scholarly journals Effect of nicorandil, on blood glucose level in alloxan induced diabetic rats and its pharmacodynamic interaction with glibenclamide

2018 ◽  
Vol 7 (12) ◽  
pp. 2378
Author(s):  
Soni .
Keyword(s):  
Blood Glucose ◽  
Blood Glucose Level ◽  
Potassium Channel ◽  
Blood Sugar ◽  
Glucose Level ◽  
Blood Sugar Level ◽  
Diabetic Rats ◽  
Fasting Blood Sugar ◽  
Potassium Channel Opener ◽  
Pharmacodynamic Interaction

Background: Diabetes increases the risk of macrovascular complications and is often associated with angina in patient. Currently nicorandil, a potassium channel opener is being frequently used for the prevention and long-term treatment of angina pectoris. Glibenclamide exerts its antidiabetic action by closing the ATP sensitive potassium channels. Simultaneous use of nicorandil may antagonizes this action and may worsens the existing diabetes. To evaluate the pharmacodynamic interaction present study has been taken to study the effect of Nicorandil, a potassium channel opener on blood glucose level of alloxan induced diabetic rats and its pharmacodynamics interaction with Glibenclamide.Methods: Albino rats, weighing 150-200gm of male sex were used for the study. Diabetes was induced by injecting alloxan monohydrate 2% solution intra peritoneally in a dose of 150mg/kg body weight. Animal with Fasting Blood Sugar level between 250-300g/dl was selected for study and they were divided into 4 groups of 5 animals each. Group I- serving as control received 0.5ml normal saline orally for 28 days. Group II was given glibenclamide (0.5mg/kg body wt) for 28 days. Group III was treated orally with nicorandil (0.3mg/kg body wt) for 28 days. Group IV was given glibenclamide (0.5mg/kg) and nicorandil (0.3mg/kg) for 28 days. Fasting Blood Sugar level was recorded in all rats on 1st,3rd,7th,14th,21st and 28th day of the treatments.Results: results showed that glibenclamide significantly reduce blood sugar level (p <0.05) Wherase nicorandil showed rise in blood glucose level (p <0.05) While the combination (glibenclamide + nicorandil) showed rise in blood glucose (p <0.05) overall.Conclusions: Nicorandil worsen the existing diabetes and to be avoided or replaced with alternative drug in case of diabetes being treated with sulfonyl urease group of drugs.

scholarly journals Comparative study of hypoglycemic effects of oral vildagliptin and voglibose on fasting blood sugar level in albino rats

2021 ◽  
Vol 9 (2) ◽  
pp. 542
Author(s):  
Mukesh Kumar ◽  
Mukesh Kumar ◽  
Akash Chandra ◽  
Uma Shankar Prasad Keshri ◽  
Rajiv Kumar
Keyword(s):  
Body Weight ◽  
Blood Glucose ◽  
Blood Glucose Level ◽  
Blood Sugar ◽  
Glucose Level ◽  
Blood Sugar Level ◽  
Fasting Blood Glucose ◽  
Fasting Blood Sugar ◽  
Group A ◽  
Group B

Background: Diabetes mellitus is a metabolic disorder in which there is increased blood sugar level, glycosuria, dyslipidemia and sometimes ketonemia occurs. Increased blood sugar level leads to characteristic symptoms such as polydipsia, polyurea, blurring of vision, polyphagia and weight loss.Methods: Healthy male Wister rats weighing between 150-250 gm were taken. Total 2 groups A and B were prepared and each group contains 6 animals. Group A was administered voglibose as 0.6 mg/70 kg body weight. Group B was administered vildagliptin as 100 mg/70 kg body weight. Diabetes was induced in group A and B by administration of 120 mg/kg body weight of nicotinamide and 60 mg/kg body weight of streptozocin intraperitoneally. Streptozocin was administered after 15-20 minutes of administration of nicotinamide. After 72 hours of streptozotocin injection, fasting blood glucose level was determined and induction of diabetes was confirmed. The fasting blood samples were collected from all the groups on further days 7, 14, 21 and 28 day to determine the glucose level by glucometer. Results: The decline in fasting blood sugar level by voglibose was 36.4% on day 7, 40.2% on day 14, 43.94% on day 21 and 46.4% on day 28. The reduction in Fasting blood sugar level by vildagliptin was 49% on day 7, 52.25% on day 14 and 54% on day 21 and 28. Thus in group B rats, decline was maximal on day 7 and little fall was recorded on subsequent days. It suggests good efficacy as vildagliptin normalized the blood glucose level effectively.  Conclusions: Vildagliptin was found significantly more effective in lowering fasting blood glucose level than voglibose.

scholarly journals Comparison between the QRMA Measurement with the Anamnesis and the Capillary Blood Glucose Test

Jurnal NERS ◽  
2020 ◽  
Vol 14 (2) ◽  
pp. 224
Author(s):  
Muflih Muflih ◽  
Suwarsi Suwarsi ◽  
Fajarina Lathu Asmarani
Keyword(s):  
Blood Glucose ◽  
Blood Glucose Level ◽  
Blood Sugar ◽  
Glucose Level ◽  
Blood Sugar Level ◽  
Capillary Blood ◽  
Capillary Blood Glucose ◽  
Blood Glucose Test ◽  
Significant Difference ◽  
Glucose Test

ABSTRACTIntroduction: The examination of patients with diabetes mellitus (DM) can be done by reviewing their complaints and through a capillary blood glucose level test to determine the value of their Random Blood Glucose Level. QRMA (Quantum Resonance Magnetic Analyzer) is claimed to be able to check the patient’s bodily condition (including blood glucose) with an accuracy of 85%. The purpose of this study was to verify the validity of the QRMA tool and its accuracy by comparing the results of the anamnesis and the examination conducted using the capillary blood glucose test method.Methods: The research method used was a cross-sectional design. The total sample consisted of 44 respondents in the working area of the Community Health Centers in Yogyakarta with the risk factor being blood sugar level instability. The sampling technique used was purposive sampling. The main variable in this study was the value of the blood sugar level measured based on the coefficient value of the QRMA tool and the value of Random Blood Glucose obtained through the capillary blood glucose test.Results: The blood glucose value was not correlated significantly with the coefficient value of QRMA. The value of blood glucose when examined alongside the result of the respondent's anamnesis showed there to be a significant difference. The value of the QRMA coefficient when examined against the results from the history of the respondents showed no significant difference. Linear regression showed that the variables of height, body weight, and IMT had a correlation with the QRMA coefficient value.Conclusion: The QRMA tool was not able to provide a picture of the actual condition of the blood glucose level of the respondents when compared with the results of the anamnesis and the blood glucose value from the capillary blood glucose test. Non-invasive health measurement devices such as QRMA are not used by nurses as a standard for determining the health status of DM patients.

scholarly journals Association of Chicken Likeness with Blood Glucose Level

2019 ◽  
Vol 4 (1) ◽  
Keyword(s):  
Blood Glucose ◽  
Blood Glucose Level ◽  
Blood Sugar ◽  
Glucose Level ◽  
Blood Sugar Level ◽  
Homo Sapiens

The target of the existing study was to relate chicken likeness with blood glucose level. Blood glucose level or blood sugar level or blood sugar level concentration is the level of the glucose existing in the blood of homo sapiens and mammals. Sum total of 100 students participate in the current research. We made a question sheet and got access to the blood sugar level of the participants. The participants were the students of Bahauddin Zakariya University, Multan, Pakistan. At the end we concluded that there is no relation between chicken likeness and blood sugar level.

scholarly journals Assessment of Inter-Connection between Suriphobia and Individual’s Blood Glucose Level: A Questionnaire Centred Project

2019 ◽  
Vol 4 (1) ◽  
Keyword(s):  
Blood Glucose ◽  
Blood Glucose Level ◽  
Blood Sugar ◽  
Glucose Level ◽  
Blood Sugar Level ◽  
Sugar Content ◽  
P Value ◽  
Sample Population ◽  
Elevated Blood Glucose Level ◽  
Total Glucose

Blood sugar level is actually the estimation of the total glucose sugar content in the one’s blood. Insulin and Glucagon are the two key hormones responsible for maintaining homeostasis which sustain blood glucose level. Hypoglycemia and Hyperglycemia are the two conditions associated with blood sugar level. In case of hypoglycemia, blood glucose level falls below the normal level of glucose in the blood while hyperglycemia is the condition of elevated blood glucose level than the normal range. Different tests are available to test the blood glucose level of an individual. The central objective of this project was to assess the inter-connection between one’s being suriphobic and their blood sugar level at fasting. Phobia is a word associated with the condition of extreme fear from a series of specified events. Suriphobia or mice fear is the term used for those individuals who extremely fear from mice, rats, rodents etc. This study was a questionnaire based project to assess the fact that if there is any inter-connection between people’s being suriphobic and their blood glucose level at fasting. For this purpose blood sugar level of the sample population was calculated using Glucometer. Statistical Analysis point towards the significant results if this study as the calculated p-value was exact of the standard p¬-value which is p ≤ 0.05. Therefore, the fact that there is a significant relation between individual’s being Suriphobe and their Blood Glucose Level at fasting is proved.

The Effectiveness of the “Panjang” Poffertjes Consumption on Blood Glucose Level

2021 ◽  
Vol 17 ◽  
Author(s):  
Sofyawati D. Talibo ◽  
Imran Tumenggung ◽  
Fatmayanti Nawai ◽  
Rahma Labatjo
Keyword(s):  
Blood Glucose ◽  
Blood Glucose Level ◽  
Blood Sugar ◽  
Glucose Level ◽  
Glycemic Index ◽  
Blood Sugar Level ◽  
Sweet Corn ◽  
Glycemic Load ◽  
Postprandial Blood Glucose ◽  
A Value

Background: Fragrant pandan leaf extract (Pandanus amayllifolius Roxb.) has pharmacological activity as an anti-diabetes, while sweet corn is believed to be a staple food or snack for people with diabetes mellitus. Thus, the foods could be used as an alternative to anti-diabetic functional food. Objective: This study aims to investigate the effectiveness of “Panjang” poffertjes consumption with the addition of pandan leaves extract and sweet corn on the blood glucose level. Methods: This study employs a randomized controlled trial approach with the pre-and post-test design. The data collected on the value of the glycemic index, glycemic load, and the results of 2 hours postprandial (pp) blood sugar level examination after consuming two Poffertjes formulas. The glycemic index (GI) was calculated by employing incremental area under the blood glucose response curve method for ten subjects and a 2-hour postprandial (pp) blood sugar level examination in 25 subjects with the range age between 18-24 years, with normal nutritional status (BMI = 18.58-23.88), 100% had no history of diabetes, did not smoke or alcohol and were not allergic to the tested food ingredients. Results: The results show that the glycemic index of control Poffertjes obtained a value of 71.88 (high category), and “Panjang” Poffertjes got 52.82 (low category). The glycemic load of control Poffertjes obtained a value of 12.78 (medium category), while “Panjang” Poffertjes attained a value of 6.37 (low category). The difference in the average reduction in blood glucose with the intervention poffertjes was 11.08 mg/dl. Conclusion: The provision of “Panjang” poffertjes has a significant effect on the decrease in two-hour postprandial blood glucose level.

scholarly journals Effect of amlodipine on blood glucose level in euglycemic and streptozotocin induced diabetic Albino rats and its pharmacodynamic interaction with glibenclamide

2017 ◽  
Vol 6 (7) ◽  
pp. 1650
Author(s):  
Manju Gari ◽  
Rati Ranjan Debbarma ◽  
Lakhan Majhee ◽  
Subhankar Choudhury
Keyword(s):  
Blood Glucose ◽  
Blood Glucose Level ◽  
Glucose Level ◽  
Fasting Blood Glucose ◽  
Diabetic Rats ◽  
Significant Rise ◽  
Albino Rats ◽  
P Value ◽  
Pharmacodynamic Interaction ◽  
Gum Acacia

Background: Diabetes is one of the largest global health emergencies of the 21st century and its co-existence with hypertension is frequent. These conditions often require polypharmacy with possible risk of drug interaction. This study is conducted to investigate the effect of amlodipine on blood glucose level in euglycemic and diabetic rats and its pharmacodynamic interaction with glibenclamide.Methods: Rats were divided into six groups of 6 rats in each group. Group 1 and 3 were non-diabetic given 1% Gum acacia and amlodipine respectively. Group 2, 4, 5 and 6 were made diabetic by using nicotinamide and streptozotocin injection intra peritoneally and given 1% Gum acacia, glibenclamide, amlodipine and amlodipine + glibenclamide respectively for the period of 28 days. Fasting Blood Glucose (FBG) levels were measured before induction of diabetes, 72 hrs after the induction, on day 0, 7th, 14th, 21st and 28th day.Results: Amlodipine produced no significant effect on FBG level in non-diabetic rats but in diabetic rats statistically significant hyperglycemia were observed on day 21st and 28th of study with the ‘p’ value (<0.05). Glibenclamide treated rats shows better controlled FBG level throughout study than concomitant administration of glibenclamide with amlodipine. Significant rise in blood FBG level with ‘P’ value (<0.05) were observed in amlodipine + glibenclamide treated group on 21st and 28th day of study.Conclusions: This study suggest amlodipine produce no effect on the FBG level of normal rats but causes significant hyperglycemia in diabetic rats. Hypoglycemic effect of glibenclamide gets blunted when co-administered with amlodipine.

PENGENDALIAN KADAR GLUKOSA DARAH OLEH TEH HIJAU DAN ATAU TEH DAUN MURBEI PADA TIKUS DIABETES

2010 ◽  
Vol 5 (2) ◽  
pp. 87
Author(s):  
Rusman Efendi ◽  
Evy Damayanthi ◽  
Lilik Kustiyah ◽  
Nastiti Kusumorini
Keyword(s):  
Blood Glucose ◽  
Blood Glucose Level ◽  
Green Tea ◽  
Glucose Level ◽  
Diabetic Rats ◽  
Feed Consumption ◽  
Font Size ◽  
High Prevalence ◽  
The Difference ◽  
Control Diabetes

<p class="MsoNormal" style="margin: 0cm 7.1pt 6pt 14.2pt; text-align: justify; text-indent: 1cm;"><span style="font-size: 10pt;">Diabetes mellitus is degeneratif disease with high prevalence that happens in many countries. Several studies had been done to control diabetes by using green tea, mullberry leaf  tea, and their mixture. The aim of this research was to analyze the influence of the administration green tea, mullbery leaf tea, and their mixtures to blood glucose level of diabetic rats both during 120 minutes after administration. This research had four phases, first to determine the best mullberry leaf tea, second to fourth phases respectively, determine turnover of blood glucose level on normal rats; attempt during 120 minutes on diabetic rats.  The result of research during 120 minutes have showed that blood glucose level on diabetic rats which were administered by green tea, mullberry leaf tea and their mixture is significantly difference with diabetic rats which were administered by water. Blood glucose level at baseline increased at 30<sup>th </sup>minutes and showed the difference significantly and then until 60<sup>th</sup> and 120<sup>th</sup> minutes and relatively stable. During 120 minutes after feed consumption, inhibition of blood glucose level occured increasingly on diabetic rats which were administered by green tea, mullberry leaf tea, and their mixture compared to diabetic rats which were administered by water.</span></p>

Anti-diabetic activity of diphenhydramine in diabetic rats

2020 ◽  
Vol 11 (4) ◽  
pp. 5067-5070
Author(s):  
Pang Jyh Chayng ◽  
Nurul Ain ◽  
Kaswandi Md Ambia ◽  
Rahim Md Noah
Keyword(s):  
Blood Glucose ◽  
Blood Glucose Level ◽  
Glucose Level ◽  
Fasting Blood Glucose ◽  
Insulin Level ◽  
Diabetic Rats ◽  
Group Iv ◽  
Diabetic Rat ◽  
Control Group ◽  
Group I

The purpose of this project is to study the anti-diabetic effect of on a diabetic rat model. A total of Twenty male Sprague rats were used and it randomly distributed into four groups which are Group I: , Group II: negative control, Group III: and Group IV: and . In diabetic model were induced with via injection at the dosage of 65mg/kg. and FBG (Fasting Blood Glucose) level of diabetic rats were assessed every three days. Blood was collected via cardiac puncture at day 21 after the induction of treatment. Insulin level of the rats was assessed with the Mercodia Rat Insulin ELISA kit. FBG level of group I (12.16 ±3.96, p&lt;0.05) and group IV (11.34 ±3.67, p&lt;0.05) were significantly decreased. Meanwhile, the for all rats did not show any significant increase. However, the insulin level was escalated in group IV (0.74+0.25, p&lt;0.05) significantly. The present study shows that the and the combination of and lowered blood glucose level and enhanced insulin secretion.

scholarly journals Hypoglycemic and antioxidative activities of ethanol seed extract of Hunteria umbellate (Hallier F.) on streptozotocin-induced diabetic rats

2021 ◽  
Vol 7 (1) ◽  
Author(s):  
Olubanke O. Ogunlana ◽  
Babatunde O. Adetuyi ◽  
Miracle Rotimi ◽  
lohor Esalomi ◽  
Alaba Adeyemi ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Blood Glucose ◽  
Blood Glucose Level ◽  
Glucose Level ◽  
Fasting Blood Glucose ◽  
Diabetic Rats ◽  
Seed Extract ◽  
The Body ◽  
High Concentration ◽  
Group 5

Abstract Background Diabetes, a global cause of mortality in developing countries is a chronic disorder affecting the metabolism of macromolecules and has been attributed to the defective production and action of insulin characterized by persistent hyperglycemic properties. This global disorder harms organs of the body such as the liver, kidney and spleen. Medicinal plants such as Hunteria umbellate have been shown to possess hypoglycemic, antioxidative and anti-diabetic properties owing to the high concentration of active phytochemical constituents like flavonoids and alkaloids. The present study seeks to evaluate the hypoglycemic activities of ethanolic seed extract of Hunteria umbellate on streptozotocin-induced diabetes rats. Methods Thirty (30) female experimental rats were randomly divided into five groups with six rats per group and were administered streptozotocin (STZ) and Hunteria umbellate as follows. Group 1 served as control and was given only distilled water, group 2 rats were administered 60 mg/kg STZ; Group 3 was administered 60 mg/kg STZ and 100 mg/kg metformin; group 4 rats were administered 60 mg/kg STZ and 800 mg/kg Hunteria umbellate, group 5 rats 60 mg/kg STZ and 400 mg/kg Hunteria umbellate. The fasting blood glucose level of each rat was measured before sacrifice. Rats were then sacrificed 24 h after the last dose of treatment. Results The results showed that Hunteria umbellate significantly reversed STZ-induced increase in fasting blood glucose and increase in body and organs weight of rats. Hunteria umbellate significantly reversed STZ-induced decrease in antioxidant enzyme in liver, kidney and spleen of rats. Hunteria umbellate significantly reversed STZ-induced increase in oxidative stress markers in liver, kidney and spleen of rats. Conclusion Collectively, our results provide convincing information that inhibition of oxidative stress and regulation of blood glucose level are major mechanisms through which Hunteria umbellate protects against streptozotocin-induced diabketes rats.

scholarly journals Treatment of Diabetic Condition in Streptozotocin Induced Diabetic Wister Rats Using Food Blends Such as Unripe Plantain, Soybean and Ginger

2019 ◽  
pp. 1-12
Author(s):  
I. Iwanegbe ◽  
M. Suleiman ◽  
A. Jimah
Keyword(s):  
Body Weight ◽  
Blood Glucose ◽  
Blood Glucose Level ◽  
Lipid Profile ◽  
Cell Volume ◽  
Glucose Level ◽  
Normal Control ◽  
Packed Cell Volume ◽  
Diabetic Rats ◽  
Diabetic Patients

Aims: To investigate the effect of food blends (plantain, soybean and ginger) on the blood glucose, lipid profile and haematological indices on streptozotocin induced diabetic rats. Methodology: A total of 35 rats of mean body weight 219.07 g separated into7 groups (5 per group) where induced by a single intraperitoneal (I.P) injection of streptozotocin (0.1 g dissolved in 5 ml of freshly prepared sodium citrate buffer 0.1 M, pH 4.5) at a dose of 40 mg/kg body weight after fasting for 12 hours and fed with flours/blends. The flours were produced from plant materials for different treatments/blends (blend A=100% unripe plantain, B=80% unripe plantain, 14% soybean, 6% ginger, C=70% unripe plantain, 26% soybean, 4% ginger, D= 60% unripe plantain, 38% soybean, 2% ginger, E= 50% unripe plantain, 50% soybean) and the phytochemicals and minerals content were determined. Blood glucose was determined at 5 days interval for 25 days. Diabetes was confirmed in rats with blood glucose concentrations >200 mg/dl. After 25 days rats were anaesthetized with chloroform vapour and blood samples collected by cardiac puncture for haematology and lipid profile determination. Results: The results showed that unripe plantain, soya beans and ginger in adequate proportion(C=70% unripe plantain, 26% soybean, 4% ginger or D= 60% unripe plantain, 38% soybean, 2% ginger) could help to reduce blood glucose, improve haematological parameters and lipid profile. Significant reduction was observed in the blood glucose level of rats fed blends C and D from 286 to 85 mg/dl and 307 to 90 mg/dl respectively at the end of experiment. These results also demonstrated that the inclusion of ginger at 6% causes rise in blood glucose level. Total cholesterol (TC) increased in all the blends. However, the lowest concentration of TC was observed in blends C and D. The highest packed cell volume (60%) and Haemoglobin (20 g/dl) level observed in rats fed blend C was significantly higher than the normal control fed conventional feeds. The increase in packed cell volume (PCV) (50%) and Hb (17 g/dl) in diabetic rats demonstrated that the formulated blend C was able to raise PCV and Hb above 50% and 17 g/dl (Normal control NC) respectively. Significant increase (P<0.05) in low density lipoprotein cholesterol (LDLc) was also observed in all the blends with blend C having the least (4.0 mg/dl) close to NC (2.0 mg/dl). Conclusion: From the results it is evident that blend C will manage and improve the health status of diabetic patients.

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