scholarly journals Therapeutic tumor vaccines — a rising star to benefit cancer patients

2021 ◽  
Vol 2 (3) ◽  
pp. 25-41
Author(s):  
Qian Wei ◽  
Zhao-Yuan Fang ◽  
Zi-Meng Zhang ◽  
Teng-Fei Zhang
Keyword(s):  
Cancer Patients ◽  
Tumor Vaccines

scholarly journals Tumor-ActivatedTCRγδ+T Cells from Gastric Cancer Patients Induce the Antitumor Immune Response ofTCRαβ+T Cells via Their Antigen-Presenting Cell-Like Effects

2014 ◽  
Vol 2014 ◽  
pp. 1-10 ◽  
Author(s):  
Chaoming Mao ◽  
Xiao Mou ◽  
Yuepeng Zhou ◽  
Guoyue Yuan ◽  
Chengcheng Xu ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
T Cells ◽  
Cancer Patients ◽  
Treg Cells ◽  
Vital Role ◽  
Tumor Vaccines ◽  
Principal Characteristics ◽  
Proliferation And Differentiation ◽  
Gastric Cancer Patients ◽  
Antigen Presenting

HumanγδT cells display the principal characteristics of professional antigen-presenting cells (APCs), in addition to playing a vital role in immunity through cytokine secretion and their cytotoxic activity. However, it is not clear whetherγδT cells perform APC-like functions under pathological conditions. In this study, we showed that, in contrast to peripheral-derivedγδT cells directly isolated from PBMCs of gastric cancer patients, tumor-activatedγδT cells not only killed tumor cells efficiently but also strongly induced primary CD4+and CD8+  αβT cells proliferation and differentiation. More importantly, they abrogated the immunosuppression induced by CD4+CD25+Treg cells and induced the cytotoxic function of CD8+  αβT cells from patients with gastric cancer. In conclusion, tumor-activatedγδT cells can induce adaptive immune responses through their APC-like functions, and these cells may be a potentially useful tool in the development of tumor vaccines and immunotherapy.

scholarly journals A Novel Anti-PD-L1 Vaccine for Cancer Immunotherapy and Immunoprevention

Cancers ◽  
2019 ◽  
Vol 11 (12) ◽  
pp. 1909 ◽  
Author(s):  
Jie Chen ◽  
Hui Liu ◽  
Tiffany Jehng ◽  
Yanqing Li ◽  
Zhoushi Chen ◽  
...  
Keyword(s):  
T Cell ◽  
Immune Responses ◽  
Cancer Patients ◽  
Tumor Cells ◽  
Tumor Regression ◽  
Critical Role ◽  
T Cell Responses ◽  
The United States ◽  
Tumor Vaccines ◽  
Cell Responses

Dendritic cells (DCs) are potent antigen-presenting cells that play a critical role in activating cellular and humoral immune responses. DC-based tumor vaccines targeting tumor-associated antigens (TAAs) have been extensively tested and demonstrated to be safe and potent in inducing anti-TAA immune responses in cancer patients. Sipuleucel-T (Provenge), a cancer vaccine of autologous DCs loaded with TAA, was approved by the United States Food and Drug Administration (FDA) for the treatment of castration-resistant prostate cancer. Sipuleucel-T prolongs patient survival, but has little or no effect on clinical disease progression or biomarker kinetics. Due to the overall limited clinical efficacy of tumor vaccines, there is a need to enhance their potency. PD-L1 is a key immune checkpoint molecule and is frequently overexpressed on tumor cells to evade antitumor immune destruction. Repeated administrations of PD-L1 or PD-1 antibodies have induced sustained tumor regression in a fraction of cancer patients. In this study, we tested whether vaccinations with DCs, loaded with a PD-L1 immunogen (PDL1-Vax), are able to induce anti-PD-L1 immune responses. We found that DCs loaded with PDL1-Vax induced anti-PD-L1 antibody and T cell responses in immunized mice and that PD-L1-specific CTLs had cytolytic activities against PD-L1+ tumor cells. We demonstrated that vaccination with PDL1-Vax DCs potently inhibited the growth of PD-L1+ tumor cells. In summary, this study demonstrates for the first time the principle and feasibility of DC vaccination (PDL1-Vax) to actively induce anti-PD-L1 antibody and T cell responses capable of inhibiting PD-L1+ tumor growth. This novel anti-PD-L1 vaccination strategy could be used for cancer treatment and prevention.

MONITORING IMMUNE RESPONSES IN CANCER PATIENTS RECEIVING TUMOR VACCINES

2003 ◽  
Vol 22 (3-4) ◽  
pp. 283-319 ◽  
Author(s):  
EDWIN B. WALKER ◽  
MARY L. (NORA) DISIS
Keyword(s):  
Immune Responses ◽  
Cancer Patients ◽  
Tumor Vaccines

Evaluating the effect of a group pre-treatment chemotherapy psycho-education session for chemotherapy-naive gynecologic cancer patients and their caregivers

2021 ◽  
Vol 160 (1) ◽  
pp. 234-243
Author(s):  
Diana Samoil ◽  
Nazek Abdelmutti ◽  
Lisa Ould Gallagher ◽  
Nazlin Jivraj ◽  
Naa Kwarley Quartey ◽  
...  
Keyword(s):  
Cancer Patients ◽  
Gynecologic Cancer ◽  
Education Session ◽  
Pre Treatment

895: Proteomic Analysis of Sera from Bladder Cancer Patients with MALDI-TOF-MS

2007 ◽  
Vol 177 (4S) ◽  
pp. 297-297
Author(s):  
Kristina Schwamborn ◽  
Rene Krieg ◽  
Ruth Knüchel-Clarke ◽  
Joachim Grosse ◽  
Gerhard Jakse
Keyword(s):  
Bladder Cancer ◽  
Cancer Patients ◽  
Proteomic Analysis ◽  
Maldi Tof Ms ◽  
Maldi Tof ◽  
Tof Ms

390: Durable Cancer Control in High Risk Prostate Cancer Patients Treated with Radical Prostatectomy

2007 ◽  
Vol 177 (4S) ◽  
pp. 130-130
Author(s):  
Markus Graefen ◽  
Jochen Walz ◽  
Andrea Gallina ◽  
Felix K.-H. Chun ◽  
Alwyn M. Reuther ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
High Risk ◽  
Radical Prostatectomy ◽  
Cancer Patients ◽  
Cancer Control ◽  
High Risk Prostate Cancer ◽  
Risk Prostate Cancer

598: Increased Risk of Newly Diagnosed Comorbidities in Prostate Cancer Patients Treated with Androgen Deprivation Therapy

2007 ◽  
Vol 177 (4S) ◽  
pp. 200-200 ◽  
Author(s):  
Andrea Gallina ◽  
Pierre I. Karakiewicz ◽  
Jochen Walz ◽  
Claudio Jeldres ◽  
Quoc-Dien Trinh ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Cancer Patients ◽  
Androgen Deprivation Therapy ◽  
Androgen Deprivation ◽  
Newly Diagnosed ◽  
Increased Risk

289: Assessment of Indirect Costs of Newly Diagnosed Prostate Cancer Patients

2007 ◽  
Vol 177 (4S) ◽  
pp. 97-97
Author(s):  
Ravishankar Jayavedappa ◽  
Sumedha Chhatre ◽  
Richard Whittington ◽  
Alan J. Wein ◽  
S. Bruce Malkowicz
Keyword(s):  
Prostate Cancer ◽  
Cancer Patients ◽  
Indirect Costs ◽  
Newly Diagnosed
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