scholarly journals Hubungan kadar glukosa darah puasa dengan obesitas pada remaja di Kecamatan Bolangitang Barat Kabupaten Bolaang Mongondow Utara

2016 ◽  
Vol 4 (2) ◽  
Author(s):  
Reiner C. Polii ◽  
Billy J. Kepel ◽  
Widdhi Bodhi ◽  
Aaltje E. Manampiring
Keyword(s):  
Blood Sugar ◽  
Blood Sugar Level ◽  
Analytical Study ◽  
Fasting Blood Glucose ◽  
Fasting Blood Sugar ◽  
Weak Correlation ◽  
Cross Sectional ◽  
Obese Adolescent ◽  
Spearman Correlation Test ◽  
Cross Sectional Design

Abstract: Obesity has become a serious problem world-wide. Obesity occurs due to the imbalance of intake and output energy. Thus, it is related with the incidence of insulin resistance and the disruption of glucose metabolism. This study was aimed to obtain the correlation between fasting blood sugar level and obesity in adolescents. This was an analytical study with a cross-sectional design. The results showed that the major category of subjects was obese I (38.33%). The highest percentage was normal blood sugar which was found in non-obese adolescent (96.8%). The Spearman correlation test showed a sweak correlation between obesity and fasting blood sugar level in adolescent (r=0.386; p=0.004). Conclusion: There was a significant weak correlation between fasting blood sugar level and obesity in adolescents.Keywords: obesity, fasting blood glucose, adolescent. Abstrak: Obesitas menjadi masalah di seluruh dunia baik di negara maju maupun negara berkembang, prevalensinya pun meningkat begitu pesat. Obesitas terjadi karena adanya ketidakseimbangan antara energi yang masuk dengan energi yang keluar. Obesitas berkaitan dengan terjadinya resitensi insulin dan gangguan metabolisme glukosa.Penelitian ini bertujuan untuk mengetahui hubungan kadar glukosa darah puasa dengan obesitas pada remaja di Kecamatan Bolangitang Barat Kabupaten Bolaang Mongondow Utara. Jenis penelitian ialah analitik dengan desain potong lintang. Hasil penelitian menunjukkan bahwa subjek penelitian terbanyak dalam kategori obes I (25,0-29,9 kg/m2) sebesar 38,33%. Kadar gula darah normal pada remaja non-obes dengan persentasi tertinggi (96,8%). Analisis korelasi Spearman pada kedua variabel memperoleh nilai koefisien korelasi r = 0,368 (p = 0,004). Simpulan: Terdapat hubungan bermakna yang lemah antara kadar gula darah puasa dan obesitas pada remaja. Kata kunci: obesitas, gula darah puasa, remaja

scholarly journals Hubungan Asupan Zink, Magnesium, dan Serat dengan Kadar Gula Darah Puasa Pasien Diabetes Mellitus Tipe 2 di RS PKU Muhammadiyah Temanggung

Jurnal Gizi ◽  
2019 ◽  
Vol 8 (2) ◽  
pp. 87
Author(s):  
Efina Amanda ◽  
Salsa Bening
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Blood Sugar ◽  
Blood Sugar Level ◽  
Fasting Blood Sugar ◽  
Fiber Intake ◽  
Cross Sectional ◽  
Magnesium Intake ◽  
Sugar Levels

Diabetes Mellitus (DM) type 2 occurs because of insulin resistance, on of the contributing factors is the lack of intake of micronutrients (zinc and magnesium) and macro (fiber). The prevalence of DM in Temanggung is 1,6%. There are 45 patients suffering from type 2 diabetes at PKU Muhammadiyah Hospital in Temanggung which have zinc, magnesium, and fiber intake below normal (deficit). The study aims to analyze the relationship of zinc, magnesium, and fiber intake with fasting blood sugar levels at PKU Muhammadiyah Hospital in Temanggung. The research is a cross sectional design with 45 responden taken with purposive sampling technique. Statistical analysis using kolmogorov smirnov normality test was tested using the spearman correlation test. Data collection of zinc, magnesium, and fiber intake using the 2x24 hour recall and FFQ form while the blood sugar level data is obtained from the patient’s medical record book. The result showed that there was a relationship between zinc intake to fasting sugar levels of patients (p=0,000), there was a correlation between magnesium intake to fasting blood sugar levels in patients (p=0,000). There is a relationship between zinc, magnesium, and fiber intake to fasting blood sugar levels. Keywords: Zink Intake, Magnesium Intake, Fiber Intake, Fasting Blood Sugar Level, Type 2 Diabetes Mellitus

scholarly journals Hubungan Nilai Ujian Try Out Lokal dengan Nilai Computer Based Test Uji Kompetensi Mahasiswa Program Profesi Dokter di Fakultas Kedokteran Universitas Sam Ratulangi Manado

2019 ◽  
Vol 7 (1) ◽  
Author(s):  
Atika I. S. Labatjo ◽  
Firginia P. Manoppo ◽  
Siemona L. E. Berhimpon
Keyword(s):  
Test Score ◽  
Graduation Rate ◽  
Analytical Study ◽  
Medical Faculty ◽  
Spearman Correlation ◽  
Design Data ◽  
Cross Sectional ◽  
Spearman Correlation Test ◽  
Computer Based ◽  
Cross Sectional Design

Abstract: The graduation rate of the Computer Based Test (CBT) in Competency Test for Medical Student Profession Program (UKMPPD) of Medical Faculty, Sam Ratulangi University is still below 50% so far. Therefore, the Medical Faculty of Sam Ratulangi University makes various efforts to increase their graduation rate, inter alia implementation of local Try Out (TO) test as a filtering test required before the CBT UKMPPD. This study was aimed to find out whether there was a correlation between the local TO test score and the CBT UKMPPD score. This was a descriptive analytical study with a cross-sectional design. Data of this study were the local TO test score and the CBT UKMPPD score of the Medical Faculty of Sam Ratulangi University. The data were analyzed with the Spearman correlation test. The results showed that there was a significant correlation (P=0.028) between the local TO test score and the CBT UKMPPD score with a very weak positive correlation value (r= 0.199). Conclusion: There was a significant correlation between the local TO test score and the CBT UKMPPD score.Keywords: TO, CBT, UKMPPD Abstrak: Angka kelulusan Computer Based Test (CBT) Ujian Kompetensi Mahasiswa Program Profesi Dokter (UKMPPD) Fakultas Kedokteran Universitas Sam Ratulangi (FK Unsrat) Manado masih berada di bawah 50%. Pihak FK Unsrat melakukan berbagai upaya agar angka kelulusan UKMPPD FK Unsrat meningkat, salah satunya yaitu dengan mengadakan ujian Try Out (TO) lokal sebagai ujian penyaring yang wajib diikuti sebelum CBT UKMPPD. Penelitian ini bertujuan untuk mengetahui apakah terdapat hubungan antara nilai ujian TO lokal dengan nilai CBT UKMPPD. Jenis penelitian ialah deskriptif analitik dengan ddesain potong lintang. Data penelitian ialah nilai ujian TO lokal dan CBT UKMPPD FK Unsrat. Data dianalisis menggunakan uji korelasi Spearman. Hasil penelitian mendapatkan hubungan bermakna (P=0,028) antara nilai ujian TO lokal dengan nilai CBT dengan tingkat keeratan positif yang sangat lemah (r=0,199). Simpulan: Terdapat hubungan bermakna antara nilai ujian TO lokal dengan nilai CBT UKMPPD.Kata kunci: TO, CBT, UKMPPD

scholarly journals GAMBARAN KADAR GULA DARAH SEWAKTU PADA MAHASISWA ANGKATAN 2015 FAKULTAS KEDOKTERAN UNIVERSITAS SAM RATULANGI MANADO

2015 ◽  
Vol 3 (3) ◽  
Author(s):  
Adriansyah L. Putra ◽  
Pemsi M. Wowor ◽  
Herlina I. S. Wungouw
Keyword(s):  
Blood Sugar ◽  
Blood Sugar Level ◽  
Female Students ◽  
Male Students ◽  
Normal Blood ◽  
Unhealthy Lifestyle ◽  
Cross Sectional ◽  
Random Blood Sugar ◽  
Cross Sectional Design ◽  
Sugar Levels

Abstract: Blood sugar or blood glucose is a universal fuel for human cells and functioning as the source of carbon for the synthesis of many other compounds. As the globalization causes changes of lifestyle that tend be unhealthy lifestyle, there is a need for early detection of blood sugar level since adolescence. This was a descriptive study with a cross sectional design. This study aimed to obtain the random blood sugar levels among college students at Medical Faculty of Sam Ratulangi University Manado. The result showed that of 51 subjects, at age 17, 5 (9.8%) had low blood sugar level and 5 (9,8%) had normal blood sugar level. At age 18, 2 students (3.9%) had low blood sugar level and 24 (47.1%) had normal blood sugar level. At age of 19, 2 students (9,8%) had low blood sugar level and 13 (25.5%) had normal blood sugar level. Of 24 male students, 19 (37.3%) had normal blood sugar level and 5 (9.8%) had low blood sugar level. Of 27 female students, 23 (45.1%) had normal blood sugar level meanwhile 4 (7.8%) had low blood sugar level.Keywords: blood sugar, studentsAbstrak: Gula darah atau glukosa darah merupakan bahan bakar universal bagi sel-sel tubuh manusia dan berfungsi sebagai sumber karbon untuk sintesis sebagian besar senyawa lainnya. Seiring arus globalisasi menyebabkan terjadinya perubahan pola hidup yang cenderung mengacu pada gaya hidup tidak sehat maka diperlukan deteksi dini gula darah sejak remaja. Penelitian ini menggunakan metode deskriptif dengan desain potong lintang. Penelitian ini bertujuan untuk mengetahui kadar gula darah sewaktu pada mahasiswa angkatan 2015 Program Studi Pendidikan Dokter Fakultas Kedokteran Universitas Sam Ratulangi Manado. Hasil penelitian menunjukkan bahwa dari 51 subyek penelitian, pada usia 17 tahun 5 orang (9,8%) dengan kadar gula rendah dan 5 orang (9,8%) dengan kadar gula darah normal. Pada usia 18 tahun diperoleh 2 orang (3,9%) dengan kadar gula rendah dan 24 orang (47,1%) dengan kadar gula darah normal. Pada usia 19 tahun diperoleh 2 orang dengan kadar gula rendah (9,8%) dan 13 orang dengan gula darah normal (25,5%). Dari 24 subyek laki-laki, 19 (37,3%) memiliki kadar gula normal dan 5 (9,8%) memiliki kadar gula darah rendah. Dari 27 subyek perempuan, 23 (45,1%) memiliki kadar gula normal dan 4 (7,8%) memiliki kadar gula darah rendah.Kata kunci: gula darah, mahasiswa

scholarly journals Comparative study of hypoglycemic effects of oral vildagliptin and voglibose on fasting blood sugar level in albino rats

2021 ◽  
Vol 9 (2) ◽  
pp. 542
Author(s):  
Mukesh Kumar ◽  
Mukesh Kumar ◽  
Akash Chandra ◽  
Uma Shankar Prasad Keshri ◽  
Rajiv Kumar
Keyword(s):  
Body Weight ◽  
Blood Glucose ◽  
Blood Glucose Level ◽  
Blood Sugar ◽  
Glucose Level ◽  
Blood Sugar Level ◽  
Fasting Blood Glucose ◽  
Fasting Blood Sugar ◽  
Group A ◽  
Group B

Background: Diabetes mellitus is a metabolic disorder in which there is increased blood sugar level, glycosuria, dyslipidemia and sometimes ketonemia occurs. Increased blood sugar level leads to characteristic symptoms such as polydipsia, polyurea, blurring of vision, polyphagia and weight loss.Methods: Healthy male Wister rats weighing between 150-250 gm were taken. Total 2 groups A and B were prepared and each group contains 6 animals. Group A was administered voglibose as 0.6 mg/70 kg body weight. Group B was administered vildagliptin as 100 mg/70 kg body weight. Diabetes was induced in group A and B by administration of 120 mg/kg body weight of nicotinamide and 60 mg/kg body weight of streptozocin intraperitoneally. Streptozocin was administered after 15-20 minutes of administration of nicotinamide. After 72 hours of streptozotocin injection, fasting blood glucose level was determined and induction of diabetes was confirmed. The fasting blood samples were collected from all the groups on further days 7, 14, 21 and 28 day to determine the glucose level by glucometer. Results: The decline in fasting blood sugar level by voglibose was 36.4% on day 7, 40.2% on day 14, 43.94% on day 21 and 46.4% on day 28. The reduction in Fasting blood sugar level by vildagliptin was 49% on day 7, 52.25% on day 14 and 54% on day 21 and 28. Thus in group B rats, decline was maximal on day 7 and little fall was recorded on subsequent days. It suggests good efficacy as vildagliptin normalized the blood glucose level effectively.  Conclusions: Vildagliptin was found significantly more effective in lowering fasting blood glucose level than voglibose.

scholarly journals HUBUNGAN KADAR GULA DARAH PUASA DENGAN JUMLAH LEUKOSIT PADA PASIEN DIABETES MELLITUS DENGAN SEPSIS

2013 ◽  
Vol 1 (1) ◽  
Author(s):  
Siti Chodijah ◽  
Agung Nugroho ◽  
Karel Pandelaki
Keyword(s):  
Diabetes Mellitus ◽  
Metabolic Disease ◽  
Blood Sugar ◽  
Fasting Blood Sugar ◽  
Cross Sectional ◽  
Cross Sectional Design ◽  
The Moment

Abstrak: Diabetes mellitus merupakan suatu kelompok penyakit metabolik dengan karakteristik hiperglikemi yang terjadi karena kelainan sekresi insulin, kerja insulin, atau kedua-duanya. Meningkatnya kepekaan terhadap infeksi pada diabetes mellitus disebabkan oleh berbagai faktor (multifaktorial), baik yang disebabkan oleh hiperglikemia maupun gangguan imunitas. Penelitian ini merupakan penelitian deskriptif analitik dengan desain cross sectional, yang mengambil data pasien secara prospektif di ruang rawat inap bagian penyakit dalam Irina C1 sampai C4, IMC, instalasi gawat darurat medik RSUP Prof.Dr.R.D Kandou Manado pada bulan November sampai desember 2012. Subjek dalam penelitian berjumlah 27 orang. Pengukuran variabel kadar gula darah puasa dan kadar leukosit yang diambil dengan selang waktu 3 hari selama pasien di rawat dari pertama terdiagnosis DM dengan sepsis sampai pasien pulang atau sepsis sudah hilang. Berdasarkan analisis koefisien korelasi Pearson antara GDP dengan jumlah leukosit diperoleh r = -0,429 dengan p = 0,013.  Simpulan: Terdapat hubungan antara kadar gula darah puasa dengan jumlah leukosit  pada pasien DM dengan sepsis dengan bentuk hubungan linear negatif, yang artinya makin tinggi kadar gula darah puasa maka makin rendah kadar leukosit. Kata kunci: GDP, leuksoit, DM dengan sepsis.     Abstract: Diabetes is one of group metabolic disease with characteristic hyperglycemia that happends because insulin disfungtion. Increasing of sensitivity to inflammation of diabetes mellitus cause by many factors. Both caused by by hyperglycemia and immunity disfunction. This research is study with analytic descriptive with cross sectional design, that taking data with prospective at interna department Irina C1 to C4, IMC, Intensif unit care at RSUP Prof.Dr.R.D Kandou Manado in November to December 2012. Total subject in this research are 27 people. The measurement of fasting blood sugar and total leukocyte that taken with time a gap 3 days as long patient still in unit care from the moment patient diagnosed with DM with sepsis until patient charge go home. Basic on analytic correlation koefisien Pearson between GDP with total leukosit found r = - 0,429 with p = 0,013. Conclutions: There is relationship between fasting blood sugar with total leukocyte in patient DM with sepsis with form linear negative means more higher fasting blood sugar, more lower total leukocyte. Keywords: GDP, leukocyte, DM with sepsis.

scholarly journals Rekomendasi Peningkatan Pemanfaatan Posyandu Oleh Ibu Balita Berdasarkan Analisis Total Customer Sacrifices

2015 ◽  
Vol 3 (1) ◽  
pp. 50
Author(s):  
Nurul Hidayatul Mukaromah ◽  
Ratna Dwi Wulandari
Keyword(s):  
Random Sampling ◽  
Analytical Study ◽  
Sampling Method ◽  
Spearman Correlation ◽  
Cross Sectional ◽  
Under Five ◽  
Under Five Children ◽  
Spearman Correlation Test ◽  
Cross Sectional Design ◽  
The Sacrifice

ABSTRACT                The coverage of under-five children weighed is an indicator of community participation in Posyandu. During 2012 until 2014, Puskesmas Kenjeran had not reached the target of this indicator. The objective of this study is to arrange recommendations for Posyandu utilization improvement based on total customer sacrifice analysis. This was a quantitative analytical study with observational approach and cross sectional design. The sampling was calculated by using multistage random sampling method. The interviews through instrument were conducted to 112 respondents to obtain information on Posyandu utilization and respondents sacrifice required to utilize Posyandu. The results showed that respondents thought time was the greatest sacrifice among monetary, energy, and psychological sacrifices. Spearman correlation test on any sacrifice required showed significant correlation (p<0.05), except for monetary sacrifice.This study concluded that even total customer sacrifices was very small, but the huge expense of time spent still made respondents to be less likely to utilize Posyandu. Therefore, efforts are needed to reduce the magnitude of the sacrifice required by community utilizing Posyandu in Puskesmas Kenjeran area. Keywords: Posyandu utilization, total customer sacrifices, under-five children                    weighed

scholarly journals Hubungan Tingkat Kecemasan dengan Kesiapan Dokter Gigi dalam Menghadapi Pandemi Covid-19

e-GIGI ◽  
2021 ◽  
Vol 9 (2) ◽  
pp. 368
Author(s):  
Michelle Wilia ◽  
Mia A. Prasetya ◽  
Putri Rejeki
Keyword(s):  
Analytical Study ◽  
Health Workers ◽  
Demographic Data ◽  
P Value ◽  
Validity And Reliability ◽  
Cross Sectional ◽  
Respiratory Problems ◽  
Spearman Correlation Test ◽  
Cross Sectional Design ◽  
The Relationship

Abstract: Coronavirus disease 2019 (Covid-19) can cause respiratory problems and affect all ages. The nature of the transmission and the mortality rate of this viral infection bring about anxiety among health workers, inter alia, dentists because they have a high risk of contracting Covid-19. This study was aimed to determine the relationship between anxiety levels and the preparedness of dentists in facing the Covid-19 pandemic. This was an analytical study with a cross-sectional design. A quantitative study was conducted using a questionnaire that has been structured and tested for its validity and reliability. The questionnaire was divided into two parts, as follows: demographic data and levels of anxiety. Data were analyzed univariately and bivariately with the Spearman correlation test. There were 276 dentists in Bali as respondents who participated in this study. The results showed that the highest level of anxiety was moderate anxiety (54.3%) and there was a relationship between level of anxiety and the number of screening and patient settings with a p-value of 0.034 (p<0.05). In conclusion, there is a relationship between level of anxiety and the dentist's preparedness in the form of number of screening and patient setting to face the Covid-19 pandemic in Bali.Keywords: Covid-19; dentist; anxiety Abstrak: Coronavirus disease 2019 (Covid-19) dapat menyebabkan gangguan pernapasan dan menyerang segala rentang usia. Sifat transmisi dan tingkat mortalitas infeksi virus ini menye-babkan kecemasan di kalangan petugas kesehatan, salah satunya dokter gigi karena memiliki risiko tinggi tertular Covid-19. Penelitian ini bertujuan untuk mengetahui hubungan antara tingkat kecemasan dan kesiapan dokter gigi dalam menghadapi pandemi Covid-19 di Bali. Jenis penelitian ialah analitik dengan desain potong lintang. Penelitian kuantitatif dilakukan menggunakan kuesioner yang telah disusun dan diuji validitas dan reliabilitasnya. Kuesioner dibagi menjadi dua bagian yaitu data demografi dan tingkat kecemasan dokter gigi. Hasil data dianalisis secara univariat dan bivariat menggunakan uji korelasi Spearman. Terdapat 276 dokter gigi di Bali yang berpartisipasi dalam penelitian ini. Hasil penelitian menunjukkan bahwa tingkat kecemasan paling tinggi ialah kecemasan sedang (54.3%) dan terdapat hubungan antara tingkat kecemasan dengan jumlah skrining dan pengaturan pasien dalam menghadapi pandemi Covid-19 di Bali dengan p=0,034 (p<0,05). Simpulan penelitian ini ialah terdapat hubungan antara tingkat kecemasan dengan kesiapan dokter gigi yang dinyatakan dalam jumlah skrining dan pengaturan pasien dalam menghadapi pandemi Covid-19 di Bali.Kata kunci: Covid-19; dokter gigi; kecemasan

scholarly journals THE ASSOCIATION OF BODY MASS INDEX, BLOOD PRESSURE AND FASTING BLOOD SUGAR WITH GENDER IN THE UNITED NATIONS STAFF OF LIBERIA

2021 ◽  
Vol 71 (5) ◽  
pp. 1797-1800
Author(s):  
Muhammad Imran Ibrahim ◽  
Khalida Nasreen ◽  
Shaheen Kamal
Keyword(s):  
Blood Pressure ◽  
Body Mass Index ◽  
Blood Sugar ◽  
Body Mass ◽  
Fasting Blood Glucose ◽  
Cross Sectional Study ◽  
Fasting Blood Sugar ◽  
Cross Sectional ◽  
Level Ii ◽  
Significant Difference

Objective: To determine the association of body mass index, blood pressure and fasting blood sugar with the gender in the UN staff of Liberia. Study Design: Cross sectional study. Place and Duration of Study: Level-II Hospital Monrovia, Liberia, from May to Aug 2017. Methodology: This study was conducted in the United Nation staff of Liberia, at level-II Hospital, where, routine medical check was conducted and anthropometric measurements as well as blood pressure and fasting blood sugar values were noted. Body mass index, fasting blood sugar and blood pressure values were recorded and fasting blood sugar and blood pressure values were compared for its relationship with varying body mass index values. Result: Total 300 individuals were monitored, out of them 226 (75.3%) were males and 74 (24.7%) were females. Mean weight of males was found to be 81 ± 14.6 Kg and for females 72.5 ± 11.6 kg there was found statistically significant (p<0.001) in both male and female and There was no significant difference of gender with Fasting blood glucose (p=0.395), systolic blood pressure (p=0.281) and diastolic blood pressure (p=0.425). Conclusion: Significant association was seen between body mass index and blood pressure in both males and female as well as for fasting blood sugar in males. Hence, simple measurement of body mass index can be used as important health prognostic marker and thus can be used in regular routine medical assessment for maintaining and following healthy living.

scholarly journals Effect of Regular Khat Chewing on Serum Fasting Sugar Level in Diabetic patients versus Healthy Individuals; A comparative study

2021 ◽  
Vol 14 ◽  
pp. 117863882110352
Author(s):  
Yordanos Mengistu ◽  
Gobena Dedefo ◽  
Mesay Arkew ◽  
Gebeyehu Asefa ◽  
Gutema Jebessa ◽  
...  
Keyword(s):  
Risk Factors ◽  
Blood Glucose ◽  
Glycemic Control ◽  
Glucose Oxidase ◽  
Blood Sugar ◽  
Poor Glycemic Control ◽  
Fasting Blood Sugar ◽  
Healthy Individuals ◽  
Cross Sectional ◽  
Khat Chewer

Background: Khat chewing is a long standing social-cultural habit in several countries. Even though many people chew khat simply for its pleasurable and stimulatory effect, evidence showed widely-held belief among khat chewers in Ethiopia and other part of the world that khat helps to lower blood glucose while some studies are contradicted on the effect of khat. There is limited data about khat’s effect on blood glucose especially in our setting, Harar estern Ethiopia. Objective: Primarily the present study aims to compare fasting blood sugar level among khat chewer diabetic and healthy individuals, and to asses risk factors associated with poor glycemic control in diabetic subjects. Method: A cross-sectional study included 200 confirmed diabetic and healthy subjects. Fasting blood sugar was determined by enzymatic method glucose oxidase and glucose hexokinase. Glycemic control was also determined for diabetic subjects based on the last 2-month diabetic clinic visits and current measurement. Result: (Median ± IQR [interquartile range]) fasting blood sugar difference among Khat chewer and non khat chewer were 159 ± 83 mg/dl and 202 ± 79 mg/dl respectively in diabetic subjects when tested by glucose oxidase. Similarly, in healthy non khat chewer and khat chewer, khat chewers has lower (Median ± IQR) fasting blood glucose level 82 ± 18 mg/dl than non khat chewers 94 ± 13 mg/dl when tested by glucose oxidase. Regarding risk factors associated with poor glycemic control in diabetic subjects, positive parental diabetes history, insulin medication, being overweight, obese were significantly associated with poor glycemic control. Conclusion: There was significant effect of khat on median FBS among khat chewers in diabetic and healthy individuals. And the proportion of glycemic control was high among diabetic subjects. Recommendation: Health care professional and patients should manage the risk factors to delay disease progression and restrain the damage. More studies should be conducted in randomized control trial manner to further elucidate khat effect on blood sugar level so that the actual effect of khat can be identified unlike in cross sectional where there may not be strong causal relationship.

scholarly journals Effect of nicorandil, on blood glucose level in alloxan induced diabetic rats and its pharmacodynamic interaction with glibenclamide

2018 ◽  
Vol 7 (12) ◽  
pp. 2378
Author(s):  
Soni .
Keyword(s):  
Blood Glucose ◽  
Blood Glucose Level ◽  
Potassium Channel ◽  
Blood Sugar ◽  
Glucose Level ◽  
Blood Sugar Level ◽  
Diabetic Rats ◽  
Fasting Blood Sugar ◽  
Potassium Channel Opener ◽  
Pharmacodynamic Interaction

Background: Diabetes increases the risk of macrovascular complications and is often associated with angina in patient. Currently nicorandil, a potassium channel opener is being frequently used for the prevention and long-term treatment of angina pectoris. Glibenclamide exerts its antidiabetic action by closing the ATP sensitive potassium channels. Simultaneous use of nicorandil may antagonizes this action and may worsens the existing diabetes. To evaluate the pharmacodynamic interaction present study has been taken to study the effect of Nicorandil, a potassium channel opener on blood glucose level of alloxan induced diabetic rats and its pharmacodynamics interaction with Glibenclamide.Methods: Albino rats, weighing 150-200gm of male sex were used for the study. Diabetes was induced by injecting alloxan monohydrate 2% solution intra peritoneally in a dose of 150mg/kg body weight. Animal with Fasting Blood Sugar level between 250-300g/dl was selected for study and they were divided into 4 groups of 5 animals each. Group I- serving as control received 0.5ml normal saline orally for 28 days. Group II was given glibenclamide (0.5mg/kg body wt) for 28 days. Group III was treated orally with nicorandil (0.3mg/kg body wt) for 28 days. Group IV was given glibenclamide (0.5mg/kg) and nicorandil (0.3mg/kg) for 28 days. Fasting Blood Sugar level was recorded in all rats on 1st,3rd,7th,14th,21st and 28th day of the treatments.Results: results showed that glibenclamide significantly reduce blood sugar level (p <0.05) Wherase nicorandil showed rise in blood glucose level (p <0.05) While the combination (glibenclamide + nicorandil) showed rise in blood glucose (p <0.05) overall.Conclusions: Nicorandil worsen the existing diabetes and to be avoided or replaced with alternative drug in case of diabetes being treated with sulfonyl urease group of drugs.

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