scholarly journals PERBANDINGAN KADAR ASAM URAT PADA SUBYEK OBES DAN NON-OBES DI FAKULTAS KEDOKTERAN UNIVERSITAS SAM RATULANGI MANADO

e-CliniC ◽  
2015 ◽  
Vol 3 (2) ◽  
Author(s):  
Elim Rau ◽  
Jeffrey Ongkowijaya ◽  
Ventje Kawengian
Keyword(s):  
Uric Acid ◽  
Body Fat ◽  
Uric Acid Level ◽  
Acid Level ◽  
Serum Uric Acid Level ◽  
Normal Serum ◽  
The Body ◽  
Obese Group ◽  
Male Students ◽  
Cross Sectional

Abstract: Uric acid is the end product of purine metabolism. Circulating uric acid in the human body is produced by the body (endogenous uric acid) as well as derived from food (exogenous uric acid). Normal serum uric acid level is <7.0 mg / dL in men and <6.0 in women. Obesity can be defined as excess body fat. One of the markers used for body fat content is body mass index (BMI). This study aimed to compare the levels of uric acid in obese and non-obese subjects. This was an analytical study with a cross sectional design. The population is students of Faculty of Medicine University of Sam Ratulangi Manado. Samples were male students of batch 2013. There were 42 male students, consisted of 21 obese and 21 non-obese students. The results showed that the average of uric acid levels in obese group was 8.05 mg/dL and in non-obese group 6.63 mg/dL. In the obese group, 67% had an increase in uric acid level meanwhile in the non-obese group only 38%. The statistical test showed a sig 0,009. Conclusion: In this study, the average of uric acid level in obese group was significantly higher than in the non-obese group. However, there were students with either normal or high uric acid levels in both groups.Keywords: uric acid, obeseAbstrak: Asam urat merupakan produk akhir metabolisme purin. Asam urat yang beredar di dalam tubuh manusia di produksi sendiri oleh tubuh (asam urat endogen) dan berasal dari makanan (asam urat eksogen). Normalnya kadar asam urat serum <7,0 mg/dL pada pria dan <6,0 mg/dL pada wanita. Obesitas dapat di definisikan sebagai kelebihan lemak tubuh. Penanda kandungan lemak tubuh yang digunakan ialah indeks masa tubuh (IMT). Penelitian ini bertujuan untuk mengetahui perbandingan kadar asam urat pada subyek obes dan non obes. Penelitian ini bersifat analitik dengan pendekatan potong lintang. Populasi penelitian ialah mahasiswa Fakultas Kedokteran Universitas Sam Ratulangi Manado. Sampel idalah mahasiswa pria angkatan 2013 dan didapatkan 42 orang yang terbagi atas 21 obes dan 21 non obes. Hasil penelitian memperlihatkan rerata kadar asam urat pada obes 8,05 mg/dL dan pada non-obes 6,63 mg/dL. Peningkatan kadar asam urat ditemukan 67% pada kelompok obes dan 38% pada kelompok non-obes. Uji statistik menunjukkan nilai sig 0,009. Simpulan: Pada penelitian ini rerata kadar asam urat pada kelompok obes lebih tinggi secara bermakna daripada kelompok non-obes. Walaupun demikian, pada kedua kelompok ditemukan mahasiswa dengan kadar asam urat normal maupun meningkat.Kata kunci: asam urat, obesitas

scholarly journals Serum uric acid level in Bangladeshi adults with essential hypertension

2020 ◽  
Vol 7 (7) ◽  
pp. 1136
Author(s):  
SK. Kabir Ahammed ◽  
A. B. M. Kamrul Hasan ◽  
Mohammed Ruhul Kabir ◽  
Gunosindhu Paul ◽  
Shishir Kumar Basak ◽  
...  
Keyword(s):  
Uric Acid ◽  
Essential Hypertension ◽  
Serum Uric Acid ◽  
Uric Acid Level ◽  
Acid Level ◽  
Serum Uric Acid Level ◽  
Control Group ◽  
Cross Sectional ◽  
Hypertensive Group ◽  
Positive Correlations

Background: The association of hyperuricemia with various cardiovascular risk factors has often led to the debate of whether hyperuricemia is an independent risk factor for essential hypertension (HTN).  The current study was conducted to see the relationship between serum uric acid and essential HTN in Bangladeshi adults.Methods: In this cross-sectional study, conducted in a tertiary hospital of Bangladesh, 155 patients with essential hypertension (newly detected or on treatment) aged ≥18 years and 100 age-sex matched normotensive subjects were investigated. Serum uric acid, plasma glucose, serum creatinine, and lipid profile were measured in all in fasting samples.Results: The frequency of hyperuricemia was higher in the hypertensive group in comparison to the normotensive control group (29.7% vs. 6.0%, p<0.001). Serum uric acid level was higher in the hypertensive subjects than the controls (6.10±0.88 vs. 5.38±0.54 mg/dL, mean±SD, p<0.001). In the hypertensive group, subjects with stage II HTN had higher serum uric acid than those with stage I HTN (6.46±0.83 vs. 5.72±0.78 mg/dL, mean±SD, p<0.001). In the hypertensive group, uric acid level showed significant positive correlations with both systolic and diastolic blood pressure though in the control group uric acid showed such correlation with systolic BP only.Conclusion: Patients with essential hypertension had higher serum uric acid compared to normotensive controls; uric acid level showed positive correlations with systolic and diastolic BP in the hypertensive subjects.

scholarly journals Relationship Between Uric Acid Level and Blood Pressure in T2DM Patient Attending in BIRDEM General Hospital

2018 ◽  
Vol 9 (2) ◽  
pp. 49-53
Author(s):  
S Ferdous ◽  
K Begum ◽  
MA Muttalib
Keyword(s):  
Blood Pressure ◽  
Uric Acid ◽  
Serum Uric Acid ◽  
Uric Acid Level ◽  
Acid Level ◽  
Stone Formation ◽  
Serum Uric Acid Level ◽  
High Serum ◽  
Normal Serum ◽  
Significant Difference

Hyperuricemia is associated with higher mortality in patients suffering from hypertension, coronary heart disease, cerebrovascular events, metabolic syndrome, insulin resistance, gout and renal stone formation and it is more in individuals with diabetes. The prevalence of hyperuricemia is high in T2DM. The aim of the present study was to assess the relationship between hyperuricemia and blood pressure in T2DM subjects and thus to help the clinician for early diagnosis, treatment and to prevent further complications. Total 350 study subjects were enrolled for this study; among them 203 were T2DM with normal level of serum uric acid level and 147 were T2DM with high serum uric acid level. It was observed that systolic blood pressure was significantly higher (134.5±9.6 mm of Hg) in T2DM with hyperuricemia (p<0.001) than T2DM with normal serum uric acid level (123.3±10.9 mm of Hg). On the other hand diastolic blood pressure was significantly higher (87.1±5.9 mm of Hg) in T2DM with hyperuricemia (p<0.001) than T2DM with normal serum uric acid level (79.6±8.3 mm of Hg). Age (years) showed no significant difference between T2DM with serum uric acid<7 mg/dl and T2DM with serum uric acid>7 mg/dl (p<0.05). In our study it was revealed that males were in greater risk of developing hyperuricemia. BMI was significantly (p<0.001) greater in T2DM subjects who had normal serum uric acid level (27.9±3.8) than with those who had serum uric acid>7 mg/dl (24.4±3.83). No significant differences were found in FBS, blood sugar 2 hours after breakfast, HbA1C, serum creatinine and blood urea between groups.Bangladesh J Med Biochem 2016; 9(2): 49-53

scholarly journals Serum Uric Acid Level in Preeclamptic Women Determine the Severity of Preeclampsia

2020 ◽  
Vol 32 (2) ◽  
pp. 67-72
Author(s):  
Khairun Nahar ◽  
Sayada Fatema Khatun ◽  
Naila Atik Khan
Keyword(s):  
Uric Acid ◽  
Serum Uric Acid ◽  
Uric Acid Level ◽  
Acid Level ◽  
Serum Uric Acid Level ◽  
Severe Preeclampsia ◽  
College Hospital ◽  
Cross Sectional ◽  
Mild Preeclampsia ◽  
Relationship Of

Background: Serum uric acid is a relatively insoluble metabolite of purine metalolism which is mainly secreted by the kidneys and the rate is dependant on renal blood flow . It increases in preeclampsia and studies show it may be marker of severe preeclampsia. Methods and materials: This cross sectional study was conducted in Dhaka Medical College Hospital in eclampsia ward of gynae & Obs department during the period from January 2010 to December 2011 with the objective to determine the serum uric acid level in preeclampsia, to compare the serum uric acid level between mild and sever preeclampsia and to find out any relationship of the serum uric acid level with hypertension in preeclampsia. The study group composed of 92 diagnosed case of preeclampsia patient. Out of the 92 cases, 42 had mild preeclampsia (group-A) and 50 had severe preeclampsia (group B). Result: The results of the study showed that the mean serum uric acid level was significantly higher in severe preeclampsia (6.91+1.02) compared to mild preeclampsia (4.99 + 0.80) and there is a positive and significant relationship of serum uric acid level with severity of hypertension in preeclampsia (p<.0001). Conclusion: There is significant association between serum uric acid level and severity of hypertension in Preeclampsia. Bangladesh J Obstet Gynaecol, 2017; Vol. 32(2) : 67-72

scholarly journals Association between Serum Uric Acid Levels and Bone Mineral Density in Postmenopausal Women: A Cross-Sectional and Longitudinal Study

Healthcare ◽  
2021 ◽  
Vol 9 (12) ◽  
pp. 1681
Author(s):  
Soyeon Kang ◽  
Dongjin Kwon ◽  
Jiwoo Lee ◽  
Youn-Jee Chung ◽  
Mee-Ran Kim ◽  
...  
Keyword(s):  
Bone Mineral Density ◽  
Uric Acid ◽  
Femoral Neck ◽  
Postmenopausal Women ◽  
Serum Uric Acid ◽  
Uric Acid Level ◽  
Acid Level ◽  
Serum Uric Acid Level ◽  
Mineral Density ◽  
Cross Sectional

Background: Uric acid is one of natural antioxidants in human body. There have been several studies on the correlation between uric acid with oxidative stress and osteoporosis. However, the data are insufficient and results are controversial. In this regard, we determined the association between uric acid levels and bone mineral density (BMD) during the postmenopausal period. Methods: We analyzed data from 328 postmenopausal women (mean age, 57.3 ± 6.5 years; mean serum uric acid level, 4.6 ± 1.0 mg/dL). The participants were divided into three groups based on tertiles of the serum uric acid level. The participants receiving hormone replacement therapy (HRT), bisphosphonates, or lipid-lowering agents were included. Results: Blood urea nitrogen, serum creatinine, and serum triglyceride levels were significantly higher in the upper tertiles of uric acid levels. No significant difference was found in the mean uric acid levels between medication users and non-users. Each HRT regimen had a different mean serum uric acid level. A cross-sectional analysis showed no significant correlation between the serum uric acid levels and BMD in the spine and femoral neck (spine BMD: 1.050 ± 0.131, 1.060 ± 0.160, 1.084 ± 0.140, p = 0.22; femoral neck BMD: 0.837 ± 0.110, 0.849 ± 0.096, 0.863 ± 0.115, p = 0.28 for each tertile of uric acid). Longitudinal analysis of data from 186 women with follow-up examinations at a mean interval of 14.6 months also revealed no difference in reduction in both spine and femoral neck BMD between tertile groups of serum uric acid (the median BMD reduction for spine: −0.02, 0.01, −0.04, p = 0.95; the median BMD reduction for femoral neck: 0.008, 0.005, −0.003, p = 0.34). Conclusions: Serum uric acid level is not associated with BMD in postmenopausal women.

scholarly journals Gambaran Kadar Asam Urat Serum pada Remaja dengan Overweight dan Obesitas

2018 ◽  
Vol 6 (1) ◽  
Author(s):  
Inggrianno G.V Matialu ◽  
Murniati Tiho ◽  
Youla A. Assa
Keyword(s):  
Uric Acid ◽  
High School Students ◽  
Uric Acid Level ◽  
Acid Level ◽  
Serum Uric Acid Level ◽  
Overweight And Obesity ◽  
School Students ◽  
Cross Sectional ◽  
Cross Sectional Design ◽  
Level Profile

Abstract: Nowadays, obesity has become a serious problem world-wide. Obesity can cause the emergence of various kinds of diseases; one of them is hyperuricemia. This condition could found in obese adult as well as in obese adolescence. This study was aimed to obtain the serum uric acid level profile among high school students with overweight and obesity. This was a descriptive study with a cross sectional design. Subjects were grade X-XI students of SMA Negeri 2 Bitung with body mass index (BMI) >85. There were 23 students involved in this study. The results showed that 60.87% subjects had hyperuricemia. Conclusion: Most adolescence with obesity tend to have uric acid level above normal value.Keywords: adolescence, obesity, hyperuricemia, serum uric acidAbstrak: Obesitas saat ini sudah menjadi sebuah permasalahan serius bagi dunia. Obesitas dapat menyebabkan timbulnya berbagai penyakit seperti hiperurisemia. Masalah hiperurisemia tidak hanya terjadi pada orang dewasa yang obes tetapi juga dapat menyerang remaja yang obes. Penelitian ini bertujuan mengetahui gambaran kadar asam urat serum pada siswa yang mengalami overweight maupun obesitas. Jenis penelitian ini ialah deskriptif dengan desain potong lintang. Subjek penelitian ialah siswa kelas X-XI SMA Negeri 2 Bitung yang memiliki IMT diatas persentil 85 sebanyak 23 siswa. Hasil penelitian menunjukkan bahwa sebanyak 60,87% siswa mengalami hiperurisemia. Simpulan: Remaja dengan obesitas cenderung memiliki kadar asam urat di atas normal.Kata kunci: remaja, obesitas, hiperurisemia, asam urat serum

scholarly journals Overview of Serum Uric Acid Levels in Adolescents with Overweight and Obesity

2019 ◽  
Vol 1 (4) ◽  
pp. 63-67
Author(s):  
Thothilath Sampan
Keyword(s):  
High School ◽  
Uric Acid ◽  
High School Students ◽  
Serum Uric Acid ◽  
Uric Acid Level ◽  
Acid Level ◽  
Serum Uric Acid Level ◽  
Overweight And Obesity ◽  
School Students ◽  
Cross Sectional

Nowadays, obesity has become a serious problem world-wide. Obesity can cause the emergence of various kinds of diseases; one of them is hyperuricemia. This condition could found in obese adult as well as in obese adolescence. This study was aimed to obtain the serum uric acid level profile among high school students with overweight and obesity. This was a descriptive study with a cross sectional design. Subjects were students of Gen Panteleon High School with body mass index (BMI) >85. There were 23 students involved in this study. The results showed that 60.87% subjects had hyperuricemia. Most adolescence with obesity tend to have uric acid level above normal value.

scholarly journals Gambaran Kadar Asam Urat Serum pada Mahasiswa dengan Indeks Massa Tubuh ≥23 kg/m2 di Fakultas Kedokteran Universitas Sam Ratulangi

2017 ◽  
Vol 5 (2) ◽  
Author(s):  
Paterick R. Rampi ◽  
Youla A. Assa ◽  
Yanti M. Mewo
Keyword(s):  
Body Mass Index ◽  
Uric Acid ◽  
Serum Uric Acid ◽  
Body Mass ◽  
Uric Acid Level ◽  
Acid Level ◽  
Serum Uric Acid Level ◽  
Overweight And Obesity ◽  
Cross Sectional ◽  
Normal Limits

Abstract: Diseases caused by high uric acid levels are still commonly found in societies world wide. There is a correlation between uric acid level and increased body mass index (BMI). Higher body mass index in this case overweight and obesity is associated with higher risk of insulin resistance and excessive leptin production which may contribute to hyperuricemia. This study was aimed to obtain the profile of serum uric acid level among students with a BMI of ≥23 kg/m2 at Faculty of Medicine, Sam Ratulangi University. This was a descriptive study with a cross sectional design. Samples were obtained by using total sampling method. There were 53 respondents that met the inclusion and exclusion criteria. The results showed that there were 48 respondents (90.6%) whose serum uric acid levels were within normal limits, one respondent (1.9%) with hyperuricemia, and four respondents (7.5%) with hypouricemia. Conclusion: The majority of respondents had uric acid level within normal limit.Keywords: serum uric acid, body mass index, students Abstrak: Penyakit yang disebabkan akibat tingginya kadar asam urat masih banyak diderita oleh masyarakat dunia sekarang ini. Terdapat hubungan antara kadar asam urat dengan peningkatan indeks massa tubuh (IMT). Semakin tinggi indeks massa tubuh dalam hal ini overweight dan obesitas berhubungan dengan semakin tinggi juga risiko terjadinya resistensi insulin dan produksi leptin yang berlebih sehingga keadaan ini dapat berkontribusi menimbulkan hiperurisemia. Tujuan penelitian ini untuk mengetahui gambaran kadar asam urat serum pada mahasiswa dengan IMT ≥23 kg/m2 di Fakultas Kedokteran Universitas Sam Ratulangi. Jenis penelitian ialah deskriptif dengan desain potong lintang. Pengambilan sampel dengan menggunakan teknik total sampling. Terdapat 53 responden yang memenuhi kriteria inklusi dan eksklusi. Hasil penelitian memperlihatkan 48 responden (90,6%) memiliki kadar asam urat serum dalam batas normal, satu responden (1,9%) dengan hiperurisemia, dan empat responden (7,5%) dengan hipourisemia. Simpulan: Sebagian besar responden memiliki kadar asam urat serum dalam batas normal.Kata kunci: asam urat serum, indeks massa tubuh, mahasiswa

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