Pilates and aerobic exercise was effective in sedentary women with initially high total cholesterol, triglyceride, and Low density lipoprotein levels. At end of the cycles of 12 weeks Pilates and aerobic exercises, has a positive effect of waist to hip ratio, blood pressure, and heart beats in sedentary females. Risk of heart and vascular disease is reduced. Pilates and aerobic exercises are recommended for decrease risk.

scholarly journals Decreased Serum Lipids in Patients with Probable Alzheimer´s Disease

2009 ◽  
Vol 9 (3) ◽  
pp. 215-220 ◽  
Author(s):  
Orhan Lepara ◽  
Amina Valjevac ◽  
Azra Alajbegović ◽  
Asija Zaćiragić ◽  
Emina Nakaš-Ićindić
Keyword(s):  
Total Cholesterol ◽  
Serum Lipids ◽  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
Epidemiologic Studies ◽  
Lipoprotein Cholesterol ◽  
Initial Assessment ◽  
Control Group ◽  
Cross Sectional ◽  
Control Subjects

Alzheimer’s disease (AD) is a multifactorial disease but its aetiology and pathophisiology are still not fully understood. Epidemiologic studies examining the association between lipids and dementia have reported conflicting results. High total cholesterol has been associated with both an increased, and decreased, risk of AD and/or vascular dementia (VAD), whereas other studies found no association. The aim of this study was to investigate the serum lipids concentration in patients with probable AD, as well as possible correlation between serum lipids concentrations and cognitive impairment.Our cross-sectional study included 30 patients with probable AD and 30 age and sex matched control subjects. The probable AD was clinically diagnosed by NINCDS-ADRDA criteria. Serum total cholesterol (TC), high-density lipoprotein cholesterol (HDL-C) and triglyceride (TG) levels were determined at the initial assessment using standard enzymatic colorimetric techniques. Low-den- sity lipoprotein cholesterol (LDL-C) and very low density lipoprotein cholesterol (VLDL-C) levels were calculated. Subjects with probable AD had significantly lower serum TG (p<0,01), TC (p<0,05), LDL-C (p<0,05) and VLDL-C (p<0,01) compared to the control group. We did not observe signifi-cant difference in HDL-C level between patients with probable AD and control subjects. Negative, although not significant correlation between TG, TC and VLDL-C and MMSE in patients with AD was observed. In the control group of subjects there was a negative correlation between TC and MMSE but it was not statistically significant (r = -0,28). Further studies are required to explore the possibility for serum lipids to serve as diagnostic and therapeutic markers of AD.

Serum Lipids and Lipoproteins

PEDIATRICS ◽  
1987 ◽  
Vol 80 (5) ◽  
pp. 789-796
Author(s):  
David S. Freedman ◽  
Sathanur R. Srinivasan ◽  
James L. Cresanta ◽  
Larry S. Webber ◽  
Gerald S. Berenson
Keyword(s):  
Total Cholesterol ◽  
Serum Lipids ◽  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
Lipoprotein Cholesterol ◽  
Blood Levels ◽  
Low Density ◽  
Low Density Lipoprotein Cholesterol ◽  
Increased Risk ◽  
Lipids And Lipoproteins

Serum lipids and lipoprotein cholesterol fractions were examined in a newborn cohort that was followed from birth to 7 years of age. Although white and female infants had higher cord blood levels of high-density lipoprotein cholesterol (HDL-C) than did black and male infants, respectively, these differences did not persist throughout early childhood. Mean levels of all serum lipids and lipoproteins increased greatly in the first 6 months of life, and by 2 years of age, levels approached those seen in adolescents. Infants consuming cow's milk had higher 6-month levels of serum total cholesterol and low-density lipoprotein cholesterol than did formula-fed infants. However, milk source in infancy did not significantly influence total cholesterol or low-density lipoprotein cholesterol levels at age 7 years. Serum lipid and lipoprotein levels at age 7 years were associated with previously measured levels as early as 6 months of age, and infants with unfavorable levels were likely to have similar adverse levels at 7 years of age. In addition, increases in obesity between 6 months and 7 years of age were positively associated with increases in levels of serum triglycerides. These results suggest that certain persons at increased risk for cardiovascular disease can be identified in infancy.

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